The network for 'cellular response to oxygen radical' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to oxygen radical

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion.

Homo sapiens
Name Description Probability Func Analog Organism
PRDX1 peroxiredoxin 1 0.982
TXN thioredoxin 0.982
PRDX4 peroxiredoxin 4 0.969
SOD1 superoxide dismutase 1, soluble 0.923
PARK7 Parkinson disease (autosomal recessive, early onset) 7 0.712
TTR transthyretin 0.560
CD320 CD320 molecule 0.389
PDZD11 PDZ domain containing 11 0.286
PRDX6 peroxiredoxin 6 0.272
KEAP1 kelch-like ECH-associated protein 1 0.242
LCAT lecithin-cholesterol acyltransferase 0.129
ALB albumin 0.114
PRDX3 peroxiredoxin 3 0.089
PRDX2 peroxiredoxin 2 0.086
MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 0.083
PGK1 phosphoglycerate kinase 1 0.058
LOXL1 lysyl oxidase-like 1 0.056
APOC3 apolipoprotein C-III 0.054
HP haptoglobin 0.045
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.036
HSPA8 heat shock 70kDa protein 8 0.031
PIR pirin (iron-binding nuclear protein) 0.026
DUSP23 dual specificity phosphatase 23 0.022
BAD BCL2-associated agonist of cell death 0.020
FGA fibrinogen alpha chain 0.019
DAD1 defender against cell death 1 0.019
LTBP2 latent transforming growth factor beta binding protein 2 0.018
NAMPT nicotinamide phosphoribosyltransferase 0.017
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 0.017
PEBP1 phosphatidylethanolamine binding protein 1 0.015
NOG noggin 0.015
ING1 inhibitor of growth family, member 1 0.015
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.013
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.013
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 0.012
TBXA2R thromboxane A2 receptor 0.012
APLF aprataxin and PNKP like factor 0.012
PLSCR1 phospholipid scramblase 1 0.012
APOC1 apolipoprotein C-I 0.011
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 0.011
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
sod1 superoxide dismutase 1, soluble 0.507
sod2 superoxide dismutase 2, mitochondrial 0.494
gstp1 glutathione S-transferase pi 0.330
cmyb transcription factor cmyb 0.298
zgc:64133 zgc:64133 0.266
zgc:112056 zgc:112056 0.194
acadm acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain 0.155
mif macrophage migration inhibitory factor 0.140
park7 parkinson disease (autosomal recessive, early onset) 7 0.126
esd esterase D/formylglutathione hydrolase 0.090
lyz lysozyme 0.088
cbr1l carbonyl reductase 1-like 0.083
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.078
csf1ra colony stimulating factor 1 receptor, a 0.070
zgc:73293 zgc:73293 0.052
nme2b.1 non-metastatic cells 2b.1, protein (NM23B) expressed in 0.048
acadl acyl-Coenzyme A dehydrogenase, long chain 0.047
aldh7a1 aldehyde dehydrogenase 7 family, member A1 0.045
ahcy S-adenosylhomocysteine hydrolase 0.042
cat catalase 0.042
cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 0.042
gstt1b glutathione S-transferase theta 1b 0.038
xylt1 xylosyltransferase 1 0.036
got2a glutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2) 0.032
zgc:113210 zgc:113210 0.031
prdx2 peroxiredoxin 2 0.030
acox1 acyl-Coenzyme A oxidase 1, palmitoyl 0.025
rpz rapunzel 0.025
cpt2 carnitine palmitoyltransferase II 0.025
zgc:110256 zgc:110256 0.024
ivd isovaleryl Coenzyme A dehydrogenase 0.023
ldhba lactate dehydrogenase Ba 0.022
brca2 breast cancer 2, early onset 0.021
gja3 gap junction protein, alpha 3 0.021
ociad1 OCIA domain containing 1 0.021
fancl Fanconi anemia, complementation group L 0.021
coq3 coenzyme Q3 homolog, methyltransferase (yeast) 0.021
manf mesencephalic astrocyte-derived neurotrophic factor 0.021
gstm glutathione S-transferase M 0.021
mycbp2 MYC binding protein 2 0.021
decr1 2,4-dienoyl CoA reductase 1, mitochondrial 0.020
zgc:110775 zgc:110775 0.019
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.019
zgc:73345 zgc:73345 0.019
zgc:110010 zgc:110010 0.018
hadha hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit 0.018
tk2 thymidine kinase 2, mitochondrial 0.017
si:dkey-165n16.1 si:dkey-165n16.1 0.017
fancb Fanconi anemia, complementation group B 0.017
cpa5 carboxypeptidase A5 0.016
sdr16c5b short chain dehydrogenase/reductase family 16C, member 5b 0.016
hsd17b12b hydroxysteroid (17-beta) dehydrogenase 12b 0.016
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.016
gpia glucose phosphate isomerase a 0.016
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.016
mdh1a malate dehydrogenase 1a, NAD (soluble) 0.016
hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 0.015
zgc:162944 zgc:162944 0.015
zgc:56466 zgc:56466 0.015
urod uroporphyrinogen decarboxylase 0.015
hopx HOP homeobox 0.015
zgc:56518 zgc:56518 0.015
adh5 alcohol dehydrogenase 5 0.015
hbae1 hemoglobin alpha embryonic-1 0.014
aldh9a1a aldehyde dehydrogenase 9 family, member A1a 0.014
pcbd1 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 0.014
zgc:112986 zgc:112986 0.013
ppox protoporphyrinogen oxidase 0.013
tmem14c transmembrane protein 14C 0.013
hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 0.013
keap1a kelch-like ECH-associated protein 1a 0.013
uxs1 UDP-glucuronic acid decarboxylase 1 0.013
bpnt1 bisphosphate nucleotidase 1 0.013
nos2b nitric oxide synthase 2b, inducible 0.012
slc8a4a solute carrier family 8 (sodium/calcium exchanger), member 4a 0.012
scn4aa sodium channel, voltage-gated, type IV, alpha, a 0.012
ptgesl prostaglandin E synthase 2-like 0.012
gclc glutamate-cysteine ligase, catalytic subunit 0.012
dera 2-deoxyribose-5-phosphate aldolase homolog (C. elegans) 0.012
acat1 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) 0.011
sat1b spermidine/spermine N1-acetyl transferase 1b 0.011
bmpr1bb bone morphogenetic protein receptor, type 1bb 0.011
pdia4 protein disulfide isomerase associated 4 0.011
gcm2 glial cells missing homolog 2 (Drosophila) 0.011
prdx3 peroxiredoxin 3 0.011
mfn2 mitofusin 2 0.010
atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.010
ddt D-dopachrome tautomerase 0.010
npsn nephrosin 0.010
brip1 BRCA1 interacting protein C-terminal helicase 1 0.010
lcp1 lymphocyte cytosolic plastin 1 0.010
oc90 otoconin 90 0.010
suclg1 succinate-CoA ligase, GDP-forming, alpha subunit 0.010
gnrhr4 gonadotropin releasing hormone receptor 4 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Fbn1 fibrillin 1 0.985
Tgfbr2 transforming growth factor, beta receptor II 0.977
Lox lysyl oxidase 0.959
Apoe apolipoprotein E 0.923
Eln elastin 0.702
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.564
Ldlr low density lipoprotein receptor 0.550
Mmp2 matrix metallopeptidase 2 0.437
Tgfbr1 transforming growth factor, beta receptor I 0.386
Smo smoothened homolog (Drosophila) 0.369
Klf1 Kruppel-like factor 1 (erythroid) 0.277
Agtr1a angiotensin II receptor, type 1a 0.237
Slc31a1 solute carrier family 31, member 1 0.198
Steap3 STEAP family member 3 0.153
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.117
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.099
Hbb-b1 hemoglobin, beta adult major chain 0.092
Mcl1 myeloid cell leukemia sequence 1 0.091
Gcsh glycine cleavage system protein H (aminomethyl carrier) 0.089
Tgfb2 transforming growth factor, beta 2 0.087
Foxc1 forkhead box C1 0.087
Mt2 metallothionein 2 0.083
Idua iduronidase, alpha-L- 0.080
Slc39a4 solute carrier family 39 (zinc transporter), member 4 0.076
Lamp2 lysosomal-associated membrane protein 2 0.072
E2f1 E2F transcription factor 1 0.070
Slc12a6 solute carrier family 12, member 6 0.068
Tenc1 tensin like C1 domain-containing phosphatase 0.067
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.067
Ifngr1 interferon gamma receptor 1 0.065
Tmed10 transmembrane emp24-like trafficking protein 10 (yeast) 0.062
Dbi diazepam binding inhibitor 0.062
Lrp1 low density lipoprotein receptor-related protein 1 0.062
Sod3 superoxide dismutase 3, extracellular 0.060
Romo1 reactive oxygen species modulator 1 0.056
Vegfa vascular endothelial growth factor A 0.055
Tal1 T-cell acute lymphocytic leukemia 1 0.053
Prnp prion protein 0.053
Duox2 dual oxidase 2 0.052
Cav1 caveolin 1, caveolae protein 0.052
Tlr4 toll-like receptor 4 0.048
Agtr2 angiotensin II receptor, type 2 0.048
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.044
Fgfr1 fibroblast growth factor receptor 1 0.040
Ndufa9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 0.039
Figf c-fos induced growth factor 0.039
Camp cathelicidin antimicrobial peptide 0.039
Rhd Rh blood group, D antigen 0.036
Col6a1 collagen, type VI, alpha 1 0.035
Mrc2 mannose receptor, C type 2 0.034
Loxl1 lysyl oxidase-like 1 0.033
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.033
Col16a1 collagen, type XVI, alpha 1 0.032
Prelp proline arginine-rich end leucine-rich repeat 0.032
Hint1 histidine triad nucleotide binding protein 1 0.032
Thbs2 thrombospondin 2 0.032
Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 0.032
Spna1 spectrin alpha 1 0.031
Kat2a K(lysine) acetyltransferase 2A 0.030
Smad1 MAD homolog 1 (Drosophila) 0.030
Thbs3 thrombospondin 3 0.030
Ngp neutrophilic granule protein 0.030
Gp1ba glycoprotein 1b, alpha polypeptide 0.030
Ptrf polymerase I and transcript release factor 0.028
Timp3 tissue inhibitor of metalloproteinase 3 0.028
Qdpr quinoid dihydropteridine reductase 0.027
Tgfb1 transforming growth factor, beta 1 0.027
Epor erythropoietin receptor 0.027
Thrb thyroid hormone receptor beta 0.027
Hyal3 hyaluronoglucosaminidase 3 0.026
Nbl1 neuroblastoma, suppression of tumorigenicity 1 0.026
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.026
Fam96a family with sequence similarity 96, member A 0.025
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 0.025
Fzd2 frizzled homolog 2 (Drosophila) 0.025
Creg1 cellular repressor of E1A-stimulated genes 1 0.024
Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 0.024
Cycs cytochrome c, somatic 0.024
Mus81 MUS81 endonuclease homolog (yeast) 0.023
Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 0.023
Col1a2 collagen, type I, alpha 2 0.023
Car1 carbonic anhydrase 1 0.023
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.023
2010106G01Rik RIKEN cDNA 2010106G01 gene 0.023
Lamb2 laminin, beta 2 0.022
Sorbs3 sorbin and SH3 domain containing 3 0.022
Leprel2 leprecan-like 2 0.022
Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) 0.022
Scara3 scavenger receptor class A, member 3 0.022
Ednra endothelin receptor type A 0.022
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.021
Jag1 jagged 1 0.021
Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein 0.021
Cp ceruloplasmin 0.021
Bcap31 B-cell receptor-associated protein 31 0.020
Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor 0.020
Lage3 L antigen family, member 3 0.020
Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.020
Nos3 nitric oxide synthase 3, endothelial cell 0.020
Cfh complement component factor h 0.020
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cox8a cytochrome c oxidase subunit VIIIa 0.096
Cyb5a cytochrome b5 type A (microsomal) 0.018
Mdfic MyoD family inhibitor domain containing 0.018
Oaz1 ornithine decarboxylase antizyme 1 0.015
Dynlrb1 dynein light chain roadblock-type 1 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
AHP1 Ahp1p 0.069
TRX2 Trx2p 0.057
SOD1 Sod1p 0.041
TSA1 Tsa1p 0.026
YJR085C hypothetical protein 0.020
HOR7 Hor7p 0.019
SRD1 Srd1p 0.013
CUP1-1 Cup1-1p 0.013
LEU2 Leu2p 0.012
YAR068W hypothetical protein 0.011
GRE2 Gre2p 0.011
CPR1 Cpr1p 0.011
YLR162W hypothetical protein 0.011
PCL9 Pcl9p 0.011
YOL038C-A hypothetical protein 0.011
YLR264C-A hypothetical protein 0.010
ARP10 Arp10p 0.010