The network for 'protein activation cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein activation cascade

A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events.

Homo sapiens
Name Description Probability Func Analog Organism
C1R complement component 1, r subcomponent 1.000
C1S complement component 1, s subcomponent 1.000
C3 complement component 3 0.979
FGB fibrinogen beta chain 0.978
KRT15 keratin 15 0.968
C1QA complement component 1, q subcomponent, A chain 0.956
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.879
TP63 tumor protein p63 0.863
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.838
FGA fibrinogen alpha chain 0.817
C1QB complement component 1, q subcomponent, B chain 0.815
KRT19 keratin 19 0.745
KRT17 keratin 17 0.668
C1QC complement component 1, q subcomponent, C chain 0.579
TEK TEK tyrosine kinase, endothelial 0.537
ALB albumin 0.488
PPL periplakin 0.446
KRT14 keratin 14 0.440
CFH complement factor H 0.439
PLG plasminogen 0.392
KRT18 keratin 18 0.387
FGG fibrinogen gamma chain 0.362
APOE apolipoprotein E 0.319
CFI complement factor I 0.313
A2M alpha-2-macroglobulin 0.312
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.300
DCN decorin 0.212
HRG histidine-rich glycoprotein 0.203
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.181
DMBT1 deleted in malignant brain tumors 1 0.177
F2 coagulation factor II (thrombin) 0.172
APCS amyloid P component, serum 0.163
MET met proto-oncogene (hepatocyte growth factor receptor) 0.160
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.157
MASP2 mannan-binding lectin serine peptidase 2 0.155
LPA lipoprotein, Lp(a) 0.151
KRT6B keratin 6B 0.139
APOH apolipoprotein H (beta-2-glycoprotein I) 0.127
C4B complement component 4B (Chido blood group) 0.124
C19orf50 chromosome 19 open reading frame 50 0.114
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.107
CFHR1 complement factor H-related 1 0.103
ALOX12 arachidonate 12-lipoxygenase 0.103
PLAT plasminogen activator, tissue 0.102
KNG1 kininogen 1 0.100
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.091
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.086
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 0.077
ANGPT2 angiopoietin 2 0.071
HP haptoglobin 0.070
C8A complement component 8, alpha polypeptide 0.061
KRT6A keratin 6A 0.057
LECT2 leukocyte cell-derived chemotaxin 2 0.057
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.056
LBP lipopolysaccharide binding protein 0.054
C7 complement component 7 0.054
C8B complement component 8, beta polypeptide 0.053
CFB complement factor B 0.053
DPT dermatopontin 0.052
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.050
CP ceruloplasmin (ferroxidase) 0.047
CYTB cytochrome b 0.047
KRT6C keratin 6C 0.043
SPP2 secreted phosphoprotein 2, 24kDa 0.040
C2 complement component 2 0.038
APOA1 apolipoprotein A-I 0.037
TAT tyrosine aminotransferase 0.036
SAA4 serum amyloid A4, constitutive 0.036
NNMT nicotinamide N-methyltransferase 0.036
LRP1 low density lipoprotein receptor-related protein 1 0.035
CFHR2 complement factor H-related 2 0.035
HPX hemopexin 0.035
KRT2 keratin 2 0.034
C6 complement component 6 0.034
CTSB cathepsin B 0.033
HABP2 hyaluronan binding protein 2 0.033
CXCL12 chemokine (C-X-C motif) ligand 12 0.032
KRT9 keratin 9 0.032
C10orf10 chromosome 10 open reading frame 10 0.031
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 0.030
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.030
CPN1 carboxypeptidase N, polypeptide 1 0.030
C4BPB complement component 4 binding protein, beta 0.028
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.028
MBL2 mannose-binding lectin (protein C) 2, soluble 0.027
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.027
FETUB fetuin B 0.027
VTN vitronectin 0.026
CD164 CD164 molecule, sialomucin 0.026
GLYAT glycine-N-acyltransferase 0.026
EMILIN1 elastin microfibril interfacer 1 0.026
IGF1 insulin-like growth factor 1 (somatomedin C) 0.025
CLU clusterin 0.024
TRIM29 tripartite motif containing 29 0.023
ITIH1 inter-alpha (globulin) inhibitor H1 0.023
RDH16 retinol dehydrogenase 16 (all-trans) 0.023
EMP1 epithelial membrane protein 1 0.023
PHYH phytanoyl-CoA 2-hydroxylase 0.022
KRT4 keratin 4 0.022
CCL16 chemokine (C-C motif) ligand 16 0.021
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
zgc:103710 zgc:103710 0.769
c3b complement component c3b 0.757
cfb complement factor B 0.507
si:dkey-76b14.4 si:dkey-76b14.4 0.490
cfhl4 complement factor H like 4 0.329
foxi3a forkhead box I3a 0.221
ucp1 uncoupling protein 1 0.179
apom apolipoprotein M 0.153
LOC100149056 pannexin-3-like 0.147
fgb fibrinogen, B beta polypeptide 0.126
calcr calcitonin receptor 0.126
bhmt betaine-homocysteine methyltransferase 0.121
cps1 carbamoyl-phosphate synthase 1, mitochondrial 0.113
LOC566708 FL cytokine receptor-like 0.110
nr1h5 nuclear receptor subfamily 1, group H, member 5 0.107
c1qc complement component 1, q subcomponent, C chain 0.102
f5 coagulation factor V 0.101
cp ceruloplasmin 0.091
vtnb vitronectin b 0.079
plg plasminogen 0.072
slc4a4b solute carrier family 4, sodium bicarbonate cotransporter, member 4b 0.071
apoea apolipoprotein Ea 0.065
ambpl alpha-1-microglobulin/bikunin precursor, like 0.065
ca15a carbonic anhydrase XV a 0.064
rbp4 retinol binding protein 4, plasma 0.061
rhcgl1 Rhesus blood group, C glycoprotein, like 1 0.057
grn1 granulin 1 0.056
fn1b fibronectin 1b 0.052
tagln2 transgelin 2 0.049
sat1a spermidine/spermine N1-acetyltransferase 1a 0.049
LOC100330224 fatty acid binding protein 1b-like 0.049
s1pr3 sphingosine-1-phosphate receptor 3 0.046
f7 coagulation factor VII 0.046
vdrb vitamin D receptor b 0.043
pcsk9 proprotein convertase subtilisin/kexin type 9 0.043
itih2 inter-alpha (globulin) inhibitor H2 0.042
zgc:112992 zgc:112992 0.040
itgb1a integrin, beta 1a 0.039
c1qb complement component 1, q subcomponent, B chain 0.038
zgc:194131 zgc:194131 0.038
c1qa complement component 1, q subcomponent, A chain 0.037
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.036
ahsg alpha-2-HS-glycoprotein 0.036
sfrp1b secreted frizzled-related protein 1b 0.036
mep1a.1 meprin A, alpha.1 0.035
apob apolipoprotein B 0.035
psmb9a proteasome (prosome, macropain) subunit, beta type, 9a 0.034
LOC560602 novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6) 0.034
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.034
sepp1b selenoprotein P, plasma, 1b 0.033
grna granulin a 0.033
ghrb growth hormone receptor b 0.033
adipor2 adiponectin receptor 2 0.032
frem1a Fras1 related extracellular matrix 1a 0.032
ghra growth hormone receptor a 0.032
cldni claudin i 0.031
cd209 CD209 molecule 0.030
cd40 CD40 antigen 0.030
si:ch211-140f21.1 si:ch211-140f21.1 0.030
pth1a parathyroid hormone 1a 0.029
LOC794635 complement C4-like 0.029
ppl periplakin 0.028
rhcgb Rhesus blood group, C glycoprotein b 0.027
hoxa1a homeo box A1a 0.027
insrb insulin receptor b 0.027
crfb7 cytokine receptor family member b7 0.026
krt8 keratin 8 0.025
angptl3 angiopoietin-like 3 0.024
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.024
pcsk2 proprotein convertase subtilisin/kexin type 2 0.024
zgc:92061 zgc:92061 0.024
wnt10a wingless-type MMTV integration site family, member 10a 0.023
dysf dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) 0.023
slc2a13 solute carrier family 2 (facilitated glucose transporter), member 13 0.022
rhag Rhesus blood group-associated glycoprotein 0.021
gcm2 glial cells missing homolog 2 (Drosophila) 0.021
c9 complement component 9 0.020
slc12a10.1 solute carrier family 12 (sodium/potassium/chloride transporters), member 10.1 0.020
mxa myxovirus (influenza) resistance A 0.020
nkd1 naked cuticle homolog 1 (Drosophila) 0.020
sdprb serum deprivation response b 0.019
si:dkey-21e7.2 si:dkey-21e7.2 0.019
fga fibrinogen alpha chain 0.019
LOC567384 interferon-induced protein with tetratricopeptide repeats 5-like 0.019
wu:fi14a03 wu:fi14a03 0.019
tlr21 toll-like receptor 21 0.018
fas Fas (TNF receptor superfamily, member 6) 0.018
asph aspartate beta-hydroxylase 0.018
cecr1b cat eye syndrome chromosome region, candidate 1b 0.018
crfb13 cytokine receptor family member b13 0.017
LOC100149559 complement C1q-like protein 4-like 0.017
si:ch211-215l11.5 si:ch211-215l11.5 0.017
slc12a10.2 solute carrier family 12 (sodium/potassium/chloride transporters), member 10.2 0.017
calcrla calcitonin receptor-like a 0.017
LOC100005283 Gig2-like protein DreE 0.017
zgc:174888 zgc:174888 0.016
slc4a11 solute carrier family 4, sodium borate transporter, member 11 0.016
chsy1 chondroitin sulfate synthase 1 0.015
krt18 keratin 18 0.015
mst1 macrophage stimulating 1 (hepatocyte growth factor-like) 0.015
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
C1qc complement component 1, q subcomponent, C chain 0.998
Klk1b5 kallikrein 1-related peptidase b5 0.996
C1ra complement component 1, r subcomponent A 0.991
Klk1b26 kallikrein 1-related petidase b26 0.981
C1qa complement component 1, q subcomponent, alpha polypeptide 0.979
Klk1b8 kallikrein 1-related peptidase b8 0.977
Klk1b1 kallikrein 1-related peptidase b1 0.973
Klk1 kallikrein 1 0.964
Folr2 folate receptor 2 (fetal) 0.930
Klk1b11 kallikrein 1-related peptidase b11 0.923
Fga fibrinogen alpha chain 0.907
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.895
Klk1b21 kallikrein 1-related peptidase b21 0.890
Klk1b4 kallikrein 1-related pepidase b4 0.871
C3 complement component 3 0.860
C4b complement component 4B (Childo blood group) 0.828
Cd59a CD59a antigen 0.817
C1qb complement component 1, q subcomponent, beta polypeptide 0.810
Cfh complement component factor h 0.803
Kng1 kininogen 1 0.793
Aif1 allograft inflammatory factor 1 0.786
Klk1b27 kallikrein 1-related peptidase b27 0.762
Klk1b3 kallikrein 1-related peptidase b3 0.754
Klk1b9 kallikrein 1-related peptidase b9 0.736
Apoe apolipoprotein E 0.727
C2 complement component 2 (within H-2S) 0.717
Fgg fibrinogen gamma chain 0.713
Cd59b CD59b antigen 0.676
C1rb complement component 1, r subcomponent B 0.673
C1s complement component 1, s subcomponent 0.608
Klk1b16 kallikrein 1-related peptidase b16 0.607
Klk1b24 kallikrein 1-related peptidase b24 0.585
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.545
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.479
F9 coagulation factor IX 0.477
Hrg histidine-rich glycoprotein 0.431
Tmem176a transmembrane protein 176A 0.402
Rarres2 retinoic acid receptor responder (tazarotene induced) 2 0.397
Cp ceruloplasmin 0.377
Mrc1 mannose receptor, C type 1 0.371
Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.361
Egfbp2 epidermal growth factor binding protein type B 0.341
Saa4 serum amyloid A 4 0.327
Cd19 CD19 antigen 0.325
Ifitm3 interferon induced transmembrane protein 3 0.311
Tyrobp TYRO protein tyrosine kinase binding protein 0.301
1300017J02Rik RIKEN cDNA 1300017J02 gene 0.286
H2-Aa histocompatibility 2, class II antigen A, alpha 0.281
Mug1 murinoglobulin 1 0.279
Tmem176b transmembrane protein 176B 0.276
Mup3 major urinary protein 3 0.275
Igh immunoglobulin heavy chain complex 0.254
Cd5l CD5 antigen-like 0.253
Pzp pregnancy zone protein 0.244
Hgd homogentisate 1, 2-dioxygenase 0.243
Cyp2c70 cytochrome P450, family 2, subfamily c, polypeptide 70 0.238
Cyp2d10 cytochrome P450, family 2, subfamily d, polypeptide 10 0.216
Agxt alanine-glyoxylate aminotransferase 0.212
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.210
Apcs serum amyloid P-component 0.204
Serpina12 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 0.195
Otc ornithine transcarbamylase 0.195
Hc hemolytic complement 0.174
Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 0.165
Nnmt nicotinamide N-methyltransferase 0.148
F13b coagulation factor XIII, beta subunit 0.132
Ahsg alpha-2-HS-glycoprotein 0.129
Col14a1 collagen, type XIV, alpha 1 0.126
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.126
Akr1c6 aldo-keto reductase family 1, member C6 0.121
Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.121
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.120
Ces1c carboxylesterase 1C 0.119
Smr3a submaxillary gland androgen regulated protein 3A 0.112
Timd2 T-cell immunoglobulin and mucin domain containing 2 0.112
Apoc4 apolipoprotein C-IV 0.108
Orm2 orosomucoid 2 0.106
Eln elastin 0.102
Ccl6 chemokine (C-C motif) ligand 6 0.099
Ambp alpha 1 microglobulin/bikunin 0.099
C9 complement component 9 0.092
Grn granulin 0.090
Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 0.090
Dpt dermatopontin 0.090
Fcgr2b Fc receptor, IgG, low affinity IIb 0.089
Ctsq cathepsin Q 0.089
Ctsh cathepsin H 0.088
Proc protein C 0.083
Hal histidine ammonia lyase 0.083
F7 coagulation factor VII 0.079
Mug2 murinoglobulin 2 0.078
Ivl involucrin 0.076
F12 coagulation factor XII (Hageman factor) 0.076
Cpn1 carboxypeptidase N, polypeptide 1 0.075
Fcna ficolin A 0.074
Ly86 lymphocyte antigen 86 0.071
Mbl2 mannose-binding lectin (protein C) 2 0.071
Cfb complement factor B 0.069
Lipc lipase, hepatic 0.068
H2-Eb1 histocompatibility 2, class II antigen E beta 0.067
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cfb complement factor B 0.822
C1s complement component 1, s subcomponent 0.770
Cp ceruloplasmin 0.490
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.334
C1r complement component 1, r subcomponent 0.235
C3 complement component 3 0.184
Fgg fibrinogen gamma chain 0.184
Tf transferrin 0.155
C1qa complement component 1, q subcomponent, A chain 0.087
C4b complement component 4B (Chido blood group) 0.084
Lbp lipopolysaccharide binding protein 0.068
Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.066
C4bpb complement component 4 binding protein, beta 0.059
C2 complement component 2 0.049
Cfi complement factor I 0.047
A2m alpha-2-macroglobulin 0.034
Emr1 EGF-like module containing, mucin-like, hormone receptor-like 1 0.031
Pzp pregnancy-zone protein 0.031
Rnase4 ribonuclease, RNase A family 4 0.031
Fabp1 fatty acid binding protein 1, liver 0.031
Cd302 CD302 molecule 0.028
Tmem176b transmembrane protein 176B 0.026
Cd48 Cd48 molecule 0.023
Icam1 intercellular adhesion molecule 1 0.023
F13a1 coagulation factor XIII, A1 polypeptide 0.021
Testin testin gene 0.021
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.020
LOC100363106 LRRG00130-like 0.016
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.016
C8b complement component 8, beta polypeptide 0.016
Efemp1 EGF-containing fibulin-like extracellular matrix protein 1 0.016
Cpb2 carboxypeptidase B2 (plasma) 0.015
Serpinf2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.015
Ctsl1 cathepsin L1 0.015
Foxi2 forkhead box I2 0.014
Abcb11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 0.014
C9 complement component 9 0.014
LOC100360501 ribonuclease inhibitor-like 0.014
Kng1 kininogen 1 0.014
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.014
Tcf21 transcription factor 21 0.014
Inhbc inhibin beta C 0.014
Mbl1 mannose-binding lectin (protein A) 1 0.014
F10 coagulation factor X 0.013
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.013
Ctsc cathepsin C 0.013
Fam115c family with sequence similarity 115, member C 0.013
Alox5ap arachidonate 5-lipoxygenase activating protein 0.013
Ccl6 chemokine (C-C motif) ligand 6 0.013
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.012
Sec62 SEC62 homolog (S. cerevisiae) 0.012
Pgcp plasma glutamate carboxypeptidase 0.012
Klk1l kallikrein 1-like peptidase 0.012
F2 coagulation factor II (thrombin) 0.012
Kng2 kininogen 2 0.011
Itih1 inter-alpha trypsin inhibitor, heavy chain 1 0.011
Serpina11 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 0.011
Azgp1 alpha-2-glycoprotein 1, zinc-binding 0.011
Cfh complement factor H 0.011
C6 complement component 6 0.011
Mrc1 mannose receptor, C type 1 0.010
Cd163 CD163 molecule 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism