The network for 'arachidonic acid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

arachidonic acid metabolic process

The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.

Name Description Probability Func Analog Organism
MAPK1 mitogen-activated protein kinase 1 0.998
DHCR7 7-dehydrocholesterol reductase 0.998
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.996
COTL1 coactosin-like 1 (Dictyostelium) 0.987
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.986
DUSP1 dual specificity phosphatase 1 0.970
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.887
MAPK14 mitogen-activated protein kinase 14 0.843
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.724
FADS2 fatty acid desaturase 2 0.637
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.520
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 0.473
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 0.459
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 0.406
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 0.316
DUSP3 dual specificity phosphatase 3 0.246
C8B complement component 8, beta polypeptide 0.207
IL8 interleukin 8 0.169
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.128
MAP2K1 mitogen-activated protein kinase kinase 1 0.127
PTPRJ protein tyrosine phosphatase, receptor type, J 0.125
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 0.110
GLYAT glycine-N-acyltransferase 0.105
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.101
ALOX12B arachidonate 12-lipoxygenase, 12R type 0.101
PEA15 phosphoprotein enriched in astrocytes 15 0.097
ADH6 alcohol dehydrogenase 6 (class V) 0.091
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.085
KNG1 kininogen 1 0.081
CXCL2 chemokine (C-X-C motif) ligand 2 0.080
OTC ornithine carbamoyltransferase 0.080
ALOXE3 arachidonate lipoxygenase 3 0.080
MAT1A methionine adenosyltransferase I, alpha 0.077
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 0.069
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.067
F9 coagulation factor IX 0.066
C8A complement component 8, alpha polypeptide 0.066
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.066
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.065
CXCL3 chemokine (C-X-C motif) ligand 3 0.058
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.058
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.057
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.056
DAO D-amino-acid oxidase 0.056
HRG histidine-rich glycoprotein 0.055
KRT5 keratin 5 0.055
FETUB fetuin B 0.052
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.051
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 0.050
BHMT betaine--homocysteine S-methyltransferase 0.048
AGXT2 alanine--glyoxylate aminotransferase 2 0.048
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.047
CFHR4 complement factor H-related 4 0.046
DAPK1 death-associated protein kinase 1 0.045
HAL histidine ammonia-lyase 0.044
PLAUR plasminogen activator, urokinase receptor 0.044
LAMC3 laminin, gamma 3 0.043
CRP C-reactive protein, pentraxin-related 0.043
ELK1 ELK1, member of ETS oncogene family 0.042
ALDOB aldolase B, fructose-bisphosphate 0.041
IL1B interleukin 1, beta 0.040
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.039
SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 0.038
C6 complement component 6 0.035
AADAC arylacetamide deacetylase (esterase) 0.035
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.035
MASP2 mannan-binding lectin serine peptidase 2 0.034
PLG plasminogen 0.034
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.033
ZNF219 zinc finger protein 219 0.033
G6PC glucose-6-phosphatase, catalytic subunit 0.032
NAMPT nicotinamide phosphoribosyltransferase 0.032
SCAND1 SCAN domain containing 1 0.032
FMO4 flavin containing monooxygenase 4 0.031
DPYS dihydropyrimidinase 0.031
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.031
GBA3 glucosidase, beta, acid 3 (cytosolic) 0.030
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 0.030
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.030
FABP1 fatty acid binding protein 1, liver 0.029
GSTA3 glutathione S-transferase alpha 3 0.029
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 0.028
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.028
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.027
TGM1 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) 0.027
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.025
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.025
IER3 immediate early response 3 0.024
CTSB cathepsin B 0.024
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.023
RDH16 retinol dehydrogenase 16 (all-trans) 0.023
KLK13 kallikrein-related peptidase 13 0.023
LPA lipoprotein, Lp(a) 0.022
XDH xanthine dehydrogenase 0.022
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.022
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.021
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 0.021
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.021
AKR1C4 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) 0.021
NR1I3 nuclear receptor subfamily 1, group I, member 3 0.020
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 0.834
Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 0.811
Cps1 carbamoyl-phosphate synthetase 1 0.782
Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 0.675
Cyp2a12 cytochrome P450, family 2, subfamily a, polypeptide 12 0.611
Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 0.507
F9 coagulation factor IX 0.473
Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 0.467
Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 0.419
Otc ornithine transcarbamylase 0.369
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.365
Mup5 major urinary protein 5 0.349
Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 0.272
Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 0.265
Hpd 4-hydroxyphenylpyruvic acid dioxygenase 0.254
Cyp2c54 cytochrome P450, family 2, subfamily c, polypeptide 54 0.250
Akr1c6 aldo-keto reductase family 1, member C6 0.237
Cyp2d9 cytochrome P450, family 2, subfamily d, polypeptide 9 0.221
Cyp2c70 cytochrome P450, family 2, subfamily c, polypeptide 70 0.218
Tat tyrosine aminotransferase 0.208
Crp C-reactive protein, pentraxin-related 0.205
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.202
Apoc4 apolipoprotein C-IV 0.201
Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 0.197
Hrg histidine-rich glycoprotein 0.191
Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 0.187
Aadac arylacetamide deacetylase (esterase) 0.168
Cyp2c39 cytochrome P450, family 2, subfamily c, polypeptide 39 0.163
Cyp2d26 cytochrome P450, family 2, subfamily d, polypeptide 26 0.158
Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 0.156
Sult1d1 sulfotransferase family 1D, member 1 0.149
Cyp3a25 cytochrome P450, family 3, subfamily a, polypeptide 25 0.149
Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 0.146
Sult1b1 sulfotransferase family 1B, member 1 0.138
Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C 0.123
G6pc glucose-6-phosphatase, catalytic 0.123
Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 0.120
Krtap6-1 keratin associated protein 6-1 0.120
Baat bile acid-Coenzyme A: amino acid N-acyltransferase 0.118
Serpina6 serine (or cysteine) peptidase inhibitor, clade A, member 6 0.115
Ugt2a3 UDP glucuronosyltransferase 2 family, polypeptide A3 0.114
Nr1i2 nuclear receptor subfamily 1, group I, member 2 0.113
Cml2 camello-like 2 0.111
Cyp2d10 cytochrome P450, family 2, subfamily d, polypeptide 10 0.110
Keg1 kidney expressed gene 1 0.107
Fmo3 flavin containing monooxygenase 3 0.100
Cyp2c68 cytochrome P450, family 2, subfamily c, polypeptide 68 0.098
Mbl2 mannose-binding lectin (protein C) 2 0.095
Azgp1 alpha-2-glycoprotein 1, zinc 0.094
Alox5ap arachidonate 5-lipoxygenase activating protein 0.094
F13b coagulation factor XIII, beta subunit 0.093
Inhbc inhibin beta-C 0.088
Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.084
Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 0.081
Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 0.079
Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic 0.079
Slco1b2 solute carrier organic anion transporter family, member 1b2 0.075
Dmgdh dimethylglycine dehydrogenase precursor 0.075
Alb albumin 0.072
Lect2 leukocyte cell-derived chemotaxin 2 0.072
C9 complement component 9 0.071
Aldob aldolase B, fructose-bisphosphate 0.070
Rdh7 retinol dehydrogenase 7 0.067
Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 0.065
Ces2a carboxylesterase 2A 0.064
Ces1c carboxylesterase 1C 0.063
Nr1i3 nuclear receptor subfamily 1, group I, member 3 0.062
Tdo2 tryptophan 2,3-dioxygenase 0.057
Hgd homogentisate 1, 2-dioxygenase 0.056
Cyp2f2 cytochrome P450, family 2, subfamily f, polypeptide 2 0.049
Ces3a carboxylesterase 3A 0.049
Cyp4a12a cytochrome P450, family 4, subfamily a, polypeptide 12a 0.048
Cyp4a31 cytochrome P450, family 4, subfamily a, polypeptide 31 0.045
Ugt3a2 UDP glycosyltransferases 3 family, polypeptide A2 0.045
Csn1s1 casein alpha s1 0.044
Acot12 acyl-CoA thioesterase 12 0.044
Glyat glycine-N-acyltransferase 0.043
Akr1d1 aldo-keto reductase family 1, member D1 0.043
F2 coagulation factor II 0.043
Mup3 major urinary protein 3 0.042
Pigr polymeric immunoglobulin receptor 0.042
Pon1 paraoxonase 1 0.041
Ppl periplakin 0.040
Bhmt betaine-homocysteine methyltransferase 0.039
Cfhr1 complement factor H-related 1 0.039
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.038
Gc group specific component 0.038
Upp2 uridine phosphorylase 2 0.038
Pik3c2g phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide 0.038
Gsta2 glutathione S-transferase, alpha 2 (Yc2) 0.037
Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 0.037
Cfhr2 complement factor H-related 2 0.036
Casp14 caspase 14 0.036
Apob apolipoprotein B 0.036
Prlr prolactin receptor 0.036
Apcs serum amyloid P-component 0.036
Mbl1 mannose-binding lectin (protein A) 1 0.035
Asgr2 asialoglycoprotein receptor 2 0.035
Mettl7b methyltransferase like 7B 0.035
Agmat agmatine ureohydrolase (agmatinase) 0.033
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 0.902
Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 0.825
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.762
Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 0.725
Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 0.560
Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 0.509
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.461
Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 0.458
Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 0.457
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.430
Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 0.407
Ugt2b UDP glycosyltransferase 2 family, polypeptide B 0.401
Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 0.389
Sult1b1 sulfotransferase family, cytosolic, 1B, member 1 0.360
Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 0.358
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.331
Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 0.319
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.283
LOC100365112 carboxylesterase-like 0.243
Sult1c3 sulfotransferase family, cytosolic, 1C, member 3 0.217
Fdxr ferredoxin reductase 0.208
Crygf crystallin, gamma F 0.188
Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 0.181
Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 0.155
Apob apolipoprotein B 0.148
Olr1701 olfactory receptor 1701 0.145
Sult1e1 sulfotransferase family 1E, estrogen-preferring, member 1 0.144
Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 0.143
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.140
Rxrg retinoid X receptor gamma 0.125
LOC494499 LOC494499 protein 0.120
Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 0.092
Adh1 alcohol dehydrogenase 1 (class I) 0.090
Fads2 fatty acid desaturase 2 0.090
Haao 3-hydroxyanthranilate 3,4-dioxygenase 0.087
Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 0.086
Ppard peroxisome proliferator-activated receptor delta 0.084
Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 0.080
Ctdsp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.077
Gckr glucokinase (hexokinase 4) regulator 0.075
Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 0.073
Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 0.072
L3mbtl3 l(3)mbt-like 3 (Drosophila) 0.071
Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 0.067
Aqp9 aquaporin 9 0.066
A1i3 alpha-1-inhibitor III 0.065
Abcb11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 0.064
Fasn fatty acid synthase 0.062
Sult1c2 sulfotransferase family, cytosolic, 1C, member 2 0.059
Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 0.057
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.055
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.055
Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 0.054
Dhfr dihydrofolate reductase 0.047
LOC293989 cytochrome P450-like 0.046
Mosc1 MOCO sulphurase C-terminal domain containing 1 0.046
Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 0.044
Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 0.043
Dpys dihydropyrimidinase 0.039
Slc23a1 solute carrier family 23 (nucleobase transporters), member 1 0.039
Dhcr7 7-dehydrocholesterol reductase 0.037
Rag1 recombination activating gene 1 0.035
Ces1e carboxylesterase 1E 0.035
Ces1c carboxylesterase 1C 0.034
Cd46 CD46 molecule, complement regulatory protein 0.032
Mettl7b methyltransferase like 7B 0.030
Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 0.029
Il8ra interleukin 8 receptor, alpha 0.029
Olr59 olfactory receptor 59 0.029
Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 0.029
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.029
RT1-M5 RT1 class Ib, locus M5 0.029
Colq collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.028
Akr1c18 aldo-keto reductase family 1, member C18 0.028
Cst8 cystatin 8 (cystatin-related epididymal specific) 0.027
Gcm1 glial cells missing homolog 1 (Drosophila) 0.027
Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 0.027
Otc ornithine carbamoyltransferase 0.027
Cps1 carbamoyl-phosphate synthetase 1 0.026
Fads1 fatty acid desaturase 1 0.026
Olr837 olfactory receptor 837 0.026
Olr1346 olfactory receptor 1346 0.026
Il1rl2 interleukin 1 receptor-like 2 0.025
Fmo1 flavin containing monooxygenase 1 0.025
Gja5 gap junction protein, alpha 5 0.024
Ppara peroxisome proliferator activated receptor alpha 0.023
Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 0.022
Qpct glutaminyl-peptide cyclotransferase 0.021
Atp4b ATPase, H+/K+ exchanging, beta polypeptide 0.021
Abcb4 ATP-binding cassette, subfamily B (MDR/TAP), member 4 0.021
Rhag Rh-associated glycoprotein 0.021
Gsta5 glutathione S-transferase Yc2 subunit 0.020
Selp selectin P 0.020
Srd5a1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 0.020
Apoa2 apolipoprotein A-II 0.020
Fgfr4 fibroblast growth factor receptor 4 0.019
Slc9a2 solute carrier family 9 (sodium/hydrogen exchanger), member 2 0.019
Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 0.019
Olr1469 olfactory receptor Olr1469 0.019
Gsta2 glutathione S-transferase A2 0.019
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism