The network for 'ectodermal cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ectodermal cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.

Mus musculus
Name Description Probability Func Analog Organism
Sox2 SRY-box containing gene 2 0.986
Nanog Nanog homeobox 0.970
Sall4 sal-like 4 (Drosophila) 0.909
Otx2 orthodenticle homolog 2 (Drosophila) 0.863
Pax2 paired box gene 2 0.821
Sall3 sal-like 3 (Drosophila) 0.709
Pax6 paired box gene 6 0.664
Tcfcp2l1 transcription factor CP2-like 1 0.537
Chd7 chromodomain helicase DNA binding protein 7 0.521
Foxg1 forkhead box G1 0.500
Esrrb estrogen related receptor, beta 0.439
Sall1 sal-like 1 (Drosophila) 0.416
Atoh7 atonal homolog 7 (Drosophila) 0.407
Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 0.388
Hmx3 H6 homeobox 3 0.378
S1pr2 sphingosine-1-phosphate receptor 2 0.296
Zic2 zinc finger protein of the cerebellum 2 0.243
Insm1 insulinoma-associated 1 0.228
Lhx3 LIM homeobox protein 3 0.217
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.209
Sox3 SRY-box containing gene 3 0.205
Emx1 empty spiracles homolog 1 (Drosophila) 0.185
Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 0.181
Atoh1 atonal homolog 1 (Drosophila) 0.177
Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.154
Hes5 hairy and enhancer of split 5 (Drosophila) 0.154
Pde6b phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide 0.146
Neurod1 neurogenic differentiation 1 0.143
Gbx2 gastrulation brain homeobox 2 0.143
Lhx1 LIM homeobox protein 1 0.139
Mta1 metastasis associated 1 0.130
Tbx10 T-box 10 0.129
Sox1 SRY-box containing gene 1 0.129
Dlx1 distal-less homeobox 1 0.127
Vangl2 vang-like 2 (van gogh, Drosophila) 0.119
Hoxd13 homeobox D13 0.104
Lmx1a LIM homeobox transcription factor 1 alpha 0.104
Cdx1 caudal type homeobox 1 0.097
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.093
Otx1 orthodenticle homolog 1 (Drosophila) 0.092
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.091
Klf4 Kruppel-like factor 4 (gut) 0.090
Fgf4 fibroblast growth factor 4 0.089
Fgf3 fibroblast growth factor 3 0.089
Arid3b AT rich interactive domain 3B (BRIGHT-like) 0.085
Cdh23 cadherin 23 (otocadherin) 0.085
Isl1 ISL1 transcription factor, LIM/homeodomain 0.084
Pou4f3 POU domain, class 4, transcription factor 3 0.082
Phox2a paired-like homeobox 2a 0.081
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.080
Ush1g Usher syndrome 1G homolog (human) 0.079
Srrm4 serine/arginine repetitive matrix 4 0.077
Arid1a AT rich interactive domain 1A (SWI-like) 0.076
Pou3f2 POU domain, class 3, transcription factor 2 0.075
Emx2 empty spiracles homolog 2 (Drosophila) 0.074
Tcfap2c transcription factor AP-2, gamma 0.074
Hmx1 H6 homeobox 1 0.069
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.069
Gatad2b GATA zinc finger domain containing 2B 0.069
Prop1 paired like homeodomain factor 1 0.068
Fgf15 fibroblast growth factor 15 0.065
Wnt7b wingless-related MMTV integration site 7B 0.065
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.064
Onecut1 one cut domain, family member 1 0.063
Foxd2 forkhead box D2 0.063
Dmgdh dimethylglycine dehydrogenase precursor 0.063
Hoxa4 homeobox A4 0.062
Cdk5r2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 0.062
Gli3 GLI-Kruppel family member GLI3 0.061
Cacng4 calcium channel, voltage-dependent, gamma subunit 4 0.060
Tlx3 T-cell leukemia, homeobox 3 0.060
Vax1 ventral anterior homeobox containing gene 1 0.059
Wnt7a wingless-related MMTV integration site 7A 0.058
Fmnl1 formin-like 1 0.057
Espn espin 0.055
Uncx UNC homeobox 0.055
Hoxb1 homeobox B1 0.055
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.054
Slc26a4 solute carrier family 26, member 4 0.053
Aym1 activator of yeast meiotic promoters 1 0.053
Gata3 GATA binding protein 3 0.052
Slc12a2 solute carrier family 12, member 2 0.052
Foxh1 forkhead box H1 0.052
Etv2 ets variant gene 2 0.051
Bdnf brain derived neurotrophic factor 0.051
BC024139 cDNA sequence BC024139 0.050
Fgf17 fibroblast growth factor 17 0.050
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.049
Neurog3 neurogenin 3 0.049
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.049
Sema5b sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 0.047
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.045
Olig3 oligodendrocyte transcription factor 3 0.045
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.045
Wnt6 wingless-related MMTV integration site 6 0.044
Rcor2 REST corepressor 2 0.043
Pax3 paired box gene 3 0.042
Syt6 synaptotagmin VI 0.042
Hoxb13 homeobox B13 0.042
Polm polymerase (DNA directed), mu 0.041
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
epb41 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) 0.329
tagln2 transgelin 2 0.086
krt8 keratin 8 0.064
pabpc1b poly A binding protein, cytoplasmic 1 b 0.057
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.050
drl draculin 0.049
dlx3b distal-less homeobox gene 3b 0.046
btg2 B-cell translocation gene 2 0.043
alas2 aminolevulinate, delta-, synthetase 2 0.040
col17a1b collagen, type XVII, alpha 1b 0.032
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.030
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.029
pea3 ETS-domain transcription factor pea3 0.028
acvr1b activin A receptor, type IB 0.028
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.028
perp PERP, TP53 apoptosis effector 0.026
brd2a bromodomain-containing 2a 0.024
klf2a Kruppel-like factor 2a 0.024
foxa3 forkhead box A3 0.021
anxa5b annexin A5b 0.020
jun jun proto-oncogene 0.019
tbx6 T-box gene 6 0.019
sox2 SRY-box containing gene 2 0.018
brd2b bromodomain containing 2b 0.017
krt4 keratin 4 0.017
rhov ras homolog gene family, member V 0.016
bhlhe40 basic helix-loop-helix family, member e40 0.015
tjp1 tight junction protein 1 (zona occludens 1) 0.015
stat3 signal transduction and activation of transcription 3 0.015
pak1 p21/Cdc42/Rac1-activated kinase 1 0.015
rasl11b RAS-like, family 11, member B 0.015
sfrp1a secreted frizzled-related protein 1a 0.014
nt5c2l1 5'-nucleotidase, cytosolic II, like 1 0.014
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.014
socs3a suppressor of cytokine signaling 3a 0.014
sdprb serum deprivation response b 0.014
gadd45bb growth arrest and DNA-damage-inducible, beta b 0.013
klf2b Kruppel-like factor 2b 0.013
hspa5 heat shock protein 5 0.013
appa amyloid beta (A4) precursor protein a 0.012
lmo2 LIM domain only 2 (rhombotin-like 1) 0.012
tp63 tumor protein p63 0.012
dspa desmoplakin a 0.012
otop1 otopetrin 1 0.011
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.011
cdh1 cadherin 1, epithelial 0.011
cahz carbonic anhydrase 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
cdi center divider 0.038
if inflated 0.036
stumps CG31317 gene product from transcript CG31317-RC 0.035
scb scab 0.035
p130CAS CG1212 gene product from transcript CG1212-RA 0.030
wun wunen 0.029
Pvr PDGF- and VEGF-receptor related 0.027
fas faint sausage 0.024
NetB Netrin-B 0.014
htl heartless 0.011
RhoL rho-like 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
FHL2 four and a half LIM domains 2 0.754
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.672
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.358
FOXD3 forkhead box D3 0.145
FN1 fibronectin 1 0.076
ENG endoglin 0.064
PDIA3 protein disulfide isomerase family A, member 3 0.042
BBS10 Bardet-Biedl syndrome 10 0.042
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.035
PXN paxillin 0.031
PTPRC protein tyrosine phosphatase, receptor type, C 0.031
TLN1 talin 1 0.028
CD63 CD63 molecule 0.027
THBS1 thrombospondin 1 0.022
SOX2 SRY (sex determining region Y)-box 2 0.021
FLNA filamin A, alpha 0.020
WNT3A wingless-type MMTV integration site family, member 3A 0.020
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.017
CTGF connective tissue growth factor 0.015
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.014
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.014
ELF5 E74-like factor 5 (ets domain transcription factor) 0.013
PLEC plectin 0.013
WNT5A wingless-type MMTV integration site family, member 5A 0.012
ITGB5 integrin, beta 5 0.012
NDP Norrie disease (pseudoglioma) 0.012
ITGA6 integrin, alpha 6 0.011
CLEC4M C-type lectin domain family 4, member M 0.011
TGFB1 transforming growth factor, beta 1 0.011
JAG1 jagged 1 0.011
ADAM9 ADAM metallopeptidase domain 9 0.011
FHL3 four and a half LIM domains 3 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism