The network for 'multicellular organismal water homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

multicellular organismal water homeostasis

Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.

Rattus norvegicus
Name Description Probability Func Analog Organism
Scnn1g sodium channel, nonvoltage-gated 1, gamma 0.359
Tacstd2 tumor-associated calcium signal transducer 2 0.177
Muc1 mucin 1, cell surface associated 0.132
Dync1h1 dynein cytoplasmic 1 heavy chain 1 0.109
Gja5 gap junction protein, alpha 5 0.107
Scnn1b sodium channel, nonvoltage-gated 1, beta 0.101
Tcp11 t-complex protein 11 0.065
Epor erythropoietin receptor 0.057
Bmp7 bone morphogenetic protein 7 0.047
RGD1310262 hypothetical LOC304650 0.042
Sostdc1 sclerostin domain containing 1 0.041
Gp2 glycoprotein 2 (zymogen granule membrane) 0.041
Prss8 protease, serine, 8 0.039
Lrch4 leucine-rich repeats and calponin homology (CH) domain containing 4 0.037
Plin perilipin 0.036
Myog myogenin 0.036
Olr1500 olfactory receptor 1500 0.034
Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.034
Stra6 stimulated by retinoic acid gene 6 0.033
Dpep1 dipeptidase 1 (renal) 0.032
Hexa hexosaminidase A 0.030
Ptges prostaglandin E synthase 0.030
Adrb3 adrenergic, beta-3-, receptor 0.029
Des desmin 0.029
Gpx2 glutathione peroxidase 2 0.027
Krt5 keratin 5 0.027
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.027
Folh1 folate hydrolase 1 0.026
Vtcn1 V-set domain containing T cell activation inhibitor 1 0.026
Prkcsh protein kinase C substrate 80K-H 0.025
Atp6v1g3 ATPase, H+ transporting, lysosomal V1 subunit G3 0.024
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.023
Taf6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.023
Ctrb1 chymotrypsinogen B1 0.022
Th tyrosine hydroxylase 0.021
Olr1082 olfactory receptor 1082 0.020
Tmem79 transmembrane protein 79 0.020
Ager advanced glycosylation end product-specific receptor 0.019
Cdcp1 CUB domain containing protein 1 0.019
Pdzk1ip1 PDZK1 interacting protein 1 0.019
Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 0.018
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.018
Samd4b sterile alpha motif domain containing 4B 0.017
Galr2 galanin receptor 2 0.017
Tinagl1 tubulointerstitial nephritis antigen-like 1 0.017
S1pr2 sphingosine-1-phosphate receptor 2 0.017
Scnn1a sodium channel, nonvoltage-gated 1 alpha 0.017
P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 0.016
Kcnk3 potassium channel, subfamily K, member 3 0.016
Tpsab1 tryptase alpha/beta 1 0.016
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.016
LOC679475 hypothetical protein LOC679475 0.016
Foxq1 forkhead box Q1 0.016
Cga glycoprotein hormones, alpha polypeptide 0.016
Hnf1b HNF1 homeobox B 0.016
Cnga4 cyclic nucleotide gated channel alpha 4 0.015
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.015
C1qtnf6 C1q and tumor necrosis factor related protein 6 0.015
Clcnka chloride channel Ka 0.015
Tmprss2 transmembrane protease, serine 2 0.015
Mcpt4 mast cell protease 4 0.015
Nradd neurotrophin receptor associated death domain 0.015
Ddr1 discoidin domain receptor tyrosine kinase 1 0.015
Tacr1 tachykinin receptor 1 0.015
Slc13a2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 0.014
Ckm creatine kinase, muscle 0.014
Eci1 enoyl-Coenzyme A delta isomerase 1 0.014
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.014
Irs3 insulin receptor substrate 3 0.014
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.013
Mylk2 myosin light chain kinase 2 0.013
Npffr2 neuropeptide FF receptor 2 0.013
Ehf ets homologous factor 0.013
Slc44a4 solute carrier family 44, member 4 0.013
Defb1 defensin beta 1 0.013
Msx2 msh homeobox 2 0.013
Prss1 protease, serine, 1 (trypsin 1) 0.012
Olr1496 olfactory receptor 1496 0.012
Rsph1 radial spoke head 1 homolog (Chlamydomonas) 0.012
Ugt8 UDP glycosyltransferase 8 0.012
Gabrr2 gamma-aminobutyric acid (GABA) receptor, rho 2 0.012
Serpina4 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.012
Acaa1b acetyl-Coenzyme A acyltransferase 1B 0.012
Ghrhr growth hormone releasing hormone receptor 0.012
Cel carboxyl ester lipase 0.012
RGD1305347 similar to RIKEN cDNA 2610528J11 0.012
Rnase1 ribonuclease, RNase A family, 1 (pancreatic) 0.012
Serpind1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.012
Cuzd1 CUB and zona pellucida-like domains 1 0.012
Tgm1 transglutaminase 1, K polypeptide 0.012
LOC652956 p55 protein 0.011
Ctf1 cardiotrophin 1 0.011
Pde1c phosphodiesterase 1C 0.011
Cldn7 claudin 7 0.011
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.011
Vdr vitamin D (1,25- dihydroxyvitamin D3) receptor 0.011
Tmem171 transmembrane protein 171 0.011
Serpina11 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 0.011
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.011
Nkx3-1 NK3 homeobox 1 0.011
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tp63 tumor protein p63 0.579
cldni claudin i 0.575
krt5 keratin 5 0.452
zgc:92533 zgc:92533 0.431
cldn7b claudin 7b 0.385
avpl arginine vasopressin-like 0.359
krt4 keratin 4 0.333
tp73 tumor protein p73 0.321
tagln2 transgelin 2 0.320
rab3c RAB3C, member RAS oncogene family 0.308
oxtl oxytocin-like 0.293
krt18 keratin 18 0.262
cldnb claudin b 0.234
uts1 urotensin 1 0.208
gad2 glutamate decarboxylase 2 0.204
cfl1 cofilin 1 (non-muscle) 0.200
anxa1a annexin A1a 0.186
cx27.5 connexin 27.5 0.156
aqp8a.1 aquaporin 8a, tandem duplicate 1 0.146
mc4r melanocortin 4 receptor 0.141
cyp1a cytochrome P450, family 1, subfamily A 0.136
drd2b dopamine receptor D2b 0.131
si:ch211-166a6.5 si:ch211-166a6.5 0.128
gad1b glutamate decarboxylase 1b 0.124
cldne claudin e 0.120
crabp1a cellular retinoic acid binding protein 1a 0.109
ntng1 netrin G1 0.107
gnrh3 gonadotropin-releasing hormone 3 0.102
nmnat2 nicotinamide nucleotide adenylyltransferase 2 0.097
calb2b calbindin 2b, (calretinin) 0.097
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.096
sst3 somatostatin 3 0.096
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.094
vgll4l vestigial like 4 like 0.091
zgc:92061 zgc:92061 0.089
otx2 orthodenticle homolog 2 0.086
vdra vitamin D receptor a 0.084
capn9 calpain 9 0.076
jup junction plakoglobin 0.073
npy8br neuropeptide Y receptor Y8b 0.068
eomesa eomesodermin homolog a 0.068
pbx1a pre-B-cell leukemia transcription factor 1a 0.068
kif5aa kinesin family member 5A, a 0.066
akap12b A kinase (PRKA) anchor protein (gravin) 12b 0.062
nppcl natriuretic peptide precursor C-like protein 0.059
chrm2a cholinergic receptor, muscarinic 2a 0.059
aqp3a aquaporin 3a 0.058
slc32a1 solute carrier family 32 (GABA vesicular transporter), member 1 0.056
nlgn4a neuroligin 4a 0.055
pcsk1nl proprotein convertase subtilisin/kexin type 1 inhibitor, like 0.053
atp1b1b ATPase, Na+/K+ transporting, beta 1b polypeptide 0.051
ascl1b achaete-scute complex-like 1b (Drosophila) 0.051
ppl periplakin 0.049
aqp1a.1 aquaporin 1a, tandem duplicate 1 0.048
esr1 estrogen receptor 1 0.048
nlgn1 neuroligin 1 0.045
adra2db adrenergic, alpha-2D-, receptor b 0.045
nkx2.3 NK2 transcription factor related 3 0.044
LOC100334363 Sperm acrosome membrane-associated protein 4-like 0.043
adra2b adrenergic, alpha-2B-, receptor 0.043
aqp7 aquaporin 7 0.042
gnrh2 gonadotropin-releasing hormone 2 0.042
grin1a glutamate receptor, ionotropic, N-methyl D-aspartate 1a 0.042
nr2f1a nuclear receptor subfamily 2, group F, member 1a 0.040
epcam epithelial cell adhesion molecule 0.040
col1a1b collagen, type I, alpha 1b 0.040
col1a1a collagen, type I, alpha 1a 0.039
slc1a2b solute carrier family 1 (glial high affinity glutamate transporter), member 2b 0.038
cacnb2a calcium channel, voltage-dependent, beta 2a 0.038
aqp10b aquaporin 10b 0.038
LOC100332193 growth hormone secretagogue receptor type 1-like 0.037
si:ch211-209p5.2 si:ch211-209p5.2 0.037
LOC100005283 Gig2-like protein DreE 0.037
bactin1 bactin1 0.036
pyya peptide YYa 0.036
pcp4a Purkinje cell protein 4a 0.036
fabp11a fatty acid binding protein 11a 0.036
ca2 carbonic anhydrase II 0.035
gfra1b gdnf family receptor alpha 1b 0.035
kiss1rb KISS1 receptor b 0.035
chrnb3a cholinergic receptor, nicotinic, beta polypeptide 3a 0.034
sox5 SRY-box containing gene 5 0.034
sncgb synuclein, gamma b (breast cancer-specific protein 1) 0.033
ghrl ghrelin/obestatin preprohormone 0.033
sox8 SRY-box containing gene 8 0.032
vipr2 vasoactive intestinal peptide receptor 2 0.032
ucn3l urocortin 3, like 0.031
adra2a adrenergic, alpha-2A-, receptor 0.031
cyt1 type I cytokeratin, enveloping layer 0.030
npy4r neuropeptide Y receptor Y4 0.030
efna5b ephrin A5b 0.030
trpv1 transient receptor potential cation channel subfamily V member 1 0.030
crh corticotropin releasing hormone 0.029
pth2 parathyroid hormone 2 0.029
klf2b Kruppel-like factor 2b 0.028
tbr1b T-box, brain, 1b 0.028
aqp8a.2 aquaporin 8a, tandem duplicate 2 0.027
tfap2a transcription factor AP-2 alpha 0.027
pycard PYD and CARD domain containing 0.027
egr1 early growth response 1 0.027
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TACSTD2 tumor-associated calcium signal transducer 2 0.857
KRT5 keratin 5 0.841
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.432
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.365
SCNN1B sodium channel, nonvoltage-gated 1, beta 0.332
CTNND1 catenin (cadherin-associated protein), delta 1 0.316
SCNN1A sodium channel, nonvoltage-gated 1 alpha 0.176
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.150
MYOCD myocardin 0.087
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.066
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.065
MKL1 megakaryoblastic leukemia (translocation) 1 0.062
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.048
TJP3 tight junction protein 3 (zona occludens 3) 0.047
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.040
LAD1 ladinin 1 0.038
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.032
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.032
CABLES1 Cdk5 and Abl enzyme substrate 1 0.029
MYOG myogenin (myogenic factor 4) 0.026
HOXA1 homeobox A1 0.019
MDFI MyoD family inhibitor 0.018
FAM107A family with sequence similarity 107, member A 0.017
JUP junction plakoglobin 0.017
EPN1 epsin 1 0.017
KCTD17 potassium channel tetramerisation domain containing 17 0.017
PTPRJ protein tyrosine phosphatase, receptor type, J 0.017
KRT6C keratin 6C 0.017
TMEM40 transmembrane protein 40 0.016
ADAMTSL4 ADAMTS-like 4 0.016
PKP3 plakophilin 3 0.016
CLDN16 claudin 16 0.014
KRTAP4-12 keratin associated protein 4-12 0.014
FGFR1 fibroblast growth factor receptor 1 0.013
MKL2 MKL/myocardin-like 2 0.013
SLC17A1 solute carrier family 17 (sodium phosphate), member 1 0.013
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.013
GLTPD1 glycolipid transfer protein domain containing 1 0.013
SCNN1G sodium channel, nonvoltage-gated 1, gamma 0.013
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.012
CATSPER1 cation channel, sperm associated 1 0.012
SPDEF SAM pointed domain containing ets transcription factor 0.012
MUC1 mucin 1, cell surface associated 0.012
WFDC2 WAP four-disulfide core domain 2 0.011
HMOX2 heme oxygenase (decycling) 2 0.011
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.011
ALOX12B arachidonate 12-lipoxygenase, 12R type 0.010
PSEN1 presenilin 1 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Trp63 transformation related protein 63 0.844
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.697
Psapl1 prosaposin-like 1 0.629
Krt6a keratin 6A 0.623
Irf6 interferon regulatory factor 6 0.612
Krt19 keratin 19 0.582
Crb3 crumbs homolog 3 (Drosophila) 0.523
Cela3b chymotrypsin-like elastase family, member 3B 0.507
Cldn3 claudin 3 0.425
Il1f5 interleukin 1 family, member 5 (delta) 0.416
Sprr1a small proline-rich protein 1A 0.407
Krt5 keratin 5 0.406
Krt15 keratin 15 0.392
Krt17 keratin 17 0.380
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.351
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.334
Rab25 RAB25, member RAS oncogene family 0.296
Alox5ap arachidonate 5-lipoxygenase activating protein 0.284
Krt1 keratin 1 0.240
Aqp2 aquaporin 2 0.236
Tmprss2 transmembrane protease, serine 2 0.224
Dsg2 desmoglein 2 0.216
Tcfap2c transcription factor AP-2, gamma 0.213
Tgm3 transglutaminase 3, E polypeptide 0.203
Cldn4 claudin 4 0.202
Foxn1 forkhead box N1 0.201
Dsc3 desmocollin 3 0.194
Elf3 E74-like factor 3 0.176
Krt71 keratin 71 0.172
Cdcp1 CUB domain containing protein 1 0.169
Elf5 E74-like factor 5 0.165
Krt8 keratin 8 0.163
Prss8 protease, serine, 8 (prostasin) 0.155
Rdh8 retinol dehydrogenase 8 0.155
Krtdap keratinocyte differentiation associated protein 0.151
Tjp1 tight junction protein 1 0.148
Krt14 keratin 14 0.138
Wnt10a wingless related MMTV integration site 10a 0.126
Pdzk1ip1 PDZK1 interacting protein 1 0.125
Lrrk2 leucine-rich repeat kinase 2 0.125
Cdx2 caudal type homeobox 2 0.124
Dlx3 distal-less homeobox 3 0.122
Trp73 transformation related protein 73 0.120
Krt33b keratin 33B 0.116
Slc5a11 solute carrier family 5 (sodium/glucose cotransporter), member 11 0.113
Trpv5 transient receptor potential cation channel, subfamily V, member 5 0.110
Flg filaggrin 0.106
Sfn stratifin 0.103
Pvalb parvalbumin 0.103
Slc7a9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 0.096
Hr hairless 0.095
1600029D21Rik RIKEN cDNA 1600029D21 gene 0.095
Fam83f family with sequence similarity 83, member F 0.094
Gm13011 predicted gene 13011 0.094
Cyp26c1 cytochrome P450, family 26, subfamily c, polypeptide 1 0.091
Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.087
Scnn1b sodium channel, nonvoltage-gated 1 beta 0.087
Rnase1 ribonuclease, RNase A family, 1 (pancreatic) 0.085
Nkx6-1 NK6 homeobox 1 0.082
Mogat2 monoacylglycerol O-acyltransferase 2 0.080
Krt31 keratin 31 0.080
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.077
Rpgrip1l Rpgrip1-like 0.077
Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like 0.076
Wnk4 WNK lysine deficient protein kinase 4 0.074
Alox12e arachidonate lipoxygenase, epidermal 0.074
Adam28 a disintegrin and metallopeptidase domain 28 0.073
Ppl periplakin 0.072
Wfdc2 WAP four-disulfide core domain 2 0.072
Krt4 keratin 4 0.070
Dct dopachrome tautomerase 0.069
Trim29 tripartite motif-containing 29 0.068
Ctrb1 chymotrypsinogen B1 0.068
Bsnd Bartter syndrome, infantile, with sensorineural deafness (Barttin) 0.067
Slc12a1 solute carrier family 12, member 1 0.067
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.066
Krt13 keratin 13 0.065
Tmem30b transmembrane protein 30B 0.065
Slc46a2 solute carrier family 46, member 2 0.064
Krt86 keratin 86 0.064
Upk3a uroplakin 3A 0.064
Krtap8-1 keratin associated protein 8-1 0.063
Calm4 calmodulin 4 0.061
Ly6g6c lymphocyte antigen 6 complex, locus G6C 0.060
Klk7 kallikrein related-peptidase 7 (chymotryptic, stratum corneum) 0.060
Krt75 keratin 75 0.059
Mpdz multiple PDZ domain protein 0.058
Pkp1 plakophilin 1 0.058
Krt72-ps keratin 72, pseudogene 0.058
Aqp3 aquaporin 3 0.057
Evpl envoplakin 0.057
Asprv1 aspartic peptidase, retroviral-like 1 0.056
Ggt1 gamma-glutamyltransferase 1 0.055
Cldn2 claudin 2 0.055
Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 0.054
Tmem79 transmembrane protein 79 0.053
Prss2 protease, serine, 2 0.052
Spint1 serine protease inhibitor, Kunitz type 1 0.052
Slc6a13 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 0.052
Trpv6 transient receptor potential cation channel, subfamily V, member 6 0.052
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism