The network for 'g protein coupled glutamate receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

g protein coupled glutamate receptor signaling pathway

A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.

Rattus norvegicus
Name Description Probability Func Analog Organism
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.609
Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.435
Rap1b RAP1B, member of RAS oncogene family 0.332
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.192
Gria1 glutamate receptor, ionotropic, AMPA 1 0.180
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.179
Cnksr2 connector enhancer of kinase suppressor of Ras 2 0.146
Grm5 glutamate receptor, metabotropic 5 0.143
Grm7 glutamate receptor, metabotropic 7 0.127
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.119
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.114
Kcnk1 potassium channel, subfamily K, member 1 0.106
Unc5a unc-5 homolog A (C. elegans) 0.099
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.098
Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 0.098
Cyth1 cytohesin 1 0.091
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.086
Grm1 glutamate receptor, metabotropic 1 0.080
Pde1b phosphodiesterase 1B, calmodulin-dependent 0.078
Chrna2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.076
Camk4 calcium/calmodulin-dependent protein kinase IV 0.075
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.072
Epha5 EphA5 0.072
Hpcal4 hippocalcin-like 4 0.067
Gabrb1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.061
Nlgn3 neuroligin 3 0.061
Cntn3 contactin 3 (plasmacytoma associated) 0.056
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.052
Azin1 antizyme inhibitor 1 0.048
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.044
Unc13c unc-13 homolog C (C. elegans) 0.041
Mobp myelin-associated oligodendrocyte basic protein 0.040
Syn2 synapsin II 0.040
Cntn1 contactin 1 0.039
Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 0.036
Atp7b ATPase, Cu++ transporting, beta polypeptide 0.035
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.034
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.033
Gabbr2 gamma-aminobutyric acid (GABA) B receptor 2 0.033
Wdr7 WD repeat domain 7 0.033
Dlg4 discs, large homolog 4 (Drosophila) 0.032
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.032
Homer1 homer homolog 1 (Drosophila) 0.032
Oprl1 opiate receptor-like 1 0.031
Kcnc1 potassium voltage gated channel, Shaw-related subfamily, member 1 0.031
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.031
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.030
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.029
Nmbr neuromedin B receptor 0.029
Cplx2 complexin 2 0.027
Grip1 glutamate receptor interacting protein 1 0.026
Npy5r neuropeptide Y receptor Y5 0.025
Syt11 synaptotagmin XI 0.025
Fgfr2 fibroblast growth factor receptor 2 0.025
Trhr2 thyrotropin releasing hormone receptor 2 0.024
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.024
Hnrnpf heterogeneous nuclear ribonucleoprotein F 0.023
LOC100360986 mCG1035404-like 0.023
Apba2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.023
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.022
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.022
Ptms parathymosin 0.022
Epas1 endothelial PAS domain protein 1 0.021
Drd1a dopamine receptor D1A 0.021
Gad2 glutamate decarboxylase 2 0.020
Syt4 synaptotagmin IV 0.020
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.020
Opn1mw opsin 1 (cone pigments), medium-wave-sensitive 0.020
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.020
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 0.020
Znf483 zinc finger protein 483 0.020
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.019
Chrm1 cholinergic receptor, muscarinic 1 0.019
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.019
Cacnb4 calcium channel, voltage-dependent, beta 4 subunit 0.018
Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 0.018
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.018
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.018
Accn1 amiloride-sensitive cation channel 1, neuronal 0.018
Elf1 E74-like factor 1 0.017
Syt7 synaptotagmin VII 0.017
Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.017
Syt1 synaptotagmin I 0.017
Elavl4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) 0.017
Syt12 synaptotagmin XII 0.017
Mgat3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 0.016
Gabra5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.016
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.016
Gria2 glutamate receptor, ionotropic, AMPA 2 0.016
Prph2 peripherin 2 0.016
Mapk10 mitogen activated protein kinase 10 0.016
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.016
Svop SV2 related protein 0.015
Clcn4-2 chloride channel 4-2 0.015
Nxph1 neurexophilin 1 0.015
Opcml opioid binding protein/cell adhesion molecule-like 0.015
Homer3 homer homolog 3 (Drosophila) 0.015
Pcyt1b phosphate cytidylyltransferase 1, choline, beta 0.014
Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) 0.014
Dpp6 dipeptidylpeptidase 6 0.014
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
GRIP1 glutamate receptor interacting protein 1 0.886
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.638
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.622
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.461
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.250
MYH14 myosin, heavy chain 14, non-muscle 0.231
GRIA4 glutamate receptor, ionotrophic, AMPA 4 0.215
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.110
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.090
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.085
PICK1 protein interacting with PRKCA 1 0.061
MYT1 myelin transcription factor 1 0.045
AFF2 AF4/FMR2 family, member 2 0.041
NSF N-ethylmaleimide-sensitive factor 0.040
MYH10 myosin, heavy chain 10, non-muscle 0.034
BCAN brevican 0.031
GAP43 growth associated protein 43 0.031
NEUROD2 neurogenic differentiation 2 0.028
KIAA1045 KIAA1045 0.026
GRIK5 glutamate receptor, ionotropic, kainate 5 0.026
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C 0.026
CA10 carbonic anhydrase X 0.025
ACTL6B actin-like 6B 0.024
SLC17A6 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 0.023
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.023
GRM3 glutamate receptor, metabotropic 3 0.022
GRM7 glutamate receptor, metabotropic 7 0.022
KCND2 potassium voltage-gated channel, Shal-related subfamily, member 2 0.022
ACSL6 acyl-CoA synthetase long-chain family member 6 0.019
GRIK2 glutamate receptor, ionotropic, kainate 2 0.019
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.019
NEUROD1 neurogenic differentiation 1 0.018
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.018
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.017
SCN8A sodium channel, voltage gated, type VIII, alpha subunit 0.017
RGS7 regulator of G-protein signaling 7 0.017
GRIK1 glutamate receptor, ionotropic, kainate 1 0.017
GPR6 G protein-coupled receptor 6 0.017
VSTM2A V-set and transmembrane domain containing 2A 0.016
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 0.015
SEZ6L seizure related 6 homolog (mouse)-like 0.015
KCNIP2 Kv channel interacting protein 2 0.015
CRHR2 corticotropin releasing hormone receptor 2 0.015
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.015
FAM5B family with sequence similarity 5, member B 0.015
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.015
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.014
KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1 0.014
PRMT8 protein arginine methyltransferase 8 0.014
FAM123A family with sequence similarity 123A 0.014
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.014
KCNQ2 potassium voltage-gated channel, KQT-like subfamily, member 2 0.014
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 0.014
GRID2 glutamate receptor, ionotropic, delta 2 0.013
RIMS1 regulating synaptic membrane exocytosis 1 0.013
CDH8 cadherin 8, type 2 0.013
RIT2 Ras-like without CAAX 2 0.013
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.013
SYT13 synaptotagmin XIII 0.013
KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3 0.012
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.012
HMP19 HMP19 protein 0.012
SLC7A10 solute carrier family 7, (neutral amino acid transporter, y+ system) member 10 0.012
DPP6 dipeptidyl-peptidase 6 0.012
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.011
FGF12 fibroblast growth factor 12 0.011
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 0.011
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 0.011
NTNG1 netrin G1 0.011
OPRK1 opioid receptor, kappa 1 0.011
MCHR1 melanin-concentrating hormone receptor 1 0.011
CADM3 cell adhesion molecule 3 0.011
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 0.011
ADORA1 adenosine A1 receptor 0.011
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.011
SLC39A12 solute carrier family 39 (zinc transporter), member 12 0.010
NRXN1 neurexin 1 0.010
PRKCG protein kinase C, gamma 0.010
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A 0.010
DCC deleted in colorectal carcinoma 0.010
NOS1 nitric oxide synthase 1 (neuronal) 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.999
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.998
Shank2 SH3/ankyrin domain gene 2 0.950
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.942
Homer1 homer homolog 1 (Drosophila) 0.901
Fbxo41 F-box protein 41 0.724
Drd1a dopamine receptor D1A 0.586
Mpped1 metallophosphoesterase domain containing 1 0.465
Shisa9 shisa homolog 9 (Xenopus laevis) 0.455
Dlg2 discs, large homolog 2 (Drosophila) 0.415
Gpr26 G protein-coupled receptor 26 0.385
3110047P20Rik RIKEN cDNA 3110047P20 gene 0.350
Grm5 glutamate receptor, metabotropic 5 0.343
Il1rapl1 interleukin 1 receptor accessory protein-like 1 0.303
Grm1 glutamate receptor, metabotropic 1 0.302
Adcy1 adenylate cyclase 1 0.256
Hs3st2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 0.253
Gad2 glutamic acid decarboxylase 2 0.242
Trpc5 transient receptor potential cation channel, subfamily C, member 5 0.225
Gpr123 G protein-coupled receptor 123 0.221
D130043K22Rik RIKEN cDNA D130043K22 gene 0.219
Arc activity regulated cytoskeletal-associated protein 0.193
Prkcc protein kinase C, gamma 0.185
Crhr1 corticotropin releasing hormone receptor 1 0.174
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.169
Syt1 synaptotagmin I 0.158
Vwc2l von Willebrand factor C domain-containing protein 2-like 0.146
Col19a1 collagen, type XIX, alpha 1 0.142
Syt2 synaptotagmin II 0.141
Emx1 empty spiracles homolog 1 (Drosophila) 0.139
Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 0.131
Neto1 neuropilin (NRP) and tolloid (TLL)-like 1 0.128
Csmd1 CUB and Sushi multiple domains 1 0.124
Cit citron 0.111
Rph3a rabphilin 3A 0.110
Iqsec3 IQ motif and Sec7 domain 3 0.108
Clec2l C-type lectin domain family, member L 0.105
Olfm3 olfactomedin 3 0.104
Myt1l myelin transcription factor 1-like 0.103
Ankrd34a ankyrin repeat domain 34A 0.101
Cntn4 contactin 4 0.100
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.096
Kcnv1 potassium channel, subfamily V, member 1 0.096
Ptpn5 protein tyrosine phosphatase, non-receptor type 5 0.092
Xkr4 X Kell blood group precursor related family member 4 0.091
Hecw1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.086
Pak7 p21 protein (Cdc42/Rac)-activated kinase 7 0.085
Mgat5b mannoside acetylglucosaminyltransferase 5, isoenzyme B 0.084
Tmem132d transmembrane protein 132D 0.081
Accn4 amiloride-sensitive cation channel 4, pituitary 0.080
Nxph2 neurexophilin 2 0.078
Grm2 glutamate receptor, metabotropic 2 0.076
Bdnf brain derived neurotrophic factor 0.074
Rims1 regulating synaptic membrane exocytosis 1 0.074
Jph4 junctophilin 4 0.073
Gjd3 gap junction protein, delta 3 0.070
Grik2 glutamate receptor, ionotropic, kainate 2 (beta 2) 0.069
Kcnc4 potassium voltage gated channel, Shaw-related subfamily, member 4 0.067
Neurod6 neurogenic differentiation 6 0.063
Grid1 glutamate receptor, ionotropic, delta 1 0.062
Ryr3 ryanodine receptor 3 0.060
Npy5r neuropeptide Y receptor Y5 0.060
Synpr synaptoporin 0.059
Rorb RAR-related orphan receptor beta 0.058
Kctd8 potassium channel tetramerisation domain containing 8 0.056
Cntnap4 contactin associated protein-like 4 0.055
Sorcs3 sortilin-related VPS10 domain containing receptor 3 0.053
Srrm4 serine/arginine repetitive matrix 4 0.052
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.051
Nptx2 neuronal pentraxin 2 0.051
Braf Braf transforming gene 0.051
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 0.050
Spock1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 0.049
Pvalb parvalbumin 0.048
Odz1 odd Oz/ten-m homolog 1 (Drosophila) 0.048
Tmem198 transmembrane protein 198 0.047
Kcnq3 potassium voltage-gated channel, subfamily Q, member 3 0.046
Frmpd3 FERM and PDZ domain containing 3 0.044
Pou4f2 POU domain, class 4, transcription factor 2 0.044
Cbln3 cerebellin 3 precursor protein 0.044
Prkcb protein kinase C, beta 0.043
Kcns2 K+ voltage-gated channel, subfamily S, 2 0.043
Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 0.043
Megf11 multiple EGF-like-domains 11 0.043
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.042
Kcnt1 potassium channel, subfamily T, member 1 0.041
Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) 0.039
6430704M03Rik RIKEN cDNA 6430704M03 gene 0.039
Anks1b ankyrin repeat and sterile alpha motif domain containing 1B 0.039
Lhfpl3 lipoma HMGIC fusion partner-like 3 0.038
Cpne4 copine IV 0.038
Hrh3 histamine receptor H3 0.037
Arpp21 cyclic AMP-regulated phosphoprotein, 21 0.037
Tacr3 tachykinin receptor 3 0.037
Ina internexin neuronal intermediate filament protein, alpha 0.037
Camk2b calcium/calmodulin-dependent protein kinase II, beta 0.037
Vstm2b V-set and transmembrane domain containing 2B 0.036
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.036
Cdh8 cadherin 8 0.036
Grik4 glutamate receptor, ionotropic, kainate 4 0.036
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism