The network for 'positive regulation of cell killing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cell killing

Any process that activates or increases the frequency, rate or extent of cell killing.

Danio rerio
Name Description Probability Func Analog Organism
zgc:64115 zgc:64115 0.742
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.163
mcl1a myeloid cell leukemia sequence 1a 0.161
scarb1 scavenger receptor class B, member 1 0.149
zgc:174863 zgc:174863 0.128
hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.126
ednrb1 endothelin receptor B 0.099
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.096
stat1a signal transduction and activation of transcription 1a 0.090
gabarapa GABA(A) receptor-associated protein a 0.083
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.082
pax7b paired box gene 7b 0.082
LOC566020 Gig2-like protein DreO 0.079
apaf1 apoptotic protease activating factor 1 0.065
sqstm1 sequestosome 1 0.061
g6pd glucose-6-phosphate dehydrogenase 0.059
ifnphi1 interferon phi 1 0.058
prkar1aa protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a 0.056
npy4r neuropeptide Y receptor Y4 0.055
b2m beta-2-microglobulin 0.053
styk1 serine/threonine/tyrosine kinase 1 0.051
tbp TATA box binding protein 0.051
gsk3b glycogen synthase kinase 3 beta 0.051
map1lc3a microtubule-associated protein 1 light chain 3 alpha 0.049
irf11 interferon regulatory factor 11 0.048
sdcbp syndecan binding protein (syntenin) 0.048
gmfg glia maturation factor, gamma 0.047
zgc:101598 zgc:101598 0.046
ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.045
psmb9a proteasome (prosome, macropain) subunit, beta type, 9a 0.045
zgc:162329 zgc:162329 0.043
zgc:63831 zgc:63831 0.041
stxbp2 syntaxin binding protein 2 0.041
znf148 zinc finger protein 148 0.040
kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.040
vps39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.039
wasa Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a 0.039
si:ch211-244b2.4 si:ch211-244b2.4 0.038
waca WW domain containing adaptor with coiled-coil a 0.037
phox2a paired-like homeobox 2a 0.037
foxp3a forkhead box P3a 0.037
ddr2b discoidin domain receptor family, member 2b 0.036
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.036
casp9 caspase 9, apoptosis-related cysteine protease 0.035
casp8 caspase 8, apoptosis-related cysteine peptidase 0.034
ugt5c2 UDP glucuronosyltransferase 5 family, polypeptide C2 0.033
cflar CASP8 and FADD-like apoptosis regulator 0.033
isg15 ISG15 ubiquitin-like modifier 0.033
ppp2r5ea protein phosphatase 2, regulatory subunit B', epsilon isoform a 0.033
rhogb ras homolog gene family, member Gb 0.032
zgc:101614 zgc:101614 0.032
LOC567441 interferon-induced protein with tetratricopeptide repeats 5-like 0.031
ptger2b prostaglandin E receptor 2b (subtype EP2) 0.031
itln1 intelectin 1 0.031
coro1a coronin, actin binding protein, 1A 0.031
zgc:162964 zgc:162964 0.030
zgc:64161 zgc:64161 0.030
litaf lipopolysaccharide-induced TNF factor 0.030
phrf1 PHD and ring finger domains 1 0.030
gnsb glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b 0.029
abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.029
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.029
grna granulin a 0.029
cxc46 CXC chemokine 46 0.029
fbxo32 F-box protein 32 0.029
pkz protein kinase containing Z-DNA binding domains 0.028
fadd Fas (tnfrsf6)-associated via death domain 0.028
hdac4 histone deacetylase 4 0.028
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.028
stat1b signal transducer and activator of transcription 1b 0.028
npy7r neuropeptide Y receptor Y7 0.028
camk2g2 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2 0.028
nitr9 novel immune-type receptor 9 0.027
pcsk7 proprotein convertase subtilisin/kexin type 7 0.027
irak4 interleukin-1 receptor-associated kinase 4 0.027
tpsn tapasin 0.027
ptk6a PTK6 protein tyrosine kinase 6a 0.027
illr1 immune-related, lectin-like receptor 1 0.026
tbc1d15 TBC1 domain family, member 15 0.026
eomesb eomesodermin homolog b 0.026
fcer1gl Fc receptor, IgE, high affinity I, gamma polypeptide like 0.026
c1qc complement component 1, q subcomponent, C chain 0.026
il10 interleukin 10 0.026
tlr9 toll-like receptor 9 0.026
LOC793458 peptide Y-like 0.026
lrrc33 leucine rich repeat containing 33 0.025
LOC100148845 neurogenin-1-like 0.025
itga2b integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) 0.025
mxa myxovirus (influenza) resistance A 0.025
zfyve28 zinc finger, FYVE domain containing 28 0.025
cd8a CD8 antigen, alpha polypeptide 0.025
defbl3 defensin, beta-like 3 0.025
ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.024
taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto 0.024
zgc:172101 zgc:172101 0.024
LOC794786 interferon-induced protein with tetratricopeptide repeats 1-like 0.024
mst1rb macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b 0.024
ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 0.024
gab1 GRB2-associated binding protein 1 0.023
k31 k31 gene 0.023
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
B2M beta-2-microglobulin 0.994
HLA-C major histocompatibility complex, class I, C 0.936
HLA-A major histocompatibility complex, class I, A 0.927
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.906
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.865
HLA-B major histocompatibility complex, class I, B 0.668
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.652
HLA-F major histocompatibility complex, class I, F 0.585
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.567
IL2RB interleukin 2 receptor, beta 0.557
HLA-G major histocompatibility complex, class I, G 0.477
CCL4 chemokine (C-C motif) ligand 4 0.408
SH2D1A SH2 domain containing 1A 0.340
HLA-E major histocompatibility complex, class I, E 0.327
SLAMF1 signaling lymphocytic activation molecule family member 1 0.309
CD84 CD84 molecule 0.258
IL8 interleukin 8 0.240
CCL5 chemokine (C-C motif) ligand 5 0.234
CCR5 chemokine (C-C motif) receptor 5 0.232
NOSTRIN nitric oxide synthase trafficker 0.208
IFNG interferon, gamma 0.177
CXCL3 chemokine (C-X-C motif) ligand 3 0.173
TAPBP TAP binding protein (tapasin) 0.149
CXCL2 chemokine (C-X-C motif) ligand 2 0.137
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.113
GBA glucosidase, beta, acid 0.111
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.105
IL6 interleukin 6 (interferon, beta 2) 0.091
CXCL9 chemokine (C-X-C motif) ligand 9 0.089
IL1B interleukin 1, beta 0.081
IL23A interleukin 23, alpha subunit p19 0.069
CCR7 chemokine (C-C motif) receptor 7 0.063
DPP4 dipeptidyl-peptidase 4 0.056
BCL2 B-cell CLL/lymphoma 2 0.055
FASLG Fas ligand (TNF superfamily, member 6) 0.054
CAV1 caveolin 1, caveolae protein, 22kDa 0.052
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.051
CCL8 chemokine (C-C motif) ligand 8 0.049
GZMK granzyme K (granzyme 3; tryptase II) 0.046
CCL13 chemokine (C-C motif) ligand 13 0.041
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.040
CCL19 chemokine (C-C motif) ligand 19 0.038
ITM2B integral membrane protein 2B 0.038
CCL20 chemokine (C-C motif) ligand 20 0.037
IL18RAP interleukin 18 receptor accessory protein 0.034
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.034
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.031
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.028
CXCR6 chemokine (C-X-C motif) receptor 6 0.028
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.028
CXCL10 chemokine (C-X-C motif) ligand 10 0.028
RNF13 ring finger protein 13 0.027
CCL2 chemokine (C-C motif) ligand 2 0.027
CCL22 chemokine (C-C motif) ligand 22 0.026
ITK IL2-inducible T-cell kinase 0.025
PVRL4 poliovirus receptor-related 4 0.025
GPR171 G protein-coupled receptor 171 0.025
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.024
XCL2 chemokine (C motif) ligand 2 0.024
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.024
VCAM1 vascular cell adhesion molecule 1 0.024
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.024
BAX BCL2-associated X protein 0.023
BID BH3 interacting domain death agonist 0.022
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.022
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.022
IL10 interleukin 10 0.021
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.021
CCL7 chemokine (C-C motif) ligand 7 0.021
RGS1 regulator of G-protein signaling 1 0.021
IRF4 interferon regulatory factor 4 0.020
CXCL13 chemokine (C-X-C motif) ligand 13 0.020
STAT4 signal transducer and activator of transcription 4 0.020
CD2 CD2 molecule 0.019
PRF1 perforin 1 (pore forming protein) 0.019
CCR4 chemokine (C-C motif) receptor 4 0.019
IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) 0.019
CCL3 chemokine (C-C motif) ligand 3 0.018
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.018
IL7R interleukin 7 receptor 0.017
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.017
UBD ubiquitin D 0.016
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.016
CD48 CD48 molecule 0.015
CXCL5 chemokine (C-X-C motif) ligand 5 0.015
TNF tumor necrosis factor 0.015
STAP2 signal transducing adaptor family member 2 0.015
IDE insulin-degrading enzyme 0.015
ICOS inducible T-cell co-stimulator 0.015
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.015
BCL2L1 BCL2-like 1 0.015
ICAM1 intercellular adhesion molecule 1 0.014
NKG7 natural killer cell group 7 sequence 0.014
SH2D1B SH2 domain containing 1B 0.014
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.014
SRGN serglycin 0.014
GNLY granulysin 0.014
KLRF1 killer cell lectin-like receptor subfamily F, member 1 0.013
NSF N-ethylmaleimide-sensitive factor 0.013
SELE selectin E 0.013
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Mus musculus
Name Description Probability Func Analog Organism
B2m beta-2 microglobulin 0.997
H2-K1 histocompatibility 2, K1, K region 0.993
H2-D1 histocompatibility 2, D region locus 1 0.992
Fyn Fyn proto-oncogene 0.959
Slamf1 signaling lymphocytic activation molecule family member 1 0.951
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.948
Tapbp TAP binding protein 0.941
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.883
H2-Q7 histocompatibility 2, Q region locus 7 0.850
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.736
Lck lymphocyte protein tyrosine kinase 0.725
Fasl Fas ligand (TNF superfamily, member 6) 0.702
Gzma granzyme A 0.638
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.616
Stat5b signal transducer and activator of transcription 5B 0.542
Pnp2 purine-nucleoside phosphorylase 2 0.526
Il2 interleukin 2 0.511
Gzmk granzyme K 0.505
Stat5a signal transducer and activator of transcription 5A 0.497
Irgm2 immunity-related GTPase family M member 2 0.458
Ncr1 natural cytotoxicity triggering receptor 1 0.433
Gzmb granzyme B 0.428
Cxcl2 chemokine (C-X-C motif) ligand 2 0.408
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.406
Xcl1 chemokine (C motif) ligand 1 0.399
Tcra T-cell receptor alpha chain 0.373
Irf9 interferon regulatory factor 9 0.359
Icos inducible T-cell co-stimulator 0.318
H2-Q6 histocompatibility 2, Q region locus 6 0.286
Itk IL2-inducible T-cell kinase 0.272
Lyz2 lysozyme 2 0.265
Il18rap interleukin 18 receptor accessory protein 0.257
Il2ra interleukin 2 receptor, alpha chain 0.228
Il2rg interleukin 2 receptor, gamma chain 0.222
Il6 interleukin 6 0.222
Il2rb interleukin 2 receptor, beta chain 0.220
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.219
Cd244 CD244 natural killer cell receptor 2B4 0.213
Il18r1 interleukin 18 receptor 1 0.193
Klra8 killer cell lectin-like receptor, subfamily A, member 8 0.177
Sh2d2a SH2 domain protein 2A 0.170
Ctsw cathepsin W 0.168
Cd28 CD28 antigen 0.155
Xcr1 chemokine (C motif) receptor 1 0.149
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.142
Lat linker for activation of T cells 0.139
Sh2d1a SH2 domain protein 1A 0.135
Il1rn interleukin 1 receptor antagonist 0.124
Cd160 CD160 antigen 0.122
Cd247 CD247 antigen 0.121
Ciita class II transactivator 0.103
Sh2d1b1 SH2 domain protein 1B1 0.102
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.100
Tnip1 TNFAIP3 interacting protein 1 0.100
Irg1 immunoresponsive gene 1 0.086
Zfp36 zinc finger protein 36 0.085
C920025E04Rik RIKEN cDNA C920025E04 gene 0.081
Ccl3 chemokine (C-C motif) ligand 3 0.078
Ccr9 chemokine (C-C motif) receptor 9 0.076
Klrb1a killer cell lectin-like receptor subfamily B member 1A 0.074
Itm2b integral membrane protein 2B 0.073
Gbp2 guanylate binding protein 2 0.071
Ccr3 chemokine (C-C motif) receptor 3 0.071
Ccr1 chemokine (C-C motif) receptor 1 0.069
Klra7 killer cell lectin-like receptor, subfamily A, member 7 0.069
Stat1 signal transducer and activator of transcription 1 0.069
Stat3 signal transducer and activator of transcription 3 0.067
Ccl5 chemokine (C-C motif) ligand 5 0.067
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.066
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.066
Cd8a CD8 antigen, alpha chain 0.065
H2-Q5 histocompatibility 2, Q region locus 5 0.064
Spna1 spectrin alpha 1 0.064
Klra3 killer cell lectin-like receptor, subfamily A, member 3 0.064
Ccl4 chemokine (C-C motif) ligand 4 0.064
Gzmc granzyme C 0.064
Nckap1l NCK associated protein 1 like 0.063
Trim21 tripartite motif-containing 21 0.061
Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 0.059
Fas Fas (TNF receptor superfamily member 6) 0.056
Mmp13 matrix metallopeptidase 13 0.055
Foxp3 forkhead box P3 0.055
Clec4d C-type lectin domain family 4, member d 0.054
Lyst lysosomal trafficking regulator 0.054
Cd80 CD80 antigen 0.053
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.053
H2-M2 histocompatibility 2, M region locus 2 0.053
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.053
Chl1 cell adhesion molecule with homology to L1CAM 0.052
H2-Q8 histocompatibility 2, Q region locus 8 0.052
Il4ra interleukin 4 receptor, alpha 0.050
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.049
Klre1 killer cell lectin-like receptor family E member 1 0.049
Gbp7 guanylate binding protein 7 0.049
Lair1 leukocyte-associated Ig-like receptor 1 0.049
Slamf7 SLAM family member 7 0.048
Ptgir prostaglandin I receptor (IP) 0.048
Il7r interleukin 7 receptor 0.048
Sele selectin, endothelial cell 0.048
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.048
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-EC2 RT1 class Ib, locus EC2 0.666
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.298
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.204
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.165
Hsph1 heat shock 105/110 protein 1 0.161
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.137
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.121
Cxcl10 chemokine (C-X-C motif) ligand 10 0.069
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.066
RT1-CE12 RT1 class I, locus CE12 0.040
Atf3 activating transcription factor 3 0.039
LOC100364500 RT1 class I, locus CE11-like 0.038
Il2rb interleukin 2 receptor, beta 0.037
Mcpt8 mast cell protease 8 0.032
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.030
Hspb1 heat shock protein 1 0.025
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.025
Gbp2 guanylate binding protein 2 0.023
Cd5 Cd5 molecule 0.022
LOC100364485 mCG1051031-like 0.020
Aif1 allograft inflammatory factor 1 0.019
Cd2 Cd2 molecule 0.018
Nkg7 natural killer cell group 7 sequence 0.018
Gzmk granzyme K 0.018
Emcn endomucin 0.018
Fut2 fucosyltransferase 2 (secretor status included) 0.017
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.015
RT1-S3 RT1 class Ib, locus S3 0.014
Serpinb9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.013
Cacng1 calcium channel, voltage-dependent, gamma subunit 1 0.013
Sept1 septin 1 0.013
Ccl5 chemokine (C-C motif) ligand 5 0.013
Il1b interleukin 1 beta 0.013
Csf1 colony stimulating factor 1 (macrophage) 0.012
Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 0.012
Ccl7 chemokine (C-C motif) ligand 7 0.012
Nras neuroblastoma ras oncogene 0.012
Gper G protein-coupled estrogen receptor 1 0.012
Asah1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.011
Rhoh ras homolog gene family, member H 0.010
Cd247 Cd247 molecule 0.010
Stip1 stress-induced phosphoprotein 1 0.010
Calcrl calcitonin receptor-like 0.010
Ly6c Ly6-C antigen 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism