The network for 'enteric nervous system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

enteric nervous system development

The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation.

Danio rerio
Name Description Probability Func Analog Organism
phox2a paired-like homeobox 2a 0.770
gfra1a gdnf family receptor alpha 1a 0.759
crestin crestin 0.701
foxd3 forkhead box D3 0.653
phox2b paired-like homeobox 2b 0.565
foxi1 forkhead box I1 0.528
hmx4 H6 family homeobox 4 0.493
foxa3 forkhead box A3 0.438
nes nestin 0.271
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.267
gfra1b gdnf family receptor alpha 1b 0.221
sox10 SRY-box containing gene 10 0.202
mab21l2 mab-21-like 2 0.193
eya1 eyes absent homolog 1 0.189
pitx2 paired-like homeodomain transcription factor 2 0.162
neurod neurogenic differentiation 0.151
foxi3b forkhead box I3b 0.132
ascl1a achaete-scute complex-like 1a (Drosophila) 0.123
neurog1 neurogenin 1 0.115
olfm1a olfactomedin 1a 0.115
foxa2 forkhead box A2 0.101
atoh8 atonal homolog 8 0.088
gbx2 gastrulation brain homeo box 2 0.083
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.083
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.078
gata3 GATA-binding protein 3 0.075
atp1a1a.2 ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide 0.065
six3a sine oculis homeobox homolog 3a 0.063
foxi3a forkhead box I3a 0.060
otx2 orthodenticle homolog 2 0.060
ahi1 Abelson helper integration site 1 0.059
nadl1.1 neural adhesion molecule L1.1 0.050
plxnb2b plexin b2b 0.050
dct dopachrome tautomerase 0.049
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.048
cntn2 contactin 2 0.048
tlx2 T-cell leukemia, homeobox 2 0.044
tfe3b transcription factor binding to IGHM enhancer 3b 0.043
slc16a10 solute carrier family 16, member 10 (aromatic amino acid transporter) 0.043
sim1a single-minded homolog 1a (Drosophila) 0.041
ebf3 early B-cell factor 3 0.040
ret1 receptor tyrosine kinase 0.039
hmx3 homeo box (H6 family) 3 0.039
lmo4a LIM domain only 4a 0.038
pax6b paired box gene 6b 0.037
bmper BMP binding endothelial regulator 0.037
dao.2 D-amino-acid oxidase 2 0.036
slc4a1b solute carrier family 4, anion exchanger, member 1b 0.036
pcdh17 protocadherin 17 0.034
tbx2b T-box 2b 0.032
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.031
pcdh19 protocadherin 19 0.031
six2a sine oculis-related homeobox 2a 0.031
grhl1 grainyhead-like 1 (Drosophila) 0.031
zeb2b zinc finger E-box binding homeobox 2b 0.030
zgc:194131 zgc:194131 0.029
vasn vasorin 0.028
m17 IL-6 subfamily cytokine M17 0.028
dlx4b distal-less homeobox gene 4b 0.028
foxa1 forkhead box A1 0.028
ppp1r14ab protein phosphatase 1, regulatory (inhibitor) subunit 14Ab 0.028
sfrp5 secreted frizzled-related protein 5 0.027
fli1b friend leukemia integration 1b 0.026
irx4b iroquois homeobox protein 4b 0.026
dnmt6 DNA (cytosine-5-)-methyltransferase 6 0.024
trpa1b transient receptor potential cation channel, subfamily A, member 1b 0.024
rx3 retinal homeobox gene 3 0.024
stmn2b stathmin-like 2b 0.024
cadm1a cell adhesion molecule 1a 0.024
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.023
vegfc vascular endothelial growth factor c 0.023
prrx1a paired related homeobox 1a 0.023
hoxa4a homeo box A4a 0.022
cdc25 cell division cycle 25 homolog 0.022
fsta follistatin a 0.022
pax8 paired box gene 8 0.022
im:7156396 im:7156396 0.022
gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.021
arhgap29a Rho GTPase activating protein 29a 0.021
loxl2b lysyl oxidase-like 2b 0.021
irx1b iroquois homeobox protein 1, b 0.020
gata2a GATA-binding protein 2a 0.020
sema3aa semaphorin 3aa 0.020
emx3 empty spiracles homeobox 3 0.019
gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a 0.019
six1b sine oculis homeobox homolog 1b 0.019
dpysl4 dihydropyrimidinase-like 4 0.019
tfeb transcription factor EB 0.018
dbx1a developing brain homeobox 1a 0.018
six4b sine oculis homeobox homolog 4b 0.018
tyrp1b tyrosinase-related protein 1b 0.018
pitx1 paired-like homeodomain transcription factor 1 0.018
gcm2 glial cells missing homolog 2 (Drosophila) 0.018
ddc dopa decarboxylase 0.018
wu:fv91b12 wu:fv91b12 0.018
met met proto-oncogene (hepatocyte growth factor receptor) 0.018
nkx2.2b NK2 transcription factor related 2b 0.017
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.017
fgf5 fibroblast growth factor 5 0.017
bhlhe22 basic helix-loop-helix family, member e22 0.016
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
MEOX2 mesenchyme homeobox 2 1.000
SOX10 SRY (sex determining region Y)-box 10 1.000
POU3F2 POU class 3 homeobox 2 1.000
PAX3 paired box 3 1.000
POU5F1 POU class 5 homeobox 1 0.999
MED12 mediator complex subunit 12 0.930
MED16 mediator complex subunit 16 0.417
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.318
SOX2 SRY (sex determining region Y)-box 2 0.295
MED29 mediator complex subunit 29 0.255
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.141
CDK19 cyclin-dependent kinase 19 0.068
VIP vasoactive intestinal peptide 0.048
HAND2 heart and neural crest derivatives expressed 2 0.040
SPRY4 sprouty homolog 4 (Drosophila) 0.038
PLCG1 phospholipase C, gamma 1 0.037
EMX1 empty spiracles homeobox 1 0.036
KAT2A K(lysine) acetyltransferase 2A 0.033
GFRA1 GDNF family receptor alpha 1 0.029
KRTAP4-12 keratin associated protein 4-12 0.027
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.027
JAM2 junctional adhesion molecule 2 0.027
LRRC15 leucine rich repeat containing 15 0.026
HOXD12 homeobox D12 0.025
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.024
NPAS1 neuronal PAS domain protein 1 0.024
TRRAP transformation/transcription domain-associated protein 0.024
HOXD13 homeobox D13 0.024
FOXF1 forkhead box F1 0.022
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa 0.021
CAV2 caveolin 2 0.019
MED10 mediator complex subunit 10 0.019
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.018
OLIG2 oligodendrocyte lineage transcription factor 2 0.018
MED25 mediator complex subunit 25 0.018
SOX11 SRY (sex determining region Y)-box 11 0.018
PAX7 paired box 7 0.017
MED14 mediator complex subunit 14 0.016
FMOD fibromodulin 0.016
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.016
SIX2 SIX homeobox 2 0.016
HOXD11 homeobox D11 0.016
MSX1 msh homeobox 1 0.015
AGTR1 angiotensin II receptor, type 1 0.015
HSPA2 heat shock 70kDa protein 2 0.015
HOXD1 homeobox D1 0.015
ACAN aggrecan 0.015
ARRB1 arrestin, beta 1 0.015
NGF nerve growth factor (beta polypeptide) 0.015
CNTN2 contactin 2 (axonal) 0.015
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.014
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.014
SIX6 SIX homeobox 6 0.014
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.014
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.013
DOK5 docking protein 5 0.013
GFRA2 GDNF family receptor alpha 2 0.013
STK25 serine/threonine kinase 25 0.013
GDNF glial cell derived neurotrophic factor 0.013
NRTN neurturin 0.012
MAPK10 mitogen-activated protein kinase 10 0.012
PENK proenkephalin 0.012
HDAC10 histone deacetylase 10 0.012
ADCY1 adenylate cyclase 1 (brain) 0.012
RET ret proto-oncogene 0.012
FNDC1 fibronectin type III domain containing 1 0.012
KIAA0100 KIAA0100 0.012
HOXD9 homeobox D9 0.012
RBMS3 RNA binding motif, single stranded interacting protein 3 0.011
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.011
POU4F2 POU class 4 homeobox 2 0.011
EN1 engrailed homeobox 1 0.011
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.011
ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 0.011
FEV FEV (ETS oncogene family) 0.011
EBF3 early B-cell factor 3 0.011
TGFBR1 transforming growth factor, beta receptor 1 0.011
CALCR calcitonin receptor 0.010
ERAL1 Era G-protein-like 1 (E. coli) 0.010
EGFR epidermal growth factor receptor 0.010
COL2A1 collagen, type II, alpha 1 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Ret ret proto-oncogene 0.999
Isl1 ISL1 transcription factor, LIM/homeodomain 0.971
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.966
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.914
Phox2a paired-like homeobox 2a 0.896
Ntf3 neurotrophin 3 0.882
Sox10 SRY-box containing gene 10 0.878
Phox2b paired-like homeobox 2b 0.847
Pax3 paired box gene 3 0.780
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.712
Gli3 GLI-Kruppel family member GLI3 0.608
Bdnf brain derived neurotrophic factor 0.576
Shh sonic hedgehog 0.546
Fgf8 fibroblast growth factor 8 0.535
Alx4 aristaless-like homeobox 4 0.530
Nrg1 neuregulin 1 0.449
Tcfap2a transcription factor AP-2, alpha 0.418
Hand2 heart and neural crest derivatives expressed transcript 2 0.331
Fgfr1 fibroblast growth factor receptor 1 0.313
Tbx1 T-box 1 0.301
Gdnf glial cell line derived neurotrophic factor 0.299
Chrd chordin 0.279
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.224
Fgfr2 fibroblast growth factor receptor 2 0.204
Meox2 mesenchyme homeobox 2 0.198
Foxc1 forkhead box C1 0.187
Prrx2 paired related homeobox 2 0.186
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.174
Bmp4 bone morphogenetic protein 4 0.171
Otx2 orthodenticle homolog 2 (Drosophila) 0.157
Hand1 heart and neural crest derivatives expressed transcript 1 0.156
Prrx1 paired related homeobox 1 0.153
Pax6 paired box gene 6 0.143
Eya1 eyes absent 1 homolog (Drosophila) 0.140
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.135
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.131
Msx1 homeobox, msh-like 1 0.122
Nrtn neurturin 0.093
Gfra3 glial cell line derived neurotrophic factor family receptor alpha 3 0.084
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.081
Rara retinoic acid receptor, alpha 0.076
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.067
Gbx2 gastrulation brain homeobox 2 0.065
Sox11 SRY-box containing gene 11 0.057
Pou5f1 POU domain, class 5, transcription factor 1 0.057
Sox2 SRY-box containing gene 2 0.053
Hoxa3 homeobox A3 0.049
Foxc2 forkhead box C2 0.048
Nog noggin 0.048
Aplnr apelin receptor 0.047
Nf1 neurofibromatosis 1 0.046
Tgfb2 transforming growth factor, beta 2 0.046
Ednrb endothelin receptor type B 0.044
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.042
Robo3 roundabout homolog 3 (Drosophila) 0.039
Pou3f3 POU domain, class 3, transcription factor 3 0.039
Hoxa1 homeobox A1 0.039
Mitf microphthalmia-associated transcription factor 0.038
Sox18 SRY-box containing gene 18 0.038
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.037
Dlx5 distal-less homeobox 5 0.034
Ebf3 early B-cell factor 3 0.033
Zeb1 zinc finger E-box binding homeobox 1 0.033
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.033
Pax2 paired box gene 2 0.033
Pitx2 paired-like homeodomain transcription factor 2 0.030
She src homology 2 domain-containing transforming protein E 0.027
Vti1a vesicle transport through interaction with t-SNAREs homolog 1A (yeast) 0.027
Rarb retinoic acid receptor, beta 0.024
Bmp7 bone morphogenetic protein 7 0.024
Nos3 nitric oxide synthase 3, endothelial cell 0.023
Bcl6b B-cell CLL/lymphoma 6, member B 0.023
Hhex hematopoietically expressed homeobox 0.023
Ntf5 neurotrophin 5 0.022
Hcrt hypocretin 0.022
Hif3a hypoxia inducible factor 3, alpha subunit 0.022
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.021
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.021
Atoh7 atonal homolog 7 (Drosophila) 0.021
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.020
Sall4 sal-like 4 (Drosophila) 0.020
Kdr kinase insert domain protein receptor 0.020
Foxd2 forkhead box D2 0.020
Pbx1 pre B-cell leukemia transcription factor 1 0.020
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.019
Gsc goosecoid homeobox 0.019
Tcf15 transcription factor 15 0.019
Sox7 SRY-box containing gene 7 0.018
Mn1 meningioma 1 0.018
Fgf10 fibroblast growth factor 10 0.018
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.018
Sox17 SRY-box containing gene 17 0.017
Ikbkap inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein 0.017
Lmx1b LIM homeobox transcription factor 1 beta 0.017
Acvr1 activin A receptor, type 1 0.017
Vegfa vascular endothelial growth factor A 0.017
Dlx6 distal-less homeobox 6 0.016
Cldn5 claudin 5 0.015
Msx2 homeobox, msh-like 2 0.015
Wnt6 wingless-related MMTV integration site 6 0.015
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism