The network for 'circadian sleep wake cycle sleep' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

circadian sleep wake cycle sleep

The part of the circadian sleep/wake cycle where the organism is asleep.

Danio rerio
Name Description Probability Func Analog Organism
drd2l dopamine receptor D2 like 0.812
vdra vitamin D receptor a 0.646
drd2a dopamine receptor D2a 0.623
ndr1 nodal-related 1 0.609
srf serum response factor 0.547
npy8ar neuropeptide Y receptor Y8a 0.521
unc45b unc-45 homolog B (C. elegans) 0.519
mxi1 max interacting protein 0.494
reln reelin 0.481
cebp1 CCAAT/enhancer binding protein (C/EBP) 1 0.467
ntf7 neurotrophin 7 0.413
insrb insulin receptor b 0.393
cry2b cryptochrome 2b 0.359
mc4r melanocortin 4 receptor 0.344
dab1a disabled homolog 1a (Drosophila) 0.343
tp53bp2 tumor protein p53 binding protein, 2 0.340
tlr21 toll-like receptor 21 0.309
oxtl oxytocin-like 0.304
adra2a adrenergic, alpha-2A-, receptor 0.301
eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) 0.283
gdnf glial cell derived neurotrophic factor 0.261
dag1 dystroglycan 1 0.261
ptgds prostaglandin D2 synthase 0.260
veph ventricular zone expressed PH domain protein 0.253
syce2 synaptonemal complex central element protein 2 0.250
esr1 estrogen receptor 1 0.239
siah2l seven in absentia homolog 2 (Drosophila)-like 0.229
smyd1b SET and MYND domain containing 1b 0.227
pde10a phosphodiesterase 10A 0.207
hcrt hypocretin (orexin) neuropeptide precursor 0.203
tbx20 T-box 20 0.198
fhla four and a half LIM domains a 0.183
scn1a sodium channel, voltage-gated, type I, alpha 0.182
gabbr1a gamma-aminobutyric acid (GABA) B receptor, 1a 0.182
ddc dopa decarboxylase 0.172
stac3 SH3 and cysteine rich domain 3 0.165
zgc:101761 zgc:101761 0.163
insra insulin receptor a 0.156
proc protein C (inactivator of coagulation factors Va and VIIIa) 0.155
ncam2 neural cell adhesion molecule 2 0.145
rag2 recombination activating gene 2 0.143
cx55.5 connexin 55.5 0.142
irx4b iroquois homeobox protein 4b 0.139
arntl1b aryl hydrocarbon receptor nuclear translocator-like 1b 0.139
tshb thyroid stimulating hormone, beta subunit 0.137
dmd dystrophin 0.136
cx35 connexin 35 0.134
tpma alpha-tropomyosin 0.131
igf2a insulin-like growth factor 2a 0.130
wnt10a wingless-type MMTV integration site family, member 10a 0.127
ing5 inhibitor of growth family, member 5a 0.126
cldnk claudin k 0.125
per3 period homolog 3 (Drosophila) 0.123
shmt2 serine hydroxymethyltransferase 2 (mitochondrial) 0.121
mchr1a melanin-concentrating hormone receptor 1a 0.117
slc8a4b solute carrier family 8 (sodium/calcium exchanger), member 4b 0.114
abcb3l1 ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 1 0.113
vps39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.113
pomca proopiomelanocortin a 0.111
lamb2 laminin, beta 2 (laminin S) 0.110
si:dkeyp-59a8.4 si:dkeyp-59a8.4 0.109
ryr2a ryanodine receptor 2a (cardiac) 0.108
pou1f1 POU domain, class 1, transcription factor 1 0.108
mpp6b membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6) 0.107
qk quaking 0.106
zgc:55582 zgc:55582 0.105
ahr1a aryl hydrocarbon receptor 1a 0.104
neurod2 neurogenic differentiation 2 0.104
cx39.9 connexin 39.9 0.100
ttna titin a 0.099
per2 period homolog 2 (Drosophila) 0.097
or115-10 odorant receptor, family F, subfamily 115, member 10 0.095
cry4 cryptochrome 4 0.093
cry1a cryptochrome 1a 0.091
zgc:112180 zgc:112180 0.091
efna5b ephrin A5b 0.090
gfra1b gdnf family receptor alpha 1b 0.088
setd5 SET domain containing 5 0.088
ucn3l urocortin 3, like 0.087
gsx1 GS homeobox 1 0.086
esrrb estrogen-related receptor beta 0.086
th tyrosine hydroxylase 0.083
slc25a27 solute carrier family 25, member 27 0.083
tnnc1b troponin C type 1b (slow) 0.081
cry5 cryptochrome 5 0.081
grid2 glutamate receptor, ionotropic, delta 2 0.081
esr2b estrogen receptor 2b 0.080
prl prolactin 0.080
mtnr1ba melatonin receptor type 1B a 0.078
arntl2 aryl hydrocarbon receptor nuclear translocator-like 2 0.078
gnrh2 gonadotropin-releasing hormone 2 0.077
ryr1b ryanodine receptor 1b (skeletal) 0.076
zbtb4 zinc finger and BTB domain containing 4 0.072
nlgn1 neuroligin 1 0.068
aldh1l1 aldehyde dehydrogenase 1 family, member L1 0.068
vldlr very low density lipoprotein receptor 0.067
tpt1 tumor protein, translationally-controlled 1 0.067
glra1 glycine receptor, alpha 1 0.067
chat choline acetyltransferase 0.065
abca5 ATP-binding cassette, sub-family A (ABC1), member 5 0.064
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Octbeta2R CG33976 gene product from transcript CG33976-RA 0.985
Dat Dopamine N acetyltransferase 0.979
CG42629 CG42629 gene product from transcript CG42629-RB 0.789
Clk Clock 0.736
cry cryptochrome 0.598
cyc cycle 0.509
Dcr-2 Dicer-2 0.414
jeb jelly belly 0.411
dnc dunce 0.358
htt huntingtin 0.335
Oamb Octopamine receptor in mushroom bodies 0.324
dnr1 defense repressor 1 0.310
CG32810 CG32810 gene product from transcript CG32810-RB 0.250
tim timeless 0.249
Ih I[[h]] channel 0.233
CG13253 CG13253 gene product from transcript CG13253-RB 0.228
G-oalpha47A G protein oalpha 47A 0.228
Fmr1 CG6203 gene product from transcript CG6203-RC 0.213
ple pale 0.212
rho-5 rhomboid-5 0.203
nAcRalpha-7E nicotinic Acetylcholine Receptor alpha 7E 0.202
Tbh Tyramine beta hydroxylase 0.195
nAcRalpha-80B nicotinic Acetylcholine Receptor alpha 80B 0.192
cwo clockwork orange 0.187
CG34139 CG34139 gene product from transcript CG34139-RD 0.180
qvr quiver 0.168
CrebB-17A Cyclic-AMP response element binding protein B at 17A 0.163
CanA1 Calcineurin A1 0.152
l(3)82Fd CG32464 gene product from transcript CG32464-RR 0.143
Or22a Odorant receptor 22a 0.137
per period 0.122
CG4857 CG4857 gene product from transcript CG4857-RD 0.117
foxo forkhead box, sub-group O 0.110
Pvf2 PDGF- and VEGF-related factor 2 0.100
Vmat Vesicular monoamine transporter 0.099
Shaw Shaker cognate w 0.097
Nf1 Neurofibromin 1 0.092
CG16778 CG16778 gene product from transcript CG16778-RA 0.078
Rab27 CG14791 gene product from transcript CG14791-RB 0.078
sinu sinuous 0.076
Glut1 Glucose transporter 1 0.071
Cyp316a1 CG8540 gene product from transcript CG8540-RA 0.071
homer CG11324 gene product from transcript CG11324-RC 0.063
CG34400 CG34400 gene product from transcript CG34400-RD 0.061
oa2 octopamine receptor 2 0.056
PGRP-SC1b CG8577 gene product from transcript CG8577-RA 0.055
pdfr PDF receptor 0.052
shi shibire 0.051
fbl fumble 0.050
Gadd45 CG11086 gene product from transcript CG11086-RA 0.049
Sema-5c Semaphorin-5c 0.048
CanB Calcineurin B 0.048
Ef1alpha48D Elongation factor 1alpha48D 0.046
PGRP-SC1a CG14746 gene product from transcript CG14746-RA 0.043
Gr28b Gustatory receptor 28b 0.043
mtt mangetout 0.043
Hmgcr HMG Coenzyme A reductase 0.042
NPFR1 neuropeptide F receptor 0.041
Acer Angiotensin-converting enzyme-related 0.040
CG9184 CG9184 gene product from transcript CG9184-RB 0.039
CG4563 CG4563 gene product from transcript CG4563-RA 0.036
CG18594 CG18594 gene product from transcript CG18594-RA 0.036
Socs36E Suppressor of cytokine signaling at 36E 0.036
E23 Early gene at 23 0.036
CG1358 CG1358 gene product from transcript CG1358-RD 0.035
PIP5K59B CG3682 gene product from transcript CG3682-RE 0.035
imd immune deficiency 0.034
crc cryptocephal 0.033
Ork1 Open rectifier K[+] channel 1 0.033
klg klingon 0.031
LpR2 CG31092 gene product from transcript CG31092-RD 0.031
Rdl Resistant to dieldrin 0.031
pico CG11940 gene product from transcript CG11940-RA 0.030
beta4GalNAcTA CG8536 gene product from transcript CG8536-RA 0.030
brp bruchpilot 0.030
Pdf Pigment-dispersing factor 0.029
5-HT7 Serotonin receptor 7 0.029
CG18437 CG18437 gene product from transcript CG18437-RB 0.029
upd2 unpaired 2 0.029
CanA-14F Calcineurin A at 14F 0.029
l(3)mbn lethal (3) malignant blood neoplasm 0.028
Hr46 Hormone receptor-like in 46 0.028
Sh Shaker 0.027
rut rutabaga 0.027
Dsk Drosulfakinin 0.025
CCKLR-17D1 CCK-like receptor at 17D1 0.025
Rya-r44F Ryanodine receptor 44F 0.025
Actbeta Activin-beta 0.025
Ac3 CG1506 gene product from transcript CG1506-RA 0.025
myoglianin CG1838 gene product from transcript CG1838-RD 0.025
Ddc Dopa decarboxylase 0.024
Gad1 Glutamic acid decarboxylase 1 0.022
nonA no on or off transient A 0.022
CG31140 CG31140 gene product from transcript CG31140-RF 0.021
Tequila CG4821 gene product from transcript CG4821-RE 0.021
nAcRbeta-64B nicotinic Acetylcholine Receptor beta 64B 0.021
Krn Keren 0.021
neuroligin CG13772 gene product from transcript CG13772-RA 0.021
CG42574 CG42574 gene product from transcript CG42574-RE 0.020
Ccap Cardioacceleratory peptide 0.020
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Homo sapiens
Name Description Probability Func Analog Organism
DLG4 discs, large homolog 4 (Drosophila) 0.998
ADORA2A adenosine A2a receptor 0.998
ACTN2 actinin, alpha 2 0.954
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.933
INSR insulin receptor 0.879
NLRC4 NLR family, CARD domain containing 4 0.832
CLOCK clock homolog (mouse) 0.782
DRD2 dopamine receptor D2 0.668
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.658
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.528
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.469
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.456
GRB10 growth factor receptor-bound protein 10 0.403
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.324
MYOZ1 myozenin 1 0.281
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.272
GAB1 GRB2-associated binding protein 1 0.265
RIPK2 receptor-interacting serine-threonine kinase 2 0.261
IRS1 insulin receptor substrate 1 0.254
AKIP1 A kinase (PRKA) interacting protein 1 0.246
AKAP11 A kinase (PRKA) anchor protein 11 0.243
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.241
LCMT1 leucine carboxyl methyltransferase 1 0.226
IRS2 insulin receptor substrate 2 0.209
RYR2 ryanodine receptor 2 (cardiac) 0.197
NECAB2 N-terminal EF-hand calcium binding protein 2 0.179
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.175
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.173
HSPH1 heat shock 105kDa/110kDa protein 1 0.169
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.158
ADORA1 adenosine A1 receptor 0.141
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.129
STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) 0.127
FKBP4 FK506 binding protein 4, 59kDa 0.127
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.126
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.126
AP1M1 adaptor-related protein complex 1, mu 1 subunit 0.122
LDOC1 leucine zipper, down-regulated in cancer 1 0.117
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.104
NLGN1 neuroligin 1 0.100
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.097
HSPA8 heat shock 70kDa protein 8 0.081
GAB2 GRB2-associated binding protein 2 0.080
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.078
PUM2 pumilio homolog 2 (Drosophila) 0.062
TBXA2R thromboxane A2 receptor 0.060
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.060
CFD complement factor D (adipsin) 0.058
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.058
KIAA1377 KIAA1377 0.056
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.055
FCGRT Fc fragment of IgG, receptor, transporter, alpha 0.054
KCTD4 potassium channel tetramerisation domain containing 4 0.052
PYCARD PYD and CARD domain containing 0.052
SETD7 SET domain containing (lysine methyltransferase) 7 0.051
CRIPT cysteine-rich PDZ-binding protein 0.050
SPRR2A small proline-rich protein 2A 0.048
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae) 0.046
KCNQ1 potassium voltage-gated channel, KQT-like subfamily, member 1 0.044
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.044
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.044
NAMPT nicotinamide phosphoribosyltransferase 0.043
TDRD3 tudor domain containing 3 0.043
KCNA3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.042
HSPA1A heat shock 70kDa protein 1A 0.039
CSNK1E casein kinase 1, epsilon 0.038
CBS cystathionine-beta-synthase 0.038
CARD16 caspase recruitment domain family, member 16 0.037
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.036
LIMK1 LIM domain kinase 1 0.036
BMI1 BMI1 polycomb ring finger oncogene 0.036
MCC mutated in colorectal cancers 0.035
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.035
HES1 hairy and enhancer of split 1, (Drosophila) 0.033
TSC22D4 TSC22 domain family, member 4 0.032
TBK1 TANK-binding kinase 1 0.031
DISC1 disrupted in schizophrenia 1 0.031
GSK3B glycogen synthase kinase 3 beta 0.031
CNR1 cannabinoid receptor 1 (brain) 0.028
CCNK cyclin K 0.027
TNP2 transition protein 2 (during histone to protamine replacement) 0.027
EGFR epidermal growth factor receptor 0.027
KIF5C kinesin family member 5C 0.027
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.027
IGF1R insulin-like growth factor 1 receptor 0.026
TBKBP1 TBK1 binding protein 1 0.026
CUL4B cullin 4B 0.026
IL18 interleukin 18 (interferon-gamma-inducing factor) 0.025
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.025
NELL2 NEL-like 2 (chicken) 0.025
SIRT1 sirtuin 1 0.024
EGLN1 egl nine homolog 1 (C. elegans) 0.024
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.024
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 0.024
PPP5C protein phosphatase 5, catalytic subunit 0.024
BBS10 Bardet-Biedl syndrome 10 0.024
MTNR1A melatonin receptor 1A 0.023
SORBS3 sorbin and SH3 domain containing 3 0.023
FRS2 fibroblast growth factor receptor substrate 2 0.023
CYTH2 cytohesin 2 0.023
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Drd1a dopamine receptor D1A 0.084
Pdyn prodynorphin 0.074
Rnf4 ring finger protein 4 0.066
Kcng2 potassium voltage-gated channel, subfamily G, member 2 0.060
Adam10 ADAM metallopeptidase domain 10 0.060
Mapk9 mitogen-activated protein kinase 9 0.052
Gip gastric inhibitory polypeptide 0.047
Mag myelin-associated glycoprotein 0.045
Adora1 adenosine A1 receptor 0.044
Ahsg alpha-2-HS-glycoprotein 0.043
Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.042
Ttr transthyretin 0.041
Casp2 caspase 2 0.041
Apoe apolipoprotein E 0.039
Nmu neuromedin U 0.038
Calcrl calcitonin receptor-like 0.037
Lim2 lens intrinsic membrane protein 2 0.037
Krt34 keratin 34 0.036
Kcnh5 potassium voltage-gated channel, subfamily H (eag-related), member 5 0.035
Olr416 olfactory receptor 416 0.034
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.034
Fga fibrinogen alpha chain 0.033
Vcsa1 variable coding sequence A1 0.031
Cacng5 calcium channel, voltage-dependent, gamma subunit 5 0.030
Prkci protein kinase C, iota 0.030
Adar adenosine deaminase, RNA-specific 0.028
Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 0.028
Crhr1 corticotropin releasing hormone receptor 1 0.028
Toe1 target of EGR1, member 1 (nuclear) 0.027
Cabp1 calcium binding protein 1 0.027
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.027
Parp14 poly (ADP-ribose) polymerase family, member 14 0.027
Pdzd2 PDZ domain containing 2 0.027
Reg3a regenerating islet-derived 3 alpha 0.027
Dhfr dihydrofolate reductase 0.026
Tmsb4x thymosin beta 4, X-linked 0.026
Agxt alanine-glyoxylate aminotransferase 0.026
Aldob aldolase B, fructose-bisphosphate 0.026
LOC24906 RoBo-1 0.025
Slc22a13 solute carrier family 22 (organic anion transporter), member 13 0.025
Nrn1l neuritin 1-like 0.025
Cdk2 cyclin dependent kinase 2 0.025
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.024
Nudt3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.024
RT1-N3 RT1 class Ib, locus N3 0.024
Syt13 synaptotagmin XIII 0.024
Chrm4 cholinergic receptor, muscarinic 4 0.023
S1pr2 sphingosine-1-phosphate receptor 2 0.023
Opn1mw opsin 1 (cone pigments), medium-wave-sensitive 0.022
Spp2 secreted phosphoprotein 2 0.022
Syt11 synaptotagmin XI 0.022
Uox urate oxidase 0.022
Otud7a OTU domain containing 7A 0.022
Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 0.021
Lin7c lin-7 homolog C (C. elegans) 0.021
Tpc1808 tropic 1808 0.021
Gjc2 gap junction protein, gamma 2 0.021
Cd48 Cd48 molecule 0.021
Insrr insulin receptor-related receptor 0.021
Dio3 deiodinase, iodothyronine, type III 0.021
Gpr6 G protein-coupled receptor 6 0.021
Rgs9 regulator of G-protein signaling 9 0.021
Stk3 serine/threonine kinase 3 (STE20 homolog, yeast) 0.021
Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 0.020
RY2G5 potential ligand-binding protein 0.019
Tlr4 toll-like receptor 4 0.019
LOC100361571 keratin associated protein 1-3-like 0.019
Bdkrb1 bradykinin receptor B1 0.019
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.018
Pdcl phosducin-like 0.018
Atxn1 ataxin 1 0.018
Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 0.018
Ambp alpha-1-microglobulin/bikunin precursor 0.018
Trpc4 transient receptor potential cation channel, subfamily C, member 4 0.018
Reg3b regenerating islet-derived 3 beta 0.017
Mybph myosin binding protein H 0.017
Gabra3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.017
Gast gastrin 0.017
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.017
Ifng interferon gamma 0.017
Kcnk15 potassium channel, subfamily K, member 15 0.017
Skap2 src kinase associated phosphoprotein 2 0.017
Glp1r glucagon-like peptide 1 receptor 0.017
Slc6a11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 0.016
Accn3 amiloride-sensitive cation channel 3 0.016
Tas2r119 taste receptor, type 2, member 119 0.016
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.016
Grik1 glutamate receptor, ionotropic, kainate 1 0.016
P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 0.016
Nsf N-ethylmaleimide-sensitive factor 0.016
Gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.016
LOC296235 similar to Cystatin S precursor (LM protein) 0.016
Hcrtr2 hypocretin (orexin) receptor 2 0.016
Nat1 N-acetyltransferase 1 0.016
Slfn2 schlafen 2 0.015
LOC286987 hemiferrin, transferrin-like protein 0.015
Gipr gastric inhibitory polypeptide receptor 0.015
Prlhr prolactin releasing hormone receptor 0.015
Crh corticotropin releasing hormone 0.015
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.015
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism