The network for 'retinal metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

retinal metabolic process

The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.

Danio rerio
Name Description Probability Func Analog Organism
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.922
dlc deltaC 0.382
tbx1 T-box 1 0.275
dct dopachrome tautomerase 0.169
gata5 GATA-binding protein 5 0.119
foxa3 forkhead box A3 0.096
hnf1ba HNF1 homeobox Ba 0.087
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.087
ntla no tail a 0.080
gsc goosecoid 0.078
dld deltaD 0.069
hand2 heart and neural crest derivatives expressed transcript 2 0.069
wnt3a wingless-type MMTV integration site family, member 3A 0.063
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.063
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.063
nr5a5 nuclear receptor subfamily 5, group A, member 5 0.061
rgrb retinal G protein coupled receptor b 0.060
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.059
pax3a paired box gene 3a 0.058
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.056
rest RE1-silencing transcription factor 0.051
zgc:73359 zgc:73359 0.049
rasl11b RAS-like, family 11, member B 0.048
cdx4 caudal type homeo box transcription factor 4 0.046
edn1 endothelin 1 0.043
crabp2a cellular retinoic acid binding protein 2, a 0.042
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.042
nkx2.5 NK2 transcription factor related 5 0.040
srd5a2a steroid-5-alpha-reductase, alpha polypeptide 2a 0.040
fgf8a fibroblast growth factor 8 a 0.037
furinb furin (paired basic amino acid cleaving enzyme) b 0.037
hprt1 hypoxanthine phosphoribosyltransferase 1 0.037
wnt11 wingless-type MMTV integration site family, member 11 0.037
stra6 stimulated by retinoic acid gene 6 homolog (mouse) 0.036
ncf1 neutrophil cytosolic factor 1 0.035
tyrp1b tyrosinase-related protein 1b 0.035
fn1 fibronectin 1 0.032
apoeb apolipoprotein Eb 0.032
krt18 keratin 18 0.032
osr1 odd-skipped related 1 (Drosophila) 0.030
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.030
rho rhodopsin 0.030
fgf24 fibroblast growth factor 24 0.029
tbx5a T-box 5a 0.029
bmp2b bone morphogenetic protein 2b 0.029
egr1 early growth response 1 0.028
agxta alanine-glyoxylate aminotransferase a 0.027
zgc:100919 zgc:100919 0.027
zgc:56548 zgc:56548 0.026
lgals9l1 lectin, galactoside-binding, soluble, 9 (galectin 9)-like 1 0.026
adra2b adrenergic, alpha-2B-, receptor 0.026
cyp1a cytochrome P450, family 1, subfamily A 0.025
nras neuroblastoma RAS viral (v-ras) oncogene homolog 0.025
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.025
prdm16 PR domain containing 16 0.025
smoc1 SPARC related modular calcium binding 1 0.024
tbp TATA box binding protein 0.024
gcga glucagon a and glucagon a-like 0.024
lmo4a LIM domain only 4a 0.024
hspb1 heat shock protein, alpha-crystallin-related, 1 0.024
slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 0.023
fadd Fas (tnfrsf6)-associated via death domain 0.023
her1 hairy-related 1 0.022
b2m beta-2-microglobulin 0.022
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.022
tp53 tumor protein p53 0.022
pcdh18b protocadherin 18b 0.021
si:ch211-93f2.1 si:ch211-93f2.1 0.021
si:dkey-53p21.1 si:dkey-53p21.1 0.021
slc3a2 solute carrier family 3, member 2 0.020
nme4 non-metastatic cells 4, protein expressed in 0.020
acta2 actin, alpha 2, smooth muscle, aorta 0.020
arl3l2 ADP-ribosylation factor-like 3, like 2 0.019
flrt3 fibronectin leucine rich transmembrane 3 0.019
cyp51 cytochrome P450, family 51 0.019
tbx2b T-box 2b 0.019
ocrl oculocerebrorenal syndrome of Lowe 0.018
prdm1a PR domain containing 1a, with ZNF domain 0.018
foxl1 forkhead box L1 0.018
LOC100001321 hypothetical protein LOC100001321 0.018
cdk7 cyclin-dependent kinase 7 0.017
slc31a1 solute carrier family 31 (copper transporters), member 1 0.017
rgs4 regulator of G-protein signalling 4 0.016
mpp1 membrane protein, palmitoylated 1 0.016
ppp1r3ca protein phosphatase 1, regulatory (inhibitor) subunit 3Ca 0.016
kdrl kinase insert domain receptor like 0.016
lbx2 ladybird homeobox homolog 2 (Drosophila) 0.015
esrra estrogen-related receptor alpha 0.015
bcdo2l beta-carotene 15, 15-dioxygenase 2, like 0.015
cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 0.015
meis3 myeloid ecotropic viral integration site 3 0.015
rbp7b retinol binding protein 7b, cellular 0.015
oep one-eyed pinhead 0.015
slmo2 slowmo homolog 2 (Drosophila) 0.015
chst11 carbohydrate (chondroitin 4) sulfotransferase 11 0.015
pmelb premelanosome protein b 0.014
itgb1b.1 integrin, beta 1b.1 0.014
acsl4a acyl-CoA synthetase long-chain family member 4a 0.014
zgc:92406 zgc:92406 0.014
ctsc cathepsin C 0.014
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
GstE6 Glutathione S transferase E6 0.024
Nacalpha Nascent polypeptide associated complex protein alpha subunit 0.020
CG2852 CG2852 gene product from transcript CG2852-RA 0.014
CG15754 CG15754 gene product from transcript CG15754-RA 0.011
retinophilin CG10233 gene product from transcript CG10233-RA 0.011
CG17597 CG17597 gene product from transcript CG17597-RA 0.011
CG11151 CG11151 gene product from transcript CG11151-RA 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.997
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.994
AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 0.962
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.101
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.063
PEX14 peroxisomal biogenesis factor 14 0.044
TTR transthyretin 0.035
BLOC1S2 biogenesis of lysosomal organelles complex-1, subunit 2 0.032
ZHX1 zinc fingers and homeoboxes 1 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Foxc1 forkhead box C1 0.330
Rarg retinoic acid receptor, gamma 0.208
Cyp26c1 cytochrome P450, family 26, subfamily c, polypeptide 1 0.134
Wnt5a wingless-related MMTV integration site 5A 0.122
Tcfap2a transcription factor AP-2, alpha 0.116
Foxc2 forkhead box C2 0.096
Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 0.078
Mecom MDS1 and EVI1 complex locus 0.064
Aadac arylacetamide deacetylase (esterase) 0.059
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.056
Ednra endothelin receptor type A 0.054
Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) 0.049
Cps1 carbamoyl-phosphate synthetase 1 0.048
Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 0.048
Hrg histidine-rich glycoprotein 0.042
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.040
Cyp2a12 cytochrome P450, family 2, subfamily a, polypeptide 12 0.039
Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 0.038
C9 complement component 9 0.037
C1qtnf5 C1q and tumor necrosis factor related protein 5 0.036
Rarb retinoic acid receptor, beta 0.034
Nrp1 neuropilin 1 0.033
Hpd 4-hydroxyphenylpyruvic acid dioxygenase 0.032
Akr1c6 aldo-keto reductase family 1, member C6 0.030
Mbl1 mannose-binding lectin (protein A) 1 0.028
Aadat aminoadipate aminotransferase 0.028
Gsta3 glutathione S-transferase, alpha 3 0.028
Rdh16 retinol dehydrogenase 16 0.028
Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 0.026
Rdh10 retinol dehydrogenase 10 (all-trans) 0.024
Baat bile acid-Coenzyme A: amino acid N-acyltransferase 0.023
Fbln1 fibulin 1 0.023
Hand2 heart and neural crest derivatives expressed transcript 2 0.023
Slc17a1 solute carrier family 17 (sodium phosphate), member 1 0.023
Ahsg alpha-2-HS-glycoprotein 0.021
Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 0.021
Car5a carbonic anhydrase 5a, mitochondrial 0.021
G6pc glucose-6-phosphatase, catalytic 0.020
Bmp4 bone morphogenetic protein 4 0.019
Rho rhodopsin 0.019
Acox2 acyl-Coenzyme A oxidase 2, branched chain 0.018
Dmgdh dimethylglycine dehydrogenase precursor 0.017
Cyp2d12 cytochrome P450, family 2, subfamily d, polypeptide 12 0.017
Mbl2 mannose-binding lectin (protein C) 2 0.016
Nr1i3 nuclear receptor subfamily 1, group I, member 3 0.016
Gsta2 glutathione S-transferase, alpha 2 (Yc2) 0.016
Inmt indolethylamine N-methyltransferase 0.016
Mesp1 mesoderm posterior 1 0.016
Cyp2d26 cytochrome P450, family 2, subfamily d, polypeptide 26 0.016
Ece1 endothelin converting enzyme 1 0.016
Sgk2 serum/glucocorticoid regulated kinase 2 0.015
Ces1c carboxylesterase 1C 0.015
Cdhr5 cadherin-related family member 5 0.015
Apoh apolipoprotein H 0.015
Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 0.015
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.014
Pon1 paraoxonase 1 0.014
Acsm3 acyl-CoA synthetase medium-chain family member 3 0.014
Agxt alanine-glyoxylate aminotransferase 0.013
Cyp3a25 cytochrome P450, family 3, subfamily a, polypeptide 25 0.013
Nme5 non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) 0.013
Apoc4 apolipoprotein C-IV 0.013
Acsm1 acyl-CoA synthetase medium-chain family member 1 0.012
Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.012
Tat tyrosine aminotransferase 0.012
Aqp8 aquaporin 8 0.012
Ch25h cholesterol 25-hydroxylase 0.012
Fmn1 formin 1 0.012
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.011
Tsku tsukushin 0.011
Fgfr2 fibroblast growth factor receptor 2 0.011
Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 0.011
Habp2 hyaluronic acid binding protein 2 0.011
Chd7 chromodomain helicase DNA binding protein 7 0.011
Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 0.011
Uox urate oxidase 0.010
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.010
F9 coagulation factor IX 0.010
Afm afamin 0.010
C4bp complement component 4 binding protein 0.010
Sirt3 sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) 0.010
Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cyb5a cytochrome b5 type A (microsomal) 0.746
Tuba1c tubulin, alpha 1C 0.411
Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 0.153
Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 0.143
Ephx1 epoxide hydrolase 1, microsomal 0.135
Acadm acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain 0.130
Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 0.112
Dad1 defender against cell death 1 0.110
Pgam1 phosphoglycerate mutase 1 (brain) 0.103
Mgst1 microsomal glutathione S-transferase 1 0.103
Hadh hydroxyacyl-Coenzyme A dehydrogenase 0.098
Idh1 isocitrate dehydrogenase 1 (NADP+), soluble 0.095
Dpyd dihydropyrimidine dehydrogenase 0.091
Akr1c14 aldo-keto reductase family 1, member C14 0.086
Vtn vitronectin 0.085
Mosc1 MOCO sulphurase C-terminal domain containing 1 0.084
Fah fumarylacetoacetate hydrolase 0.084
Mgst2 microsomal glutathione S-transferase 2 0.082
Sult1a1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.082
Ube2f ubiquitin-conjugating enzyme E2F (putative) 0.082
Acp2 acid phosphatase 2, lysosomal 0.081
Rpn1 ribophorin I 0.080
Akr1c12 aldo-keto reductase family 1, member C12 0.080
Fmo2 flavin containing monooxygenase 2 0.078
Rplp2 ribosomal protein, large P2 0.077
Fmo3 flavin containing monooxygenase 3 0.073
Decr2 2,4-dienoyl CoA reductase 2, peroxisomal 0.072
Gstp1 glutathione S-transferase pi 1 0.069
Dpm2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 0.069
Eci1 enoyl-Coenzyme A delta isomerase 1 0.068
Adh1 alcohol dehydrogenase 1 (class I) 0.063
LOC100360843 ribosomal protein S19-like 0.059
Aldh6a1 aldehyde dehydrogenase 6 family, member A1 0.055
Dapk3 death-associated protein kinase 3 0.055
Ptgr1 prostaglandin reductase 1 0.053
Slc22a18 solute carrier family 22, member 18 0.053
Slc35b1 solute carrier family 35, member B1 0.053
Slc23a1 solute carrier family 23 (nucleobase transporters), member 1 0.053
Slc40a1 solute carrier family 39 (iron-regulated transporter), member 1 0.052
Obp3 alpha-2u globulin PGCL4 0.049
Akr1c19 aldo-keto reductase family 1, member C19 0.048
Pkhd1l1 polycystic kidney and hepatic disease 1-like 1 0.048
Mettl7a methyltransferase like 7A 0.048
Gstm2 glutathione S-transferase mu 2 0.042
Tas2r105 taste receptor, type 2, member 105 0.042
Rpn2 ribophorin II 0.042
Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 0.042
Mosc2 MOCO sulphurase C-terminal domain containing 2 0.042
Fmo1 flavin containing monooxygenase 1 0.041
Selenbp1 selenium binding protein 1 0.041
Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 0.041
Pparg peroxisome proliferator-activated receptor gamma 0.041
PCOLCE2 procollagen C-endopeptidase enhancer 2 0.041
Fabp12 fatty acid binding protein 12 0.040
Slc5a7 solute carrier family 5 (choline transporter), member 7 0.038
Bbox1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.038
Dpp4 dipeptidylpeptidase 4 0.038
Ghr growth hormone receptor 0.036
Ppia peptidylprolyl isomerase A (cyclophilin A) 0.036
Rup2 urinary protein 2 0.036
Il7r interleukin 7 receptor 0.036
Bdh2 3-hydroxybutyrate dehydrogenase, type 2 0.034
Omd osteomodulin 0.034
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.034
Ang1 angiogenin, ribonuclease A family, member 1 0.033
Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 0.033
Adfp adipose differentiation related protein 0.033
Il15 interleukin 15 0.033
Calm1 calmodulin 1 0.032
Ces1d carboxylesterase 1D 0.032
G6pd glucose-6-phosphate dehydrogenase 0.032
Asgr2 asialoglycoprotein receptor 2 0.031
Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 0.031
Bche butyrylcholinesterase 0.031
Copz1 coatomer protein complex, subunit zeta 1 0.030
Bphl biphenyl hydrolase-like (serine hydrolase) 0.030
Mup5 major urinary protein 5 0.029
Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 0.029
Nqo1 NAD(P)H dehydrogenase, quinone 1 0.029
Gsta3 glutathione S-transferase A3 0.028
Rarres1 retinoic acid receptor responder (tazarotene induced) 1 0.028
Slco1b3 solute carrier organic anion transporter family, member 1b3 0.028
Kbtbd3 kelch repeat and BTB (POZ) domain containing 3 0.028
Cd36 CD36 molecule (thrombospondin receptor) 0.027
Tmem66 transmembrane protein 66 0.026
Rbks ribokinase 0.026
Nqo2 NAD(P)H dehydrogenase, quinone 2 0.026
Tysnd1 trypsin domain containing 1 0.026
PVR poliovirus receptor 0.026
Nat1 N-acetyltransferase 1 0.025
Alb albumin 0.025
Pex11a peroxisomal biogenesis factor 11 alpha 0.025
Otc ornithine carbamoyltransferase 0.025
Anxa2 annexin A2 0.025
Ephx2 epoxide hydrolase 2, cytoplasmic 0.025
Gcdh glutaryl-Coenzyme A dehydrogenase 0.024
Ttpa tocopherol (alpha) transfer protein 0.024
Ces1f carboxylesterase 1F 0.024
LOC362855 P55 0.024
RGD1309534 similar to RIKEN cDNA 4931406C07 0.024
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism