The network for 'regulation of cytokine mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cytokine mediated signaling pathway

Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.

Danio rerio
Name Description Probability Func Analog Organism
atf3 activating transcription factor 3 0.198
slit3 slit (Drosophila) homolog 3 0.090
il6r interleukin 6 receptor 0.079
junb jun B proto-oncogene 0.064
gro2 groucho 2 0.063
fabp11a fatty acid binding protein 11a 0.061
stat3 signal transduction and activation of transcription 3 0.060
hdac4 histone deacetylase 4 0.055
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.050
copeb core promoter element binding protein 0.049
msxa muscle segment homeobox A 0.049
sh3gl1b SH3-domain GRB2-like 1b 0.049
irf11 interferon regulatory factor 11 0.043
tnfsf10l2 tumor necrosis factor (ligand) superfamily, member 10 like 2 0.043
pabpc1b poly A binding protein, cytoplasmic 1 b 0.042
nrp2b neuropilin 2b 0.042
dusp5 dual specificity phosphatase 5 0.039
grna granulin a 0.039
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.039
card14 caspase recruitment domain family, member 14 0.038
pdcd2 programmed cell death 2 0.038
si:dkeyp-110g5.2 si:dkeyp-110g5.2 0.037
vtg1 vitellogenin 1 0.037
ipo7 importin 7 0.035
mmp9 matrix metalloproteinase 9 0.035
ift88 intraflagellar transport 88 homolog 0.034
cntn2 contactin 2 0.034
LOC566020 Gig2-like protein DreO 0.034
zgc:66286 zgc:66286 0.033
robo2 roundabout homolog 2 0.032
s1pr2 sphingosine-1-phosphate receptor 2 0.032
rc3 rabconnectin 3 0.031
plxnb2a plexin b2a 0.030
adrb2a adrenergic receptor, beta 2a 0.030
tnfsf10l3 tumor necrosis factor (ligand) superfamily, member 10 like 3 0.029
plxna4 plexin A4 0.029
slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 0.029
ctbp2l C-terminal binding protein 2, like 0.029
ush1c Usher syndrome 1C (autosomal recessive, severe) 0.028
cep70 centrosomal protein 70 0.028
rarga retinoic acid receptor gamma a 0.028
dvl3 dishevelled, dsh homolog 3 (Drosophila) 0.027
cacna1da calcium channel, voltage-dependent, L type, alpha 1D subunit, a 0.027
mpx myeloid-specific peroxidase 0.027
junbl jun B proto-oncogene, like 0.027
socs3a suppressor of cytokine signaling 3a 0.027
epb4.1l4 erythrocyte protein band 4.1-like 4 0.027
smg7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.027
coro1a coronin, actin binding protein, 1A 0.027
alcama activated leukocyte cell adhesion molecule a 0.026
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.026
vdra vitamin D receptor a 0.025
caspa caspase a 0.025
ube4b ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) 0.025
dopey1 dopey family member 1 0.025
zgc:64051 zgc:64051 0.024
scn1ba sodium channel, voltage-gated, type I, beta a 0.024
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.024
slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 0.024
sat1a spermidine/spermine N1-acetyltransferase 1a 0.023
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.023
ifnphi1 interferon phi 1 0.023
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.023
anxa2a annexin A2a 0.023
polm polymerase (DNA directed), mu 0.023
vangl2 vang-like 2 (van gogh, Drosophila) 0.023
zgc:112257 zgc:112257 0.023
ckap5 cytoskeleton associated protein 5 0.022
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.022
fxr2 fragile X mental retardation, autosomal homolog 2 0.022
ripk2 receptor-interacting serine-threonine kinase 2 0.022
card9 caspase recruitment domain family, member 9 0.022
LOC100151531 zinc finger protein Gfi-1b-like 0.021
stc1l stanniocalcin 1, like 0.021
igf1rb insulin-like growth factor 1b receptor 0.021
si:dkeyp-81f3.1 si:dkeyp-81f3.1 0.021
nrg2a neuregulin 2a 0.021
dync1h1 dynein, cytoplasmic 1, heavy chain 1 0.021
c1qc complement component 1, q subcomponent, C chain 0.021
ldb2a LIM-domain binding factor 2a 0.021
myhc4 myosin heavy chain 4 0.020
nudt9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 0.020
zgc:92851 zgc:92851 0.020
nrp1a neuropilin 1a 0.020
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.020
amotl2a angiomotin like 2a 0.020
ca2 carbonic anhydrase II 0.020
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.020
insra insulin receptor a 0.020
mycbp2 MYC binding protein 2 0.019
gmfg glia maturation factor, gamma 0.019
scn1bb sodium channel, voltage-gated, type I, beta b 0.019
twist1a twist1a 0.019
stk36 serine/threonine kinase 36 (fused homolog, Drosophila) 0.019
mapk4 mitogen-activated protein kinase 4 0.019
dlx5a distal-less homeobox gene 5a 0.019
zgc:136878 zgc:136878 0.019
btg2 B-cell translocation gene 2 0.019
nod1 nucleotide-binding oligomerization domain containing 1 0.019
ptger2a prostaglandin E receptor 2a (subtype EP2) 0.019
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
IRAK1 interleukin-1 receptor-associated kinase 1 0.999
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.989
TRAF6 TNF receptor-associated factor 6 0.987
EGFR epidermal growth factor receptor 0.985
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.980
ZNF43 zinc finger protein 43 0.931
IL1R1 interleukin 1 receptor, type I 0.922
MYD88 myeloid differentiation primary response gene (88) 0.908
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.850
ZNF273 zinc finger protein 273 0.832
ZNF253 zinc finger protein 253 0.795
CAV1 caveolin 1, caveolae protein, 22kDa 0.759
CCR5 chemokine (C-C motif) receptor 5 0.736
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.695
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.680
ZNF675 zinc finger protein 675 0.659
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.575
JAK2 Janus kinase 2 0.566
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.537
RXRA retinoid X receptor, alpha 0.534
IL1B interleukin 1, beta 0.525
IRAK2 interleukin-1 receptor-associated kinase 2 0.492
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.491
GHR growth hormone receptor 0.485
SYK spleen tyrosine kinase 0.468
C1QA complement component 1, q subcomponent, A chain 0.404
SOCS3 suppressor of cytokine signaling 3 0.381
PML promyelocytic leukemia 0.374
HCK hemopoietic cell kinase 0.344
FAS Fas (TNF receptor superfamily, member 6) 0.344
CCL4 chemokine (C-C motif) ligand 4 0.327
ZNF117 zinc finger protein 117 0.314
SPRR2A small proline-rich protein 2A 0.285
GAS6 growth arrest-specific 6 0.255
RARA retinoic acid receptor, alpha 0.245
RNF31 ring finger protein 31 0.243
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.236
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.235
CCL2 chemokine (C-C motif) ligand 2 0.232
UBASH3B ubiquitin associated and SH3 domain containing B 0.229
ZNF93 zinc finger protein 93 0.225
ZNF91 zinc finger protein 91 0.204
CXCL9 chemokine (C-X-C motif) ligand 9 0.202
NLRC4 NLR family, CARD domain containing 4 0.200
ZNF430 zinc finger protein 430 0.200
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.196
BIRC3 baculoviral IAP repeat containing 3 0.192
NCOR2 nuclear receptor corepressor 2 0.192
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.190
IL1RAP interleukin 1 receptor accessory protein 0.187
PIAS4 protein inhibitor of activated STAT, 4 0.187
EP300 E1A binding protein p300 0.180
STAT1 signal transducer and activator of transcription 1, 91kDa 0.171
CCL8 chemokine (C-C motif) ligand 8 0.163
ZNF254 zinc finger protein 254 0.158
PELI3 pellino homolog 3 (Drosophila) 0.150
APOC1 apolipoprotein C-I 0.142
STAT4 signal transducer and activator of transcription 4 0.141
ZNF708 zinc finger protein 708 0.138
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.137
AXL AXL receptor tyrosine kinase 0.132
CCL5 chemokine (C-C motif) ligand 5 0.121
ZNF746 zinc finger protein 746 0.118
IL1RN interleukin 1 receptor antagonist 0.114
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.113
CD14 CD14 molecule 0.111
NCOA1 nuclear receptor coactivator 1 0.109
DAXX death-domain associated protein 0.107
TMEM173 transmembrane protein 173 0.106
GRB2 growth factor receptor-bound protein 2 0.106
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.105
PRMT6 protein arginine methyltransferase 6 0.101
HNF4A hepatocyte nuclear factor 4, alpha 0.097
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.095
MED25 mediator complex subunit 25 0.092
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.091
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.091
ZNF680 zinc finger protein 680 0.091
ZNF85 zinc finger protein 85 0.088
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.088
TLR2 toll-like receptor 2 0.087
TLR4 toll-like receptor 4 0.086
IDE insulin-degrading enzyme 0.084
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.082
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.082
ALB albumin 0.081
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.078
C1QB complement component 1, q subcomponent, B chain 0.078
ICAM1 intercellular adhesion molecule 1 0.077
A2M alpha-2-macroglobulin 0.077
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.076
MED28 mediator complex subunit 28 0.074
SKIL SKI-like oncogene 0.074
CXCL2 chemokine (C-X-C motif) ligand 2 0.073
GAB1 GRB2-associated binding protein 1 0.071
ZNF107 zinc finger protein 107 0.068
HP haptoglobin 0.068
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.067
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.065
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.065
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism