IMP

Process View

Homo sapiens

10 genes annotated in human

leukotriene metabolic process

The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "leukotriene metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "leukotriene metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
NCF4	neutrophil cytosolic factor 4, 40kDa	1.000
NCF2	neutrophil cytosolic factor 2	1.000
CYBA	cytochrome b-245, alpha polypeptide	0.999
PRKCB	protein kinase C, beta	0.979
PRKCD	protein kinase C, delta	0.914
TRIM9	tripartite motif containing 9	0.901
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.883
LY96	lymphocyte antigen 96	0.647
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.569
TICAM2	toll-like receptor adaptor molecule 2	0.537
PRKCA	protein kinase C, alpha	0.469
ALOX5	arachidonate 5-lipoxygenase	0.351
UBASH3B	ubiquitin associated and SH3 domain containing B	0.295
ALOX12B	arachidonate 12-lipoxygenase, 12R type	0.250	Human
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.246
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.232	Human
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.220
KRT5	keratin 5	0.179
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.143
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.136
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.118
MYD88	myeloid differentiation primary response gene (88)	0.104
ALOXE3	arachidonate lipoxygenase 3	0.103	Human
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.095	Human
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.090
PASK	PAS domain containing serine/threonine kinase	0.079
ALOX5AP	arachidonate 5-lipoxygenase-activating protein	0.076
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.068
GMPR2	guanosine monophosphate reductase 2	0.060
SETD7	SET domain containing (lysine methyltransferase) 7	0.055
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.054
SIRT6	sirtuin 6	0.041
RNASE6	ribonuclease, RNase A family, k6	0.040
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.035	Human
TGM1	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)	0.032
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.031
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.029
SH2D2A	SH2 domain containing 2A	0.028
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.027
CTSG	cathepsin G	0.025
GLB1	galactosidase, beta 1	0.024
SLA	Src-like-adaptor	0.024
ALOX15B	arachidonate 15-lipoxygenase, type B	0.022	Human
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.021
SH3BP2	SH3-domain binding protein 2	0.021
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.021
HPD	4-hydroxyphenylpyruvate dioxygenase	0.020
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.020
CDA	cytidine deaminase	0.020
ELANE	elastase, neutrophil expressed	0.019
TYROBP	TYRO protein tyrosine kinase binding protein	0.019
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.019
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.018
SH3KBP1	SH3-domain kinase binding protein 1	0.017
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.016
RDH16	retinol dehydrogenase 16 (all-trans)	0.015
ABCC6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0.015
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.015
CAMP	cathelicidin antimicrobial peptide	0.015
PRKCQ	protein kinase C, theta	0.014
PLEKHG6	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	0.014
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	0.014
HP	haptoglobin	0.014
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.014
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.014
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.014
EVPL	envoplakin	0.013
SPRY4	sprouty homolog 4 (Drosophila)	0.013
ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	0.013
CFP	complement factor properdin	0.013
PILRA	paired immunoglobin-like type 2 receptor alpha	0.013
B3GNT3	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	0.013
VAV1	vav 1 guanine nucleotide exchange factor	0.013
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.012
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.012
F10	coagulation factor X	0.012
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.012
PIP	prolactin-induced protein	0.012
ORM1	orosomucoid 1	0.012
NAGA	N-acetylgalactosaminidase, alpha-	0.011
FABP1	fatty acid binding protein 1, liver	0.011
HEBP1	heme binding protein 1	0.011
ARG1	arginase, liver	0.011
ARSE	arylsulfatase E (chondrodysplasia punctata 1)	0.011
ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	0.011
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.011
MAT1A	methionine adenosyltransferase I, alpha	0.010
MS4A2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.010
AKAP8L	A kinase (PRKA) anchor protein 8-like	0.010
ALDH3A1	aldehyde dehydrogenase 3 family, member A1	0.010
TBXAS1	thromboxane A synthase 1 (platelet)	0.010
AQP7	aquaporin 7	0.010