IMP
Process View
interleukin 6 mediated signaling pathway
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "interleukin 6 mediated signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 1.000 | ||
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 1.000 | Human | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.999 | Human | |
| JAK1 | Janus kinase 1 | 0.995 | ||
| IL6ST | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 0.982 | ||
| GHR | growth hormone receptor | 0.977 | ||
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.967 | ||
| JAK2 | Janus kinase 2 | 0.944 | ||
| EGFR | epidermal growth factor receptor | 0.940 | ||
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.900 | ||
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.485 | ||
| INSR | insulin receptor | 0.483 | ||
| SOCS3 | suppressor of cytokine signaling 3 | 0.458 | ||
| IL6R | interleukin 6 receptor | 0.370 | ||
| GRB2 | growth factor receptor-bound protein 2 | 0.312 | ||
| IRF9 | interferon regulatory factor 9 | 0.305 | ||
| IFNAR2 | interferon (alpha, beta and omega) receptor 2 | 0.247 | ||
| IL4R | interleukin 4 receptor | 0.238 | ||
| IRS1 | insulin receptor substrate 1 | 0.232 | ||
| ZNF746 | zinc finger protein 746 | 0.207 | ||
| STAT5A | signal transducer and activator of transcription 5A | 0.187 | Human | |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.167 | ||
| CDC73 | cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.151 | ||
| STAT2 | signal transducer and activator of transcription 2, 113kDa | 0.146 | Human | |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.118 | ||
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 0.117 | ||
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.110 | ||
| NMI | N-myc (and STAT) interactor | 0.101 | ||
| STAT4 | signal transducer and activator of transcription 4 | 0.100 | Human | |
| IL12RB2 | interleukin 12 receptor, beta 2 | 0.087 | Human | |
| IFNGR1 | interferon gamma receptor 1 | 0.065 | ||
| IL6 | interleukin 6 (interferon, beta 2) | 0.061 | ||
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | 0.057 | ||
| RTF1 | Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.056 | ||
| CAPN1 | calpain 1, (mu/I) large subunit | 0.048 | ||
| IGF1R | insulin-like growth factor 1 receptor | 0.043 | ||
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.042 | ||
| SH2B1 | SH2B adaptor protein 1 | 0.035 | ||
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.035 | ||
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.032 | ||
| ICAM1 | intercellular adhesion molecule 1 | 0.029 | ||
| TMEM173 | transmembrane protein 173 | 0.026 | ||
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.025 | ||
| GRB10 | growth factor receptor-bound protein 10 | 0.025 | ||
| LIF | leukemia inhibitory factor (cholinergic differentiation factor) | 0.024 | ||
| IL2RB | interleukin 2 receptor, beta | 0.021 | ||
| PLCG1 | phospholipase C, gamma 1 | 0.020 | ||
| IRF1 | interferon regulatory factor 1 | 0.019 | ||
| STAT5B | signal transducer and activator of transcription 5B | 0.018 | Human | |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.018 | ||
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.015 | ||
| LEO1 | Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.015 | ||
| NSF | N-ethylmaleimide-sensitive factor | 0.014 | ||
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.013 | ||
| SPRR2A | small proline-rich protein 2A | 0.013 | ||
| OSMR | oncostatin M receptor | 0.013 | Human | |
| IL1B | interleukin 1, beta | 0.012 | ||
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.012 | ||
| PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | 0.010 |