IMP

Process View

Homo sapiens

17 genes annotated in human

arp2 3 complex mediated actin nucleation

The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "arp2 3 complex mediated actin nucleation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "arp2 3 complex mediated actin nucleation" (in gray)

Name	Description	Probability	Func Analog Organism
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	1.000
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	1.000
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	1.000
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	1.000
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.999
GAS7	growth arrest-specific 7	0.997
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.996	Yeast Fly
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.995
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.968
WASL	Wiskott-Aldrich syndrome-like	0.965	Yeast Fly
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.956
NCKAP1	NCK-associated protein 1	0.886
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.868
BAIAP2	BAI1-associated protein 2	0.763
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.721
WIPF1	WAS/WASL interacting protein family, member 1	0.675
PFDN1	prefoldin subunit 1	0.642
MED15	mediator complex subunit 15	0.622
ABI1	abl-interactor 1	0.605	Human
ABI2	abl-interactor 2	0.556
WASF1	WAS protein family, member 1	0.282
TRIM39	tripartite motif containing 39	0.273	Human
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.188
TPM4	tropomyosin 4	0.188
TRIM5	tripartite motif containing 5	0.186	Human
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.169	Human
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.141
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.120
COTL1	coactosin-like 1 (Dictyostelium)	0.119
PFN1	profilin 1	0.116
ZNF263	zinc finger protein 263	0.115
WDR1	WD repeat domain 1	0.111
IQGAP1	IQ motif containing GTPase activating protein 1	0.110	Human
FMR1	fragile X mental retardation 1	0.103
ZNF473	zinc finger protein 473	0.087
ADAM19	ADAM metallopeptidase domain 19	0.087
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.081
CTTN	cortactin	0.077
SOS1	son of sevenless homolog 1 (Drosophila)	0.066
ARPC1A	actin related protein 2/3 complex, subunit 1A, 41kDa	0.062
MYH9	myosin, heavy chain 9, non-muscle	0.062
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.054
WASF2	WAS protein family, member 2	0.053	Human
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.053
TRIM17	tripartite motif containing 17	0.049	Human
GRB2	growth factor receptor-bound protein 2	0.049
TRIM21	tripartite motif containing 21	0.048	Human
SORBS3	sorbin and SH3 domain containing 3	0.046
MYL12B	myosin, light chain 12B, regulatory	0.044
FMNL1	formin-like 1	0.042
SAMD9	sterile alpha motif domain containing 9	0.036
CYTH2	cytohesin 2	0.033
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.033
TRIM26	tripartite motif containing 26	0.031
VAV1	vav 1 guanine nucleotide exchange factor	0.030
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.029
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.029
MSN	moesin	0.029
ITSN1	intersectin 1 (SH3 domain protein)	0.028
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.028
CAPZB	capping protein (actin filament) muscle Z-line, beta	0.028
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.028
PRKCG	protein kinase C, gamma	0.027
EPS8	epidermal growth factor receptor pathway substrate 8	0.027
PRLHR	prolactin releasing hormone receptor	0.025
NCF2	neutrophil cytosolic factor 2	0.025
CORO1C	coronin, actin binding protein, 1C	0.025	Human Yeast
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.024
IFI16	interferon, gamma-inducible protein 16	0.023
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.022
TRIM52	tripartite motif containing 52	0.021
TRIM34	tripartite motif containing 34	0.021
RGS19	regulator of G-protein signaling 19	0.021
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.021
CFL1	cofilin 1 (non-muscle)	0.020
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.020
PLSCR1	phospholipid scramblase 1	0.020
RNF126	ring finger protein 126	0.019
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.019
CAPZA1	capping protein (actin filament) muscle Z-line, alpha 1	0.018
TRIM43	tripartite motif containing 43	0.017
TMOD3	tropomodulin 3 (ubiquitous)	0.017
TNK2	tyrosine kinase, non-receptor, 2	0.017
TRIP10	thyroid hormone receptor interactor 10	0.016
SPRR2A	small proline-rich protein 2A	0.015
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.015
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.015
NMI	N-myc (and STAT) interactor	0.015
SP100	SP100 nuclear antigen	0.015
UBE2U	ubiquitin-conjugating enzyme E2U (putative)	0.015
TRIM8	tripartite motif containing 8	0.015
PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	0.015
STAT1	signal transducer and activator of transcription 1, 91kDa	0.014
NCK1	NCK adaptor protein 1	0.014
ATXN7L3	ataxin 7-like 3	0.013
DEF6	differentially expressed in FDCP 6 homolog (mouse)	0.013
ACCN2	amiloride-sensitive cation channel 2, neuronal	0.012
LCP1	lymphocyte cytosolic protein 1 (L-plastin)	0.012
KIAA0408	KIAA0408	0.012
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.012
MCOLN1	mucolipin 1	0.012
TMEM106A	transmembrane protein 106A	0.011
PICALM	phosphatidylinositol binding clathrin assembly protein	0.011
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.011
C3orf10	chromosome 3 open reading frame 10	0.011
HOMER3	homer homolog 3 (Drosophila)	0.011
TRIM32	tripartite motif containing 32	0.011
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.010
GNGT2	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2	0.010
NCKAP1L	NCK-associated protein 1-like	0.010	Human
COPG	coatomer protein complex, subunit gamma	0.010
NCKIPSD	NCK interacting protein with SH3 domain	0.010
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	0.010
MKRN3	makorin ring finger protein 3	0.010