IMP

Process View

Homo sapiens

16 genes annotated in human

skeletal muscle contraction

A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "skeletal muscle contraction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "skeletal muscle contraction" (in gray)

Name	Description	Probability	Func Analog Organism
TNNC1	troponin C type 1 (slow)	1.000	Human Rat
TNNI1	troponin I type 1 (skeletal, slow)	0.999	Human
TNNT3	troponin T type 3 (skeletal, fast)	0.998
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.997
LIN7B	lin-7 homolog B (C. elegans)	0.991
SMYD1	SET and MYND domain containing 1	0.960
MYOZ1	myozenin 1	0.952
DTNA	dystrobrevin, alpha	0.940
TRIM63	tripartite motif containing 63	0.929
LDB3	LIM domain binding 3	0.897
COX6A2	cytochrome c oxidase subunit VIa polypeptide 2	0.895
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.888	Human Zebrafish
CKM	creatine kinase, muscle	0.873
TNNI2	troponin I type 2 (skeletal, fast)	0.818
TNNT2	troponin T type 2 (cardiac)	0.814	Human
MYL1	myosin, light chain 1, alkali; skeletal, fast	0.807
MYH1	myosin, heavy chain 1, skeletal muscle, adult	0.805	Human
MYBPC2	myosin binding protein C, fast type	0.766
MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	0.745
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.744
MYH2	myosin, heavy chain 2, skeletal muscle, adult	0.725	Human
TTN	titin	0.697
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.660
ACTN3	actinin, alpha 3	0.647
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.553
ACTA1	actin, alpha 1, skeletal muscle	0.528
MYBPH	myosin binding protein H	0.492
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.453
TNNC2	troponin C type 2 (fast)	0.437
MYH6	myosin, heavy chain 6, cardiac muscle, alpha	0.342	Human Zebrafish
CAV3	caveolin 3	0.337
CHUK	conserved helix-loop-helix ubiquitous kinase	0.306
CHRNA1	cholinergic receptor, nicotinic, alpha 1 (muscle)	0.279
MYD88	myeloid differentiation primary response gene (88)	0.275
SYNM	synemin, intermediate filament protein	0.265
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.255
MYBPC1	myosin binding protein C, slow type	0.254
TICAM2	toll-like receptor adaptor molecule 2	0.248
ACTA2	actin, alpha 2, smooth muscle, aorta	0.244
MYL3	myosin, light chain 3, alkali; ventricular, skeletal, slow	0.242
MYH8	myosin, heavy chain 8, skeletal muscle, perinatal	0.235
SGCA	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	0.224
ASCC2	activating signal cointegrator 1 complex subunit 2	0.207
ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	0.190
MYH4	myosin, heavy chain 4, skeletal muscle	0.188	Human
TNNI3	troponin I type 3 (cardiac)	0.169	Human
MYOZ2	myozenin 2	0.136
CACNA1S	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.128
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.126
FLNA	filamin A, alpha	0.122
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.119
SLN	sarcolipin	0.100
PGAM2	phosphoglycerate mutase 2 (muscle)	0.099
ACTC1	actin, alpha, cardiac muscle 1	0.094
SRPK3	SRSF protein kinase 3	0.093
SYNPO2L	synaptopodin 2-like	0.092
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.086
HAP1	huntingtin-associated protein 1	0.071
MB	myoglobin	0.068	Rat
HSPB3	heat shock 27kDa protein 3	0.063
PYGM	phosphorylase, glycogen, muscle	0.062
CHRND	cholinergic receptor, nicotinic, delta	0.058	Human Rat
ARRDC3	arrestin domain containing 3	0.057
RAPSN	receptor-associated protein of the synapse	0.055
SNTB1	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	0.053
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.053
TRPM7	transient receptor potential cation channel, subfamily M, member 7	0.051
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.051
CHRNG	cholinergic receptor, nicotinic, gamma	0.051	Human Rat
HSPG2	heparan sulfate proteoglycan 2	0.050
MYOG	myogenin (myogenic factor 4)	0.049
HSPB2	heat shock 27kDa protein 2	0.048
TRPM6	transient receptor potential cation channel, subfamily M, member 6	0.047
HRC	histidine rich calcium binding protein	0.045
CASQ2	calsequestrin 2 (cardiac muscle)	0.044
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.043
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.041
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.041
PLD3	phospholipase D family, member 3	0.040
MYF6	myogenic factor 6 (herculin)	0.038
DES	desmin	0.038
SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	0.038
TNNI3K	TNNI3 interacting kinase	0.037
ACTN2	actinin, alpha 2	0.037
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.037
UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	0.034
CASQ1	calsequestrin 1 (fast-twitch, skeletal muscle)	0.033
MYOM1	myomesin 1, 185kDa	0.033
PDPK1	3-phosphoinositide dependent protein kinase-1	0.033
TNNT1	troponin T type 1 (skeletal, slow)	0.033
CACNB1	calcium channel, voltage-dependent, beta 1 subunit	0.032
CACNG1	calcium channel, voltage-dependent, gamma subunit 1	0.032
CLCN1	chloride channel 1, skeletal muscle	0.030
MYBPC3	myosin binding protein C, cardiac	0.030
RPL3L	ribosomal protein L3-like	0.029
GFI1B	growth factor independent 1B transcription repressor	0.029
MYH3	myosin, heavy chain 3, skeletal muscle, embryonic	0.028
APOBEC2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	0.026
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.026
TCAP	titin-cap (telethonin)	0.025
RICTOR	RPTOR independent companion of MTOR, complex 2	0.025
RYR1	ryanodine receptor 1 (skeletal)	0.025
PKD2L1	polycystic kidney disease 2-like 1	0.025
KCNJ16	potassium inwardly-rectifying channel, subfamily J, member 16	0.025	Human
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.023
ENO3	enolase 3 (beta, muscle)	0.023
IRAK1	interleukin-1 receptor-associated kinase 1	0.022
ITGB1BP3	integrin beta 1 binding protein 3	0.020
SMPX	small muscle protein, X-linked	0.020
KCNJ10	potassium inwardly-rectifying channel, subfamily J, member 10	0.020	Human
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.020
JPH2	junctophilin 2	0.019
CMA1	chymase 1, mast cell	0.018
DUSP13	dual specificity phosphatase 13	0.018
FBXO40	F-box protein 40	0.018
CA3	carbonic anhydrase III, muscle specific	0.018
MAPT	microtubule-associated protein tau	0.018
PPFIA4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.018
PHKG1	phosphorylase kinase, gamma 1 (muscle)	0.018
FBP2	fructose-1,6-bisphosphatase 2	0.017
LENG8	leukocyte receptor cluster (LRC) member 8	0.017
HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	0.017
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.016
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	0.016
S100A1	S100 calcium binding protein A1	0.015
ADRA2B	adrenergic, alpha-2B-, receptor	0.015
MYL9	myosin, light chain 9, regulatory	0.015
NRAP	nebulin-related anchoring protein	0.014
ALPK3	alpha-kinase 3	0.014
SCN4A	sodium channel, voltage-gated, type IV, alpha subunit	0.014
MYL7	myosin, light chain 7, regulatory	0.014
CKMT2	creatine kinase, mitochondrial 2 (sarcomeric)	0.014
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.014
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.014
OMP	olfactory marker protein	0.013
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.013
ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	0.013
ZNF512B	zinc finger protein 512B	0.013
TPM3	tropomyosin 3	0.013
CLCNKB	chloride channel Kb	0.012
ARR3	arrestin 3, retinal (X-arrestin)	0.012
COL20A1	collagen, type XX, alpha 1	0.012
KRT36	keratin 36	0.012
MYH13	myosin, heavy chain 13, skeletal muscle	0.012	Human
DRP2	dystrophin related protein 2	0.012
AMPD1	adenosine monophosphate deaminase 1	0.012
PCDH12	protocadherin 12	0.012
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.012
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.011
MYLK2	myosin light chain kinase 2	0.011
OSM	oncostatin M	0.011
SGSH	N-sulfoglucosamine sulfohydrolase	0.011
MYF5	myogenic factor 5	0.011
HFE2	hemochromatosis type 2 (juvenile)	0.011
TPM1	tropomyosin 1 (alpha)	0.011
BCAN	brevican	0.011
SPAG8	sperm associated antigen 8	0.011
TMEM98	transmembrane protein 98	0.010
PNMT	phenylethanolamine N-methyltransferase	0.010
KCNE1	potassium voltage-gated channel, Isk-related family, member 1	0.010
TRADD	TNFRSF1A-associated via death domain	0.010
ACTG1	actin, gamma 1	0.010
DRD2	dopamine receptor D2	0.010
GRN	granulin	0.010
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.010