IMP

Process View

Homo sapiens

3 genes annotated in human

Multi-species View

negative regulation of muscle contraction

GO:0045932

Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of muscle contraction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of muscle contraction" (in gray)

Name	Description	Probability	Func Analog Organism
NCF4	neutrophil cytosolic factor 4, 40kDa	0.989
NCF2	neutrophil cytosolic factor 2	0.988
HDAC6	histone deacetylase 6	0.976
PRKCB	protein kinase C, beta	0.973
CYBA	cytochrome b-245, alpha polypeptide	0.901
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.900
VPS29	vacuolar protein sorting 29 homolog (S. cerevisiae)	0.848
PRKCA	protein kinase C, alpha	0.794
BBS10	Bardet-Biedl syndrome 10	0.566
TNNC1	troponin C type 1 (slow)	0.561
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.472
TRIM9	tripartite motif containing 9	0.411
PRKCD	protein kinase C, delta	0.295
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.274
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.218
TNNI1	troponin I type 1 (skeletal, slow)	0.190
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.166
ARRDC3	arrestin domain containing 3	0.164
HTT	huntingtin	0.142
TNNI2	troponin I type 2 (skeletal, fast)	0.131
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.113
LDB3	LIM domain binding 3	0.092
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.068
PRKG1	protein kinase, cGMP-dependent, type I	0.068	Mouse
IL8	interleukin 8	0.068
SETD7	SET domain containing (lysine methyltransferase) 7	0.063
MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	0.060
TUBB2B	tubulin, beta 2B	0.050
RIN3	Ras and Rab interactor 3	0.050
ADORA2A	adenosine A2a receptor	0.049
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.049
CKM	creatine kinase, muscle	0.048
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.047
RGS2	regulator of G-protein signaling 2, 24kDa	0.047	Mouse
REEP5	receptor accessory protein 5	0.046
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.046
TNNC2	troponin C type 2 (fast)	0.045
MRVI1	murine retrovirus integration site 1 homolog	0.043	Mouse
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.043
OSBP2	oxysterol binding protein 2	0.042
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.042
ACTA1	actin, alpha 1, skeletal muscle	0.039
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.035
FRZB	frizzled-related protein	0.035
SGCA	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	0.034
ACTB	actin, beta	0.034
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.030
LRFN1	leucine rich repeat and fibronectin type III domain containing 1	0.030
CFL2	cofilin 2 (muscle)	0.029
SIRT6	sirtuin 6	0.029
NACAD	NAC alpha domain containing	0.028
PYGM	phosphorylase, glycogen, muscle	0.028
PDE6G	phosphodiesterase 6G, cGMP-specific, rod, gamma	0.028
TNNI3	troponin I type 3 (cardiac)	0.027
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.027
TRIM63	tripartite motif containing 63	0.027
COX6A2	cytochrome c oxidase subunit VIa polypeptide 2	0.026
ATP13A2	ATPase type 13A2	0.025
TMEM98	transmembrane protein 98	0.025
TBC1D10A	TBC1 domain family, member 10A	0.025
PKN1	protein kinase N1	0.025
TNNT2	troponin T type 2 (cardiac)	0.025	Human
ZKSCAN5	zinc finger with KRAB and SCAN domains 5	0.025
BIN1	bridging integrator 1	0.024
PASK	PAS domain containing serine/threonine kinase	0.023
MME	membrane metallo-endopeptidase	0.022
ACTN3	actinin, alpha 3	0.022
MYH6	myosin, heavy chain 6, cardiac muscle, alpha	0.022
C7orf36	chromosome 7 open reading frame 36	0.022
TNNT3	troponin T type 3 (skeletal, fast)	0.022	Human
CHD3	chromodomain helicase DNA binding protein 3	0.021
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.021
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.020
FRA10AC1	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	0.020
MYH2	myosin, heavy chain 2, skeletal muscle, adult	0.020
EZR	ezrin	0.020
DUSP1	dual specificity phosphatase 1	0.020
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.020
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.019
RAMP1	receptor (G protein-coupled) activity modifying protein 1	0.019
CXCL3	chemokine (C-X-C motif) ligand 3	0.019
EGR3	early growth response 3	0.019
MYBPH	myosin binding protein H	0.019
ZNF768	zinc finger protein 768	0.019
MYBPC2	myosin binding protein C, fast type	0.019
ARRB2	arrestin, beta 2	0.018
PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)	0.018
MYL3	myosin, light chain 3, alkali; ventricular, skeletal, slow	0.018
AKAP12	A kinase (PRKA) anchor protein 12	0.018
CDCP1	CUB domain containing protein 1	0.017
TPM1	tropomyosin 1 (alpha)	0.017
NINL	ninein-like	0.017
OPRD1	opioid receptor, delta 1	0.017
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.017
TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	0.016
ACTG1	actin, gamma 1	0.016
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.016
RABAC1	Rab acceptor 1 (prenylated)	0.016
MYH1	myosin, heavy chain 1, skeletal muscle, adult	0.016
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.016
CAV2	caveolin 2	0.016
NBEAL2	neurobeachin-like 2	0.016
SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	0.016
PGAM2	phosphoglycerate mutase 2 (muscle)	0.015
CTSB	cathepsin B	0.015
ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	0.015
SIRT2	sirtuin 2	0.015
ACTN2	actinin, alpha 2	0.015
PTPRA	protein tyrosine phosphatase, receptor type, A	0.015
ZNF250	zinc finger protein 250	0.015
RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	0.014
PDE4B	phosphodiesterase 4B, cAMP-specific	0.014
AKAP8L	A kinase (PRKA) anchor protein 8-like	0.014
PPFIA4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.014
HMOX2	heme oxygenase (decycling) 2	0.014
PTP4A3	protein tyrosine phosphatase type IVA, member 3	0.014
MIIP	migration and invasion inhibitory protein	0.014
CALCRL	calcitonin receptor-like	0.014	Rat
PLEKHF1	pleckstrin homology domain containing, family F (with FYVE domain) member 1	0.014
MYOG	myogenin (myogenic factor 4)	0.014
SDPR	serum deprivation response	0.013
LMOD1	leiomodin 1 (smooth muscle)	0.013
TBXA2R	thromboxane A2 receptor	0.013
HDAC11	histone deacetylase 11	0.013
ITPR3	inositol 1,4,5-trisphosphate receptor, type 3	0.013
SYNPO2L	synaptopodin 2-like	0.013
HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	0.013
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.013
MAN2A2	mannosidase, alpha, class 2A, member 2	0.013
TAZ	tafazzin	0.013
MYH4	myosin, heavy chain 4, skeletal muscle	0.013
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.013
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.013
FGF8	fibroblast growth factor 8 (androgen-induced)	0.013
FCHO1	FCH domain only 1	0.013
ACTC1	actin, alpha, cardiac muscle 1	0.013
GNAS	GNAS complex locus	0.013
GP1BB	glycoprotein Ib (platelet), beta polypeptide	0.013
TCAP	titin-cap (telethonin)	0.013
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.012
MYH11	myosin, heavy chain 11, smooth muscle	0.012
ZRANB1	zinc finger, RAN-binding domain containing 1	0.012
DSCAML1	Down syndrome cell adhesion molecule like 1	0.012
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.012
ZFAND5	zinc finger, AN1-type domain 5	0.012
CBX8	chromobox homolog 8	0.012
HLF	hepatic leukemia factor	0.012
NPPB	natriuretic peptide B	0.012
MPP3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.012
PRSS23	protease, serine, 23	0.012
P2RY1	purinergic receptor P2Y, G-protein coupled, 1	0.012
RYR1	ryanodine receptor 1 (skeletal)	0.012
IMPDH1	IMP (inosine 5'-monophosphate) dehydrogenase 1	0.012
TPM2	tropomyosin 2 (beta)	0.012
HRC	histidine rich calcium binding protein	0.012
TTN	titin	0.012
P2RX1	purinergic receptor P2X, ligand-gated ion channel, 1	0.012
MYL1	myosin, light chain 1, alkali; skeletal, fast	0.012
FBXO25	F-box protein 25	0.012
CA3	carbonic anhydrase III, muscle specific	0.011
SLN	sarcolipin	0.011
CAV3	caveolin 3	0.011
KCNMB1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	0.011
KCNIP3	Kv channel interacting protein 3, calsenilin	0.011
RIMS4	regulating synaptic membrane exocytosis 4	0.011
MYH3	myosin, heavy chain 3, skeletal muscle, embryonic	0.011
SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3	0.011
CLN6	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	0.011
USP2	ubiquitin specific peptidase 2	0.011
IL1B	interleukin 1, beta	0.011
SRL	sarcalumenin	0.011
SMPX	small muscle protein, X-linked	0.011
SRPK3	SRSF protein kinase 3	0.011
PLN	phospholamban	0.011
PDE4D	phosphodiesterase 4D, cAMP-specific	0.011
RGS14	regulator of G-protein signaling 14	0.010
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.010
ATF3	activating transcription factor 3	0.010
FHL1	four and a half LIM domains 1	0.010
ZNF205	zinc finger protein 205	0.010
SIX1	SIX homeobox 1	0.010
ROM1	retinal outer segment membrane protein 1	0.010
ENO3	enolase 3 (beta, muscle)	0.010
GPRC5B	G protein-coupled receptor, family C, group 5, member B	0.010
C9orf167	chromosome 9 open reading frame 167	0.010
TBX1	T-box 1	0.010
RGS5	regulator of G-protein signaling 5	0.010
SH3BP1	SH3-domain binding protein 1	0.010
UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	0.010
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.010
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.010
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.010
CSNK1E	casein kinase 1, epsilon	0.010