The network for 'negative regulation of muscle contraction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of muscle contraction

Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.

Homo sapiens
Name Description Probability Func Analog Organism
NCF4 neutrophil cytosolic factor 4, 40kDa 0.989
NCF2 neutrophil cytosolic factor 2 0.988
HDAC6 histone deacetylase 6 0.976
PRKCB protein kinase C, beta 0.973
CYBA cytochrome b-245, alpha polypeptide 0.901
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.900
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 0.848
PRKCA protein kinase C, alpha 0.794
BBS10 Bardet-Biedl syndrome 10 0.566
TNNC1 troponin C type 1 (slow) 0.561
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.472
TRIM9 tripartite motif containing 9 0.411
PRKCD protein kinase C, delta 0.295
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.274
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.218
TNNI1 troponin I type 1 (skeletal, slow) 0.190
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.166
ARRDC3 arrestin domain containing 3 0.164
HTT huntingtin 0.142
TNNI2 troponin I type 2 (skeletal, fast) 0.131
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.113
LDB3 LIM domain binding 3 0.092
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.068
PRKG1 protein kinase, cGMP-dependent, type I 0.068
IL8 interleukin 8 0.068
SETD7 SET domain containing (lysine methyltransferase) 7 0.063
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 0.060
TUBB2B tubulin, beta 2B 0.050
RIN3 Ras and Rab interactor 3 0.050
ADORA2A adenosine A2a receptor 0.049
MYH7 myosin, heavy chain 7, cardiac muscle, beta 0.049
CKM creatine kinase, muscle 0.048
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.047
RGS2 regulator of G-protein signaling 2, 24kDa 0.047
REEP5 receptor accessory protein 5 0.046
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.046
TNNC2 troponin C type 2 (fast) 0.045
MRVI1 murine retrovirus integration site 1 homolog 0.043
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.043
OSBP2 oxysterol binding protein 2 0.042
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.042
ACTA1 actin, alpha 1, skeletal muscle 0.039
PTK2B PTK2B protein tyrosine kinase 2 beta 0.035
FRZB frizzled-related protein 0.035
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 0.034
ACTB actin, beta 0.034
FOS FBJ murine osteosarcoma viral oncogene homolog 0.030
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 0.030
CFL2 cofilin 2 (muscle) 0.029
SIRT6 sirtuin 6 0.029
NACAD NAC alpha domain containing 0.028
PYGM phosphorylase, glycogen, muscle 0.028
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 0.028
TNNI3 troponin I type 3 (cardiac) 0.027
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.027
TRIM63 tripartite motif containing 63 0.027
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 0.026
ATP13A2 ATPase type 13A2 0.025
TMEM98 transmembrane protein 98 0.025
TBC1D10A TBC1 domain family, member 10A 0.025
PKN1 protein kinase N1 0.025
TNNT2 troponin T type 2 (cardiac) 0.025
ZKSCAN5 zinc finger with KRAB and SCAN domains 5 0.025
BIN1 bridging integrator 1 0.024
PASK PAS domain containing serine/threonine kinase 0.023
MME membrane metallo-endopeptidase 0.022
ACTN3 actinin, alpha 3 0.022
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.022
C7orf36 chromosome 7 open reading frame 36 0.022
TNNT3 troponin T type 3 (skeletal, fast) 0.022
CHD3 chromodomain helicase DNA binding protein 3 0.021
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.021
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.020
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 0.020
MYH2 myosin, heavy chain 2, skeletal muscle, adult 0.020
EZR ezrin 0.020
DUSP1 dual specificity phosphatase 1 0.020
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.020
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 0.019
RAMP1 receptor (G protein-coupled) activity modifying protein 1 0.019
CXCL3 chemokine (C-X-C motif) ligand 3 0.019
EGR3 early growth response 3 0.019
MYBPH myosin binding protein H 0.019
ZNF768 zinc finger protein 768 0.019
MYBPC2 myosin binding protein C, fast type 0.019
ARRB2 arrestin, beta 2 0.018
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.018
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.018
AKAP12 A kinase (PRKA) anchor protein 12 0.018
CDCP1 CUB domain containing protein 1 0.017
TPM1 tropomyosin 1 (alpha) 0.017
NINL ninein-like 0.017
OPRD1 opioid receptor, delta 1 0.017
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.017
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.016
ACTG1 actin, gamma 1 0.016
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.016
RABAC1 Rab acceptor 1 (prenylated) 0.016
MYH1 myosin, heavy chain 1, skeletal muscle, adult 0.016
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.016
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
pvalb4 parvalbumin 4 0.052
cmlc1 cardiac myosin light chain-1 0.029
tnnc2 troponin C type 2 (fast) 0.026
m17 IL-6 subfamily cytokine M17 0.020
mylz3 myosin, light polypeptide 3, skeletal muscle 0.018
nme2b.2 non-metastatic cells 2b.2, protein (NM23B) expressed in 0.017
adrb2a adrenergic receptor, beta 2a 0.016
ctsc cathepsin C 0.016
cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.016
etf1 eukaryotic translation termination factor 1 0.014
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.014
tmem38a transmembrane protein 38A 0.013
ldb3a LIM-domain binding factor 3a 0.012
fabp11a fatty acid binding protein 11a 0.012
acadm acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain 0.012
slc25a4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 0.011
mmp13a matrix metalloproteinase 13a 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.968
Cckbr cholecystokinin B receptor 0.895
Pnpla2 patatin-like phospholipase domain containing 2 0.792
Kl klotho 0.776
Nos1 nitric oxide synthase 1, neuronal 0.691
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.523
Adrb1 adrenergic receptor, beta 1 0.485
Hpca hippocalcin 0.374
ND6 NADH dehydrogenase subunit 6 0.364
Gucy1a3 guanylate cyclase 1, soluble, alpha 3 0.356
Mb myoglobin 0.339
Prkg1 protein kinase, cGMP-dependent, type I 0.325
Sparcl1 SPARC-like 1 0.307
Ppp1r9b protein phosphatase 1, regulatory subunit 9B 0.269
Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.266
Rgs4 regulator of G-protein signaling 4 0.263
Il6 interleukin 6 0.260
Ednrb endothelin receptor type B 0.255
Abcc9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.241
Sstr4 somatostatin receptor 4 0.238
Sstr1 somatostatin receptor 1 0.215
Bdkrb2 bradykinin receptor, beta 2 0.191
Drd2 dopamine receptor D2 0.186
Lag3 lymphocyte-activation gene 3 0.164
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.150
Prkaca protein kinase, cAMP dependent, catalytic, alpha 0.126
Darc Duffy blood group, chemokine receptor 0.123
Lama2 laminin, alpha 2 0.120
Nos3 nitric oxide synthase 3, endothelial cell 0.117
Ptafr platelet-activating factor receptor 0.116
Sst somatostatin 0.115
Tek endothelial-specific receptor tyrosine kinase 0.114
Trpv1 transient receptor potential cation channel, subfamily V, member 1 0.098
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.098
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.093
Rho rhodopsin 0.091
Kit kit oncogene 0.089
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.089
Pparg peroxisome proliferator activated receptor gamma 0.085
Gabrb2 gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 0.084
Krt86 keratin 86 0.083
Ptprn2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.083
Clcnka chloride channel Ka 0.080
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.078
Shc3 src homology 2 domain-containing transforming protein C3 0.076
Vip vasoactive intestinal polypeptide 0.076
Emcn endomucin 0.073
Maf avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog 0.071
Adrb3 adrenergic receptor, beta 3 0.070
Fgf4 fibroblast growth factor 4 0.070
Kcne2 potassium voltage-gated channel, Isk-related subfamily, gene 2 0.070
Ccr1l1 chemokine (C-C motif) receptor 1-like 1 0.068
Kcnk3 potassium channel, subfamily K, member 3 0.065
Npy2r neuropeptide Y receptor Y2 0.065
Cd247 CD247 antigen 0.064
Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit 0.064
Grm2 glutamate receptor, metabotropic 2 0.060
Plau plasminogen activator, urokinase 0.060
Zfr2 zinc finger RNA binding protein 2 0.060
Pvalb parvalbumin 0.059
Mrvi1 MRV integration site 1 0.057
Fbn1 fibrillin 1 0.056
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.055
Cnr1 cannabinoid receptor 1 (brain) 0.055
Slc12a1 solute carrier family 12, member 1 0.054
Mef2c myocyte enhancer factor 2C 0.054
Galr2 galanin receptor 2 0.054
Ap1s2 adaptor-related protein complex 1, sigma 2 subunit 0.053
Ddah1 dimethylarginine dimethylaminohydrolase 1 0.053
Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) 0.053
Spock1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 0.053
Nos2 nitric oxide synthase 2, inducible 0.052
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.051
Adrb2 adrenergic receptor, beta 2 0.048
Ren1 renin 1 structural 0.045
Adora2b adenosine A2b receptor 0.045
Vamp2 vesicle-associated membrane protein 2 0.043
C5ar1 complement component 5a receptor 1 0.042
Hrh1 histamine receptor H1 0.041
Ptprb protein tyrosine phosphatase, receptor type, B 0.038
Cox8b cytochrome c oxidase, subunit VIIIb 0.038
Gjd2 gap junction protein, delta 2 0.037
Tac2 tachykinin 2 0.036
Sult4a1 sulfotransferase family 4A, member 1 0.034
Sdpr serum deprivation response 0.033
Mtap1a microtubule-associated protein 1 A 0.033
Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.033
Gfap glial fibrillary acidic protein 0.033
Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 0.033
Ldb2 LIM domain binding 2 0.033
Sncb synuclein, beta 0.033
Kitl kit ligand 0.032
Cdh11 cadherin 11 0.032
Tyrobp TYRO protein tyrosine kinase binding protein 0.032
Cryaa crystallin, alpha A 0.031
Eltd1 EGF, latrophilin seven transmembrane domain containing 1 0.031
Grk6 G protein-coupled receptor kinase 6 0.031
Pde6a phosphodiesterase 6A, cGMP-specific, rod, alpha 0.030
Dmkn dermokine 0.030
Crhr1 corticotropin releasing hormone receptor 1 0.030
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Rattus norvegicus
Name Description Probability Func Analog Organism
Adora1 adenosine A1 receptor 0.168
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.124
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.083
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.078
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.047
Accn2 amiloride-sensitive cation channel 2, neuronal 0.046
Fgf14 fibroblast growth factor 14 0.045
Tpsb2 tryptase beta 2 0.045
Adora2a adenosine A2a receptor 0.044
Gad2 glutamate decarboxylase 2 0.040
Ucn urocortin 0.030
Trhr thyrotropin releasing hormone receptor 0.027
Gast gastrin 0.022
Oprk1 opioid receptor, kappa 1 0.021
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.020
Cd40lg CD40 ligand 0.020
Lrrc56 leucine rich repeat containing 56 0.019
Sycp3 synaptonemal complex protein 3 0.019
Atp2a3 ATPase, Ca++ transporting, ubiquitous 0.018
Cckar cholecystokinin A receptor 0.018
Olr416 olfactory receptor 416 0.017
Epor erythropoietin receptor 0.017
Testin testin gene 0.017
Uhmk1 U2AF homology motif (UHM) kinase 1 0.017
Hrh3 histamine receptor H3 0.017
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.017
Grm6 glutamate receptor, metabotropic 6 0.016
Csrnp2 cysteine-serine-rich nuclear protein 2 0.016
Asb9 ankyrin repeat and SOCS box-containing 9 0.016
Hcrt hypocretin 0.016
Aqp2 aquaporin 2 (collecting duct) 0.015
Nfasc neurofascin 0.015
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.015
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.015
Nkx6-1 NK6 homeobox 1 0.014
Cxcr5 chemokine (C-X-C motif) receptor 5 0.014
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.014
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.014
Tnni1 troponin I type 1 (skeletal, slow) 0.014
Sparcl1 SPARC-like 1 (hevin) 0.014
Ar androgen receptor 0.013
Adora3 adenosine A3 receptor 0.013
Mchr1 melanin-concentrating hormone receptor 1 0.013
RGD1564327 similar to integrin alpha 8 0.013
Crhbp corticotropin releasing hormone binding protein 0.013
Pcdhb12 protocadherin beta 12 0.013
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.013
Mag myelin-associated glycoprotein 0.013
Kcnn3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 0.012
Clstn3 calsyntenin 3 0.012
Gpr176 G protein-coupled receptor 176 0.012
Chrna1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.012
Folh1 folate hydrolase 1 0.012
Myo9a myosin IXA 0.012
Znf483 zinc finger protein 483 0.012
Cd79b Cd79b molecule, immunoglobulin-associated beta 0.012
Agtr1a angiotensin II receptor, type 1a 0.012
Iapp islet amyloid polypeptide 0.012
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.012
Prrx1 paired related homeobox 1 0.011
Pdyn prodynorphin 0.011
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.011
Sprr1al small proline-rich protein 1A-like 0.011
Dpysl3 dihydropyrimidinase-like 3 0.011
Fgf7 fibroblast growth factor 7 0.011
Aspg asparaginase homolog (S. cerevisiae) 0.011
Strn striatin, calmodulin binding protein 0.011
Acrv1 acrosomal vesicle protein 1 0.011
Git1 G protein-coupled receptor kinase interacting ArfGAP 1 0.011
Cpa3 carboxypeptidase A3, mast cell 0.011
Tgm1 transglutaminase 1, K polypeptide 0.011
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.011
Prp15 proline-rich protein 15 0.011
Grin3a glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.011
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.011
Rab15 RAB15, member RAS oncogene family 0.010
Il8ra interleukin 8 receptor, alpha 0.010
Ncan neurocan 0.010
Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.010
Pcsk1 proprotein convertase subtilisin/kexin type 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism