IMP

Process View

Homo sapiens

2 genes annotated in human

chronological cell aging

The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "chronological cell aging"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "chronological cell aging" (in gray)

Name	Description	Probability	Func Analog Organism
ACTB	actin, beta	0.903	Yeast
CFL1	cofilin 1 (non-muscle)	0.688
ZYX	zyxin	0.405
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.252
CFL2	cofilin 2 (muscle)	0.206
PLAU	plasminogen activator, urokinase	0.203
FLNA	filamin A, alpha	0.124
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.117
TPM1	tropomyosin 1 (alpha)	0.112
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.099
TGFB1	transforming growth factor, beta 1	0.092
TPM4	tropomyosin 4	0.082
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.073
ACTN1	actinin, alpha 1	0.065
MYH9	myosin, heavy chain 9, non-muscle	0.060
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.059
PLAT	plasminogen activator, tissue	0.057
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.055
HIST1H3B	histone cluster 1, H3b	0.038
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.038
FN1	fibronectin 1	0.036
LMNA	lamin A/C	0.033
TUBA1C	tubulin, alpha 1c	0.033
ACTG1	actin, gamma 1	0.032	Yeast
MYL9	myosin, light chain 9, regulatory	0.029
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.029
USP46	ubiquitin specific peptidase 46	0.028
SNX9	sorting nexin 9	0.027
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.025
WDR1	WD repeat domain 1	0.024
WDR48	WD repeat domain 48	0.024
DTX1	deltex homolog 1 (Drosophila)	0.024
CSNK2A2	casein kinase 2, alpha prime polypeptide	0.022	Yeast
CSRP1	cysteine and glycine-rich protein 1	0.020
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.020
CDK11A	cyclin-dependent kinase 11A	0.018
ARRB2	arrestin, beta 2	0.017
PLP2	proteolipid protein 2 (colonic epithelium-enriched)	0.017
PLAUR	plasminogen activator, urokinase receptor	0.017
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.015
PDLIM7	PDZ and LIM domain 7 (enigma)	0.015
PTRF	polymerase I and transcript release factor	0.015
TGFB3	transforming growth factor, beta 3	0.015
ORM1	orosomucoid 1	0.015
SMCR7L	Smith-Magenis syndrome chromosome region, candidate 7-like	0.015
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.014
CHD4	chromodomain helicase DNA binding protein 4	0.013
EHD2	EH-domain containing 2	0.012
SIRT5	sirtuin 5	0.012
VTN	vitronectin	0.012
ZNHIT1	zinc finger, HIT-type containing 1	0.012
HDAC6	histone deacetylase 6	0.012
BCAP31	B-cell receptor-associated protein 31	0.012
SIRT4	sirtuin 4	0.011
TMSB4X	thymosin beta 4, X-linked	0.011
FBRSL1	fibrosin-like 1	0.011
HIST1H4F	histone cluster 1, H4f	0.011
SEC61B	Sec61 beta subunit	0.011
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.011
EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	0.011
SNX18	sorting nexin 18	0.011
OSBP	oxysterol binding protein	0.011
CYR61	cysteine-rich, angiogenic inducer, 61	0.011
FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	0.010
PDAP1	PDGFA associated protein 1	0.010
MYH11	myosin, heavy chain 11, smooth muscle	0.010
MSN	moesin	0.010
KIF5C	kinesin family member 5C	0.010