IMP

Process View

Homo sapiens

3 genes annotated in human

positive regulation of plasminogen activation

Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of plasminogen activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of plasminogen activation" (in gray)

Name	Description	Probability	Func Analog Organism
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	1.000
PLAUR	plasminogen activator, urokinase receptor	0.895
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.721
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.447
GAST	gastrin	0.413
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.285
KNG1	kininogen 1	0.259
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.158
PIGR	polymeric immunoglobulin receptor	0.110
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.110
ORM1	orosomucoid 1	0.083
ELF3	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	0.081
WFDC2	WAP four-disulfide core domain 2	0.075
ICAM1	intercellular adhesion molecule 1	0.070
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.069
FGB	fibrinogen beta chain	0.069
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.068
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.062
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.055
STC1	stanniocalcin 1	0.052
IL8	interleukin 8	0.050
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.050
GJB1	gap junction protein, beta 1, 32kDa	0.050
SAA4	serum amyloid A4, constitutive	0.048
ECM1	extracellular matrix protein 1	0.047
C4BPB	complement component 4 binding protein, beta	0.045
CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	0.044
FOSL1	FOS-like antigen 1	0.043
LCN2	lipocalin 2	0.043
CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	0.042
PRSS8	protease, serine, 8	0.041
IGFBP3	insulin-like growth factor binding protein 3	0.040
LAMC3	laminin, gamma 3	0.039
MUC4	mucin 4, cell surface associated	0.039
TMPRSS11D	transmembrane protease, serine 11D	0.038
C8A	complement component 8, alpha polypeptide	0.036
TMPRSS2	transmembrane protease, serine 2	0.036	Human
RAB17	RAB17, member RAS oncogene family	0.036
TFR2	transferrin receptor 2	0.035
HNF4A	hepatocyte nuclear factor 4, alpha	0.035
AMBP	alpha-1-microglobulin/bikunin precursor	0.034
CPN1	carboxypeptidase N, polypeptide 1	0.034
RDH16	retinol dehydrogenase 16 (all-trans)	0.033
FXYD3	FXYD domain containing ion transport regulator 3	0.033
AMT	aminomethyltransferase	0.033
CRP	C-reactive protein, pentraxin-related	0.032
HPX	hemopexin	0.031
TFF1	trefoil factor 1	0.031
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.031
S100A2	S100 calcium binding protein A2	0.030
TFF3	trefoil factor 3 (intestinal)	0.030
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.029
C8G	complement component 8, gamma polypeptide	0.029
F2	coagulation factor II (thrombin)	0.029
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.029
XDH	xanthine dehydrogenase	0.028
GCGR	glucagon receptor	0.027
SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	0.027
MTA2	metastasis associated 1 family, member 2	0.027
SPHK1	sphingosine kinase 1	0.026
GCKR	glucokinase (hexokinase 4) regulator	0.026
CPA3	carboxypeptidase A3 (mast cell)	0.025
SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0.025
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.025
CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	0.025
PDZK1IP1	PDZK1 interacting protein 1	0.025
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.024
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.024
GPRC5A	G protein-coupled receptor, family C, group 5, member A	0.024
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.023
APOB	apolipoprotein B (including Ag(x) antigen)	0.023
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.023
THBD	thrombomodulin	0.023
LAMB3	laminin, beta 3	0.023
SPP2	secreted phosphoprotein 2, 24kDa	0.022
C9	complement component 9	0.022
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.022
CP	ceruloplasmin (ferroxidase)	0.022
CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	0.021
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.021
PRSS22	protease, serine, 22	0.021
TTR	transthyretin	0.021
TMPRSS4	transmembrane protease, serine 4	0.020	Human
VIL1	villin 1	0.020
ALB	albumin	0.020
G0S2	G0/G1switch 2	0.020
ITIH1	inter-alpha (globulin) inhibitor H1	0.020
PON3	paraoxonase 3	0.020
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.020
FTCD	formiminotransferase cyclodeaminase	0.019
APCS	amyloid P component, serum	0.019
LECT2	leukocyte cell-derived chemotaxin 2	0.019
TNC	tenascin C	0.019
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.019
C1orf116	chromosome 1 open reading frame 116	0.019
DMBT1	deleted in malignant brain tumors 1	0.019
TAT	tyrosine aminotransferase	0.019
AFM	afamin	0.019
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.019
SLPI	secretory leukocyte peptidase inhibitor	0.019
RAB25	RAB25, member RAS oncogene family	0.019
B3GNT3	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	0.019
ADAM12	ADAM metallopeptidase domain 12	0.018
CPB2	carboxypeptidase B2 (plasma)	0.018
ITIH2	inter-alpha (globulin) inhibitor H2	0.018
TM4SF5	transmembrane 4 L six family member 5	0.018
HABP2	hyaluronan binding protein 2	0.018	Human
PDPN	podoplanin	0.018
SGK2	serum/glucocorticoid regulated kinase 2	0.018
MFAP4	microfibrillar-associated protein 4	0.018
MUC5B	mucin 5B, oligomeric mucus/gel-forming	0.018
TMC5	transmembrane channel-like 5	0.018
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.018
CCL20	chemokine (C-C motif) ligand 20	0.018
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.018
F11	coagulation factor XI	0.018
FUT3	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	0.018
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.018
SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	0.017
IL22RA1	interleukin 22 receptor, alpha 1	0.017
TSPAN1	tetraspanin 1	0.017
COL4A1	collagen, type IV, alpha 1	0.017
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.017
SLC34A2	solute carrier family 34 (sodium phosphate), member 2	0.017
SPP1	secreted phosphoprotein 1	0.017
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.017
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.017
PGR	progesterone receptor	0.017
APOF	apolipoprotein F	0.017
CDHR2	cadherin-related family member 2	0.017
GGTLC1	gamma-glutamyltransferase light chain 1	0.017
LRP1	low density lipoprotein receptor-related protein 1	0.017
PRODH2	proline dehydrogenase (oxidase) 2	0.016
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.016
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.016
ARG1	arginase, liver	0.016
PRR15L	proline rich 15-like	0.016
AHSG	alpha-2-HS-glycoprotein	0.016
AGR2	anterior gradient homolog 2 (Xenopus laevis)	0.016
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.016
ALDOB	aldolase B, fructose-bisphosphate	0.016
DUOX2	dual oxidase 2	0.016
PKLR	pyruvate kinase, liver and RBC	0.016
EMP1	epithelial membrane protein 1	0.016
GPR110	G protein-coupled receptor 110	0.016
HPN	hepsin	0.016
TCN1	transcobalamin I (vitamin B12 binding protein, R binder family)	0.016
F10	coagulation factor X	0.015
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.015
HOMER3	homer homolog 3 (Drosophila)	0.015
ST14	suppression of tumorigenicity 14 (colon carcinoma)	0.015
GCNT3	glucosaminyl (N-acetyl) transferase 3, mucin type	0.015
APOA1	apolipoprotein A-I	0.015
GRIP1	glutamate receptor interacting protein 1	0.015
SLC5A1	solute carrier family 5 (sodium/glucose cotransporter), member 1	0.015
APOD	apolipoprotein D	0.015
MAPK15	mitogen-activated protein kinase 15	0.015
PLXNB1	plexin B1	0.015
BHMT	betaine--homocysteine S-methyltransferase	0.015
C9orf7	chromosome 9 open reading frame 7	0.015
PROZ	protein Z, vitamin K-dependent plasma glycoprotein	0.015
PDLIM4	PDZ and LIM domain 4	0.015
DPT	dermatopontin	0.015
AGXT	alanine-glyoxylate aminotransferase	0.015
SPRR3	small proline-rich protein 3	0.015
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.015
ECHDC2	enoyl CoA hydratase domain containing 2	0.014
IGFBP1	insulin-like growth factor binding protein 1	0.014
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.014
BSPRY	B-box and SPRY domain containing	0.014
SULT1C2	sulfotransferase family, cytosolic, 1C, member 2	0.014
ITGB6	integrin, beta 6	0.014
PRMT2	protein arginine methyltransferase 2	0.014
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.014
LGALS4	lectin, galactoside-binding, soluble, 4	0.014
ATP2C2	ATPase, Ca++ transporting, type 2C, member 2	0.014
HBQ1	hemoglobin, theta 1	0.014
OVOL2	ovo-like 2 (Drosophila)	0.014
TM4SF1	transmembrane 4 L six family member 1	0.014
TM4SF4	transmembrane 4 L six family member 4	0.014
DIO1	deiodinase, iodothyronine, type I	0.014
PDGFC	platelet derived growth factor C	0.014
PROM1	prominin 1	0.014
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.014
GLP1R	glucagon-like peptide 1 receptor	0.013
LIPC	lipase, hepatic	0.013
RHBDL1	rhomboid, veinlet-like 1 (Drosophila)	0.013
STAT5A	signal transducer and activator of transcription 5A	0.013
S100A14	S100 calcium binding protein A14	0.013
LPA	lipoprotein, Lp(a)	0.013	Human
APOM	apolipoprotein M	0.013
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.013
UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	0.013
CDX1	caudal type homeobox 1	0.013
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	0.013
GNA15	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	0.013
ADH6	alcohol dehydrogenase 6 (class V)	0.013
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.013
CXCL3	chemokine (C-X-C motif) ligand 3	0.013
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.013
ABCC6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0.013
TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	0.013
PLG	plasminogen	0.013	Human
GPX2	glutathione peroxidase 2 (gastrointestinal)	0.012
RORC	RAR-related orphan receptor C	0.012
TUBB6	tubulin, beta 6	0.012
SLC6A14	solute carrier family 6 (amino acid transporter), member 14	0.012
ITIH3	inter-alpha (globulin) inhibitor H3	0.012
EPS8L1	EPS8-like 1	0.012
C8B	complement component 8, beta polypeptide	0.012
TACSTD2	tumor-associated calcium signal transducer 2	0.012
OSMR	oncostatin M receptor	0.012
ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	0.012
MASP2	mannan-binding lectin serine peptidase 2	0.012
GNMT	glycine N-methyltransferase	0.012
NRP2	neuropilin 2	0.012
MUC1	mucin 1, cell surface associated	0.012
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.012
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.012
CCND1	cyclin D1	0.012
DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	0.012
C19orf46	chromosome 19 open reading frame 46	0.012
PNRC2	proline-rich nuclear receptor coactivator 2	0.012
CCNO	cyclin O	0.012
FUT2	fucosyltransferase 2 (secretor status included)	0.012
GUCY2D	guanylate cyclase 2D, membrane (retina-specific)	0.012
DPYS	dihydropyrimidinase	0.012
ANGPTL4	angiopoietin-like 4	0.012
SPINK5	serine peptidase inhibitor, Kazal type 5	0.012
SLC38A3	solute carrier family 38, member 3	0.012
CLDN3	claudin 3	0.012
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.012
IGF1	insulin-like growth factor 1 (somatomedin C)	0.012
CTSE	cathepsin E	0.011
VTCN1	V-set domain containing T cell activation inhibitor 1	0.011
TMEM158	transmembrane protein 158 (gene/pseudogene)	0.011
ESR2	estrogen receptor 2 (ER beta)	0.011
INHBA	inhibin, beta A	0.011
C10orf46	chromosome 10 open reading frame 46	0.011
SEC14L2	SEC14-like 2 (S. cerevisiae)	0.011
SCGB2A1	secretoglobin, family 2A, member 1	0.011
MICAL2	microtubule associated monoxygenase, calponin and LIM domain containing 2	0.011
SLC28A3	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3	0.011
FCGBP	Fc fragment of IgG binding protein	0.011
RHCG	Rh family, C glycoprotein	0.011
HRH1	histamine receptor H1	0.011
SCGB3A1	secretoglobin, family 3A, member 1	0.011
FOXA1	forkhead box A1	0.011
SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.011
LBP	lipopolysaccharide binding protein	0.011
PLXNB3	plexin B3	0.011
RNF186	ring finger protein 186	0.011
GRB7	growth factor receptor-bound protein 7	0.011
EFNA1	ephrin-A1	0.011
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.011
CFI	complement factor I	0.011
TMEM30B	transmembrane protein 30B	0.011
VTN	vitronectin	0.011
PLA2G10	phospholipase A2, group X	0.011
F12	coagulation factor XII (Hageman factor)	0.011
RAB26	RAB26, member RAS oncogene family	0.011
TREM1	triggering receptor expressed on myeloid cells 1	0.011
ZCWPW1	zinc finger, CW type with PWWP domain 1	0.011
PI3	peptidase inhibitor 3, skin-derived	0.011
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.011
VIPR1	vasoactive intestinal peptide receptor 1	0.011
CDH16	cadherin 16, KSP-cadherin	0.011
CFB	complement factor B	0.011
C6	complement component 6	0.011
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.011
MALL	mal, T-cell differentiation protein-like	0.010
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.010
CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	0.010
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.010
SDC1	syndecan 1	0.010
GJB5	gap junction protein, beta 5, 31.1kDa	0.010
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.010
GLS2	glutaminase 2 (liver, mitochondrial)	0.010
EHF	ets homologous factor	0.010
CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2	0.010
ANGPT2	angiopoietin 2	0.010
CA9	carbonic anhydrase IX	0.010
FOLR2	folate receptor 2 (fetal)	0.010
GOLT1A	golgi transport 1A	0.010
PROCR	protein C receptor, endothelial	0.010
SLC9A2	solute carrier family 9 (sodium/hydrogen exchanger), member 2	0.010
F9	coagulation factor IX	0.010
STAB2	stabilin 2	0.010
CLDN4	claudin 4	0.010