IMP

Process View

Homo sapiens

23 genes annotated in human

regulation of lyase activity

Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of lyase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of lyase activity" (in gray)

Name	Description	Probability	Func Analog Organism
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.993
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.978	Fly
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.956
DRD2	dopamine receptor D2	0.843
GUCY2C	guanylate cyclase 2C (heat stable enterotoxin receptor)	0.827
ADORA2A	adenosine A2a receptor	0.810
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.753
GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	0.654	Rat
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.516	Human
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.413	Yeast
VAC14	Vac14 homolog (S. cerevisiae)	0.403
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.365
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.290
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.286
CRH	corticotropin releasing hormone	0.253
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.238
TBC1D10A	TBC1 domain family, member 10A	0.224
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.221	Human
MPDZ	multiple PDZ domain protein	0.213
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.175
BCR	breakpoint cluster region	0.173
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.161
RALBP1	ralA binding protein 1	0.160
PDZK1	PDZ domain containing 1	0.155	Human
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.124
NSF	N-ethylmaleimide-sensitive factor	0.102
GOPC	golgi-associated PDZ and coiled-coil motif containing	0.096
GFI1B	growth factor independent 1B transcription repressor	0.093
ADORA1	adenosine A1 receptor	0.085	Human
GPR6	G protein-coupled receptor 6	0.074
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.064
MEOX2	mesenchyme homeobox 2	0.064
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	0.063
NAMPT	nicotinamide phosphoribosyltransferase	0.062
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.061
EZR	ezrin	0.055
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.051
SRI	sorcin	0.050
SH3GL3	SH3-domain GRB2-like 3	0.049
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.048
RALGDS	ral guanine nucleotide dissociation stimulator	0.048
ARRDC3	arrestin domain containing 3	0.046
NECAB2	N-terminal EF-hand calcium binding protein 2	0.041
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.039	Yeast
GHRHR	growth hormone releasing hormone receptor	0.039	Human Rat
GFAP	glial fibrillary acidic protein	0.038
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.037
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.036
SLC26A3	solute carrier family 26, member 3	0.036
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.035
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.034
SSTR3	somatostatin receptor 3	0.033
CEND1	cell cycle exit and neuronal differentiation 1	0.033
AQP7	aquaporin 7	0.033
GLP1R	glucagon-like peptide 1 receptor	0.032	Human
ADRB3	adrenergic, beta-3-, receptor	0.032
CRHR2	corticotropin releasing hormone receptor 2	0.031	Human
RIN1	Ras and Rab interactor 1	0.031
CALCR	calcitonin receptor	0.031
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.030
SSTR4	somatostatin receptor 4	0.029
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.029
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.029
DRD1	dopamine receptor D1	0.029
AKAP10	A kinase (PRKA) anchor protein 10	0.028
NPPA	natriuretic peptide A	0.028
CALCA	calcitonin-related polypeptide alpha	0.028
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.028
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.027
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.027
FKBP8	FK506 binding protein 8, 38kDa	0.027
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.027
KCNJ9	potassium inwardly-rectifying channel, subfamily J, member 9	0.026
ODF1	outer dense fiber of sperm tails 1	0.026
NTSR2	neurotensin receptor 2	0.025
HTR4	5-hydroxytryptamine (serotonin) receptor 4	0.025	Human
RHO	rhodopsin	0.024
ACHE	acetylcholinesterase	0.024
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.023
CCKBR	cholecystokinin B receptor	0.023
TSHR	thyroid stimulating hormone receptor	0.023
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.023	Human
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.023
EMX1	empty spiracles homeobox 1	0.022
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.022
DTX2	deltex homolog 2 (Drosophila)	0.022
GRM5	glutamate receptor, metabotropic 5	0.022	Human
AFF2	AF4/FMR2 family, member 2	0.022
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.021
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.021	Human
ACRV1	acrosomal vesicle protein 1	0.021
PTPRN	protein tyrosine phosphatase, receptor type, N	0.020
HTR1E	5-hydroxytryptamine (serotonin) receptor 1E	0.020	Human
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.020
FEZF2	FEZ family zinc finger 2	0.020
KCNH1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.020
PAWR	PRKC, apoptosis, WT1, regulator	0.020
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.020
PRKCG	protein kinase C, gamma	0.020
CD151	CD151 molecule (Raph blood group)	0.019
FGF4	fibroblast growth factor 4	0.019
SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	0.019
RNF5	ring finger protein 5	0.019
PEBP1	phosphatidylethanolamine binding protein 1	0.019
LBX1	ladybird homeobox 1	0.019
SOD1	superoxide dismutase 1, soluble	0.018
P2RY1	purinergic receptor P2Y, G-protein coupled, 1	0.018
EMP3	epithelial membrane protein 3	0.018
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.018
RBMXL2	RNA binding motif protein, X-linked-like 2	0.018
SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	0.017
PTGIR	prostaglandin I2 (prostacyclin) receptor (IP)	0.017
HTR3A	5-hydroxytryptamine (serotonin) receptor 3A	0.017
CADM3	cell adhesion molecule 3	0.017
MAP2K1	mitogen-activated protein kinase kinase 1	0.017
NELL2	NEL-like 2 (chicken)	0.017
RAP2B	RAP2B, member of RAS oncogene family	0.017
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.017
OPRD1	opioid receptor, delta 1	0.017
KCNC3	potassium voltage-gated channel, Shaw-related subfamily, member 3	0.016
GDF10	growth differentiation factor 10	0.016
IGSF21	immunoglobin superfamily, member 21	0.016
ELAVL3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.016
IL1RAPL1	interleukin 1 receptor accessory protein-like 1	0.016
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.016
NOS1AP	nitric oxide synthase 1 (neuronal) adaptor protein	0.016
CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	0.016
GRM7	glutamate receptor, metabotropic 7	0.016
CHRNB4	cholinergic receptor, nicotinic, beta 4	0.016
GLRA1	glycine receptor, alpha 1	0.016
PAX3	paired box 3	0.016
CNTN2	contactin 2 (axonal)	0.016
GUCA2B	guanylate cyclase activator 2B (uroguanylin)	0.016
SVOP	SV2 related protein homolog (rat)	0.016
TBR1	T-box, brain, 1	0.016
NELL1	NEL-like 1 (chicken)	0.016
OR2H1	olfactory receptor, family 2, subfamily H, member 1	0.015
SMR3A	submaxillary gland androgen regulated protein 3A	0.015
OPCML	opioid binding protein/cell adhesion molecule-like	0.015
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.015
OPRK1	opioid receptor, kappa 1	0.015
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.015
SPTB	spectrin, beta, erythrocytic	0.015
SLC34A1	solute carrier family 34 (sodium phosphate), member 1	0.015
DPYSL4	dihydropyrimidinase-like 4	0.015
MPP2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	0.015
GIF	gastric intrinsic factor (vitamin B synthesis)	0.015
AKAP1	A kinase (PRKA) anchor protein 1	0.015
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.014
GJD2	gap junction protein, delta 2, 36kDa	0.014
NPPB	natriuretic peptide B	0.014
CRYBB3	crystallin, beta B3	0.014
RAMP1	receptor (G protein-coupled) activity modifying protein 1	0.014
DPP6	dipeptidyl-peptidase 6	0.014
PAX7	paired box 7	0.014
PNLIPRP1	pancreatic lipase-related protein 1	0.014
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.014
KCNF1	potassium voltage-gated channel, subfamily F, member 1	0.014
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	0.014
KCNT1	potassium channel, subfamily T, member 1	0.014
CORO1C	coronin, actin binding protein, 1C	0.014
HCRT	hypocretin (orexin) neuropeptide precursor	0.014
LGALS4	lectin, galactoside-binding, soluble, 4	0.014
BZW1	basic leucine zipper and W2 domains 1	0.014
KCNJ3	potassium inwardly-rectifying channel, subfamily J, member 3	0.014
RYR2	ryanodine receptor 2 (cardiac)	0.014
GP5	glycoprotein V (platelet)	0.013
NPY2R	neuropeptide Y receptor Y2	0.013
BAG1	BCL2-associated athanogene	0.013
MLN	motilin	0.013
THPO	thrombopoietin	0.013
HCRTR1	hypocretin (orexin) receptor 1	0.013
ADRB2	adrenergic, beta-2-, receptor, surface	0.013
SEZ6L	seizure related 6 homolog (mouse)-like	0.013
NCR2	natural cytotoxicity triggering receptor 2	0.013
HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.013
NHLH1	nescient helix loop helix 1	0.013
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.013
TRPM3	transient receptor potential cation channel, subfamily M, member 3	0.013
CLCNKB	chloride channel Kb	0.013
CNR1	cannabinoid receptor 1 (brain)	0.013
CLTB	clathrin, light chain B	0.013
CARTPT	CART prepropeptide	0.013
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.013	Human
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	0.013
TEF	thyrotrophic embryonic factor	0.012
GAP43	growth associated protein 43	0.012
CACNG3	calcium channel, voltage-dependent, gamma subunit 3	0.012
CDX2	caudal type homeobox 2	0.012
OPRM1	opioid receptor, mu 1	0.012	Rat
YAP1	Yes-associated protein 1	0.012
ARPP19	cAMP-regulated phosphoprotein, 19kDa	0.012
CANX	calnexin	0.012
NF2	neurofibromin 2 (merlin)	0.012
SLC6A5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.012
GNG4	guanine nucleotide binding protein (G protein), gamma 4	0.012
EGR4	early growth response 4	0.012
KCNC4	potassium voltage-gated channel, Shaw-related subfamily, member 4	0.012
CALB2	calbindin 2	0.012
SOX1	SRY (sex determining region Y)-box 1	0.012
INA	internexin neuronal intermediate filament protein, alpha	0.012
RAMP3	receptor (G protein-coupled) activity modifying protein 3	0.012
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.012
SLC5A2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.012
SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.012
CDK5R2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.012
ADCY8	adenylate cyclase 8 (brain)	0.011
TNP2	transition protein 2 (during histone to protamine replacement)	0.011
CRP	C-reactive protein, pentraxin-related	0.011
PLA2G5	phospholipase A2, group V	0.011
NOX1	NADPH oxidase 1	0.011
ATP4B	ATPase, H+/K+ exchanging, beta polypeptide	0.011
FGF18	fibroblast growth factor 18	0.011
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.011
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D	0.011	Human
TACR1	tachykinin receptor 1	0.011
EFR3B	EFR3 homolog B (S. cerevisiae)	0.011
HPN	hepsin	0.011
FGF6	fibroblast growth factor 6	0.011
MUC13	mucin 13, cell surface associated	0.011
CHRM5	cholinergic receptor, muscarinic 5	0.011
TRH	thyrotropin-releasing hormone	0.011
TMEM59L	transmembrane protein 59-like	0.011
GRIK1	glutamate receptor, ionotropic, kainate 1	0.011
SCTR	secretin receptor	0.011	Human
CELA2B	chymotrypsin-like elastase family, member 2B	0.011
WNT1	wingless-type MMTV integration site family, member 1	0.011
GABRA6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	0.011
KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.011
NXPH2	neurexophilin 2	0.011
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.011
RHBDL1	rhomboid, veinlet-like 1 (Drosophila)	0.011
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.011
BBS1	Bardet-Biedl syndrome 1	0.011
GALR3	galanin receptor 3	0.011
POU4F2	POU class 4 homeobox 2	0.011
COPG2	coatomer protein complex, subunit gamma 2	0.011
KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1	0.011
CACNA1H	calcium channel, voltage-dependent, T type, alpha 1H subunit	0.011
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.011
NEUROD2	neurogenic differentiation 2	0.011
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.011
GRPR	gastrin-releasing peptide receptor	0.011
TNP1	transition protein 1 (during histone to protamine replacement)	0.011
OPRL1	opiate receptor-like 1	0.011
PAX8	paired box 8	0.011
GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	0.010
RET	ret proto-oncogene	0.010
ADRA2B	adrenergic, alpha-2B-, receptor	0.010
ZP2	zona pellucida glycoprotein 2 (sperm receptor)	0.010
RASL10A	RAS-like, family 10, member A	0.010
PTEN	phosphatase and tensin homolog	0.010
SYN1	synapsin I	0.010
CYP46A1	cytochrome P450, family 46, subfamily A, polypeptide 1	0.010
MC2R	melanocortin 2 receptor (adrenocorticotropic hormone)	0.010
APOB	apolipoprotein B (including Ag(x) antigen)	0.010
ADRA1A	adrenergic, alpha-1A-, receptor	0.010
PDE1B	phosphodiesterase 1B, calmodulin-dependent	0.010
SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.010
NNAT	neuronatin	0.010
SYN2	synapsin II	0.010
FLT4	fms-related tyrosine kinase 4	0.010
P2RX3	purinergic receptor P2X, ligand-gated ion channel, 3	0.010
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.010
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	0.010	Human
TREH	trehalase (brush-border membrane glycoprotein)	0.010
EXTL1	exostoses (multiple)-like 1	0.010
CDV3	CDV3 homolog (mouse)	0.010
MTMR7	myotubularin related protein 7	0.010
GRIK3	glutamate receptor, ionotropic, kainate 3	0.010