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Homo sapiens

1 genes annotated in human

phospholipase c activating adrenergic receptor signaling pathway

The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "phospholipase c activating adrenergic receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "phospholipase c activating adrenergic receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
MPDZ	multiple PDZ domain protein	1.000
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	1.000
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.998
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.976
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.947
ARRDC3	arrestin domain containing 3	0.568
SSTR3	somatostatin receptor 3	0.305
PTEN	phosphatase and tensin homolog	0.250
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.171
PTPRA	protein tyrosine phosphatase, receptor type, A	0.162
BAI1	brain-specific angiogenesis inhibitor 1	0.109
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.101
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.082
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.080	Human
PLEKHA2	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2	0.068
GPR6	G protein-coupled receptor 6	0.059
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D	0.053	Human
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.052	Human
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.051
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.047	Human
TSHR	thyroid stimulating hormone receptor	0.045
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.042
MED28	mediator complex subunit 28	0.042
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.042
GHRHR	growth hormone releasing hormone receptor	0.039
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.038
YAP1	Yes-associated protein 1	0.034
DRD1	dopamine receptor D1	0.034	Human
AQP7	aquaporin 7	0.031
EMX1	empty spiracles homeobox 1	0.030
ACRV1	acrosomal vesicle protein 1	0.030
HTR4	5-hydroxytryptamine (serotonin) receptor 4	0.028	Human
AFF2	AF4/FMR2 family, member 2	0.028
CCK	cholecystokinin	0.028
HTR3A	5-hydroxytryptamine (serotonin) receptor 3A	0.028
GRM5	glutamate receptor, metabotropic 5	0.027
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	0.027
DSCAML1	Down syndrome cell adhesion molecule like 1	0.027
ZP2	zona pellucida glycoprotein 2 (sperm receptor)	0.024
KRT33B	keratin 33B	0.024
TBR1	T-box, brain, 1	0.024
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.024
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.023
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.023
NTSR1	neurotensin receptor 1 (high affinity)	0.023
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	0.022
SLC14A2	solute carrier family 14 (urea transporter), member 2	0.022
VIPR2	vasoactive intestinal peptide receptor 2	0.022
CRP	C-reactive protein, pentraxin-related	0.022
TRH	thyrotropin-releasing hormone	0.022
SMCP	sperm mitochondria-associated cysteine-rich protein	0.022
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.021
COPG2	coatomer protein complex, subunit gamma 2	0.021
CHRNB4	cholinergic receptor, nicotinic, beta 4	0.021
FEZF2	FEZ family zinc finger 2	0.021
ADRB3	adrenergic, beta-3-, receptor	0.021	Human
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.021
ADRB2	adrenergic, beta-2-, receptor, surface	0.021	Human
CCR3	chemokine (C-C motif) receptor 3	0.020
ADRA1A	adrenergic, alpha-1A-, receptor	0.020
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.019
CNTFR	ciliary neurotrophic factor receptor	0.019
OR2H1	olfactory receptor, family 2, subfamily H, member 1	0.019
ODF1	outer dense fiber of sperm tails 1	0.019
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.019
CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	0.019
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.019
ADRA2B	adrenergic, alpha-2B-, receptor	0.019
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.019
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	0.018	Human
NELL1	NEL-like 1 (chicken)	0.018
PYY	peptide YY	0.018
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.018
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.018
CALCR	calcitonin receptor	0.018
CACNG3	calcium channel, voltage-dependent, gamma subunit 3	0.018
SPTB	spectrin, beta, erythrocytic	0.018
SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.018
CILP	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	0.017
TBC1D10A	TBC1 domain family, member 10A	0.017
RELN	reelin	0.017
SCTR	secretin receptor	0.017
KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6	0.017
GFRA2	GDNF family receptor alpha 2	0.016
HTR6	5-hydroxytryptamine (serotonin) receptor 6	0.016
CCKBR	cholecystokinin B receptor	0.016
RIMS1	regulating synaptic membrane exocytosis 1	0.016
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.016
TG	thyroglobulin	0.016
RET	ret proto-oncogene	0.016
KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	0.016
CDH8	cadherin 8, type 2	0.015
KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1	0.015
GPC5	glypican 5	0.015
PDE1B	phosphodiesterase 1B, calmodulin-dependent	0.015
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.015
ZNF157	zinc finger protein 157	0.015
HRH3	histamine receptor H3	0.015
AMOT	angiomotin	0.014
MYF6	myogenic factor 6 (herculin)	0.014
SEZ6L	seizure related 6 homolog (mouse)-like	0.014
SLC18A1	solute carrier family 18 (vesicular monoamine), member 1	0.014
RASL10A	RAS-like, family 10, member A	0.014
CNNM1	cyclin M1	0.014
PDYN	prodynorphin	0.014
SLC17A2	solute carrier family 17 (sodium phosphate), member 2	0.014
ACCN1	amiloride-sensitive cation channel 1, neuronal	0.014
GABRA6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	0.014
PAX6	paired box 6	0.014
CAMK1G	calcium/calmodulin-dependent protein kinase IG	0.014
CADM3	cell adhesion molecule 3	0.014
TBX5	T-box 5	0.014
KRT9	keratin 9	0.014
WNT8B	wingless-type MMTV integration site family, member 8B	0.014
GH2	growth hormone 2	0.014
AANAT	aralkylamine N-acetyltransferase	0.014
HOXC11	homeobox C11	0.014
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.014
UCP1	uncoupling protein 1 (mitochondrial, proton carrier)	0.013
MYOD1	myogenic differentiation 1	0.013
KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.013
SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	0.013
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.013
OPRK1	opioid receptor, kappa 1	0.013
PNOC	prepronociceptin	0.013
CRYBB1	crystallin, beta B1	0.013
MUSK	muscle, skeletal, receptor tyrosine kinase	0.013
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.013
NPY1R	neuropeptide Y receptor Y1	0.013
UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.013
DPP6	dipeptidyl-peptidase 6	0.013
RHO	rhodopsin	0.013
TNP2	transition protein 2 (during histone to protamine replacement)	0.013
OPRM1	opioid receptor, mu 1	0.013
GRM7	glutamate receptor, metabotropic 7	0.013
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.013
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.013
THPO	thrombopoietin	0.013
LGI1	leucine-rich, glioma inactivated 1	0.013
LEP	leptin	0.013
RIMS4	regulating synaptic membrane exocytosis 4	0.013
OCA2	oculocutaneous albinism II	0.013
NTSR2	neurotensin receptor 2	0.012
APOC3	apolipoprotein C-III	0.012
ATP2B3	ATPase, Ca++ transporting, plasma membrane 3	0.012
NXPH3	neurexophilin 3	0.012
GUCY1A2	guanylate cyclase 1, soluble, alpha 2	0.012
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.012
OPRL1	opiate receptor-like 1	0.012
DRD2	dopamine receptor D2	0.012
CPLX2	complexin 2	0.012
POU4F1	POU class 4 homeobox 1	0.012
AGXT	alanine-glyoxylate aminotransferase	0.012
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.012
CYP2F1	cytochrome P450, family 2, subfamily F, polypeptide 1	0.012
HTR2B	5-hydroxytryptamine (serotonin) receptor 2B	0.012	Human
TFF2	trefoil factor 2	0.012
DLG2	discs, large homolog 2 (Drosophila)	0.012
CTRC	chymotrypsin C (caldecrin)	0.012
TEF	thyrotrophic embryonic factor	0.012
LNX1	ligand of numb-protein X 1	0.012
P2RY1	purinergic receptor P2Y, G-protein coupled, 1	0.012
B4GALNT1	beta-1,4-N-acetyl-galactosaminyl transferase 1	0.012
SIX3	SIX homeobox 3	0.012
OPCML	opioid binding protein/cell adhesion molecule-like	0.012
SLC22A2	solute carrier family 22 (organic cation transporter), member 2	0.012
REPS2	RALBP1 associated Eps domain containing 2	0.012
EFS	embryonal Fyn-associated substrate	0.012
AVPR1B	arginine vasopressin receptor 1B	0.012
NPY5R	neuropeptide Y receptor Y5	0.012
MTMR7	myotubularin related protein 7	0.012
DGKQ	diacylglycerol kinase, theta 110kDa	0.012
KRT2	keratin 2	0.012
POU3F1	POU class 3 homeobox 1	0.012
UNC13A	unc-13 homolog A (C. elegans)	0.012
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.012
ADAM2	ADAM metallopeptidase domain 2	0.012
SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5	0.012
ZNF132	zinc finger protein 132	0.012
ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)	0.011
TLX3	T-cell leukemia homeobox 3	0.011
SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.011
TACR2	tachykinin receptor 2	0.011
PADI4	peptidyl arginine deiminase, type IV	0.011
FOXI1	forkhead box I1	0.011
CRHR2	corticotropin releasing hormone receptor 2	0.011
PLA2G1B	phospholipase A2, group IB (pancreas)	0.011
SCRT1	scratch homolog 1, zinc finger protein (Drosophila)	0.011
BFSP1	beaded filament structural protein 1, filensin	0.011
GFRA4	GDNF family receptor alpha 4	0.011
KCNJ3	potassium inwardly-rectifying channel, subfamily J, member 3	0.011
CALCA	calcitonin-related polypeptide alpha	0.011
FGF6	fibroblast growth factor 6	0.011
DCHS2	dachsous 2 (Drosophila)	0.011
NPY2R	neuropeptide Y receptor Y2	0.011
MAS1	MAS1 oncogene	0.011
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.011
GUCY2C	guanylate cyclase 2C (heat stable enterotoxin receptor)	0.011
CHRNA2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	0.011
NKX2-1	NK2 homeobox 1	0.011
SMR3A	submaxillary gland androgen regulated protein 3A	0.011
ATP10A	ATPase, class V, type 10A	0.011
SCN2A	sodium channel, voltage-gated, type II, alpha subunit	0.011
PDE3A	phosphodiesterase 3A, cGMP-inhibited	0.011
STMN2	stathmin-like 2	0.011
ANK1	ankyrin 1, erythrocytic	0.011
MC5R	melanocortin 5 receptor	0.011
PADI1	peptidyl arginine deiminase, type I	0.011
GRIK1	glutamate receptor, ionotropic, kainate 1	0.011
PCSK2	proprotein convertase subtilisin/kexin type 2	0.011
EMX2	empty spiracles homeobox 2	0.011
STAR	steroidogenic acute regulatory protein	0.010
ATP4B	ATPase, H+/K+ exchanging, beta polypeptide	0.010
KCNC4	potassium voltage-gated channel, Shaw-related subfamily, member 4	0.010
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.010
CHRND	cholinergic receptor, nicotinic, delta	0.010
SCN5A	sodium channel, voltage-gated, type V, alpha subunit	0.010
CCL11	chemokine (C-C motif) ligand 11	0.010
GIF	gastric intrinsic factor (vitamin B synthesis)	0.010
IL6R	interleukin 6 receptor	0.010
DCC	deleted in colorectal carcinoma	0.010
HOXD10	homeobox D10	0.010
DLGAP3	discs, large (Drosophila) homolog-associated protein 3	0.010
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.010
ADRA1D	adrenergic, alpha-1D-, receptor	0.010
FRMPD4	FERM and PDZ domain containing 4	0.010
SCN1B	sodium channel, voltage-gated, type I, beta	0.010
AQP6	aquaporin 6, kidney specific	0.010
RGS7	regulator of G-protein signaling 7	0.010