IMP

Process View

Homo sapiens

8 genes annotated in human

negative regulation of biomineral tissue development

Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of biomineral tissue development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of biomineral tissue development" (in gray)

Name	Description	Probability	Func Analog Organism
CCR5	chemokine (C-C motif) receptor 5	1.000	Human
CCL5	chemokine (C-C motif) ligand 5	0.999	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.923
CCL4	chemokine (C-C motif) ligand 4	0.903	Human
CCR7	chemokine (C-C motif) receptor 7	0.750	Human
IFNG	interferon, gamma	0.625
IL2RB	interleukin 2 receptor, beta	0.603
IL8	interleukin 8	0.498
CCL2	chemokine (C-C motif) ligand 2	0.424	Human
AXL	AXL receptor tyrosine kinase	0.377
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.277	Human
CCL19	chemokine (C-C motif) ligand 19	0.275	Human
CCR1	chemokine (C-C motif) receptor 1	0.270
CXCR6	chemokine (C-X-C motif) receptor 6	0.270	Human
CCL22	chemokine (C-C motif) ligand 22	0.269	Human
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.238
CXCL10	chemokine (C-X-C motif) ligand 10	0.238
CCL8	chemokine (C-C motif) ligand 8	0.232	Human
IL1B	interleukin 1, beta	0.224
CXCL13	chemokine (C-X-C motif) ligand 13	0.224
CXCR3	chemokine (C-X-C motif) receptor 3	0.213	Human
DPP4	dipeptidyl-peptidase 4	0.199
CXCL11	chemokine (C-X-C motif) ligand 11	0.152
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.145
KDM2B	lysine (K)-specific demethylase 2B	0.116
CCR4	chemokine (C-C motif) receptor 4	0.113	Human
CCL7	chemokine (C-C motif) ligand 7	0.113	Human
CCL13	chemokine (C-C motif) ligand 13	0.110	Human
CCR2	chemokine (C-C motif) receptor 2	0.104	Human
CCL3	chemokine (C-C motif) ligand 3	0.098
IL6	interleukin 6 (interferon, beta 2)	0.095
PCGF1	polycomb group ring finger 1	0.093
CCL11	chemokine (C-C motif) ligand 11	0.091	Human
CD40LG	CD40 ligand	0.082
IRF4	interferon regulatory factor 4	0.069
CD2	CD2 molecule	0.069
IL2RG	interleukin 2 receptor, gamma	0.066
SLAMF7	SLAM family member 7	0.063
CXCL2	chemokine (C-X-C motif) ligand 2	0.055
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.053
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.048
RGS1	regulator of G-protein signaling 1	0.047
IL21R	interleukin 21 receptor	0.046
IL7R	interleukin 7 receptor	0.044
TNF	tumor necrosis factor	0.042
MATK	megakaryocyte-associated tyrosine kinase	0.041
ALB	albumin	0.039
CXCR5	chemokine (C-X-C motif) receptor 5	0.039	Human
CXCR4	chemokine (C-X-C motif) receptor 4	0.037	Human
CCR3	chemokine (C-C motif) receptor 3	0.035	Human
TAL1	T-cell acute lymphocytic leukemia 1	0.034
SSX4	synovial sarcoma, X breakpoint 4	0.033
CCR6	chemokine (C-C motif) receptor 6	0.032	Human
CD83	CD83 molecule	0.032
IL1R2	interleukin 1 receptor, type II	0.031
CXCL3	chemokine (C-X-C motif) ligand 3	0.030
SELE	selectin E	0.029
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.028
IDE	insulin-degrading enzyme	0.026
CCL21	chemokine (C-C motif) ligand 21	0.024
CCL20	chemokine (C-C motif) ligand 20	0.024	Human
IL10	interleukin 10	0.023
RERE	arginine-glutamic acid dipeptide (RE) repeats	0.023
ADAMDEC1	ADAM-like, decysin 1	0.021
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.020
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.020
CCL1	chemokine (C-C motif) ligand 1	0.020	Human
LTB	lymphotoxin beta (TNF superfamily, member 3)	0.019
UBD	ubiquitin D	0.018
SOD2	superoxide dismutase 2, mitochondrial	0.018
CLEC7A	C-type lectin domain family 7, member A	0.018
LAMP3	lysosomal-associated membrane protein 3	0.018
GPR171	G protein-coupled receptor 171	0.018
CCR9	chemokine (C-C motif) receptor 9	0.017	Human
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.017
IL1F5	interleukin 1 family, member 5 (delta)	0.016
IL1RN	interleukin 1 receptor antagonist	0.015
VCAM1	vascular cell adhesion molecule 1	0.015
LGALS2	lectin, galactoside-binding, soluble, 2	0.015
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.014
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.014
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.014
IL13	interleukin 13	0.014
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.013
CD69	CD69 molecule	0.013
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.013
BCL2A1	BCL2-related protein A1	0.013
AQP9	aquaporin 9	0.013
RUNX1	runt-related transcription factor 1	0.012
MSR1	macrophage scavenger receptor 1	0.012
EBI3	Epstein-Barr virus induced 3	0.012
IL1A	interleukin 1, alpha	0.012
FPR3	formyl peptide receptor 3	0.012
LAG3	lymphocyte-activation gene 3	0.012
RNF2	ring finger protein 2	0.011
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.011
CH25H	cholesterol 25-hydroxylase	0.011
IL18RAP	interleukin 18 receptor accessory protein	0.011
PLAU	plasminogen activator, urokinase	0.011
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.010