IMP

Process View

Homo sapiens

23 genes annotated in human

cardiac conduction

Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cardiac conduction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cardiac conduction" (in gray)

Name	Description	Probability	Func Analog Organism
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.999	Human
KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1	0.990	Human
DSP	desmoplakin	0.983
KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	0.928
DSC2	desmocollin 2	0.925
MPZL2	myelin protein zero-like 2	0.922	Human
DLG4	discs, large homolog 4 (Drosophila)	0.911
JUP	junction plakoglobin	0.862
KCNE1	potassium voltage-gated channel, Isk-related family, member 1	0.814
LIN7B	lin-7 homolog B (C. elegans)	0.779
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.776
ACTN2	actinin, alpha 2	0.753
MPZL3	myelin protein zero-like 3	0.731	Human
KRT14	keratin 14	0.693
CTNND1	catenin (cadherin-associated protein), delta 1	0.653	Human
CABP1	calcium binding protein 1	0.591
DSG2	desmoglein 2	0.537
TJP1	tight junction protein 1 (zona occludens 1)	0.467
ERBB2IP	erbb2 interacting protein	0.467
PKP3	plakophilin 3	0.459	Human
SMAD2	SMAD family member 2	0.409
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.408	Human
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.337	Human
SFN	stratifin	0.322
ZFYVE9	zinc finger, FYVE domain containing 9	0.291
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.247
SNTG2	syntrophin, gamma 2	0.223
PTPRN	protein tyrosine phosphatase, receptor type, N	0.213
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.210
PSEN1	presenilin 1	0.206
APC	adenomatous polyposis coli	0.201
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.162
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.150	Human
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.137
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.124
KRT8	keratin 8	0.121
PKP2	plakophilin 2	0.101
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.099
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.096
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.090
HDAC4	histone deacetylase 4	0.088
CTNNBIP1	catenin, beta interacting protein 1	0.074
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.072	Human
LAD1	ladinin 1	0.067
SMAD4	SMAD family member 4	0.066
TRIM29	tripartite motif containing 29	0.065
SPTB	spectrin, beta, erythrocytic	0.064
MARK3	MAP/microtubule affinity-regulating kinase 3	0.061
KCNC1	potassium voltage-gated channel, Shaw-related subfamily, member 1	0.060
EGFR	epidermal growth factor receptor	0.054
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.053	Human
KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.052
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.052
FRMD5	FERM domain containing 5	0.048
GLE1	GLE1 RNA export mediator homolog (yeast)	0.045
CAPN2	calpain 2, (m/II) large subunit	0.042
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.040
MYOZ1	myozenin 1	0.039
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.039
DNAJB5	DnaJ (Hsp40) homolog, subfamily B, member 5	0.038
DISC1	disrupted in schizophrenia 1	0.037
SKIL	SKI-like oncogene	0.036
GJB3	gap junction protein, beta 3, 31kDa	0.034	Human
DSG1	desmoglein 1	0.034	Human
DSG3	desmoglein 3	0.033	Human
KCNH1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.032	Human
KCNQ3	potassium voltage-gated channel, KQT-like subfamily, member 3	0.032	Human
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.031
KRT5	keratin 5	0.031
SEZ6L	seizure related 6 homolog (mouse)-like	0.030
ACTL6B	actin-like 6B	0.030
GRIN2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	0.030
DPP6	dipeptidyl-peptidase 6	0.028
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.028
KCNB2	potassium voltage-gated channel, Shab-related subfamily, member 2	0.028	Human
AKAP6	A kinase (PRKA) anchor protein 6	0.028
KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.027	Human
SYN2	synapsin II	0.027
ARVCF	armadillo repeat gene deleted in velocardiofacial syndrome	0.026	Human
BTRC	beta-transducin repeat containing	0.026
SMAD3	SMAD family member 3	0.026
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.025
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.025	Human
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.025
DSC3	desmocollin 3	0.024	Human
SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	0.024
CCKBR	cholecystokinin B receptor	0.024
DSC1	desmocollin 1	0.024	Human
SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	0.024
KCNG3	potassium voltage-gated channel, subfamily G, member 3	0.024	Human
ST8SIA5	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	0.024
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.023
CDK5R2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.023
NLGN1	neuroligin 1	0.023
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.022
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.022
TGFBR1	transforming growth factor, beta receptor 1	0.022
CAV1	caveolin 1, caveolae protein, 22kDa	0.022
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.021
CDH15	cadherin 15, type 1, M-cadherin (myotubule)	0.021	Human
ARHGAP22	Rho GTPase activating protein 22	0.021
OBSCN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.021
KCNA2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.021	Human
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.021	Human
CPLX2	complexin 2	0.020
BSN	bassoon (presynaptic cytomatrix protein)	0.020
TMEM59L	transmembrane protein 59-like	0.020
ADAM11	ADAM metallopeptidase domain 11	0.020
KRT18	keratin 18	0.019
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.019
CAV3	caveolin 3	0.018
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.018
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.018
KCNJ10	potassium inwardly-rectifying channel, subfamily J, member 10	0.018	Human
HRH3	histamine receptor H3	0.017
ACTR1A	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	0.017
EHD1	EH-domain containing 1	0.017
TCF4	transcription factor 4	0.017
KRT6A	keratin 6A	0.016
FRS2	fibroblast growth factor receptor substrate 2	0.016
TUBB2B	tubulin, beta 2B	0.016
COL17A1	collagen, type XVII, alpha 1	0.016
MEF2C	myocyte enhancer factor 2C	0.016
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.016
IRF6	interferon regulatory factor 6	0.016
KCNIP1	Kv channel interacting protein 1	0.016
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.015
GRID1	glutamate receptor, ionotropic, delta 1	0.015
GJB5	gap junction protein, beta 5, 31.1kDa	0.015	Human
ATP2B3	ATPase, Ca++ transporting, plasma membrane 3	0.015
SLITRK3	SLIT and NTRK-like family, member 3	0.015
UNC13A	unc-13 homolog A (C. elegans)	0.015
GRB7	growth factor receptor-bound protein 7	0.015
OSBP2	oxysterol binding protein 2	0.014
DUSP26	dual specificity phosphatase 26 (putative)	0.014
ACHE	acetylcholinesterase	0.014
CNKSR2	connector enhancer of kinase suppressor of Ras 2	0.014
TTR	transthyretin	0.014
KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6	0.014	Human
GLIS2	GLIS family zinc finger 2	0.014
TACR1	tachykinin receptor 1	0.014
HPCA	hippocalcin	0.014
TRIM33	tripartite motif containing 33	0.014
KCNH6	potassium voltage-gated channel, subfamily H (eag-related), member 6	0.014	Human
SLC4A3	solute carrier family 4, anion exchanger, member 3	0.014
OPRM1	opioid receptor, mu 1	0.013
SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.013
NCAN	neurocan	0.013
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.013
MYBPC2	myosin binding protein C, fast type	0.013
SGCA	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	0.013
OPCML	opioid binding protein/cell adhesion molecule-like	0.013
GRIK1	glutamate receptor, ionotropic, kainate 1	0.012
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.012
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	0.012
PERP	PERP, TP53 apoptosis effector	0.012
PKP4	plakophilin 4	0.012	Human
MYT1	myelin transcription factor 1	0.012
CRHR2	corticotropin releasing hormone receptor 2	0.012
SCN2A	sodium channel, voltage-gated, type II, alpha subunit	0.012	Human
SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.012
ITGB4	integrin, beta 4	0.012
NOS1	nitric oxide synthase 1 (neuronal)	0.012
NECAB2	N-terminal EF-hand calcium binding protein 2	0.012
TGFA	transforming growth factor, alpha	0.012
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.012	Human
PRKCG	protein kinase C, gamma	0.012
DDN	dendrin	0.012
KRT6B	keratin 6B	0.011
SLC8A2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.011
FGFBP1	fibroblast growth factor binding protein 1	0.011
GSK3B	glycogen synthase kinase 3 beta	0.011
GRIA3	glutamate receptor, ionotrophic, AMPA 3	0.011
GAB1	GRB2-associated binding protein 1	0.011
CXADR	coxsackie virus and adenovirus receptor	0.011
ACTN3	actinin, alpha 3	0.011
KCNF1	potassium voltage-gated channel, subfamily F, member 1	0.011	Human
PGAM2	phosphoglycerate mutase 2 (muscle)	0.011
OPRD1	opioid receptor, delta 1	0.011
OPRK1	opioid receptor, kappa 1	0.011
MT3	metallothionein 3	0.011
NRXN1	neurexin 1	0.011
TNNT2	troponin T type 2 (cardiac)	0.011
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.011
SCN3B	sodium channel, voltage-gated, type III, beta	0.011
ANK1	ankyrin 1, erythrocytic	0.010	Human
NPAS1	neuronal PAS domain protein 1	0.010
AVPR1B	arginine vasopressin receptor 1B	0.010
GRIK3	glutamate receptor, ionotropic, kainate 3	0.010
SULT4A1	sulfotransferase family 4A, member 1	0.010
GPR87	G protein-coupled receptor 87	0.010
KCNJ9	potassium inwardly-rectifying channel, subfamily J, member 9	0.010	Human
MAP1A	microtubule-associated protein 1A	0.010
KCNN3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	0.010
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.010
KRT16	keratin 16	0.010
FOXN1	forkhead box N1	0.010
APOBEC2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	0.010
PLEKHA7	pleckstrin homology domain containing, family A member 7	0.010
ATP1B2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.010