IMP

Process View

Mus musculus

1 genes annotated in mouse

fast calcium ion dependent exocytosis of neurotransmitter

The fast, initial phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on low affinity calcium sensors and typically begins a fraction of a millisecond after Ca2+ influx, and decays rapidly (1-10ms) with a decay constant of around 5-10ms. The underlying molecular mechanisms of this process are distinct from those of the later, slow phase of release.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "fast calcium ion dependent exocytosis of neurotransmitter"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "fast calcium ion dependent exocytosis of neurotransmitter" (in gray)

Name	Description	Probability	Func Analog Organism
Syp	synaptophysin	0.966
Syt9	synaptotagmin IX	0.830	Mouse
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.779
Syt6	synaptotagmin VI	0.636	Mouse
Syt3	synaptotagmin III	0.560	Mouse
Sstr3	somatostatin receptor 3	0.518
Crhr1	corticotropin releasing hormone receptor 1	0.502
Syt10	synaptotagmin X	0.468	Mouse
Syt7	synaptotagmin VII	0.343	Mouse
Snap25	synaptosomal-associated protein 25	0.331
Stx1a	syntaxin 1A (brain)	0.312
Sult4a1	sulfotransferase family 4A, member 1	0.306
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.300
Srcin1	SRC kinase signaling inhibitor 1	0.238
Syn2	synapsin II	0.207
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.202
Kcna6	potassium voltage-gated channel, shaker-related, subfamily, member 6	0.197
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.165
Elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.160
Ret	ret proto-oncogene	0.159
Jph3	junctophilin 3	0.152
Kifc2	kinesin family member C2	0.152
Necab2	N-terminal EF-hand calcium binding protein 2	0.148
Mmp24	matrix metallopeptidase 24	0.146
Rnf208	ring finger protein 208	0.144
Cux2	cut-like homeobox 2	0.131
Arhgdig	Rho GDP dissociation inhibitor (GDI) gamma	0.123
Sh3gl2	SH3-domain GRB2-like 2	0.120
Sncb	synuclein, beta	0.120
Kif1a	kinesin family member 1A	0.119
Gdap1l1	ganglioside-induced differentiation-associated protein 1-like 1	0.118
Hpca	hippocalcin	0.115
Actl6b	actin-like 6B	0.114
Cntn4	contactin 4	0.114
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.113
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.106
Shc3	src homology 2 domain-containing transforming protein C3	0.101
Scn8a	sodium channel, voltage-gated, type VIII, alpha	0.100
Rnf112	ring finger protein 112	0.094
St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.087
Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	0.085
Sez6l	seizure related 6 homolog like	0.084
Cacna2d3	calcium channel, voltage-dependent, alpha2/delta subunit 3	0.084
Mgat3	mannoside acetylglucosaminyltransferase 3	0.083
Srrm3	serine/arginine repetitive matrix 3	0.081
Kif5a	kinesin family member 5A	0.081
C1ql1	complement component 1, q subcomponent-like 1	0.081
Nefl	neurofilament, light polypeptide	0.080
Mmp17	matrix metallopeptidase 17	0.079
Grin2c	glutamate receptor, ionotropic, NMDA2C (epsilon 3)	0.076
Fgf12	fibroblast growth factor 12	0.071
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.069
Vamp2	vesicle-associated membrane protein 2	0.067
Slc6a17	solute carrier family 6 (neurotransmitter transporter), member 17	0.065
Shd	src homology 2 domain-containing transforming protein D	0.065
Pcsk1n	proprotein convertase subtilisin/kexin type 1 inhibitor	0.063
Pcsk2	proprotein convertase subtilisin/kexin type 2	0.063
Nfe2l3	nuclear factor, erythroid derived 2, like 3	0.062
Sez6	seizure related gene 6	0.057
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.055
Syn1	synapsin I	0.054
Stx1b	syntaxin 1B	0.054
Nptx1	neuronal pentraxin 1	0.054
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.054
Apbb1	amyloid beta (A4) precursor protein-binding, family B, member 1	0.054
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.052
Wasf3	WAS protein family, member 3	0.050
Cpne6	copine VI	0.049
Ina	internexin neuronal intermediate filament protein, alpha	0.048
Fgf9	fibroblast growth factor 9	0.047
Dlg4	discs, large homolog 4 (Drosophila)	0.047
Bcan	brevican	0.046
Cyp46a1	cytochrome P450, family 46, subfamily a, polypeptide 1	0.045
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.045
Stmn4	stathmin-like 4	0.045
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.044
Rab25	RAB25, member RAS oncogene family	0.043
Cdh4	cadherin 4	0.043
Kiss1r	KISS1 receptor	0.041
Fam164c	family with sequence similarity 164, member C	0.041
Rprml	reprimo-like	0.039
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.039
Gnaz	guanine nucleotide binding protein, alpha z subunit	0.037
Slc12a5	solute carrier family 12, member 5	0.037
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.036
Cnr1	cannabinoid receptor 1 (brain)	0.036
Drd2	dopamine receptor D2	0.036
Pclo	piccolo (presynaptic cytomatrix protein)	0.035
Slc1a6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.035
Avp	arginine vasopressin	0.035
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.034
Adcy3	adenylate cyclase 3	0.034
Sox15	SRY-box containing gene 15	0.033
Trim46	tripartite motif-containing 46	0.033
Slc8a2	solute carrier family 8 (sodium/calcium exchanger), member 2	0.033
Spnb3	spectrin beta 3	0.033
Accn1	amiloride-sensitive cation channel 1, neuronal (degenerin)	0.033
Grm1	glutamate receptor, metabotropic 1	0.033
Jag2	jagged 2	0.033
Abcc8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.033
Ntsr2	neurotensin receptor 2	0.033
Adam11	a disintegrin and metallopeptidase domain 11	0.032
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.032
Bai1	brain-specific angiogenesis inhibitor 1	0.032
Nxph1	neurexophilin 1	0.031
Hsf4	heat shock transcription factor 4	0.031
Gng3	guanine nucleotide binding protein (G protein), gamma 3	0.031
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.031
Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	0.031
Vsnl1	visinin-like 1	0.030
Syt2	synaptotagmin II	0.030	Mouse
Muc5ac	mucin 5, subtypes A and C, tracheobronchial/gastric	0.030
Gjd2	gap junction protein, delta 2	0.029
Prkcz	protein kinase C, zeta	0.029
Alox12b	arachidonate 12-lipoxygenase, 12R type	0.029
Ncan	neurocan	0.028
Rasgrf1	RAS protein-specific guanine nucleotide-releasing factor 1	0.028
Cplx1	complexin 1	0.028
Aplp1	amyloid beta (A4) precursor-like protein 1	0.028
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.028
Col9a2	collagen, type IX, alpha 2	0.028
Th	tyrosine hydroxylase	0.027
Odz1	odd Oz/ten-m homolog 1 (Drosophila)	0.027
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.027
Pcnxl2	pecanex-like 2 (Drosophila)	0.026
Hrk	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.026
Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	0.026
Slc29a4	solute carrier family 29 (nucleoside transporters), member 4	0.026
Syngr3	synaptogyrin 3	0.026
Slc22a17	solute carrier family 22 (organic cation transporter), member 17	0.026
Sstr2	somatostatin receptor 2	0.025
Pacrg	PARK2 co-regulated	0.025
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.025
Cdx2	caudal type homeobox 2	0.024
Abcb9	ATP-binding cassette, sub-family B (MDR/TAP), member 9	0.024
Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3	0.024
Neurl1a	neuralized homolog 1A (Drosophila)	0.024
Mobp	myelin-associated oligodendrocytic basic protein	0.024
Syt13	synaptotagmin XIII	0.023	Mouse
Foxq1	forkhead box Q1	0.023
Hrh3	histamine receptor H3	0.023
Cdh8	cadherin 8	0.023
Sohlh1	spermatogenesis and oogenesis specific basic helix-loop-helix 1	0.023
Cadm4	cell adhesion molecule 4	0.022
Kif5c	kinesin family member 5C	0.022
Npcd	neuronal pentraxin chromo domain	0.022
Maneal	mannosidase, endo-alpha-like	0.022
Sgsm1	small G protein signaling modulator 1	0.022
Lrfn1	leucine rich repeat and fibronectin type III domain containing 1	0.022
Cx3cl1	chemokine (C-X3-C motif) ligand 1	0.022
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.022
Stac2	SH3 and cysteine rich domain 2	0.021
Scn10a	sodium channel, voltage-gated, type X, alpha	0.021
AI118078	expressed sequence AI118078	0.021
Tmem59l	transmembrane protein 59-like	0.021
Amigo1	adhesion molecule with Ig like domain 1	0.021
Ak5	adenylate kinase 5	0.020
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.020
Sv2b	synaptic vesicle glycoprotein 2 b	0.020
Snap91	synaptosomal-associated protein 91	0.020
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.020
Col25a1	collagen, type XXV, alpha 1	0.020
L1cam	L1 cell adhesion molecule	0.020
Prkar1b	protein kinase, cAMP dependent regulatory, type I beta	0.019
Hr	hairless	0.019
Nptx2	neuronal pentraxin 2	0.019
Cdh22	cadherin 22	0.019
AI428936	expressed sequence AI428936	0.019
Hcn1	hyperpolarization-activated, cyclic nucleotide-gated K+ 1	0.019
Htr6	5-hydroxytryptamine (serotonin) receptor 6	0.019
Mog	myelin oligodendrocyte glycoprotein	0.019
Car7	carbonic anhydrase 7	0.019
Fam19a5	family with sequence similarity 19, member A5	0.019
Sept3	septin 3	0.018
Cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.018
Neurod1	neurogenic differentiation 1	0.018
Pacsin1	protein kinase C and casein kinase substrate in neurons 1	0.018
Wnt9a	wingless-type MMTV integration site 9A	0.018
Cend1	cell cycle exit and neuronal differentiation 1	0.017
Slc4a3	solute carrier family 4 (anion exchanger), member 3	0.017
Pgbd5	piggyBac transposable element derived 5	0.017
Calb1	calbindin 1	0.017
Ppara	peroxisome proliferator activated receptor alpha	0.017
Cntfr	ciliary neurotrophic factor receptor	0.017
Tmem198	transmembrane protein 198	0.017
Sez6l2	seizure related 6 homolog like 2	0.017
Syt17	synaptotagmin XVII	0.016	Mouse
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.016
Sgip1	SH3-domain GRB2-like (endophilin) interacting protein 1	0.016
Vstm2b	V-set and transmembrane domain containing 2B	0.016
Scg2	secretogranin II	0.016
Adarb1	adenosine deaminase, RNA-specific, B1	0.016
Mapt	microtubule-associated protein tau	0.016
Rundc3a	RUN domain containing 3A	0.016
Dcc	deleted in colorectal carcinoma	0.016
Prox1	prospero-related homeobox 1	0.016
Kcnc4	potassium voltage gated channel, Shaw-related subfamily, member 4	0.016
Fgf14	fibroblast growth factor 14	0.015
Adrb1	adrenergic receptor, beta 1	0.015
Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	0.015
Ttyh1	tweety homolog 1 (Drosophila)	0.015
Cplx2	complexin 2	0.015
Nudt11	nudix (nucleoside diphosphate linked moiety X)-type motif 11	0.015
Sebox	SEBOX homeobox	0.015
Serpinb5	serine (or cysteine) peptidase inhibitor, clade B, member 5	0.015
Sst	somatostatin	0.015
Cnih3	cornichon homolog 3 (Drosophila)	0.015
Pcsk1	proprotein convertase subtilisin/kexin type 1	0.015
Prss22	protease, serine, 22	0.015
Npas1	neuronal PAS domain protein 1	0.015
Lin7b	lin-7 homolog B (C. elegans)	0.015
Epha5	Eph receptor A5	0.015
Tmprss5	transmembrane protease, serine 5 (spinesin)	0.015
Celf4	CUGBP, Elav-like family member 4	0.015
Faah	fatty acid amide hydrolase	0.015
Stmn3	stathmin-like 3	0.015
Ptprn	protein tyrosine phosphatase, receptor type, N	0.015
D3Bwg0562e	DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed	0.014
Frmd5	FERM domain containing 5	0.014
Myt1l	myelin transcription factor 1-like	0.014
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.014
Homer1	homer homolog 1 (Drosophila)	0.014
Syngr1	synaptogyrin 1	0.014
Wnk2	WNK lysine deficient protein kinase 2	0.014
Adora1	adenosine A1 receptor	0.014
Rap1gap	Rap1 GTPase-activating protein	0.014
Crmp1	collapsin response mediator protein 1	0.014
Atcay	ataxia, cerebellar, Cayman type homolog (human)	0.014
Slitrk1	SLIT and NTRK-like family, member 1	0.014
Scn5a	sodium channel, voltage-gated, type V, alpha	0.014
Kcnk3	potassium channel, subfamily K, member 3	0.014
Rps6kl1	ribosomal protein S6 kinase-like 1	0.014
Ppp1r1a	protein phosphatase 1, regulatory (inhibitor) subunit 1A	0.014
Tubb4	tubulin, beta 4	0.013
Htt	huntingtin	0.013
Tcte1	t-complex-associated testis expressed 1	0.013
Agxt	alanine-glyoxylate aminotransferase	0.013
Cntn3	contactin 3	0.013
Arc	activity regulated cytoskeletal-associated protein	0.013
Mpp3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.013
Prrt3	proline-rich transmembrane protein 3	0.013
Prph	peripherin	0.013
Pip5kl1	phosphatidylinositol-4-phosphate 5-kinase-like 1	0.013
Gip	gastric inhibitory polypeptide	0.013
Ccdc164	coiled-coil domain containing 164	0.013
Hap1	huntingtin-associated protein 1	0.013
Crym	crystallin, mu	0.013
Dtna	dystrobrevin alpha	0.013
Ugt8a	UDP galactosyltransferase 8A	0.013
H1foo	H1 histone family, member O, oocyte-specific	0.012
Grik5	glutamate receptor, ionotropic, kainate 5 (gamma 2)	0.012
Tff2	trefoil factor 2 (spasmolytic protein 1)	0.012
Chrna4	cholinergic receptor, nicotinic, alpha polypeptide 4	0.012
Kcnh3	potassium voltage-gated channel, subfamily H (eag-related), member 3	0.012
Pnoc	prepronociceptin	0.012
Cpne9	copine family member IX	0.012
Odz2	odd Oz/ten-m homolog 2 (Drosophila)	0.012
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.012
Ggt7	gamma-glutamyltransferase 7	0.012
Fcho1	FCH domain only 1	0.012
Clic3	chloride intracellular channel 3	0.012
Rtn4r	reticulon 4 receptor	0.012
Lrrc16b	leucine rich repeat containing 16B	0.012
Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	0.012
Ablim2	actin-binding LIM protein 2	0.012
Cbx7	chromobox homolog 7	0.012
Plekha7	pleckstrin homology domain containing, family A member 7	0.012
Shisa9	shisa homolog 9 (Xenopus laevis)	0.012
Slc16a11	solute carrier family 16 (monocarboxylic acid transporters), member 11	0.012
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.012
Diras1	DIRAS family, GTP-binding RAS-like 1	0.012
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.012
Lhb	luteinizing hormone beta	0.012
Rbp2	retinol binding protein 2, cellular	0.012
Dmrt1	doublesex and mab-3 related transcription factor 1	0.011
Slc18a3	solute carrier family 18 (vesicular monoamine), member 3	0.011
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.011
Dlgap3	discs, large (Drosophila) homolog-associated protein 3	0.011
Nrip3	nuclear receptor interacting protein 3	0.011
5330417C22Rik	RIKEN cDNA 5330417C22 gene	0.011
Aifm3	apoptosis-inducing factor, mitochondrion-associated 3	0.011
Gpr156	G protein-coupled receptor 156	0.011
Wwc1	WW, C2 and coiled-coil domain containing 1	0.011
Sec14l2	SEC14-like 2 (S. cerevisiae)	0.011
Barx2	BarH-like homeobox 2	0.011
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.011
Foxa3	forkhead box A3	0.011
Gjb6	gap junction protein, beta 6	0.011
Krt13	keratin 13	0.011
Igsf21	immunoglobin superfamily, member 21	0.011
Chga	chromogranin A	0.011
Fam184b	family with sequence similarity 184, member B	0.011
Slit1	slit homolog 1 (Drosophila)	0.011
Srrm4	serine/arginine repetitive matrix 4	0.011
Ncald	neurocalcin delta	0.011
Pip5k1c	phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma	0.010
Fndc5	fibronectin type III domain containing 5	0.010
E130309D14Rik	RIKEN cDNA E130309D14 gene	0.010
Nos1	nitric oxide synthase 1, neuronal	0.010
Lingo1	leucine rich repeat and Ig domain containing 1	0.010
Bsn	bassoon	0.010
Padi3	peptidyl arginine deiminase, type III	0.010
Inpp5j	inositol polyphosphate 5-phosphatase J	0.010
Pex5l	peroxisomal biogenesis factor 5-like	0.010
Aatk	apoptosis-associated tyrosine kinase	0.010
Lypd2	Ly6/Plaur domain containing 2	0.010