IMP
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Mus musculus
0 genes annotated in mouse
common variable immunodeficiency
DOID:12177
A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).
In addition to gene-name show these genes:
Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Igh | immunoglobulin heavy chain complex | 1.000 | ||
| Cd19 | CD19 antigen | 1.000 | Human | |
| Cd79a | CD79A antigen (immunoglobulin-associated alpha) | 1.000 | ||
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.860 | Human | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.750 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.580 | ||
| Cd22 | CD22 antigen | 0.401 | ||
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.298 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.297 | ||
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.291 | ||
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.237 | ||
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.221 | ||
| Tnf | tumor necrosis factor | 0.201 | ||
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.171 | ||
| Blnk | B-cell linker | 0.168 | ||
| Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.124 | ||
| Btk | Bruton agammaglobulinemia tyrosine kinase | 0.120 | ||
| Rag1 | recombination activating gene 1 | 0.100 | ||
| Cd79b | CD79B antigen | 0.085 | ||
| Bcl6 | B-cell leukemia/lymphoma 6 | 0.073 | ||
| Sykb | spleen tyrosine kinase | 0.068 | ||
| Trp53 | transformation related protein 53 | 0.068 | ||
| Igk | immunoglobulin kappa chain complex | 0.067 | ||
| Card11 | caspase recruitment domain family, member 11 | 0.062 | ||
| Tnfrsf13c | tumor necrosis factor receptor superfamily, member 13c | 0.055 | ||
| Cd40 | CD40 antigen | 0.055 | ||
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.052 | ||
| Traf3ip2 | TRAF3 interacting protein 2 | 0.052 | ||
| Tcrd | T-cell receptor delta chain | 0.048 | ||
| Ltb | lymphotoxin B | 0.047 | ||
| Plcg2 | phospholipase C, gamma 2 | 0.044 | ||
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.042 | ||
| Tnip1 | TNFAIP3 interacting protein 1 | 0.042 | ||
| Irf4 | interferon regulatory factor 4 | 0.038 | ||
| Prkcd | protein kinase C, delta | 0.038 | Human | |
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.036 | ||
| Ikzf3 | IKAROS family zinc finger 3 | 0.035 | ||
| Ifng | interferon gamma | 0.032 | ||
| Rag2 | recombination activating gene 2 | 0.030 | ||
| Ltbr | lymphotoxin B receptor | 0.029 | ||
| Foxp3 | forkhead box P3 | 0.027 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.026 | ||
| Bcl3 | B-cell leukemia/lymphoma 3 | 0.026 | ||
| H2-Ob | histocompatibility 2, O region beta locus | 0.022 | ||
| Tnfrsf13b | tumor necrosis factor receptor superfamily, member 13b | 0.021 | ||
| Tcrb | T-cell receptor beta chain | 0.020 | ||
| Spib | Spi-B transcription factor (Spi-1/PU.1 related) | 0.020 | ||
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.020 | ||
| Lat | linker for activation of T cells | 0.019 | ||
| Fcer2a | Fc receptor, IgE, low affinity II, alpha polypeptide | 0.019 | ||
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.017 | ||
| Cxcr5 | chemokine (C-X-C motif) receptor 5 | 0.017 | ||
| Ebf1 | early B-cell factor 1 | 0.015 | ||
| Pten | phosphatase and tensin homolog | 0.014 | ||
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.013 | ||
| Lta | lymphotoxin A | 0.011 | ||
| Icos | inducible T-cell co-stimulator | 0.011 | ||
| Blk | B lymphoid kinase | 0.010 |