IMP
Process View
relaxation of vascular smooth muscle
A process in which the extent of vascular smooth muscle contraction is reduced. Vascular smooth muscle relaxation is mediated via a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.
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Click on a gene's description to view its network relationships with genes known to be involved in "relaxation of vascular smooth muscle"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Gucy1b3 | guanylate cyclase 1, soluble, beta 3 | 0.988 | Mouse | |
| Gucy1a3 | guanylate cyclase 1, soluble, alpha 3 | 0.825 | ||
| Prkg1 | protein kinase, cGMP-dependent, type I | 0.543 | ||
| Trpv1 | transient receptor potential cation channel, subfamily V, member 1 | 0.491 | ||
| Sparcl1 | SPARC-like 1 | 0.361 | ||
| Mef2c | myocyte enhancer factor 2C | 0.288 | ||
| Rgs5 | regulator of G-protein signaling 5 | 0.235 | Mouse | |
| Kcna1 | potassium voltage-gated channel, shaker-related subfamily, member 1 | 0.209 | ||
| Mrvi1 | MRV integration site 1 | 0.204 | ||
| Darc | Duffy blood group, chemokine receptor | 0.160 | ||
| Tek | endothelial-specific receptor tyrosine kinase | 0.158 | ||
| Abcc9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 0.155 | ||
| Nos1 | nitric oxide synthase 1, neuronal | 0.149 | ||
| Rgs4 | regulator of G-protein signaling 4 | 0.146 | Mouse | |
| Bmpr2 | bone morphogenic protein receptor, type II (serine/threonine kinase) | 0.137 | ||
| Sst | somatostatin | 0.122 | ||
| Sema6d | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | 0.113 | ||
| Emcn | endomucin | 0.108 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.100 | ||
| Mb | myoglobin | 0.099 | ||
| Cacna1d | calcium channel, voltage-dependent, L type, alpha 1D subunit | 0.084 | ||
| Vip | vasoactive intestinal polypeptide | 0.076 | ||
| Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 | 0.070 | ||
| Ednrb | endothelin receptor type B | 0.067 | ||
| Ptprb | protein tyrosine phosphatase, receptor type, B | 0.064 | ||
| Eltd1 | EGF, latrophilin seven transmembrane domain containing 1 | 0.059 | ||
| Cnr1 | cannabinoid receptor 1 (brain) | 0.055 | ||
| Smad1 | MAD homolog 1 (Drosophila) | 0.054 | ||
| Cdh11 | cadherin 11 | 0.051 | ||
| Ptprm | protein tyrosine phosphatase, receptor type, M | 0.048 | ||
| Sgcb | sarcoglycan, beta (dystrophin-associated glycoprotein) | 0.047 | ||
| Gpm6b | glycoprotein m6b | 0.044 | ||
| Btbd3 | BTB (POZ) domain containing 3 | 0.044 | ||
| Gpr98 | G protein-coupled receptor 98 | 0.043 | ||
| Scn7a | sodium channel, voltage-gated, type VII, alpha | 0.041 | ||
| Hpca | hippocalcin | 0.041 | ||
| Kit | kit oncogene | 0.038 | ||
| Camk4 | calcium/calmodulin-dependent protein kinase IV | 0.037 | ||
| Sdpr | serum deprivation response | 0.036 | ||
| Ldb2 | LIM domain binding 2 | 0.033 | ||
| Rgs7 | regulator of G protein signaling 7 | 0.032 | ||
| Ppp1r3c | protein phosphatase 1, regulatory (inhibitor) subunit 3C | 0.031 | ||
| Npr3 | natriuretic peptide receptor 3 | 0.031 | ||
| Kif5c | kinesin family member 5C | 0.031 | ||
| Tspan2 | tetraspanin 2 | 0.030 | ||
| Kcnb1 | potassium voltage gated channel, Shab-related subfamily, member 1 | 0.029 | ||
| Kcnj8 | potassium inwardly-rectifying channel, subfamily J, member 8 | 0.028 | ||
| Ppp1r9b | protein phosphatase 1, regulatory subunit 9B | 0.027 | ||
| Nefm | neurofilament, medium polypeptide | 0.027 | ||
| Cntn1 | contactin 1 | 0.025 | ||
| Rasgrp1 | RAS guanyl releasing protein 1 | 0.025 | ||
| Atp1b2 | ATPase, Na+/K+ transporting, beta 2 polypeptide | 0.025 | ||
| Tac2 | tachykinin 2 | 0.023 | ||
| Gpr83 | G protein-coupled receptor 83 | 0.023 | ||
| Cacna2d1 | calcium channel, voltage-dependent, alpha2/delta subunit 1 | 0.022 | ||
| Lama2 | laminin, alpha 2 | 0.022 | ||
| Scg2 | secretogranin II | 0.021 | ||
| Tmeff2 | transmembrane protein with EGF-like and two follistatin-like domains 2 | 0.021 | ||
| Atp1a2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 0.020 | ||
| Dkk3 | dickkopf homolog 3 (Xenopus laevis) | 0.020 | ||
| Mtap1a | microtubule-associated protein 1 A | 0.020 | ||
| Nrgn | neurogranin | 0.018 | ||
| Syt1 | synaptotagmin I | 0.018 | ||
| Kitl | kit ligand | 0.017 | ||
| Fam105a | family with sequence similarity 105, member A | 0.017 | ||
| Dtna | dystrobrevin alpha | 0.017 | ||
| Sema3c | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.017 | ||
| Cacnb2 | calcium channel, voltage-dependent, beta 2 subunit | 0.015 | ||
| Pkia | protein kinase inhibitor, alpha | 0.015 | ||
| St6galnac5 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | 0.015 | ||
| Kcnh1 | potassium voltage-gated channel, subfamily H (eag-related), member 1 | 0.014 | ||
| Mbp | myelin basic protein | 0.014 | ||
| Aoc3 | amine oxidase, copper containing 3 | 0.014 | ||
| Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.014 | ||
| Cacna1c | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.014 | ||
| Gfap | glial fibrillary acidic protein | 0.014 | ||
| Pvrl3 | poliovirus receptor-related 3 | 0.013 | ||
| S100b | S100 protein, beta polypeptide, neural | 0.013 | ||
| Cygb | cytoglobin | 0.013 | ||
| Dnajb5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | 0.012 | ||
| Tmem47 | transmembrane protein 47 | 0.012 | ||
| Tm4sf1 | transmembrane 4 superfamily member 1 | 0.012 | ||
| Pip4k2a | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.012 | ||
| Nos2 | nitric oxide synthase 2, inducible | 0.011 | ||
| Nr4a2 | nuclear receptor subfamily 4, group A, member 2 | 0.011 | ||
| Ogn | osteoglycin | 0.011 | ||
| Gria3 | glutamate receptor, ionotropic, AMPA3 (alpha 3) | 0.011 | ||
| Olr1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.011 | ||
| Epas1 | endothelial PAS domain protein 1 | 0.011 | ||
| Flt1 | FMS-like tyrosine kinase 1 | 0.011 | ||
| Cacna2d3 | calcium channel, voltage-dependent, alpha2/delta subunit 3 | 0.011 | ||
| Trpc6 | transient receptor potential cation channel, subfamily C, member 6 | 0.010 | ||
| Grem2 | gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) | 0.010 | ||
| Cul9 | cullin 9 | 0.010 | ||
| Cd200 | CD200 antigen | 0.010 | ||
| Pcdh7 | protocadherin 7 | 0.010 |