IMP
Process View
g protein coupled receptor signaling pathway coupled to cgmp nucleotide second messenger
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP).
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Click on a gene's description to view its network relationships with genes known to be involved in "g protein coupled receptor signaling pathway coupled to cgmp nucleotide second messenger"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Ren1 | renin 1 structural | 0.992 | ||
| Ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 0.845 | ||
| Agtr1a | angiotensin II receptor, type 1a | 0.842 | Mouse | |
| Lepr | leptin receptor | 0.778 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.731 | ||
| Nos1 | nitric oxide synthase 1, neuronal | 0.517 | ||
| Slc12a1 | solute carrier family 12, member 1 | 0.447 | ||
| Bdkrb2 | bradykinin receptor, beta 2 | 0.309 | Mouse | |
| Wt1 | Wilms tumor 1 homolog | 0.243 | ||
| Agt | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.229 | ||
| Efemp2 | epidermal growth factor-containing fibulin-like extracellular matrix protein 2 | 0.155 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.153 | ||
| Ldlr | low density lipoprotein receptor | 0.148 | ||
| Nos2 | nitric oxide synthase 2, inducible | 0.106 | Rat | |
| Il6 | interleukin 6 | 0.104 | ||
| Fbn1 | fibrillin 1 | 0.098 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.084 | ||
| Vdr | vitamin D receptor | 0.082 | ||
| Agtr2 | angiotensin II receptor, type 2 | 0.076 | ||
| Agtrap | angiotensin II, type I receptor-associated protein | 0.054 | ||
| Gnas | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus | 0.049 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.047 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.039 | ||
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.038 | ||
| Pcdh12 | protocadherin 12 | 0.036 | ||
| Aqp2 | aquaporin 2 | 0.027 | ||
| Crim1 | cysteine rich transmembrane BMP regulator 1 (chordin like) | 0.026 | ||
| Fbln1 | fibulin 1 | 0.024 | ||
| Tead2 | TEA domain family member 2 | 0.024 | ||
| Lox | lysyl oxidase | 0.023 | ||
| Eln | elastin | 0.023 | ||
| Nr3c2 | nuclear receptor subfamily 3, group C, member 2 | 0.023 | ||
| Cav1 | caveolin 1, caveolae protein | 0.020 | ||
| Umod | uromodulin | 0.020 | ||
| Tlr2 | toll-like receptor 2 | 0.019 | ||
| Csf1 | colony stimulating factor 1 (macrophage) | 0.018 | ||
| Robo2 | roundabout homolog 2 (Drosophila) | 0.016 | ||
| Hic1 | hypermethylated in cancer 1 | 0.016 | ||
| Ppargc1a | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | 0.015 | ||
| Apoe | apolipoprotein E | 0.014 | ||
| Wnt5a | wingless-related MMTV integration site 5A | 0.014 | ||
| Cyp19a1 | cytochrome P450, family 19, subfamily a, polypeptide 1 | 0.014 | ||
| Itgb3 | integrin beta 3 | 0.014 | ||
| Mmp9 | matrix metallopeptidase 9 | 0.013 | ||
| Vegfa | vascular endothelial growth factor A | 0.012 | ||
| Pcdh18 | protocadherin 18 | 0.012 | ||
| Gja4 | gap junction protein, alpha 4 | 0.012 | ||
| Bcl6b | B-cell CLL/lymphoma 6, member B | 0.012 | ||
| Mfap2 | microfibrillar-associated protein 2 | 0.011 | ||
| Col4a3 | collagen, type IV, alpha 3 | 0.011 | ||
| Gjc1 | gap junction protein, gamma 1 | 0.011 | ||
| Gli2 | GLI-Kruppel family member GLI2 | 0.010 | ||
| Tlr4 | toll-like receptor 4 | 0.010 |