IMP

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Rattus norvegicus

4 genes annotated in rat

Multi-species View

positive regulation of leukocyte degranulation

GO:0043302

Any process that activates or increases the frequency, rate or extent of leukocyte degranulation.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of leukocyte degranulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of leukocyte degranulation" (in gray)

Name	Description	Probability	Func Analog Organism
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.159
Fut2	fucosyltransferase 2 (secretor status included)	0.113
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.097
Csf1	colony stimulating factor 1 (macrophage)	0.095
Gzmk	granzyme K	0.093
Folr2	folate receptor 2 (fetal)	0.092
Slc14a2	solute carrier family 14 (urea transporter), member 2	0.087
Ptafr	platelet-activating factor receptor	0.081
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.076
Igsf6	immunoglobulin superfamily, member 6	0.071
RT1-Ba	RT1 class II, locus Ba	0.068
RGD1310262	hypothetical LOC304650	0.061
Cybb	cytochrome b-245, beta polypeptide	0.059
Prkg2	protein kinase, cGMP-dependent, type II	0.057
Cdcp1	CUB domain containing protein 1	0.056
Neurl3	neuralized homolog 3 (Drosophila)	0.055
Tgfbr3	transforming growth factor, beta receptor III	0.055
Igsf7	immunoglobulin superfamily, member 7	0.054
Mrgprf	MAS-related GPR, member F	0.054
Cfp	complement factor properdin	0.051
Grin2c	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.050
Slc22a25	solute carrier family 22, member 25	0.050
Bdkrb2	bradykinin receptor B2	0.049
Igh-6	immunoglobulin heavy chain 6	0.043
P2ry14	purinergic receptor P2Y, G-protein coupled, 14	0.042
Olr1867	olfactory receptor 1867	0.042
C5ar1	complement component 5a receptor 1	0.041
Cyp4a8	cytochrome P450, family 4, subfamily a, polypeptide 8	0.040
Hck	hemopoietic cell kinase	0.039
Ly86	lymphocyte antigen 86	0.039
Chrm2	cholinergic receptor, muscarinic 2	0.039
Ptprc	protein tyrosine phosphatase, receptor type, C	0.037
Gcnt3	glucosaminyl (N-acetyl) transferase 3, mucin type	0.037
Ghrhr	growth hormone releasing hormone receptor	0.036	Rat
St18	suppression of tumorigenicity 18	0.034
Pax6	paired box 6	0.033
Cx3cr1	chemokine (C-X3-C motif) receptor 1	0.033
Ciita	class II, major histocompatibility complex, transactivator	0.033
Ptpn18	protein tyrosine phosphatase, non-receptor type 18	0.032
Cd38	CD38 molecule	0.032
Prlhr	prolactin releasing hormone receptor	0.032
Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	0.032
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.032
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1	0.032
Slc22a7	solute carrier family 22 (organic anion transporter), member 7	0.032
Chrna7	cholinergic receptor, nicotinic, alpha 7	0.031
Nkg7	natural killer cell group 7 sequence	0.031
Slco2b1	solute carrier organic anion transporter family, member 2b1	0.030
Pde3a	phosphodiesterase 3A, cGMP inhibited	0.030
Hpgds	hematopoietic prostaglandin D synthase	0.030
Dspp	dentin sialophosphoprotein	0.028
Cd86	CD86 molecule	0.028
Cd53	Cd53 molecule	0.027
Dnase1l3	deoxyribonuclease 1-like 3	0.027
Cyp27b1	cytochrome P450, family 27, subfamily b, polypeptide 1	0.027
Lep	leptin	0.027
Il1b	interleukin 1 beta	0.027
Th	tyrosine hydroxylase	0.027
Ccl5	chemokine (C-C motif) ligand 5	0.026
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.026
Fev	FEV (ETS oncogene family)	0.026
Oprk1	opioid receptor, kappa 1	0.025
Gja6	gap junction protein, alpha 6	0.025
Casp1	caspase 1	0.025
Ecel1	endothelin converting enzyme-like 1	0.025
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.024
Sh3bp1	SH3-domain binding protein 1	0.024
Hcrt	hypocretin	0.024
Ccr5	chemokine (C-C motif) receptor 5	0.024
Ncan	neurocan	0.023
RGD1566083	similar to hypothetical protein MGC24047	0.023
Ncr3	natural cytotoxicity triggering receptor 3	0.023
Cpa3	carboxypeptidase A3, mast cell	0.023
Gabrg1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	0.023
Il2rb	interleukin 2 receptor, beta	0.023
Klrc2	killer cell lectin-like receptor subfamily C, member 2	0.023
Klrb1a	killer cell lectin-like receptor subfamily B, member 1A	0.022
Hbegf	heparin-binding EGF-like growth factor	0.022
RGD1559748	similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)	0.022
Shox2	short stature homeobox 2	0.022
Atp2a3	ATPase, Ca++ transporting, ubiquitous	0.022
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.022
Rftn2	raftlin family member 2	0.022
Ms4a11	membrane-spanning 4-domains, subfamily A, member 11	0.022	Rat
Oprl1	opiate receptor-like 1	0.022
Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.022
Prl3d4	prolactin family 3, subfamily d, member 4	0.021
RGD1559588	similar to cell surface receptor FDFACT	0.021
Znf532	zinc finger protein 532	0.021
Hand1	heart and neural crest derivatives expressed 1	0.021
RGD1306474	similar to RIKEN cDNA 9530003J23	0.020
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.020
Tgoln1	trans-golgi network protein	0.020
RGD1561143	similar to cell surface receptor FDFACT	0.020
Apba1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.020
Il13ra2	interleukin 13 receptor, alpha 2	0.020
Grm8	glutamate receptor, metabotropic 8	0.020
Acrv1	acrosomal vesicle protein 1	0.020
Slc16a8	solute carrier family 16, member 8 (monocarboxylic acid transporter 3)	0.020
Cd68	Cd68 molecule	0.020
Cxcl13	chemokine (C-X-C motif) ligand 13	0.019
Kynu	kynureninase (L-kynurenine hydrolase)	0.019
N5	DNA binding protein N5	0.019
Hcst	hematopoietic cell signal transducer	0.019
Crisp1	cysteine-rich secretory protein 1	0.019
Oprm1	opioid receptor, mu 1	0.019
Cd3g	CD3 molecule, gamma	0.019
Ptprz1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.019
Cast	calpastatin	0.018
Fgb	fibrinogen beta chain	0.018
Il2rg	interleukin 2 receptor, gamma	0.018
Olr1493	olfactory receptor gene Olr1493	0.018
Cmklr1	chemokine-like receptor 1	0.018
P2ry6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.018
Dhrs9	dehydrogenase/reductase (SDR family) member 9	0.018
Tcrb	T-cell receptor beta chain	0.018
Casp8	caspase 8	0.018
Clec4a3	C-type lectin domain family 4, member a3	0.018
Slco1a1	solute carrier organic anion transporter family, member 1a1	0.018
Gabrr3	gamma-aminobutyric acid (GABA) receptor, rho 3	0.018
Adora2a	adenosine A2a receptor	0.017
Mmp12	matrix metallopeptidase 12	0.017
Meis3	Meis homeobox 3	0.017
Mcpt2	mast cell protease 2	0.017
Ctsj	cathepsin J	0.017
Bcl2a1d	B-cell leukemia/lymphoma 2 related protein A1d	0.017
Olr1697	olfactory receptor 1697	0.017
Mpeg1	macrophage expressed 1	0.017
Krt31	keratin 31	0.017
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.017
Mep1a	meprin 1 alpha	0.017
Zg16	zymogen granule protein 16	0.017
LOC304903	similar to Pappalysin-2 precursor (Pregnancy-associated plasma protein-A2) (PAPP-A2) (Pregnancy-associated plasma protein-E1) (PAPP-E)	0.017
Pax8	paired box 8	0.017
Mgat3	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	0.017
Itgam	integrin, alpha M	0.017
Sell	selectin L	0.017
Slc15a3	solute carrier family 15, member 3	0.016
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.016
Phox2a	paired-like homeobox 2a	0.016
Hrh2	histamine receptor H 2	0.016
Krt1	keratin 1	0.016
Npffr2	neuropeptide FF receptor 2	0.016
Cxcr3	chemokine (C-X-C motif) receptor 3	0.016
Notch3	Notch homolog 3 (Drosophila)	0.016
Tlr4	toll-like receptor 4	0.016
Klhdc8a	kelch domain containing 8A	0.016
Pik3cd	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.016
Slc30a1	solute carrier family 30 (zinc transporter), member 1	0.016
Calcrl	calcitonin receptor-like	0.016	Rat
Syt7	synaptotagmin VII	0.015
Grin2b	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.015
Vom2r27	vomeronasal 2 receptor, 27	0.015
Ednra	endothelin receptor type A	0.015
Cyp2c13	cytochrome P450, family 2, subfamily c, polypeptide 13	0.015
Olr414	olfactory receptor 414	0.015
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.015
RGD1304644	similar to RIKEN cDNA 2310046K01	0.015
Psp	parotid secretory protein	0.015
LOC308990	hypothetical protein LOC308990	0.015
Gpr176	G protein-coupled receptor 176	0.015
Fgf16	fibroblast growth factor 16	0.015
Reg3g	regenerating islet-derived 3 gamma	0.015
Hrh3	histamine receptor H3	0.015
Rup2	urinary protein 2	0.015
RT1-A3	RT1 class I, locus A3	0.015
Uhmk1	U2AF homology motif (UHM) kinase 1	0.015
Faslg	Fas ligand (TNF superfamily, member 6)	0.015
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.015
Grm4	glutamate receptor, metabotropic 4	0.015
Tnfsf9	tumor necrosis factor (ligand) superfamily, member 9	0.015
C3ar1	complement component 3a receptor 1	0.015
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.015
Adam3a	ADAM metallopeptidase domain 3A (cyritestin 1)	0.015
Irf5	interferon regulatory factor 5	0.015
Tbx2	T-box 2	0.014
Mamdc4	MAM domain containing 4	0.014
Mylk2	myosin light chain kinase 2	0.014
Fgd4	FYVE, RhoGEF and PH domain containing 4	0.014
LOC56764	dnaj-like protein	0.014
Lat	linker for activation of T cells	0.014
Ctla2a	cytotoxic T lymphocyte-associated protein 2 alpha	0.014
Mmp2	matrix metallopeptidase 2	0.014
Il9r	interleukin 9 receptor	0.014
Tubb3	tubulin, beta 3	0.014
Lst1	leukocyte specific transcript 1	0.014
Vwa3a	von Willebrand factor A domain containing 3A	0.014
Ptpn7	protein tyrosine phosphatase, non-receptor type 7	0.014
Slc2a5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	0.014
Cd247	Cd247 molecule	0.014
Tbxas1	thromboxane A synthase 1, platelet	0.014
Olr1496	olfactory receptor 1496	0.014
Aplnr	apelin receptor	0.014
RT1-Bb	RT1 class II, locus Bb	0.014
Csf1r	colony stimulating factor 1 receptor	0.013
Nfasc	neurofascin	0.013
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.013
Rac2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.013
LOC100360919	Immunoglobulin lambda-like polypeptide 1-like	0.013
Slc6a11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.013
Gabra6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	0.013
Gfra2	GDNF family receptor alpha 2	0.013
Pld4	phospholipase D family, member 4	0.013
Lepr	leptin receptor	0.013
Neu3	sialidase 3 (membrane sialidase)	0.013
Abp1	amiloride binding protein 1 (amine oxidase, copper-containing)	0.013
Il1rl1	interleukin 1 receptor-like 1	0.013
Kcnh7	potassium voltage-gated channel, subfamily H (eag-related), member 7	0.013
Clec9a	C-type lectin domain family 9, member a	0.013
Adra2b	adrenergic, alpha-2B-, receptor	0.013
Mr1	major histocompatibility complex, class I-related	0.013
Rhox5	reproductive homeobox 5	0.013
Drd3	dopamine receptor D3	0.013
Prl6a1	prolactin family 6, subfamily a, member 1	0.013
Tmem8a	transmembrane protein 8A	0.013
Arhgap4	Rho GTPase activating protein 4	0.013
Dcaf7	DDB1 and CUL4 associated factor 7	0.013
Fcgr3a	Fc fragment of IgG, low affinity IIIa, receptor	0.013
Ucn	urocortin	0.012
Prss27	protease, serine 27	0.012
Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.012
Lilrb3l	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like	0.012
Pclo	piccolo (presynaptic cytomatrix protein)	0.012
Atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.012
Tlr7	toll-like receptor 7	0.012
Chrnb3	cholinergic receptor, nicotinic, beta 3	0.012
Fgf14	fibroblast growth factor 14	0.012
Csn2	casein beta	0.012
Pgf	placental growth factor	0.012
Kcna3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.012
Gjb4	gap junction protein, beta 4	0.012
Sebox	SEBOX homeobox	0.012
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.012
Gpr1	G protein-coupled receptor 1	0.012
Ptgfr	prostaglandin F receptor	0.012
Cyp2c7	cytochrome P450, family 2, subfamily c, polypeptide 7	0.012
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.012
Padi3	peptidyl arginine deiminase, type III	0.012
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.012
Opn1mw	opsin 1 (cone pigments), medium-wave-sensitive	0.012
Sla	src-like adaptor	0.012
Lck	lymphocyte-specific protein tyrosine kinase	0.012
LOC100362634	myeloid/lymphoid or mixed-lineage leukemia 2	0.012
Nrarp	Notch-regulated ankyrin repeat protein	0.012
Bin2	bridging integrator 2	0.012
Rhobtb2	Rho-related BTB domain containing 2	0.012
Gip	gastric inhibitory polypeptide	0.012
Zic1	Zic family member 1 (odd-paired homolog, Drosophila)	0.012
Heatr5a	HEAT repeat containing 5A	0.012
F2rl1	coagulation factor II (thrombin) receptor-like 1	0.011	Human
Prf1	perforin 1 (pore forming protein)	0.011
Sh2b3	SH2B adaptor protein 3	0.011
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.011
Mutyh	mutY homolog (E. coli)	0.011
Olr416	olfactory receptor 416	0.011
Socs3	suppressor of cytokine signaling 3	0.011
Cyp21a1	cytochrome P450, family 21, subfamily a, polypeptide 1	0.011
Plin	perilipin	0.011
Wap	whey acidic protein	0.011
Ap3m1	adaptor-related protein complex 3, mu 1 subunit	0.011
Itgad	integrin, alpha D	0.011
Cd4	Cd4 molecule	0.011
Havcr1	hepatitis A virus cellular receptor 1	0.011
Sstr3	somatostatin receptor 3	0.011
Syt8	synaptotagmin VIII	0.011
Tyrp1	tyrosinase-related protein 1	0.011
Gng7	guanine nucleotide binding protein (G protein), gamma 7	0.011
Lims1	LIM and senescent cell antigen-like domains 1	0.011
Dock8	dedicator of cytokinesis 8	0.011
Ceacam9	carcinoembryonic antigen-related cell adhesion molecule 9	0.011
Prss1	protease, serine, 1 (trypsin 1)	0.011
Ncr1	natural cytotoxicity triggering receptor 1	0.011
Olr1082	olfactory receptor 1082	0.011
Myo1d	myosin ID	0.011
Dcc	deleted in colorectal carcinoma	0.011
Hdac7	histone deacetylase 7	0.011
Fam46a	family with sequence similarity 46, member A	0.011
Nmbr	neuromedin B receptor	0.011
Glis2	GLIS family zinc finger 2	0.011
Prm2	protamine 2	0.011
Olr837	olfactory receptor 837	0.011
Casp2	caspase 2	0.011
Lcp2	lymphocyte cytosolic protein 2	0.011
C1qtnf6	C1q and tumor necrosis factor related protein 6	0.011
Mef2d	myocyte enhancer factor 2D	0.011
Ripk3	receptor-interacting serine-threonine kinase 3	0.011
LOC679840	similar to germinal histone H4 gene	0.011
Gpr6	G protein-coupled receptor 6	0.011
Slc14a1	solute carrier family 14 (urea transporter), member 1	0.011
Psg19	pregnancy specific glycoprotein 19	0.011
Tpsab1	tryptase alpha/beta 1	0.011
Grpr	gastrin releasing peptide receptor	0.011
Hhip	Hedgehog-interacting protein	0.010
Nmur1	neuromedin U receptor 1	0.010
Spata2L	spermatogenesis associated 2-like	0.010
Cand1	cullin-associated and neddylation-dissociated 1	0.010
Apoa4	apolipoprotein A-IV	0.010
Agxt2	alanine-glyoxylate aminotransferase 2	0.010
Lrrc10b	leucine rich repeat containing 10B	0.010
Cyp2d4	cytochrome P450, family 2, subfamily d, polypeptide 4	0.010
Olr1641	olfactory receptor 1641	0.010
Klra17	killer cell lectin-like receptor, subfamily A, member 17	0.010
Cxcl10	chemokine (C-X-C motif) ligand 10	0.010
RGD1310185	similar to RIKEN cDNA 9030625A04	0.010
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.010
Syk	spleen tyrosine kinase	0.010
Cd40lg	CD40 ligand	0.010
Pfkfb4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	0.010
Rnf207	ring finger protein 207	0.010
Slc28a3	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3	0.010
Lgals4	lectin, galactoside-binding, soluble, 4	0.010
Grm6	glutamate receptor, metabotropic 6	0.010
Krt86	keratin 86	0.010