IMP

Process View

Rattus norvegicus

3 genes annotated in rat

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

GO:2001240

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" (in gray)

Name	Description	Probability	Func Analog Organism
Sirpa	signal-regulatory protein alpha	0.209
Fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.193	Rat
Cd86	CD86 molecule	0.161
Dock8	dedicator of cytokinesis 8	0.160
Il1a	interleukin 1 alpha	0.140
Epn1	Epsin 1	0.130
Ptafr	platelet-activating factor receptor	0.124
LOC100364854	similar to RIKEN cDNA A430107P09 gene-like	0.110
RGD1561143	similar to cell surface receptor FDFACT	0.102
Ccl3	chemokine (C-C motif) ligand 3	0.100
Inpp5d	inositol polyphosphate-5-phosphatase D	0.099
Ptprc	protein tyrosine phosphatase, receptor type, C	0.097
Igsf6	immunoglobulin superfamily, member 6	0.096
Hck	hemopoietic cell kinase	0.095	Rat
Ptpn7	protein tyrosine phosphatase, non-receptor type 7	0.094
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.094
C5ar1	complement component 5a receptor 1	0.092
Neurl3	neuralized homolog 3 (Drosophila)	0.089
Cd37	CD37 molecule	0.088
Il2rg	interleukin 2 receptor, gamma	0.085
F2rl1	coagulation factor II (thrombin) receptor-like 1	0.083
Il1b	interleukin 1 beta	0.079	Human
Sdc3	syndecan 3	0.076
Bcl2l1	Bcl2-like 1	0.076
Syk	spleen tyrosine kinase	0.073
Cd14	CD14 molecule	0.072
Ccl4	chemokine (C-C motif) ligand 4	0.070
Rara	retinoic acid receptor, alpha	0.069
Prkcd	protein kinase C, delta	0.069
Cdc42bpb	CDC42 binding protein kinase beta (DMPK-like)	0.066
Casp1	caspase 1	0.064
Tgfb1	transforming growth factor, beta 1	0.063
Mobkl2a	MOB1, Mps One Binder kinase activator-like 2A (yeast)	0.063
Lepr	leptin receptor	0.063
Adrbk1	adrenergic, beta, receptor kinase 1	0.062
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.060
Tcrb	T-cell receptor beta chain	0.059
Ralgds	ral guanine nucleotide dissociation stimulator	0.057
Slc15a3	solute carrier family 15, member 3	0.051
Cfp	complement factor properdin	0.051
Il2rb	interleukin 2 receptor, beta	0.050
Smad7	SMAD family member 7	0.050
Map6	microtubule-associated protein 6	0.049
Bak1	BCL2-antagonist/killer 1	0.047
Cd3g	CD3 molecule, gamma	0.047
Itgam	integrin, alpha M	0.045
Hk1	hexokinase 1	0.045
Ceacam10	carcinoembryonic antigen-related cell adhesion molecule 10	0.044
Serpine1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.039
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.039
Rps6ka1	ribosomal protein S6 kinase polypeptide 1	0.037
RGD1559588	similar to cell surface receptor FDFACT	0.037
Cd247	Cd247 molecule	0.036
Fcnb	ficolin B	0.036
Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.035	Rat
Cybb	cytochrome b-245, beta polypeptide	0.035
LOC100364500	RT1 class I, locus CE11-like	0.035
Edn1	endothelin 1	0.034
S1pr2	sphingosine-1-phosphate receptor 2	0.033
Socs3	suppressor of cytokine signaling 3	0.033
Prdm2	PR domain containing 2, with ZNF domain	0.031
Vav1	vav 1 guanine nucleotide exchange factor	0.031
Tlr2	toll-like receptor 2	0.030
Pcnxl3	pecanex-like 3 (Drosophila)	0.030
Bcl2a1d	B-cell leukemia/lymphoma 2 related protein A1d	0.029
Dchs1	dachsous 1 (Drosophila)	0.028
Fgfr2	fibroblast growth factor receptor 2	0.028
LOC24906	RoBo-1	0.028
Fgf5	fibroblast growth factor 5	0.028
Stat6	signal transducer and activator of transcription 6	0.028
Ppp1r9b	protein phosphatase 1, regulatory subunit 9B	0.028
Rab3il1	RAB3A interacting protein (rabin3)-like 1	0.027
Cxcl6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.027
Csk	c-src tyrosine kinase	0.026
Rgs19	regulator of G-protein signaling 19	0.026
Ctbp1	C-terminal binding protein 1	0.026
Adap1	ArfGAP with dual PH domains 1	0.026
Zbp1	Z-DNA binding protein 1	0.026
Pctk1	PCTAIRE protein kinase 1	0.026
Ptpn18	protein tyrosine phosphatase, non-receptor type 18	0.026
Pik3r2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.026
Adrb2	adrenergic, beta-2-, receptor, surface	0.025
Myo1g	myosin IG	0.025
Cfd	complement factor D (adipsin)	0.025
Arhgap25	Rho GTPase activating protein 25	0.025
Cbl	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.025
Ccr5	chemokine (C-C motif) receptor 5	0.024
Stxbp2	syntaxin binding protein 2	0.024
Klf13	Kruppel-like factor 13	0.024
Acp5	acid phosphatase 5, tartrate resistant	0.023
RGD1562618	similar to RIKEN cDNA 6030419C18 gene	0.023
Plek	pleckstrin	0.023
Cxcl10	chemokine (C-X-C motif) ligand 10	0.023
Cxcl1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.023
Ier5l	immediate early response 5-like	0.022
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.022
Icam1	intercellular adhesion molecule 1	0.022
Mmp12	matrix metallopeptidase 12	0.022
Ocln	occludin	0.022
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.022
Arl11	ADP-ribosylation factor-like 11	0.022
Lilrb4	leukocyte immunoglobulin-like receptor, subfamily B, member 4	0.022
Ctse	cathepsin E	0.022
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.022
Map4k1	mitogen activated protein kinase kinase kinase kinase 1	0.022
Mark2	MAP/microtubule affinity-regulating kinase 2	0.021
Adora2a	adenosine A2a receptor	0.021
Creb1	cAMP responsive element binding protein 1	0.021
Bid	BH3 interacting domain death agonist	0.021
RT1-DOa	RT1 class II, locus DOa	0.021
Fosl1	fos-like antigen 1	0.020
Cx3cl1	chemokine (C-X3-C motif) ligand 1	0.020
Cd38	CD38 molecule	0.020
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.020
Pla2g2a	phospholipase A2, group IIA (platelets, synovial fluid)	0.020
Ptprs	protein tyrosine phosphatase, receptor type, S	0.020
Flt1	FMS-related tyrosine kinase 1	0.020
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.020
Bin2	bridging integrator 2	0.020
Tgfbr2	transforming growth factor, beta receptor II	0.020
LOC679840	similar to germinal histone H4 gene	0.019
Fnbp1	formin binding protein 1	0.019
Ccl2	chemokine (C-C motif) ligand 2	0.019
Homer1	homer homolog 1 (Drosophila)	0.019
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.019
Tmem171	transmembrane protein 171	0.019
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.019
Arrb2	arrestin, beta 2	0.019
Itgb7	integrin, beta 7	0.019
Fam26f	family with sequence similarity 26, member F	0.019
Tyrobp	Tyro protein tyrosine kinase binding protein	0.019
Csf1	colony stimulating factor 1 (macrophage)	0.019
Klhl6	kelch-like 6 (Drosophila)	0.019
Gata6	GATA binding protein 6	0.018
Homer3	homer homolog 3 (Drosophila)	0.018
Arhgap23	Rho GTPase activating protein 23	0.018
Ptger4	prostaglandin E receptor 4 (subtype EP4)	0.018
P2ry6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.018
Ncf4	neutrophil cytosolic factor 4	0.018
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.018
Sema6b	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	0.018
Krtap1-5	keratin associated protein 1-5	0.018
Rhd	Rh blood group, D antigen	0.018
Akt1	v-akt murine thymoma viral oncogene homolog 1	0.018
Fgfr1	Fibroblast growth factor receptor 1	0.017
Kmo	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.017
Cmklr1	chemokine-like receptor 1	0.017
Hcls1	hematopoietic cell specific Lyn substrate 1	0.017
Smap2	small ArfGAP2	0.016
Gnb2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.016
Mprip	myosin phosphatase Rho interacting protein	0.016
Cd3d	CD3 molecule, delta	0.016
Unc5b	unc-5 homolog B (C. elegans)	0.016	Human
Cplx1	complexin 1	0.016
Tnf	tumor necrosis factor (TNF superfamily, member 2)	0.016
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.016
Sstr1	somatostatin receptor 1	0.016
Cd4	Cd4 molecule	0.015
Gna15	guanine nucleotide binding protein, alpha 15	0.015
Sf1	splicing factor 1	0.015
Ccl5	chemokine (C-C motif) ligand 5	0.015
Lst1	leukocyte specific transcript 1	0.015
Xylt1	xylosyltransferase 1	0.015
Csnk1g2	casein kinase 1, gamma 2	0.015
Crhr1	corticotropin releasing hormone receptor 1	0.015
Pawr	PRKC, apoptosis, WT1, regulator	0.015
Prkch	protein kinase C, eta	0.015
Cdk5rap2	CDK5 regulatory subunit associated protein 2	0.015
Il6	interleukin 6	0.015
Fcgr3a	Fc fragment of IgG, low affinity IIIa, receptor	0.015
Mov10	Moloney leukemia virus 10	0.015
Arl5c	ADP-ribosylation factor-like 5C	0.014
LOC290595	hypothetical gene supported by AF152002	0.014
Cxcr4	chemokine (C-X-C motif) receptor 4	0.014
Ubtf	upstream binding transcription factor, RNA polymerase I	0.014
Vcam1	vascular cell adhesion molecule 1	0.014
Pou2f2	POU class 2 homeobox 2	0.014
Cela1	chymotrypsin-like elastase family, member 1	0.014
Sla	src-like adaptor	0.014
Msl1	male-specific lethal 1 homolog (Drosophila)	0.014
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.014
Cxcl2	chemokine (C-X-C motif) ligand 2	0.014
Ets1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.014
Uqcrc2	ubiquinol cytochrome c reductase core protein 2	0.013
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.013
Pld2	phospholipase D2	0.013
Ciita	class II, major histocompatibility complex, transactivator	0.013
Nxph3	neurexophilin 3	0.013
Plau	plasminogen activator, urokinase	0.013
Gria1	glutamate receptor, ionotropic, AMPA 1	0.013
Bspry	B-box and SPRY domain containing	0.013
Nfya	nuclear transcription factor-Y alpha	0.013
Anpep	alanyl (membrane) aminopeptidase	0.013
Sh2b2	SH2B adaptor protein 2	0.013
Homer2	homer homolog 2 (Drosophila)	0.013
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.012
Tgfbr3	transforming growth factor, beta receptor III	0.012
Itpr2	inositol 1,4,5-triphosphate receptor, type 2	0.012
Tcea2	transcription elongation factor A (SII), 2	0.012
Nab1	Ngfi-A binding protein 1	0.012
Slc29a2	solute carrier family 29 (nucleoside transporters), member 2	0.012
Pcdhgc3	protocadherin gamma subfamily C, 3	0.012
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.012
Slc10a2	solute carrier family 10 (sodium/bile acid cotransporter family), member 2	0.012
Tbxas1	thromboxane A synthase 1, platelet	0.012
LOC100363783	rCG53773-like	0.012
Adprh	ADP-ribosylarginine hydrolase	0.012
Pld1	phospholipase D1	0.012
Usf2	upstream transcription factor 2, c-fos interacting	0.012
Itpr3	inositol 1,4,5-triphosphate receptor, type 3	0.012
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.012
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.012
Bst1	bone marrow stromal cell antigen 1	0.011
Slco2a1	solute carrier organic anion transporter family, member 2a1	0.011
Il18	interleukin 18	0.011
Mmp9	matrix metallopeptidase 9	0.011
Ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.011
LOC100366002	cytochrome P450 11B1, mitochondrial-like	0.011
Cdkn2b	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.011
Gfra1	GDNF family receptor alpha 1	0.011
Plcg2	phospholipase C, gamma 2	0.011
Txnrd2	thioredoxin reductase 2	0.011
Map3k3	mitogen activated protein kinase kinase kinase 3	0.011
Ripk3	receptor-interacting serine-threonine kinase 3	0.011
Ptgfr	prostaglandin F receptor	0.011
Cd200r1	CD200 receptor 1	0.011
Alox5	arachidonate 5-lipoxygenase	0.011
Ccl6	chemokine (C-C motif) ligand 6	0.011
Cd40	CD40 molecule, TNF receptor superfamily member 5	0.011
Smad1	SMAD family member 1	0.011
Socs1	suppressor of cytokine signaling 1	0.011
Hpcal1	hippocalcin-like 1	0.011
Arhgap4	Rho GTPase activating protein 4	0.011
Cask	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.011
Tcfe2a	transcription factor E2a	0.011
Sult5a1	sulfotransferase family 5A, member 1	0.011
LOC308990	hypothetical protein LOC308990	0.011
Add1	adducin 1 (alpha)	0.011
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.011
Rap2a	RAS related protein 2a	0.011
Gna11	guanine nucleotide binding protein, alpha 11	0.010
Tp53	tumor protein p53	0.010
Lcp2	lymphocyte cytosolic protein 2	0.010
Il4ra	interleukin 4 receptor, alpha	0.010
Pdgfb	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.010
Palm	paralemmin	0.010
Lcn2	lipocalin 2	0.010
Bmf	Bcl2 modifying factor	0.010
F13a1	coagulation factor XIII, A1 polypeptide	0.010
Cish	cytokine inducible SH2-containing protein	0.010
Aif1	allograft inflammatory factor 1	0.010
Usp3	ubiquitin specific peptidase 3	0.010
Foxq1	forkhead box Q1	0.010
Gja5	gap junction protein, alpha 5	0.010
Pik3cd	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.010
Map3k1	mitogen activated protein kinase kinase kinase 1	0.010
Bcar1	breast cancer anti-estrogen resistance 1	0.010
Calcrl	calcitonin receptor-like	0.010
Klk1b21	kallikrein 1-related peptidase b21	0.010
Trhr2	thyrotropin releasing hormone receptor 2	0.010
Ccr1	chemokine (C-C motif) receptor 1	0.010
Egfl7	EGF-like-domain, multiple 7	0.010
Icos	inducible T-cell co-stimulator	0.010
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.010