The network for 'ras protein signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ras protein signal transduction

A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.

Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 1.000
Rho1 CG8416 gene product from transcript CG8416-RB 0.937
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.928
puc puckered 0.905
Lnk CG17367 gene product from transcript CG17367-RC 0.813
phl pole hole 0.774
rap retina aberrant in pattern 0.730
trio CG18214 gene product from transcript CG18214-RA 0.726
Shc SHC-adaptor protein 0.692
Rac1 CG2248 gene product from transcript CG2248-RA 0.691
rok Rho-kinase 0.651
ttk tramtrack 0.621
plexB plexin B 0.597
chic chickadee 0.584
drk downstream of receptor kinase 0.581
synj synaptojanin 0.572
Lis-1 Lissencephaly-1 0.572
bun bunched 0.565
Src64B Src oncogene at 64B 0.559
msn misshapen 0.553
Abi Abelson interacting protein 0.532
aop anterior open 0.532
put punt 0.528
mbc myoblast city 0.523
Arf51F ADP ribosylation factor 51F 0.497
Apc APC-like 0.454
csw corkscrew 0.453
gek genghis khan 0.451
Sos Son of sevenless 0.437
ena enabled 0.432
LanA Laminin A 0.430
Git CG16728 gene product from transcript CG16728-RA 0.429
tutl turtle 0.384
cnn centrosomin 0.370
lqf liquid facets 0.369
Cdc42 CG12530 gene product from transcript CG12530-RA 0.364
Mad Mothers against dpp 0.360
Pk61C Protein kinase 61C 0.337
RanBPM Ran-binding protein M 0.336
CG4853 CG4853 gene product from transcript CG4853-RA 0.331
tsr twinstar 0.318
emc extra macrochaetae 0.315
pyd polychaetoid 0.315
aPKC atypical protein kinase C 0.313
robo3 CG5423 gene product from transcript CG5423-RA 0.312
MTF-1 Metal response element-binding Transcription Factor-1 0.306
Rcd1 Reduction in Cnn dots 1 0.302
raps rapsynoid 0.298
mbt mushroom bodies tiny 0.286
fz frizzled 0.285
sev sevenless 0.283
kuz kuzbanian 0.283
RhoBTB CG5701 gene product from transcript CG5701-RA 0.278
sax saxophone 0.276
Hem HEM-protein 0.275
Gug Grunge 0.268
p120ctn Adherens junction protein p120 0.268
dm diminutive 0.261
Rheb CG1081 gene product from transcript CG1081-RA 0.259
mop myopic 0.255
Vps35 Vacuolar protein sorting 35 0.254
lgs legless 0.250
CG5180 CG5180 gene product from transcript CG5180-RB 0.249
trn tartan 0.248
cdi center divider 0.246
yki yorkie 0.245
par-1 CG8201 gene product from transcript CG8201-RA 0.242
didum dilute class unconventional myosin 0.241
CG7787 CG7787 gene product from transcript CG7787-RA 0.239
Dsor1 Downstream of raf1 0.231
E(bx) Enhancer of bithorax 0.224
key kenny 0.220
Ric Ras which interacts with Calmodulin 0.220
Oda Ornithine decarboxylase antizyme 0.217
CG15436 CG15436 gene product from transcript CG15436-RA 0.217
Saf-B Scaffold attachment factor B 0.216
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.211
baz bazooka 0.208
sgg shaggy 0.208
l(2)k14710 lethal (2) k14710 0.208
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.204
CG6015 CG6015 gene product from transcript CG6015-RA 0.203
Stat92E Signal-transducer and activator of transcription protein at 92E 0.200
Pkn Protein kinase related to protein kinase N 0.200
lea leak 0.199
InR Insulin-like receptor 0.198
jar jaguar 0.191
Akt1 CG4006 gene product from transcript CG4006-RA 0.187
Alk CG8250 gene product from transcript CG8250-RA 0.186
stg string 0.183
NetB Netrin-B 0.183
Prp31 CG6876 gene product from transcript CG6876-RA 0.182
CG1792 CG1792 gene product from transcript CG1792-RA 0.181
CG15609 CG15609 gene product from transcript CG15609-RE 0.180
SF2 CG6987 gene product from transcript CG6987-RA 0.179
bif bifocal 0.176
CG4751 CG4751 gene product from transcript CG4751-RA 0.174
Rac2 CG8556 gene product from transcript CG8556-RA 0.174
hipk homeodomain interacting protein kinase 0.172
hts hu li tai shao 0.169
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
sem-5 Protein SEM-5 0.584
bet-2 Protein BET-2 0.550
CELE_F14E5.2 Protein F14E5.2 0.429
smp-1 Protein SMP-1 0.392
lag-1 Protein LAG-1 0.388
let-60 Protein LET-60 0.387
egl-18 Protein EGL-18 0.353
sur-2 Protein SUR-2 0.336
lin-36 Protein LIN-36 0.307
zoo-1 Protein ZOO-1 0.295
zfp-3 Protein ZFP-3 0.253
eor-2 Protein EOR-2 0.239
lin-25 Protein LIN-25 0.201
sup-17 Protein SUP-17 0.182
mom-5 Protein MOM-5 0.178
mig-2 Protein MIG-2 0.166
sam-10 Protein SAM-10 0.161
nmy-2 Protein NMY-2 0.158
rig-6 Protein RIG-6 0.157
goa-1 Protein GOA-1 0.155
plc-1 Protein PLC-1 0.151
ina-1 Protein INA-1 0.149
lin-45 Protein LIN-45 0.148
T04F8.6 Protein T04F8.6 0.143
eor-1 Protein EOR-1 0.137
rpm-1 Protein RPM-1 0.133
CELE_F47G4.4 Protein F47G4.4 0.132
snf-1 Protein SNF-1 0.127
rpn-6.1 Protein RPN-6.1 0.123
C11E4.6 Protein C11E4.6 0.122
dab-1 Protein DAB-1 0.121
tam-1 Protein TAM-1 0.111
pek-1 Protein PEK-1 0.108
pig-1 Protein PIG-1 0.106
ccf-1 Protein CCF-1 0.105
sel-12 Protein SEL-12 0.105
rsd-6 Protein RSD-6 0.102
bar-1 Protein BAR-1 0.102
unc-14 Protein UNC-14 0.102
pat-3 Protein PAT-3 0.100
CELE_F08D12.1 Protein F08D12.1 0.098
eef-1A.2 Protein EEF-1A.2 0.095
xpo-1 Protein XPO-1 0.094
CELE_T10C6.6 Protein T10C6.6 0.094
fzr-1 Protein FZR-1 0.093
egl-27 Protein EGL-27 0.090
abl-1 Protein ABL-1 0.090
pry-1 Protein PRY-1 0.090
pkn-1 Protein PKN-1 0.089
sym-4 Protein SYM-4 0.087
rbc-1 Protein RBC-1 0.086
Y55F3BR.8 Protein Y55F3BR.8 0.085
gck-2 Protein GCK-2 0.085
daf-12 Protein DAF-12 0.085
atgp-2 Protein ATGP-2 0.084
tbb-2 Protein TBB-2 0.083
mig-5 Protein MIG-5 0.080
rab-14 Protein RAB-14 0.080
cdf-1 Protein CDF-1 0.079
par-6 Protein PAR-6 0.079
pak-1 Protein PAK-1 0.077
epg-2 Protein EPG-2 0.077
sma-6 Protein SMA-6 0.076
W02B8.2 Protein W02B8.2 0.075
let-19 Protein LET-19 0.074
F59A3.4 Protein F59A3.4 0.074
CELE_T26A8.1 Protein T26A8.1 0.074
sax-3 Protein SAX-3 0.072
ced-10 Protein CED-10 0.072
mat-2 Protein MAT-2 0.072
cki-2 Protein CKI-2 0.071
ulp-2 Protein ULP-2 0.071
dpy-22 Protein DPY-22 0.071
kin-4 Protein KIN-4 0.070
egl-8 Protein EGL-8 0.070
mek-2 Protein MEK-2 0.069
gpb-1 Protein GPB-1 0.068
CELE_Y41D4B.4 Protein Y41D4B.4 0.067
ver-3 Protein VER-3 0.067
math-33 Protein MATH-33 0.067
K08E3.5 Protein K08E3.5 0.066
CELE_F56D5.6 Protein F56D5.6 0.066
CELE_C10C6.6 Protein C10C6.6 0.065
atg-9 Protein ATG-9 0.065
rgl-1 Protein RGL-1 0.065
rab-5 Protein RAB-5 0.064
plc-3 Protein PLC-3 0.064
srgp-1 Protein SRGP-1 0.064
ubq-1 Protein UBQ-1 0.064
obr-3 Protein OBR-3 0.064
set-16 Protein SET-16 0.064
fkh-9 Protein FKH-9 0.063
F52G3.1 Protein F52G3.1 0.063
scc-3 Protein SCC-3 0.062
alx-1 Protein ALX-1 0.062
unc-53 Protein UNC-53 0.062
eat-6 Protein EAT-6 0.062
sto-4 Protein STO-4 0.061
chd-7 Protein CHD-7 0.061
tag-303 Protein TAG-303 0.061
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Danio rerio
Name Description Probability Func Analog Organism
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.615
itgb1b.2 integrin, beta 1b.2 0.448
pvrl1b poliovirus receptor-related 1b 0.295
krt4 keratin 4 0.281
gna13b guanine nucleotide binding protein (G protein), alpha 13b 0.246
sox11b SRY-box containing gene 11b 0.222
cnn2 calponin 2 0.210
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.201
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.198
gna13a guanine nucleotide binding protein (G protein), alpha 13a 0.197
tpm4 tropomyosin 4 0.193
nf1a neurofibromin 1a 0.191
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.173
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.170
spna2 spectrin alpha 2 0.168
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.163
cdc42 cell division cycle 42 0.155
pitx3 paired-like homeodomain transcription factor 3 0.146
rnd3a Rho family GTPase 3a 0.140
sumo3a SMT3 suppressor of mif two 3 homolog 3a 0.139
celsr1a cadherin EGF LAG seven-pass G-type receptor 1a 0.137
gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a 0.134
emx2 empty spiracles homeobox 2 0.128
fzd3a frizzled homolog 3a 0.126
alcamb activated leukocyte cell adhesion molecule b 0.121
ryr3 ryanodine receptor 3 0.120
si:ch211-232m7.1 si:ch211-232m7.1 0.119
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.117
snai1a snail homolog 1a (Drosophila) 0.116
tuba1l tubulin, alpha 1, like 0.115
prickle1a prickle-like 1 (Drosophila) a 0.110
pob partial optokinetic response b 0.109
rtcd1 RNA terminal phosphate cyclase domain 1 0.107
gng5 guanine nucleotide binding protein (G protein), gamma 5 0.107
actn1 actinin, alpha 1 0.106
gpc4 glypican 4 0.103
lef1 lymphocyte enhancer binding factor 1 0.103
rab25 RAB25, member RAS oncogene family 0.103
sf3b1 splicing factor 3b, subunit 1 0.102
adrb2a adrenergic receptor, beta 2a 0.101
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.101
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.099
yap1 Yes-associated protein 1 0.099
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.098
phf21a PHD finger protein 21A 0.097
ube2v2 ubiquitin-conjugating enzyme E2 variant 2 0.094
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.091
zgc:101761 zgc:101761 0.089
wnt11 wingless-type MMTV integration site family, member 11 0.087
kdrl kinase insert domain receptor like 0.086
bactin1 bactin1 0.085
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.085
itgb1b integrin, beta 1b 0.084
arpc5a actin related protein 2/3 complex, subunit 5A 0.083
gna11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.082
itgb1b.1 integrin, beta 1b.1 0.080
arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.080
lbr lamin B receptor 0.078
rhoab ras homolog gene family, member Ab 0.078
vcp valosin containing protein 0.078
rtn1a reticulon 1a 0.077
tuba1 tubulin, alpha 1 0.076
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.076
zgc:112425 zgc:112425 0.076
LOC565459 tight junction protein ZO-1-like 0.073
aplnra apelin receptor a 0.073
mapk1 mitogen-activated protein kinase 1 0.072
pfn2 profilin 2 0.072
emilin1a elastin microfibril interfacer 1a 0.071
ctnnb1 catenin (cadherin-associated protein), beta 1 0.069
col14a1 collagen, type XIV, alpha 1 0.069
LOC569128 hypothetical protein LOC569128 0.068
mmd2 progestin and adipoQ receptor 10 0.067
plxnb2a plexin b2a 0.066
ptprfb protein tyrosine phosphatase, receptor type, f, b 0.066
hmga1a high mobility group AT-hook 1a 0.066
mphosph10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 0.065
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.065
ppargc1al peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like 0.065
cx43 connexin 43 0.065
nf1b neurofibromin 1b 0.064
mapk3 mitogen-activated protein kinase 3 0.064
jup junction plakoglobin 0.063
calm3b calmodulin 3b (phosphorylase kinase, delta) 0.062
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.062
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.062
znf703 zinc finger protein 703 0.062
icn2 ictacalcin 2 0.061
npc1 Niemann-Pick disease, type C1 0.059
gnai2l guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like 0.059
esrrga estrogen-related receptor gamma a 0.059
edc4 enhancer of mRNA decapping 4 0.059
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.059
anxa2a annexin A2a 0.058
unc5b unc-5 homolog B (C. elegans) 0.058
ncor1 nuclear receptor co-repressor 1 0.057
fbn2b fibrillin 2b 0.057
fgf17 fibroblast growth factor 17 0.056
ywhaqa tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a 0.055
sdcbp syndecan binding protein (syntenin) 0.054
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Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
EGFR epidermal growth factor receptor 1.000
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1.000
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 1.000
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.000
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1.000
MAPK1 mitogen-activated protein kinase 1 1.000
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1.000
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 1.000
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 1.000
SFN stratifin 1.000
MAPK14 mitogen-activated protein kinase 14 1.000
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.999
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.999
MAP2K1 mitogen-activated protein kinase kinase 1 0.999
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.999
ARRB1 arrestin, beta 1 0.999
RICTOR RPTOR independent companion of MTOR, complex 2 0.998
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.998
FGFR2 fibroblast growth factor receptor 2 0.997
SH3KBP1 SH3-domain kinase binding protein 1 0.997
ARRB2 arrestin, beta 2 0.996
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.995
RB1 retinoblastoma 1 0.995
GSK3B glycogen synthase kinase 3 beta 0.993
RHOA ras homolog gene family, member A 0.991
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.991
PTK2 PTK2 protein tyrosine kinase 2 0.990
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.990
STK4 serine/threonine kinase 4 0.987
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.985
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.985
IGF1R insulin-like growth factor 1 receptor 0.985
CCNE1 cyclin E1 0.984
SRPK2 SRSF protein kinase 2 0.983
TSC2 tuberous sclerosis 2 0.976
BRAF v-raf murine sarcoma viral oncogene homolog B1 0.975
JAG1 jagged 1 0.971
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.971
ABI1 abl-interactor 1 0.970
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.964
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.953
STK3 serine/threonine kinase 3 0.953
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.951
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.947
DUSP1 dual specificity phosphatase 1 0.946
S100A11 S100 calcium binding protein A11 0.946
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.943
GRB7 growth factor receptor-bound protein 7 0.938
MARK3 MAP/microtubule affinity-regulating kinase 3 0.938
GABARAPL1 GABA(A) receptor-associated protein like 1 0.937
KIF23 kinesin family member 23 0.934
SRPK1 SRSF protein kinase 1 0.933
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.933
MAPK3 mitogen-activated protein kinase 3 0.931
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.930
SKP2 S-phase kinase-associated protein 2 (p45) 0.928
SH3BP2 SH3-domain binding protein 2 0.927
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.925
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.919
CAV1 caveolin 1, caveolae protein, 22kDa 0.917
FGF1 fibroblast growth factor 1 (acidic) 0.917
NCK2 NCK adaptor protein 2 0.915
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.910
CDC25B cell division cycle 25 homolog B (S. pombe) 0.910
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.906
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.903
RBL1 retinoblastoma-like 1 (p107) 0.902
MAP2K4 mitogen-activated protein kinase kinase 4 0.900
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.896
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.893
S100A6 S100 calcium binding protein A6 0.891
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.891
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.887
S100A8 S100 calcium binding protein A8 0.884
PKN3 protein kinase N3 0.881
E2F4 E2F transcription factor 4, p107/p130-binding 0.878
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.875
PLCG1 phospholipase C, gamma 1 0.871
SRSF10 serine/arginine-rich splicing factor 10 0.870
FOS FBJ murine osteosarcoma viral oncogene homolog 0.870
EEA1 early endosome antigen 1 0.868
FGFR1 fibroblast growth factor receptor 1 0.866
NCKAP1 NCK-associated protein 1 0.864
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.862
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.858
MPRIP myosin phosphatase Rho interacting protein 0.857
HMOX2 heme oxygenase (decycling) 2 0.848
UBC ubiquitin C 0.847
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.847
PEA15 phosphoprotein enriched in astrocytes 15 0.846
SORBS3 sorbin and SH3 domain containing 3 0.845
S100A1 S100 calcium binding protein A1 0.842
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.842
DOCK1 dedicator of cytokinesis 1 0.839
CDT1 chromatin licensing and DNA replication factor 1 0.837
CCND1 cyclin D1 0.833
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.832
DSP desmoplakin 0.825
LRRC7 leucine rich repeat containing 7 0.823
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Mus musculus
Name Description Probability Func Analog Organism
Grb2 growth factor receptor bound protein 2 0.999
Ctnnb1 catenin (cadherin associated protein), beta 1 0.998
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.996
Cbl Casitas B-lineage lymphoma 0.995
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.994
Epha4 Eph receptor A4 0.994
Shc1 src homology 2 domain-containing transforming protein C1 0.992
Ephb2 Eph receptor B2 0.991
Efnb2 ephrin B2 0.991
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.986
Inpp5d inositol polyphosphate-5-phosphatase D 0.985
Lepr leptin receptor 0.983
Hdac7 histone deacetylase 7 0.980
Ntf3 neurotrophin 3 0.977
Nf1 neurofibromatosis 1 0.972
Rac1 RAS-related C3 botulinum substrate 1 0.970
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.970
Nos3 nitric oxide synthase 3, endothelial cell 0.968
Mapk3 mitogen-activated protein kinase 3 0.961
Src Rous sarcoma oncogene 0.961
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.960
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.950
Akt1 thymoma viral proto-oncogene 1 0.945
Plxna1 plexin A1 0.941
Braf Braf transforming gene 0.938
Plcg1 phospholipase C, gamma 1 0.937
Raf1 v-raf-leukemia viral oncogene 1 0.937
Flii flightless I homolog (Drosophila) 0.936
Pnpla2 patatin-like phospholipase domain containing 2 0.920
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.920
Pxn paxillin 0.919
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.913
S1pr3 sphingosine-1-phosphate receptor 3 0.904
Lrrk2 leucine-rich repeat kinase 2 0.904
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.900
Jup junction plakoglobin 0.893
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.889
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.882
Sox10 SRY-box containing gene 10 0.882
Myo1f myosin IF 0.872
Arrb2 arrestin, beta 2 0.872
Pthlh parathyroid hormone-like peptide 0.870
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.866
Mdm2 transformed mouse 3T3 cell double minute 2 0.865
Mtor mechanistic target of rapamycin (serine/threonine kinase) 0.863
Ret ret proto-oncogene 0.863
Arhgef2 rho/rac guanine nucleotide exchange factor (GEF) 2 0.861
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.853
Git1 G protein-coupled receptor kinase-interactor 1 0.848
Plec plectin 0.843
Gab1 growth factor receptor bound protein 2-associated protein 1 0.842
Egfr epidermal growth factor receptor 0.841
Sh3kbp1 SH3-domain kinase binding protein 1 0.837
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.836
Pdgfb platelet derived growth factor, B polypeptide 0.833
Ccr2 chemokine (C-C motif) receptor 2 0.833
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.832
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.830
Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 0.825
Capn1 calpain 1 0.825
Lama5 laminin, alpha 5 0.821
Mapk11 mitogen-activated protein kinase 11 0.818
Spry4 sprouty homolog 4 (Drosophila) 0.811
Cd44 CD44 antigen 0.808
Vangl2 vang-like 2 (van gogh, Drosophila) 0.808
Hmha1 histocompatibility (minor) HA-1 0.804
Itga3 integrin alpha 3 0.804
Cttn cortactin 0.800
Rgs14 regulator of G-protein signaling 14 0.799
Rasal3 RAS protein activator like 3 0.796
Mapk14 mitogen-activated protein kinase 14 0.795
Ptpre protein tyrosine phosphatase, receptor type, E 0.791
Apc adenomatosis polyposis coli 0.785
Capn2 calpain 2 0.785
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.781
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.780
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.776
Btk Bruton agammaglobulinemia tyrosine kinase 0.774
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.774
Dok2 docking protein 2 0.773
Nckap1l NCK associated protein 1 like 0.769
Tnks1bp1 tankyrase 1 binding protein 1 0.768
Myo18a myosin XVIIIA 0.761
Prkce protein kinase C, epsilon 0.755
Sh3bp1 SH3-domain binding protein 1 0.753
S1pr1 sphingosine-1-phosphate receptor 1 0.741
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.739
Ctnnd1 catenin (cadherin associated protein), delta 1 0.737
Cyfip1 cytoplasmic FMR1 interacting protein 1 0.735
Selplg selectin, platelet (p-selectin) ligand 0.731
Prkcd protein kinase C, delta 0.730
Eps15 epidermal growth factor receptor pathway substrate 15 0.726
Tgfb1 transforming growth factor, beta 1 0.726
Add1 adducin 1 (alpha) 0.725
Plekho2 pleckstrin homology domain containing, family O member 2 0.716
Ccl2 chemokine (C-C motif) ligand 2 0.716
Hdac1 histone deacetylase 1 0.708
Itga5 integrin alpha 5 (fibronectin receptor alpha) 0.704
Rasgrp1 RAS guanyl releasing protein 1 0.704
Prkd2 protein kinase D2 0.701
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Hk1 hexokinase 1 0.282
Rap1b RAP1B, member of RAS oncogene family 0.219
Dlg3 discs, large homolog 3 (Drosophila) 0.219
Ptafr platelet-activating factor receptor 0.212
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.193
Fkbp1a FK506 binding protein 1a 0.182
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.176
Nptn neuroplastin 0.160
Col5a2 collagen, type V, alpha 2 0.154
Mapk1 mitogen activated protein kinase 1 0.146
Pctk1 PCTAIRE protein kinase 1 0.140
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.140
Cugbp2 CUG triplet repeat, RNA binding protein 2 0.139
Ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.138
Fgfr2 fibroblast growth factor receptor 2 0.137
Epn2 epsin 2 0.125
Hpcal1 hippocalcin-like 1 0.123
Bgn biglycan 0.121
Anxa2 annexin A2 0.120
Mapk3 mitogen activated protein kinase 3 0.118
Klf6 Kruppel-like factor 6 0.112
Nsf N-ethylmaleimide-sensitive factor 0.112
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.111
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.111
Nckap1 NCK-associated protein 1 0.108
Adora2a adenosine A2a receptor 0.108
Inpp5d inositol polyphosphate-5-phosphatase D 0.106
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.105
Mapk6 mitogen-activated protein kinase 6 0.105
Tcf3 transcription factor 3 0.104
Col1a1 collagen, type I, alpha 1 0.103
Rab11a RAB11a, member RAS oncogene family 0.102
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.101
Prkg2 protein kinase, cGMP-dependent, type II 0.100
Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.099
Arf3 ADP-ribosylation factor 3 0.099
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.099
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.099
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.098
Pctk2 PCTAIRE protein kinase 2 0.097
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.097
Csnk1g3 casein kinase 1, gamma 3 0.096
Rab1b RAB1B, member RAS oncogene family 0.096
Lphn2 latrophilin 2 0.095
Jtb jumping translocation breakpoint 0.094
Vim vimentin 0.094
Prkar1a protein kinase, cAMP-dependent, regulatory, type I, alpha 0.093
S100a4 S100 calcium-binding protein A4 0.093
Utrn utrophin 0.092
Pitpna phosphatidylinositol transfer protein, alpha 0.092
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.092
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.091
Rab7a RAB7A, member RAS oncogene family 0.091
Strn striatin, calmodulin binding protein 0.091
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.089
Kitlg KIT ligand 0.088
Zc3h7b zinc finger CCCH-type containing 7B 0.087
Ap2b1 adaptor-related protein complex 2, beta 1 subunit 0.087
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.087
Dgkg diacylglycerol kinase, gamma 0.086
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.086
Pja2 praja 2, RING-H2 motif containing 0.085
Synpo synaptopodin 0.084
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.084
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.083
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.083
Fzr1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.083
Dlg1 discs, large homolog 1 (Drosophila) 0.082
Mllt1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.081
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.080
Slc23a2 solute carrier family 23 (nucleobase transporters), member 2 0.080
Chn1 chimerin (chimaerin) 1 0.080
Sdc3 syndecan 3 0.080
Kcnab1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 0.080
Tns1 tensin 1 0.079
Git1 G protein-coupled receptor kinase interacting ArfGAP 1 0.078
Homer3 homer homolog 3 (Drosophila) 0.077
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.077
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.077
Sf3b1 splicing factor 3b, subunit 1 0.077
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.076
Lgals3 lectin, galactoside-binding, soluble, 3 0.076
Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.076
Inpp4a inositol polyphosphate-4-phosphatase, type 1 0.076
Rhoa ras homolog gene family, member A 0.075
Nos3 nitric oxide synthase 3, endothelial cell 0.075
Pmp22 peripheral myelin protein 22 0.075
Bcat1 branched chain aminotransferase 1, cytosolic 0.074
Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.074
Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.074
Thbd thrombomodulin 0.074
Ppp1r13b protein phosphatase 1, regulatory (inhibitor) subunit 13B 0.074
Sstr1 somatostatin receptor 1 0.073
Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 0.073
Adrbk1 adrenergic, beta, receptor kinase 1 0.072
Ier5 immediate early response 5 0.072
Adar adenosine deaminase, RNA-specific 0.072
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.072
Prnp prion protein 0.072
Vcam1 vascular cell adhesion molecule 1 0.072
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ROM2 Rom2p 0.930
RHO1 Rho1p 0.839
GPB2 Gpb2p 0.588
IRA1 Ira1p 0.485
GYL1 Gyl1p 0.476
GPR1 Gpr1p 0.423
TPK2 Tpk2p 0.380
BNI1 Bni1p 0.288
YKR017C hypothetical protein 0.277
RAS2 Ras2p 0.257
DNF3 Dnf3p 0.253
SEC3 Sec3p 0.225
KOG1 Kog1p 0.208
SPA2 Spa2p 0.204
STE5 Ste5p 0.193
YIP3 Yip3p 0.190
TCO89 Tco89p 0.167
PKC1 Pkc1p 0.163
GDI1 Gdi1p 0.140
MKK1 Mkk1p 0.135
MDS3 Mds3p 0.134
SLM1 Slm1p 0.127
CDC25 Cdc25p 0.126
SEC4 Sec4p 0.116
CDC12 Cdc12p 0.110
GIC2 Gic2p 0.107
REG1 Reg1p 0.106
AVO1 Avo1p 0.104
YOL087C hypothetical protein 0.103
WSC3 Wsc3p 0.102
VPS15 Vps15p 0.102
NVJ1 Nvj1p 0.101
PEP5 Pep5p 0.101
YPK1 Ypk1p 0.101
BUD14 Bud14p 0.094
BST1 Bst1p 0.089
RIM15 Rim15p 0.087
BCP1 Bcp1p 0.087
ECM25 Ecm25p 0.087
TSC11 Tsc11p 0.086
CRM1 Crm1p 0.085
TPK1 Tpk1p 0.085
CYR1 Cyr1p 0.080
KSS1 Kss1p 0.079
YPT31 Ypt31p 0.076
BUD2 Bud2p 0.076
INP53 Inp53p 0.075
FUS3 Fus3p 0.071
MKK2 Mkk2p 0.069
WSC2 Wsc2p 0.068
WSC4 Wsc4p 0.068
KDX1 Kdx1p 0.067
BOI1 Boi1p 0.067
SEC15 Sec15p 0.065
YPT1 Ypt1p 0.064
SLT2 Slt2p 0.063
CHS1 Chs1p 0.062
PTP2 Ptp2p 0.061
DPB2 Dpb2p 0.059
SIA1 Sia1p 0.058
STT4 Stt4p 0.058
TPS2 Tps2p 0.058
MSG5 Msg5p 0.057
BEM2 Bem2p 0.057
TSA2 Tsa2p 0.057
OSH7 Osh7p 0.056
RGC1 Rgc1p 0.056
BMH1 Bmh1p 0.056
BUD6 Bud6p 0.054
TRS31 Trs31p 0.054
SEC2 Sec2p 0.053
BMH2 Bmh2p 0.052
FMS1 Fms1p 0.052
VPS27 Vps27p 0.051
FYV8 Fyv8p 0.051
BEM3 Bem3p 0.051
CDC24 Cdc24p 0.051
NUP192 Nup192p 0.051
GSH1 Gsh1p 0.050
RFC1 Rfc1p 0.050
YPT53 Ypt53p 0.049
ATG11 Atg11p 0.049
APM2 Apm2p 0.049
SSK2 Ssk2p 0.047
RIB1 Rib1p 0.046
MNN9 Mnn9p 0.046
PDR12 Pdr12p 0.046
CMK1 Cmk1p 0.046
BCY1 Bcy1p 0.045
STE11 Ste11p 0.045
AFI1 Afi1p 0.044
CKS1 Cks1p 0.044
RHO3 Rho3p 0.044
CCS1 Ccs1p 0.044
SSL2 Ssl2p 0.042
CUE5 Cue5p 0.042
YPL066W hypothetical protein 0.042
MKS1 Mks1p 0.042
FKH1 Fkh1p 0.041
FMP27 Fmp27p 0.041