The network for 'ceramide biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ceramide biosynthetic process

The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.

Mus musculus
Name Description Probability Func Analog Organism
Elovl1 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 0.869
Orai1 ORAI calcium release-activated calcium modulator 1 0.539
Ctgf connective tissue growth factor 0.398
Cyr61 cysteine rich protein 61 0.346
0610031J06Rik RIKEN cDNA 0610031J06 gene 0.266
Blnk B-cell linker 0.266
Ptgir prostaglandin I receptor (IP) 0.246
Dpp7 dipeptidylpeptidase 7 0.218
Rragc Ras-related GTP binding C 0.201
Ptges prostaglandin E synthase 0.185
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.176
Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.170
Thbs1 thrombospondin 1 0.167
Ctsd cathepsin D 0.159
Asah1 N-acylsphingosine amidohydrolase 1 0.154
Lgmn legumain 0.154
Tmem9b TMEM9 domain family, member B 0.152
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.147
Scarb2 scavenger receptor class B, member 2 0.145
Anxa4 annexin A4 0.120
Bcap31 B-cell receptor-associated protein 31 0.117
Inpp5j inositol polyphosphate 5-phosphatase J 0.111
Mfsd1 major facilitator superfamily domain containing 1 0.106
Ctsz cathepsin Z 0.097
Cstb cystatin B 0.097
Tcirg1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 0.090
Tnc tenascin C 0.084
1600012H06Rik RIKEN cDNA 1600012H06 gene 0.084
Atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.083
Litaf LPS-induced TN factor 0.080
Mag myelin-associated glycoprotein 0.080
Gns glucosamine (N-acetyl)-6-sulfatase 0.079
Alox5ap arachidonate 5-lipoxygenase activating protein 0.079
Pttg1ip pituitary tumor-transforming 1 interacting protein 0.077
Nrcam neuron-glia-CAM-related cell adhesion molecule 0.077
Plekhg6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 0.076
Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) 0.074
Atf3 activating transcription factor 3 0.072
Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 0.069
Cckbr cholecystokinin B receptor 0.067
Sumf1 sulfatase modifying factor 1 0.067
Scpep1 serine carboxypeptidase 1 0.065
Soat1 sterol O-acyltransferase 1 0.064
Fuca1 fucosidase, alpha-L- 1, tissue 0.062
Lamp2 lysosomal-associated membrane protein 2 0.062
Anxa5 annexin A5 0.061
Tpp1 tripeptidyl peptidase I 0.061
F3 coagulation factor III 0.059
Amotl2 angiomotin-like 2 0.059
Padi2 peptidyl arginine deiminase, type II 0.057
Mybph myosin binding protein H 0.054
Tspan31 tetraspanin 31 0.054
Edem1 ER degradation enhancer, mannosidase alpha-like 1 0.051
Coch coagulation factor C homolog (Limulus polyphemus) 0.051
Tspo2 translocator protein 2 0.050
Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 0.050
Syt3 synaptotagmin III 0.049
Gp1ba glycoprotein 1b, alpha polypeptide 0.048
P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 0.048
Cdsn corneodesmosin 0.047
Scg2 secretogranin II 0.044
Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a 0.044
Tmem40 transmembrane protein 40 0.043
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.043
Bnipl BCL2/adenovirus E1B 19kD interacting protein like 0.042
Rab25 RAB25, member RAS oncogene family 0.042
Tll1 tolloid-like 0.042
Ctsa cathepsin A 0.041
Kcnd1 potassium voltage-gated channel, Shal-related family, member 1 0.041
Hexb hexosaminidase B 0.041
Ldb3 LIM domain binding 3 0.040
Nap1l2 nucleosome assembly protein 1-like 2 0.039
Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.039
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.038
Rnh1 ribonuclease/angiogenin inhibitor 1 0.037
Nucb2 nucleobindin 2 0.037
Gabrd gamma-aminobutyric acid (GABA) A receptor, subunit delta 0.036
P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 0.035
Npcd neuronal pentraxin chromo domain 0.035
Sprr1a small proline-rich protein 1A 0.035
Prss23 protease, serine, 23 0.035
St14 suppression of tumorigenicity 14 (colon carcinoma) 0.035
Gata1 GATA binding protein 1 0.034
Ctsl cathepsin L 0.034
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.034
Lass2 LAG1 homolog, ceramide synthase 2 0.033
Thbs2 thrombospondin 2 0.033
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.033
Capn2 calpain 2 0.033
Fos FBJ osteosarcoma oncogene 0.033
Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor 0.033
Shisa5 shisa homolog 5 (Xenopus laevis) 0.032
Anxa3 annexin A3 0.032
Col8a1 collagen, type VIII, alpha 1 0.032
Scamp2 secretory carrier membrane protein 2 0.032
Lgals2 lectin, galactose-binding, soluble 2 0.032
AI118078 expressed sequence AI118078 0.030
Pla2g10 phospholipase A2, group X 0.030
Ly6g6c lymphocyte antigen 6 complex, locus G6C 0.030
Degs1 degenerative spermatocyte homolog 1 (Drosophila) 0.030
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
st8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.519
manf mesencephalic astrocyte-derived neurotrophic factor 0.251
ncam1b neural cell adhesion molecule 1b 0.117
spry4 sprouty (Drosophila) homolog 4 0.116
lpp LIM domain containing preferred translocation partner in lipoma 0.116
sox21a SRY-box containing gene 21a 0.097
lndc1 ly6/neurotoxin domain containing 1 0.090
fkbp14 FK506 binding protein 14 0.086
st8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.073
st8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.072
rplp1 ribosomal protein, large, P1 0.072
zgc:56419 zgc:56419 0.069
zgc:73136 zgc:73136 0.060
pitpna phosphatidylinositol transfer protein, alpha 0.054
fkbp10 FK506 binding protein 10 0.053
LOC564867 novel protein similar to LAG1 homolog, ceramide synthase family 0.046
vtg1 vitellogenin 1 0.046
mapk1 mitogen-activated protein kinase 1 0.044
zgc:153675 zgc:153675 0.044
sass6 spindle assembly 6 homolog (C. elegans) 0.042
vtg6 vitellogenin 6 0.041
fzd5 frizzled homolog 5 0.038
xbp1 X-box binding protein 1 0.034
ctsd cathepsin D 0.034
trh1 trh1 protein 0.034
rcn3 reticulocalbin 3, EF-hand calcium binding domain 0.032
dnd dead end 0.032
vtg7 vitellogenin 7 0.031
msi1 musashi homolog 1 (Drosophila) 0.030
nod1 nucleotide-binding oligomerization domain containing 1 0.028
fzd2 frizzled homolog 2 0.026
etv5a ets variant 5a 0.025
tcf12 transcription factor 12 0.025
etv5b ets variant 5b 0.025
ift81 intraflagellar transport 81 homolog 0.023
ccdc151 coiled-coil domain containing 151 0.023
birc5b baculoviral IAP repeat-containing 5B 0.023
met met proto-oncogene (hepatocyte growth factor receptor) 0.023
otpb orthopedia homolog b 0.022
hsp47 heat shock protein 47 0.021
zgc:171494 zgc:171494 0.021
ssr4 signal sequence receptor, delta 0.021
zgc:56280 zgc:56280 0.020
barhl1.1 BarH-like 1.1 0.020
fam46c family with sequence similarity 46, member C 0.020
zgc:114095 zgc:114095 0.020
kdelr2l KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, like 0.019
pgm3 phosphoglucomutase 3 0.019
lrmp lymphoid-restricted membrane protein 0.019
uap1 UDP-N-acteylglucosamine pyrophosphorylase 1 0.019
nar no arches 0.019
lzts2a leucine zipper, putative tumor suppressor 2a 0.019
sult3st1 sulfotransferase family 3, cytosolic sulfotransferase 1 0.018
ssr2 signal sequence receptor, beta 0.018
sulf1 sulfatase 1 0.018
ext1a exostoses (multiple) 1a 0.018
spon1b spondin 1b 0.017
st8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 0.017
igf1rb insulin-like growth factor 1b receptor 0.017
atoh1b atonal homolog 1b 0.016
atp6v1h ATPase, H+ transporting, lysosomal, V1 subunit H 0.015
nr5a2 nuclear receptor subfamily 5, group A, member 2 0.015
sult3st2 sulfotransferase family 3, cytosolic sulfotransferase 2 0.015
ndel1b nudE nuclear distribution gene E homolog like 1 (A. nidulans) B 0.015
prok2 prokineticin 2 0.015
grhl3 grainyhead-like 3 0.015
lipg lipase, endothelial 0.015
zgc:92744 zgc:92744 0.014
hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 0.014
plekhh1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 0.014
skib nuclear oncoprotein skib 0.013
aqp11 aquaporin 11 0.013
tgfbr1b transforming growth factor, beta receptor 1 b 0.013
matn4 matrilin 4 0.013
plekhg5a pleckstrin homology domain containing, family G (with RhoGef domain) member 5a 0.013
mapk4 mitogen-activated protein kinase 4 0.013
fgfrl1a fibroblast growth factor receptor-like 1a 0.013
gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.013
riok3 RIO kinase 3 (yeast) 0.012
tnfaip8 tumor necrosis factor, alpha-induced protein 8 0.012
pglyrp2 peptidoglycan recognition protein 2 0.012
nr4a1 nuclear receptor subfamily 4, group A, member 1 0.012
srl sarcalumenin 0.012
zgc:56706 zgc:56706 0.012
ca8 carbonic anhydrase VIII 0.012
si:xx-bac7cse.2 si:xx-bac7cse.2 0.012
slc9a3r1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.012
card9 caspase recruitment domain family, member 9 0.012
hoxb2a homeo box B2a 0.012
nod2 nucleotide-binding oligomerization domain containing 2 0.012
zgc:153260 zgc:153260 0.012
stau1 staufen, RNA binding protein, homolog 1 (Drosophila) 0.012
srpx sushi-repeat-containing protein 0.011
bin1 bridging integrator 1 0.011
slc25a27 solute carrier family 25, member 27 0.011
bmp6 bone morphogenetic protein 6 0.011
sfrp1a secreted frizzled-related protein 1a 0.011
zgc:66484 zgc:66484 0.011
mknk2a MAP kinase-interacting serine/threonine kinase 2a 0.011
cyp19a1b cytochrome P450, family 19, subfamily A, polypeptide 1b 0.011
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
mi minus 0.047
sxc super sex combs 0.021
trc tricornered 0.017
CG32528 CG32528 gene product from transcript CG32528-RA 0.013
mnd minidiscs 0.013
l(1)G0232 lethal (1) G0232 0.012
Tak1 TGF-beta activated kinase 1 0.012
CG12007 CG12007 gene product from transcript CG12007-RA 0.011
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
NUMB numb homolog (Drosophila) 0.127
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.047
ZNF71 zinc finger protein 71 0.045
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.028
LAMP1 lysosomal-associated membrane protein 1 0.024
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.023
NOXA1 NADPH oxidase activator 1 0.022
NCF1 neutrophil cytosolic factor 1 0.021
SURF4 surfeit 4 0.018
PRKCZ protein kinase C, zeta 0.017
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.017
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.016
MAPT microtubule-associated protein tau 0.014
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.012
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.012
PRKCB protein kinase C, beta 0.010
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism