The network for 'release of sequestered calcium ion into cytosol by sarcoplasmic reticulum' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.

Mus musculus
Name Description Probability Func Analog Organism
Ldb3 LIM domain binding 3 0.913
Hrc histidine rich calcium binding protein 0.847
Ccr1 chemokine (C-C motif) receptor 1 0.824
Hbb-b1 hemoglobin, beta adult major chain 0.780
Casq2 calsequestrin 2 0.769
Ryr2 ryanodine receptor 2, cardiac 0.700
Cox6a2 cytochrome c oxidase, subunit VI a, polypeptide 2 0.614
Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) 0.614
Spna1 spectrin alpha 1 0.609
Spnb1 spectrin beta 1 0.587
Ttn titin 0.581
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.575
Casq1 calsequestrin 1 0.568
Actn2 actinin alpha 2 0.512
Ccl2 chemokine (C-C motif) ligand 2 0.498
Myom2 myomesin 2 0.493
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.469
Srpk3 serine/arginine-rich protein specific kinase 3 0.419
Cav3 caveolin 3 0.387
Myl1 myosin, light polypeptide 1 0.336
Ccr2 chemokine (C-C motif) receptor 2 0.320
Myoz2 myozenin 2 0.221
Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult 0.212
Smyd1 SET and MYND domain containing 1 0.208
Yipf7 Yip1 domain family, member 7 0.200
Prkcc protein kinase C, gamma 0.169
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.166
Ckm creatine kinase, muscle 0.162
Fktn fukutin 0.152
Scn1a sodium channel, voltage-gated, type I, alpha 0.148
Sh3bgr SH3-binding domain glutamic acid-rich protein 0.131
Phkg1 phosphorylase kinase gamma 1 0.130
Klf1 Kruppel-like factor 1 (erythroid) 0.126
Uros uroporphyrinogen III synthase 0.124
Ckmt2 creatine kinase, mitochondrial 2 0.119
Sgcg sarcoglycan, gamma (dystrophin-associated glycoprotein) 0.109
Myom1 myomesin 1 0.106
Dtna dystrobrevin alpha 0.099
Gja1 gap junction protein, alpha 1 0.099
Tcap titin-cap 0.097
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.088
Cep290 centrosomal protein 290 0.086
Cmya5 cardiomyopathy associated 5 0.084
Alpk3 alpha-kinase 3 0.083
Pygm muscle glycogen phosphorylase 0.082
Actc1 actin, alpha, cardiac muscle 1 0.078
Frmd5 FERM domain containing 5 0.077
Cox8b cytochrome c oxidase, subunit VIIIb 0.076
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.076
Apobec2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 0.075
Scn1b sodium channel, voltage-gated, type I, beta 0.068
Popdc2 popeye domain containing 2 0.068
Pvalb parvalbumin 0.067
Snta1 syntrophin, acidic 1 0.063
Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.057
Ppfia4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.054
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.054
Fech ferrochelatase 0.051
Add2 adducin 2 (beta) 0.049
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.049
Gnao1 guanine nucleotide binding protein, alpha O 0.049
Tnnt2 troponin T2, cardiac 0.048
Sln sarcolipin 0.047
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.046
Usp13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.046
Atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.045
Rbm24 RNA binding motif protein 24 0.045
Ache acetylcholinesterase 0.044
Exoc6 exocyst complex component 6 0.044
Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 0.043
Col19a1 collagen, type XIX, alpha 1 0.041
Hbb-b2 hemoglobin, beta adult minor chain 0.040
Tnnc2 troponin C2, fast 0.040
Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 0.038
Tuba8 tubulin, alpha 8 0.037
Pgam2 phosphoglycerate mutase 2 0.034
Txlnb taxilin beta 0.033
Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.033
Lmod3 leiomodin 3 (fetal) 0.032
Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.032
Des desmin 0.031
Tnnt3 troponin T3, skeletal, fast 0.031
Adam23 a disintegrin and metallopeptidase domain 23 0.030
Mstn myostatin 0.030
Mpeg1 macrophage expressed gene 1 0.029
Scn5a sodium channel, voltage-gated, type V, alpha 0.029
Ptpro protein tyrosine phosphatase, receptor type, O 0.029
Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 0.027
Myl3 myosin, light polypeptide 3 0.027
Capn3 calpain 3 0.027
Asb12 ankyrin repeat and SOCS box-containing 12 0.026
Smpx small muscle protein, X-linked 0.026
Cdh13 cadherin 13 0.026
Dag1 dystroglycan 1 0.026
Ryr3 ryanodine receptor 3 0.025
Etl4 enhancer trap locus 4 0.025
Epor erythropoietin receptor 0.025
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.024
Hspb3 heat shock protein 3 0.024
Prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.023
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
GSTM1 glutathione S-transferase mu 1 0.998
CCR5 chemokine (C-C motif) receptor 5 0.993
GSTM2 glutathione S-transferase mu 2 (muscle) 0.964
CCL5 chemokine (C-C motif) ligand 5 0.933
CXCL9 chemokine (C-X-C motif) ligand 9 0.483
CCL22 chemokine (C-C motif) ligand 22 0.392
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.382
DTNA dystrobrevin, alpha 0.349
CCL2 chemokine (C-C motif) ligand 2 0.317
GSTM4 glutathione S-transferase mu 4 0.285
KIAA1683 KIAA1683 0.271
CCL4 chemokine (C-C motif) ligand 4 0.270
IFNG interferon, gamma 0.209
IL2RB interleukin 2 receptor, beta 0.177
IL8 interleukin 8 0.148
CCL8 chemokine (C-C motif) ligand 8 0.128
CXCR6 chemokine (C-X-C motif) receptor 6 0.119
CCR7 chemokine (C-C motif) receptor 7 0.111
ACVR1B activin A receptor, type IB 0.102
CCR4 chemokine (C-C motif) receptor 4 0.100
CCR2 chemokine (C-C motif) receptor 2 0.090
IL6 interleukin 6 (interferon, beta 2) 0.085
IL10 interleukin 10 0.081
CXCL13 chemokine (C-X-C motif) ligand 13 0.074
IL1B interleukin 1, beta 0.057
CCL7 chemokine (C-C motif) ligand 7 0.056
TGFBR1 transforming growth factor, beta receptor 1 0.054
SPTB spectrin, beta, erythrocytic 0.049
CCR1 chemokine (C-C motif) receptor 1 0.048
CCL13 chemokine (C-C motif) ligand 13 0.045
TTN titin 0.045
CCL19 chemokine (C-C motif) ligand 19 0.040
IRF4 interferon regulatory factor 4 0.037
AKAP6 A kinase (PRKA) anchor protein 6 0.035
CXCR3 chemokine (C-X-C motif) receptor 3 0.033
CD40LG CD40 ligand 0.030
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.030
IL21R interleukin 21 receptor 0.029
IDE insulin-degrading enzyme 0.028
CXCL10 chemokine (C-X-C motif) ligand 10 0.028
MYO10 myosin X 0.028
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.026
DARC Duffy blood group, chemokine receptor 0.025
DPP4 dipeptidyl-peptidase 4 0.025
CXCL3 chemokine (C-X-C motif) ligand 3 0.025
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.025
SLAMF7 SLAM family member 7 0.024
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.023
CCR3 chemokine (C-C motif) receptor 3 0.023
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.023
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.023
EHD1 EH-domain containing 1 0.023
IL1RN interleukin 1 receptor antagonist 0.023
TNF tumor necrosis factor 0.022
CXCL11 chemokine (C-X-C motif) ligand 11 0.022
CFL1 cofilin 1 (non-muscle) 0.022
CXCL2 chemokine (C-X-C motif) ligand 2 0.021
MAPK4 mitogen-activated protein kinase 4 0.020
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.019
DTNB dystrobrevin, beta 0.019
GSTM3 glutathione S-transferase mu 3 (brain) 0.019
RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 0.017
ARRB1 arrestin, beta 1 0.017
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.016
SELE selectin E 0.016
IL1F5 interleukin 1 family, member 5 (delta) 0.016
RGS1 regulator of G-protein signaling 1 0.015
CXCR2 chemokine (C-X-C motif) receptor 2 0.015
CCL11 chemokine (C-C motif) ligand 11 0.015
CCL3 chemokine (C-C motif) ligand 3 0.015
IL1A interleukin 1, alpha 0.014
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.014
CXCL5 chemokine (C-X-C motif) ligand 5 0.013
CD83 CD83 molecule 0.013
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.013
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.012
IL1R2 interleukin 1 receptor, type II 0.012
CCL20 chemokine (C-C motif) ligand 20 0.012
CLEC4A C-type lectin domain family 4, member A 0.012
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.012
CCR6 chemokine (C-C motif) receptor 6 0.012
TRAPPC1 trafficking protein particle complex 1 0.011
ARF3 ADP-ribosylation factor 3 0.011
IL7R interleukin 7 receptor 0.011
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.011
CD86 CD86 molecule 0.011
FPR3 formyl peptide receptor 3 0.011
RHAG Rh-associated glycoprotein 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Asph aspartate-beta-hydroxylase 0.487
Ldb3 LIM domain binding 3 0.323
Pygm phosphorylase, glycogen, muscle 0.257
Tmod4 tropomodulin 4 0.244
Pgam2 phosphoglycerate mutase 2 (muscle) 0.217
Ccl4 chemokine (C-C motif) ligand 4 0.171
Myl1 myosin, light chain 1 0.162
Nexn nexilin (F actin binding protein) 0.137
Cav3 caveolin 3 0.123
Casq2 calsequestrin 2 (cardiac muscle) 0.120
Mybpc1 myosin binding protein C, slow type 0.115
Asb12 ankyrin repeat and SOCS box-containing 12 0.115
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.109
Apobec2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 0.100
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.097
Myo9a myosin IXA 0.097
Gstm1 glutathione S-transferase mu 1 0.096
Myh6 myosin, heavy chain 6, cardiac muscle, alpha 0.094
Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.093
Unc45b unc-45 homolog B (C. elegans) 0.093
Pkia protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.088
Ckm creatine kinase, muscle 0.079
Phka1 phosphorylase kinase, alpha 1 0.077
Sh3bgr SH3 domain binding glutamic acid-rich protein 0.071
Cd4 Cd4 molecule 0.068
Lrrc39 leucine rich repeat containing 39 0.067
Ampd1 adenosine monophosphate deaminase 1 (isoform M) 0.064
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.060
Fitm1 fat storage-inducing transmembrane protein 1 0.059
Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.057
Rasa2 RAS p21 protein activator 2 0.056
Chrna1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.055
Tnni3k TNNI3 interacting kinase 0.055
Ckmt2 creatine kinase, mitochondrial 2, sarcomeric 0.053
Casq1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.051
Smpx small muscle protein, X-linked 0.050
Rgs1 regulator of G-protein signaling 1 0.049
Cdon Cdon homolog (mouse) 0.048
Phex phosphate regulating endopeptidase homolog, X-linked 0.048
Art1 ADP-ribosyltransferase 1 0.048
Rhag Rh-associated glycoprotein 0.047
Pde3a phosphodiesterase 3A, cGMP inhibited 0.045
Trim63 tripartite motif-containing 63 0.045
P2ry1 purinergic receptor P2Y, G-protein coupled, 1 0.044
Neb nebulin 0.043
Rpl3l ribosomal protein L3-like 0.043
Il1b interleukin 1 beta 0.043
Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.042
Tnnt3 troponin T type 3 (skeletal, fast) 0.041
Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.040
Hcrtr2 hypocretin (orexin) receptor 2 0.040
Ccr5 chemokine (C-C motif) receptor 5 0.040
Slc26a2 solute carrier family 26 (sulfate transporter), member 2 0.040
Myh4 myosin, heavy chain 4, skeletal muscle 0.040
Top2a topoisomerase (DNA) II alpha 0.039
Inpp4b inositol polyphosphate-4-phosphatase, type II 0.039
Tnni1 troponin I type 1 (skeletal, slow) 0.039
Bmp6 bone morphogenetic protein 6 0.039
Myoc myocilin 0.039
Capn6 calpain 6 0.038
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.038
Sele selectin E 0.038
Lama2 laminin, alpha 2 0.038
Utrn utrophin 0.038
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.037
Ttn titin 0.037
Cacng1 calcium channel, voltage-dependent, gamma subunit 1 0.037
Nrxn1 neurexin 1 0.037
Trim72 tripartite motif-containing 72 0.036
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.036
Itpr1 inositol 1,4,5-triphosphate receptor, type 1 0.035
Irs1 insulin receptor substrate 1 0.035
Myoz1 myozenin 1 0.034
Neu2 sialidase 2 (cytosolic sialidase) 0.034
Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult 0.034
Myom2 myomesin 2 0.034
LOC681849 similar to Protein C6orf142 homolog 0.033
Ncr1 natural cytotoxicity triggering receptor 1 0.032
Scn4b sodium channel, voltage-gated, type IV, beta 0.032
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.032
Lims1 LIM and senescent cell antigen-like domains 1 0.031
C1qtnf3 C1q and tumor necrosis factor related protein 3 0.031
Akap6 A kinase (PRKA) anchor protein 6 0.030
Selp selectin P 0.030
Asb2 ankyrin repeat and SOCS box-containing 2 0.030
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.029
Nrap nebulin-related anchoring protein 0.029
Cntn2 contactin 2 (axonal) 0.029
Kbtbd10 kelch repeat and BTB (POZ) domain containing 10 0.028
Mos Moloney sarcoma oncogene 0.028
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.028
Opcml opioid binding protein/cell adhesion molecule-like 0.027
Adrbk2 adrenergic, beta, receptor kinase 2 0.027
Cntn6 contactin 6 0.027
Atp1b4 ATPase, (Na+)/K+ transporting, beta 4 polypeptide 0.026
Cox8b cytochrome c oxidase, subunit VIIIb 0.026
Calcrl calcitonin receptor-like 0.026
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.026
Tnnc2 troponin C type 2 (fast) 0.025
Cd83 CD83 molecule 0.025
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism