IMP
Process View
The network for 'rap protein signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
rap protein signal transduction
A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Ephb2 | Eph receptor B2 | 0.996 | |
| Efnb2 | ephrin B2 | 0.988 | |
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.828 | |
| Actr3 | ARP3 actin-related protein 3 homolog (yeast) | 0.803 | |
| Epha4 | Eph receptor A4 | 0.795 | |
| Ptpn12 | protein tyrosine phosphatase, non-receptor type 12 | 0.681 | |
| Cbfb | core binding factor beta | 0.651 | |
| Sept7 | septin 7 | 0.551 | |
| Ephb3 | Eph receptor B3 | 0.521 | |
| Tpm4 | tropomyosin 4 | 0.491 | |
| Capza2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.440 | |
| Efnb1 | ephrin B1 | 0.421 | |
| Rap1b | RAS related protein 1b | 0.339 | |
| Plxna4 | plexin A4 | 0.263 | |
| Actr2 | ARP2 actin-related protein 2 homolog (yeast) | 0.258 | |
| Hey1 | hairy/enhancer-of-split related with YRPW motif 1 | 0.246 | |
| Ptp4a2 | protein tyrosine phosphatase 4a2 | 0.234 | |
| Sdcbp | syndecan binding protein | 0.205 | |
| Fam49b | family with sequence similarity 49, member B | 0.189 | |
| Pnoc | prepronociceptin | 0.180 | |
| Ltb | lymphotoxin B | 0.168 | |
| Gata5 | GATA binding protein 5 | 0.167 | |
| Htr5b | 5-hydroxytryptamine (serotonin) receptor 5B | 0.162 | |
| 2810008M24Rik | RIKEN cDNA 2810008M24 gene | 0.160 | |
| Capza1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.159 | |
| Grb2 | growth factor receptor bound protein 2 | 0.157 | |
| Mtpn | myotrophin | 0.145 | |
| Pip4k2a | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.136 | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.135 | |
| Plekhg5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | 0.133 | |
| Tmem123 | transmembrane protein 123 | 0.132 | |
| Tmeff2 | transmembrane protein with EGF-like and two follistatin-like domains 2 | 0.131 | |
| Rap2a | RAS related protein 2a | 0.128 | |
| Cdk5r1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 0.123 | |
| Efna3 | ephrin A3 | 0.121 | |
| Cdc42ep1 | CDC42 effector protein (Rho GTPase binding) 1 | 0.120 | |
| Enc1 | ectodermal-neural cortex 1 | 0.119 | |
| Braf | Braf transforming gene | 0.119 | |
| Stx7 | syntaxin 7 | 0.114 | |
| Skil | SKI-like | 0.114 | |
| Rps6ka3 | ribosomal protein S6 kinase polypeptide 3 | 0.114 | |
| Adrb1 | adrenergic receptor, beta 1 | 0.113 | |
| Tnfsf14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.108 | |
| Efna5 | ephrin A5 | 0.106 | |
| Cdc34 | cell division cycle 34 homolog (S. cerevisiae) | 0.096 | |
| Fam102b | family with sequence similarity 102, member B | 0.091 | |
| Plxna1 | plexin A1 | 0.091 | |
| Ppp1r1b | protein phosphatase 1, regulatory (inhibitor) subunit 1B | 0.089 | |
| Raf1 | v-raf-leukemia viral oncogene 1 | 0.089 | |
| Rims2 | regulating synaptic membrane exocytosis 2 | 0.087 | |
| Arpc5 | actin related protein 2/3 complex, subunit 5 | 0.086 | |
| Rab10 | RAB10, member RAS oncogene family | 0.086 | |
| Plxna2 | plexin A2 | 0.085 | |
| Picalm | phosphatidylinositol binding clathrin assembly protein | 0.083 | |
| Arhgef15 | Rho guanine nucleotide exchange factor (GEF) 15 | 0.083 | |
| Rasa2 | RAS p21 protein activator 2 | 0.081 | |
| Celsr2 | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) | 0.081 | |
| Vsx2 | visual system homeobox 2 | 0.080 | |
| Dkk3 | dickkopf homolog 3 (Xenopus laevis) | 0.079 | |
| Stk17b | serine/threonine kinase 17b (apoptosis-inducing) | 0.077 | |
| Fscn1 | fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus) | 0.077 | |
| Ngef | neuronal guanine nucleotide exchange factor | 0.077 | |
| Osbpl8 | oxysterol binding protein-like 8 | 0.076 | |
| Egr1 | early growth response 1 | 0.076 | |
| Socs5 | suppressor of cytokine signaling 5 | 0.076 | |
| Esr1 | estrogen receptor 1 (alpha) | 0.075 | |
| Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.075 | |
| Epha2 | Eph receptor A2 | 0.075 | |
| Agfg1 | ArfGAP with FG repeats 1 | 0.074 | |
| Rtkn | rhotekin | 0.073 | |
| Bzw1 | basic leucine zipper and W2 domains 1 | 0.073 | |
| Rap2c | RAP2C, member of RAS oncogene family | 0.073 | |
| Atp2a3 | ATPase, Ca++ transporting, ubiquitous | 0.071 | |
| Fam84a | family with sequence similarity 84, member A | 0.071 | |
| Tiam1 | T-cell lymphoma invasion and metastasis 1 | 0.070 | |
| Gnai3 | guanine nucleotide binding protein (G protein), alpha inhibiting 3 | 0.069 | |
| Rnf115 | ring finger protein 115 | 0.066 | |
| Kcnk2 | potassium channel, subfamily K, member 2 | 0.066 | |
| Pak2 | p21 protein (Cdc42/Rac)-activated kinase 2 | 0.065 | |
| Bin1 | bridging integrator 1 | 0.065 | |
| Plxna3 | plexin A3 | 0.065 | |
| Dusp6 | dual specificity phosphatase 6 | 0.064 | |
| Sh3rf1 | SH3 domain containing ring finger 1 | 0.063 | |
| Nf1 | neurofibromatosis 1 | 0.063 | |
| Pak3 | p21 protein (Cdc42/Rac)-activated kinase 3 | 0.062 | |
| Efs | embryonal Fyn-associated substrate | 0.061 | |
| Ap2s1 | adaptor-related protein complex 2, sigma 1 subunit | 0.060 | |
| Nipsnap3b | nipsnap homolog 3B (C. elegans) | 0.060 | |
| Adam11 | a disintegrin and metallopeptidase domain 11 | 0.060 | |
| Pou3f1 | POU domain, class 3, transcription factor 1 | 0.060 | |
| Sorcs3 | sortilin-related VPS10 domain containing receptor 3 | 0.059 | |
| Nr4a2 | nuclear receptor subfamily 4, group A, member 2 | 0.058 | |
| Fjx1 | four jointed box 1 (Drosophila) | 0.057 | |
| Acot9 | acyl-CoA thioesterase 9 | 0.057 | |
| Ugcg | UDP-glucose ceramide glucosyltransferase | 0.057 | |
| Src | Rous sarcoma oncogene | 0.056 | |
| Sh3glb1 | SH3-domain GRB2-like B1 (endophilin) | 0.055 | |
| Mmp16 | matrix metallopeptidase 16 | 0.055 | |
| Syt1 | synaptotagmin I | 0.055 | |
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.055 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| ABI1 | abl-interactor 1 | 0.989 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.989 | |
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.988 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.950 | |
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.944 | |
| RASSF5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.927 | |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.897 | |
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.862 | |
| EGFR | epidermal growth factor receptor | 0.858 | |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.805 | |
| RALGDS | ral guanine nucleotide dissociation stimulator | 0.654 | |
| CLASP1 | cytoplasmic linker associated protein 1 | 0.646 | |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | 0.623 | |
| LAT | linker for activation of T cells | 0.576 | |
| FGFR1 | fibroblast growth factor receptor 1 | 0.488 | |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.462 | |
| WASL | Wiskott-Aldrich syndrome-like | 0.457 | |
| GRB2 | growth factor receptor-bound protein 2 | 0.432 | |
| DNM1 | dynamin 1 | 0.390 | |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.359 | |
| PLCG1 | phospholipase C, gamma 1 | 0.358 | |
| ABL2 | v-abl Abelson murine leukemia viral oncogene homolog 2 | 0.356 | |
| MAP4K1 | mitogen-activated protein kinase kinase kinase kinase 1 | 0.350 | |
| RAP1A | RAP1A, member of RAS oncogene family | 0.337 | |
| GAB1 | GRB2-associated binding protein 1 | 0.302 | |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.296 | |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 0.283 | |
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.267 | |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.246 | |
| CBLB | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 0.227 | |
| CSNK1G2 | casein kinase 1, gamma 2 | 0.222 | |
| RIN1 | Ras and Rab interactor 1 | 0.200 | |
| STK4 | serine/threonine kinase 4 | 0.191 | |
| GAB2 | GRB2-associated binding protein 2 | 0.183 | |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.175 | |
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.172 | |
| NCK1 | NCK adaptor protein 1 | 0.171 | |
| MEOX2 | mesenchyme homeobox 2 | 0.168 | |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.153 | |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.152 | |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.146 | |
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.127 | |
| PTCHD2 | patched domain containing 2 | 0.125 | |
| RUNDC3A | RUN domain containing 3A | 0.102 | |
| DYNC1I1 | dynein, cytoplasmic 1, intermediate chain 1 | 0.098 | |
| PKN2 | protein kinase N2 | 0.092 | |
| BCR | breakpoint cluster region | 0.091 | |
| CDK17 | cyclin-dependent kinase 17 | 0.091 | |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.087 | |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 0.087 | |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.083 | |
| ATP8 | ATP synthase F0 subunit 8 | 0.074 | |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4 | 0.072 | |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.058 | |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.055 | |
| STK3 | serine/threonine kinase 3 | 0.054 | |
| CORO1C | coronin, actin binding protein, 1C | 0.054 | |
| BAG1 | BCL2-associated athanogene | 0.053 | |
| SH3PXD2A | SH3 and PX domains 2A | 0.050 | |
| PXN | paxillin | 0.045 | |
| PIK3AP1 | phosphoinositide-3-kinase adaptor protein 1 | 0.043 | |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.043 | |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.041 | |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.040 | |
| DNM2 | dynamin 2 | 0.040 | |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.040 | |
| RAP1B | RAP1B, member of RAS oncogene family | 0.036 | |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.036 | |
| BRAF | v-raf murine sarcoma viral oncogene homolog B1 | 0.035 | |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.035 | |
| AXL | AXL receptor tyrosine kinase | 0.033 | |
| MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.033 | |
| DGKZ | diacylglycerol kinase, zeta | 0.032 | |
| PEBP1 | phosphatidylethanolamine binding protein 1 | 0.031 | |
| REPS2 | RALBP1 associated Eps domain containing 2 | 0.031 | |
| PTPRA | protein tyrosine phosphatase, receptor type, A | 0.030 | |
| KRT8 | keratin 8 | 0.029 | |
| RHOU | ras homolog gene family, member U | 0.029 | |
| SHCBP1 | SHC SH2-domain binding protein 1 | 0.028 | |
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.028 | |
| MAPK8 | mitogen-activated protein kinase 8 | 0.027 | |
| BLNK | B-cell linker | 0.027 | |
| LY6G6F | lymphocyte antigen 6 complex, locus G6F | 0.027 | |
| HIPK1 | homeodomain interacting protein kinase 1 | 0.026 | |
| CENPE | centromere protein E, 312kDa | 0.026 | |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.026 | |
| PAK2 | p21 protein (Cdc42/Rac)-activated kinase 2 | 0.026 | |
| RHEB | Ras homolog enriched in brain | 0.026 | |
| CLTB | clathrin, light chain B | 0.025 | |
| ADRBK1 | adrenergic, beta, receptor kinase 1 | 0.024 | |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.024 | |
| SPRR2A | small proline-rich protein 2A | 0.024 | |
| RAP2C | RAP2C, member of RAS oncogene family | 0.023 | |
| MAP2 | microtubule-associated protein 2 | 0.023 | |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.022 | |
| NCKAP1 | NCK-associated protein 1 | 0.022 | |
| NEB | nebulin | 0.022 | |
| DR1 | down-regulator of transcription 1, TBP-binding (negative cofactor 2) | 0.022 | |
| SAMD4A | sterile alpha motif domain containing 4A | 0.021 | |
| KIF5B | kinesin family member 5B | 0.021 |