IMP
Process View
The network for 'negative regulation of serine type peptidase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of serine type peptidase activity
Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Serpina3k | serine (or cysteine) peptidase inhibitor, clade A, member 3K | 0.998 | |
| Spink1 | serine peptidase inhibitor, Kazal type 1 | 0.968 | |
| Apcs | amyloid P component, serum | 0.742 | |
| Asgr1 | asialoglycoprotein receptor 1 | 0.683 | |
| Proc | protein C | 0.636 | |
| Cyp3a2 | cytochrome P450, family 3, subfamily a, polypeptide 2 | 0.564 | |
| Apoh | apolipoprotein H (beta-2-glycoprotein I) | 0.463 | |
| Alb | albumin | 0.457 | |
| Ahsg | alpha-2-HS-glycoprotein | 0.455 | |
| Ambp | alpha-1-microglobulin/bikunin precursor | 0.442 | |
| Fabp1 | fatty acid binding protein 1, liver | 0.396 | |
| Apoa5 | apolipoprotein A-V | 0.346 | |
| Dmgdh | dimethylglycine dehydrogenase | 0.270 | |
| Spp2 | secreted phosphoprotein 2 | 0.263 | |
| Serpina11 | serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 | 0.246 | |
| Azgp1 | alpha-2-glycoprotein 1, zinc-binding | 0.241 | |
| Pemt | phosphatidylethanolamine N-methyltransferase | 0.211 | |
| A1i3 | alpha-1-inhibitor III | 0.207 | |
| Acsm2 | acyl-CoA synthetase medium-chain family member 2 | 0.171 | |
| Ugt2b | UDP glycosyltransferase 2 family, polypeptide B | 0.164 | |
| Orm1 | orosomucoid 1 | 0.158 | |
| Rup2 | urinary protein 2 | 0.153 | |
| LOC299282 | Serine protease inhibitor | 0.151 | |
| F2 | coagulation factor II (thrombin) | 0.119 | |
| Apoa2 | apolipoprotein A-II | 0.118 | |
| Kynu | kynureninase (L-kynurenine hydrolase) | 0.114 | |
| Hpd | 4-hydroxyphenylpyruvate dioxygenase | 0.102 | |
| Cyp2a2 | cytochrome P450, family 2, subfamily a, polypeptide 2 | 0.100 | |
| Gucy1b2 | guanylate cyclase 1, soluble, beta 2 | 0.086 | |
| Serpind1 | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | 0.083 | |
| Fga | fibrinogen alpha chain | 0.079 | |
| Abcb11 | ATP-binding cassette, subfamily B (MDR/TAP), member 11 | 0.076 | |
| Serpina3n | serine (or cysteine) peptidase inhibitor, clade A, member 3N | 0.062 | |
| Hpx | hemopexin | 0.055 | |
| Slc27a5 | solute carrier family 27 (fatty acid transporter), member 5 | 0.052 | |
| C9 | complement component 9 | 0.052 | |
| Slco1b3 | solute carrier organic anion transporter family, member 1b3 | 0.051 | |
| LOC100361261 | rCG23560-like | 0.049 | |
| Lbp | lipopolysaccharide binding protein | 0.047 | |
| Slc10a1 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1 | 0.046 | |
| Apoa4 | apolipoprotein A-IV | 0.042 | |
| Cyp2d1 | cytochrome P450, family 2, subfamily d, polypeptide 1 | 0.039 | |
| Pzp | pregnancy-zone protein | 0.037 | |
| Serpina1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.037 | |
| Sult1b1 | sulfotransferase family, cytosolic, 1B, member 1 | 0.036 | |
| Hsd17b6 | hydroxysteroid (17-beta) dehydrogenase 6 | 0.035 | |
| Prodh2 | proline dehydrogenase (oxidase) 2 | 0.035 | |
| Baat | bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) | 0.035 | |
| Serpina7 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 | 0.033 | |
| Lipc | lipase, hepatic | 0.033 | |
| Gc | group specific component | 0.032 | |
| A2m | alpha-2-macroglobulin | 0.032 | |
| Slco1a4 | solute carrier organic anion transporter family, member 1a4 | 0.028 | |
| C4bpb | complement component 4 binding protein, beta | 0.027 | |
| Masp2 | mannan-binding lectin serine peptidase 2 | 0.026 | |
| Sult1c3 | sulfotransferase family, cytosolic, 1C, member 3 | 0.026 | |
| Serpina4 | serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 | 0.026 | |
| Serpinb5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.025 | |
| Fabp12 | fatty acid binding protein 12 | 0.025 | |
| Nr1h4 | nuclear receptor subfamily 1, group H, member 4 | 0.024 | |
| Kng1 | kininogen 1 | 0.024 | |
| Cyp4a10 | cytochrome P450, family 4, subfamily a, polypeptide 10 | 0.024 | |
| Cyp2d3 | cytochrome P450, family 2, subfamily d, polypeptide 3 | 0.024 | |
| Tdo2 | tryptophan 2,3-dioxygenase | 0.024 | |
| Nr5a2 | nuclear receptor subfamily 5, group A, member 2 | 0.023 | |
| Cyp4f1 | cytochrome P450, family 4, subfamily f, polypeptide 1 | 0.022 | |
| Asgr2 | asialoglycoprotein receptor 2 | 0.022 | |
| Slc22a7 | solute carrier family 22 (organic anion transporter), member 7 | 0.021 | |
| Pah | phenylalanine hydroxylase | 0.020 | |
| Cyp2d2 | cytochrome P450, family 2, subfamily d, polypeptide 2 | 0.020 | |
| RGD1560925 | similar to 2610034M16Rik protein | 0.020 | |
| Afm | afamin | 0.020 | |
| RGD1564599 | RGD1564599 | 0.019 | |
| Klkb1 | kallikrein B, plasma 1 | 0.019 | |
| Odf3b | outer dense fiber of sperm tails 3B | 0.019 | |
| Vill | villin-like | 0.019 | |
| Gfap | glial fibrillary acidic protein | 0.019 | |
| C8b | complement component 8, beta polypeptide | 0.019 | |
| Prl8a4 | prolactin family 8, subfamily a, member 4 | 0.018 | |
| Foxa2 | forkhead box A2 | 0.018 | |
| Acsm5 | acyl-CoA synthetase medium-chain family member 5 | 0.018 | |
| Gckr | glucokinase (hexokinase 4) regulator | 0.017 | |
| Ces1c | carboxylesterase 1C | 0.016 | |
| Gpx2 | glutathione peroxidase 2 | 0.016 | |
| Thrsp | thyroid hormone responsive | 0.016 | |
| F12 | coagulation factor XII (Hageman factor) | 0.015 | |
| Mug1 | murinoglobulin 1 | 0.015 | |
| Agxt2 | alanine-glyoxylate aminotransferase 2 | 0.015 | |
| Serpina6 | serine (or cysteine) peptidase inhibitor, clade A, member 6 | 0.015 | |
| Pon1 | paraoxonase 1 | 0.014 | |
| Itih4 | inter alpha-trypsin inhibitor, heavy chain 4 | 0.014 | |
| Scgb2a2 | secretoglobin, family 2A, member 2 | 0.014 | |
| Otc | ornithine carbamoyltransferase | 0.014 | |
| Mst1 | Macrophage stimulating 1 (hepatocyte growth factor-like) | 0.014 | |
| Fgb | fibrinogen beta chain | 0.013 | |
| Kng2 | kininogen 2 | 0.013 | |
| Hsd17b2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.013 | |
| Mcpt4 | mast cell protease 4 | 0.013 | |
| Serpinc1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 0.013 | |
| Rab17 | RAB17, member RAS oncogene family | 0.013 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| S100A10 | S100 calcium binding protein A10 | 0.999 | |
| ANXA5 | annexin A5 | 0.984 | |
| ANXA1 | annexin A1 | 0.894 | |
| ANXA2 | annexin A2 | 0.662 | |
| FN1 | fibronectin 1 | 0.561 | |
| S100A11 | S100 calcium binding protein A11 | 0.506 | |
| VIM | vimentin | 0.331 | |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.309 | |
| ANXA4 | annexin A4 | 0.233 | |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.230 | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.189 | |
| AHNAK | AHNAK nucleoprotein | 0.187 | |
| MSN | moesin | 0.164 | |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 0.142 | |
| EMP1 | epithelial membrane protein 1 | 0.110 | |
| CAST | calpastatin | 0.070 | |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.060 | |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.055 | |
| MYOF | myoferlin | 0.054 | |
| CTSB | cathepsin B | 0.052 | |
| EMP3 | epithelial membrane protein 3 | 0.050 | |
| NMT2 | N-myristoyltransferase 2 | 0.048 | |
| S100A6 | S100 calcium binding protein A6 | 0.042 | |
| HEXB | hexosaminidase B (beta polypeptide) | 0.039 | |
| SSR1 | signal sequence receptor, alpha | 0.037 | |
| ITGB5 | integrin, beta 5 | 0.035 | |
| NPC2 | Niemann-Pick disease, type C2 | 0.033 | |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | 0.032 | |
| S100A4 | S100 calcium binding protein A4 | 0.028 | |
| ANXA3 | annexin A3 | 0.026 | |
| TUBB6 | tubulin, beta 6 | 0.023 | |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.023 | |
| ACOT9 | acyl-CoA thioesterase 9 | 0.023 | |
| CLIC1 | chloride intracellular channel 1 | 0.020 | |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | 0.020 | |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.020 | |
| CAV2 | caveolin 2 | 0.019 | |
| SDCBP | syndecan binding protein (syntenin) | 0.018 | |
| CORO1C | coronin, actin binding protein, 1C | 0.018 | |
| CD59 | CD59 molecule, complement regulatory protein | 0.017 | |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.017 | |
| AHR | aryl hydrocarbon receptor | 0.013 | |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.012 | |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | 0.011 | |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.011 | |
| CD58 | CD58 molecule | 0.011 | |
| MYL12B | myosin, light chain 12B, regulatory | 0.011 | |
| KLF4 | Kruppel-like factor 4 (gut) | 0.011 | |
| IL13RA1 | interleukin 13 receptor, alpha 1 | 0.010 | |
| BAG3 | BCL2-associated athanogene 3 | 0.010 |