The network for 'lamellipodium assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lamellipodium assembly

Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.

Name Description Probability Func Analog Organism
cdc42 cell division cycle 42 0.328
igfbp3 insulin-like growth factor binding protein 3 0.223
robo1 roundabout homolog 1 0.155
gab1 GRB2-associated binding protein 1 0.120
waca WW domain containing adaptor with coiled-coil a 0.113
wnt4a wingless-type MMTV integration site family, member 4a 0.103
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.103
ythdf1 YTH domain family, member 1 0.101
gsna gelsolin a 0.100
sncb synuclein, beta 0.095
nrp2b neuropilin 2b 0.094
arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.093
mitfa microphthalmia-associated transcription factor a 0.086
rhoab ras homolog gene family, member Ab 0.083
ptprfb protein tyrosine phosphatase, receptor type, f, b 0.081
dvl2 dishevelled, dsh homolog 2 (Drosophila) 0.080
dag1 dystroglycan 1 0.080
gfi1.1 growth factor independent 1.1 0.075
fzd7a frizzled homolog 7a 0.075
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.073
sept8a septin 8a 0.071
ap1g1 adaptor-related protein complex 1, gamma 1 subunit 0.070
stm starmaker 0.069
cotl1 coactosin-like 1 (Dictyostelium) 0.067
zgc:91930 zgc:91930 0.067
me2 malic enzyme 2, NAD(+)-dependent, mitochondrial 0.066
acta1a actin, alpha 1a, skeletal muscle 0.065
cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.063
stac3 SH3 and cysteine rich domain 3 0.062
lta4h leukotriene A4 hydrolase 0.060
atp6v1al ATPase, H+ transporting, lysosomal V1 subunit A, like 0.058
aldoab aldolase a, fructose-bisphosphate, b 0.058
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.057
p4ha2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 0.056
rcn1 reticulocalbin 1, EF-hand calcium binding domain 0.055
xirp1 xin actin-binding repeat containing 1 0.055
lhx2b LIM homeobox 2b 0.054
oep one-eyed pinhead 0.053
spry4 sprouty (Drosophila) homolog 4 0.052
zgc:66286 zgc:66286 0.052
gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.052
gsk3b glycogen synthase kinase 3 beta 0.051
map2k6 mitogen-activated protein kinase kinase 6 0.051
ndel1a nudE nuclear distribution gene E homolog like 1 (A. nidulans) A 0.051
bactin1 bactin1 0.050
gng3 guanine nucleotide binding protein (G protein), gamma 3 0.049
spry2 sprouty homolog 2 0.049
hk1 hexokinase 1 0.048
cnn2 calponin 2 0.048
ppm1aa protein phosphatase, Mg2+/Mn2+ dependent, 1Aa 0.048
kif7 kinesin family member 7 0.048
copeb core promoter element binding protein 0.048
cyt1 type I cytokeratin, enveloping layer 0.048
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.048
dzip1 DAZ interacting protein 1 0.045
ergic2 ERGIC and golgi 2 0.045
im:7154036 im:7154036 0.045
mknk2b MAP kinase-interacting serine/threonine kinase 2b 0.045
flot1b flotillin 1b 0.045
cdh2 cadherin 2, neuronal 0.045
zgc:113625 zgc:113625 0.044
arpc5b actin related protein 2/3 complex, subunit 5B 0.044
myl9l myosin, light polypeptide 9, like 0.043
msxb muscle segment homeobox B 0.043
ube2i2 ubiquitin-conjugating enzyme E2I2 0.042
vdac3 voltage-dependent anion channel 3 0.042
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.042
snd1 staphylococcal nuclease domain containing 1 0.041
ahcyl1 S-adenosylhomocysteine hydrolase-like 1 0.041
ift46 intraflagellar transport protein 46 0.041
tcea1 transcription elongation factor A (SII), 1 0.041
taf1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.041
wdr1 WD repeat domain 1 0.040
acsbg2 acyl-CoA synthetase bubblegum family member 2 0.040
fgfr3 fibroblast growth factor receptor 3 0.040
zgc:195154 zgc:195154 0.040
id:ibd2050 id:ibd2050 0.039
skia nuclear oncoprotein skia 0.039
ap2m1a adaptor-related protein complex 2, mu 1 subunit, a 0.039
smyhc1 slow myosin heavy chain 1 0.038
ephb4b eph receptor B4b 0.038
tbx2b T-box 2b 0.038
rc3 rabconnectin 3 0.038
cdk8 cyclin-dependent kinase 8 0.038
bnip3lb BCL2/adenovirus E1B interacting protein 3-like b 0.038
wnt10a wingless-type MMTV integration site family, member 10a 0.037
nsfa N-ethylmaleimide-sensitive factor a 0.037
actr3 ARP3 actin-related protein 3 homolog (yeast) 0.037
ctnnb1 catenin (cadherin-associated protein), beta 1 0.037
ywhag1 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1 0.037
map4k5 mitogen-activated protein kinase kinase kinase kinase 5 0.037
ppp2r2d protein phosphatase 2, regulatory subunit B, delta isoform 0.036
midn midnolin 0.036
irx3a iroquois homeobox protein 3a 0.036
axin1 axin 1 0.035
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.035
tp63 tumor protein p63 0.035
mycbp2 MYC binding protein 2 0.035
aldoaa aldolase a, fructose-bisphosphate, a 0.035
ulk2 unc-51-like kinase 2 (C. elegans) 0.034
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
cdc-42 Protein CDC-42 0.517
mig-2 Protein MIG-2 0.301
unc-96 Protein UNC-96 0.181
hmp-1 Protein HMP-1 0.175
unc-32 Protein UNC-32 0.168
C06G3.6 Protein C06G3.6 0.161
ina-1 Protein INA-1 0.143
lmn-1 Protein LMN-1 0.118
goa-1 Protein GOA-1 0.118
sax-3 Protein SAX-3 0.113
CELE_T04H1.2 Protein T04H1.2 0.101
unc-73 Protein UNC-73 0.100
C52B9.4 Protein C52B9.4 0.094
etr-1 Protein ETR-1 0.093
cam-1 Protein CAM-1 0.093
arx-1 Protein ARX-1 0.093
ced-10 Protein CED-10 0.092
vps-32.1 Protein VPS-32.1 0.092
unc-16 Protein UNC-16 0.089
unc-9 Protein UNC-9 0.083
pkn-1 Protein PKN-1 0.080
clh-5 Protein CLH-5 0.080
unc-104 Protein UNC-104 0.079
unc-36 Protein UNC-36 0.078
gsp-1 Protein GSP-1 0.070
air-2 Protein AIR-2 0.065
sel-12 Protein SEL-12 0.061
unc-108 Protein UNC-108 0.058
pph-4.1 Protein PPH-4.1 0.058
rgs-7 Protein RGS-7 0.058
lir-1 Protein LIR-1 0.056
F38A5.1 Protein F38A5.1 0.055
CELE_B0238.10 Protein B0238.10 0.055
syg-1 Protein SYG-1 0.054
EEED8.10 Protein EEED8.10 0.053
rig-4 Protein RIG-4 0.043
memb-1 Protein MEMB-1 0.043
K10C3.4 Protein K10C3.4 0.041
tag-175 Protein TAG-175 0.041
Y77E11A.1 Protein Y77E11A.1 0.041
cpna-5 Protein CPNA-5 0.041
pqn-55 Protein PQN-55 0.041
gmeb-1 Protein GMEB-1 0.040
tba-1 Protein TBA-1 0.039
unc-60 Protein UNC-60 0.039
C24A3.2 Protein C24A3.2 0.036
acs-17 Protein ACS-17 0.035
mab-5 Protein MAB-5 0.035
hid-1 Protein HID-1 0.035
abl-1 Protein ABL-1 0.035
C11E4.6 Protein C11E4.6 0.034
cdf-1 Protein CDF-1 0.034
sem-5 Protein SEM-5 0.034
snf-1 Protein SNF-1 0.034
C34F6.10 Protein C34F6.10 0.033
gex-3 Protein GEX-3 0.032
hlh-30 Protein HLH-30 0.032
emb-9 Protein EMB-9 0.032
F21A10.2 Protein F21A10.2 0.032
C11H1.3 Protein C11H1.3 0.032
C18A3.4 Protein C18A3.4 0.031
glit-1 Protein GLIT-1 0.031
pat-3 Protein PAT-3 0.031
C06G1.5 Protein C06G1.5 0.031
unc-68 Protein UNC-68 0.030
ykt-6 Protein YKT-6 0.030
rsbp-1 Protein RSBP-1 0.028
tag-241 Protein TAG-241 0.028
C46C11.1 Protein C46C11.1 0.028
atg-11 Protein ATG-11 0.028
ost-1 Protein OST-1 0.028
T04F8.6 Protein T04F8.6 0.028
dpm-1 Protein DPM-1 0.028
nhr-49 Protein NHR-49 0.027
sorb-1 Protein SORB-1 0.027
cst-1 Protein CST-1 0.027
twk-31 Protein TWK-31 0.027
D2013.6 Protein D2013.6 0.027
C18E9.2 Protein C18E9.2 0.026
scpl-2 Protein SCPL-2 0.026
T19A6.1 Protein T19A6.1 0.026
T03G6.3 Protein T03G6.3 0.025
swan-2 Protein SWAN-2 0.025
xnp-1 Protein XNP-1 0.025
W06A7.2 Protein W06A7.2 0.025
tat-5 Protein TAT-5 0.024
F41H10.3 Protein F41H10.3 0.024
sad-1 Protein SAD-1 0.024
sor-1 Protein SOR-1 0.024
ehs-1 Protein EHS-1 0.024
F54E4.3 Protein F54E4.3 0.023
R151.8 Protein R151.8 0.023
C52E12.4 Protein C52E12.4 0.023
K04G7.1 Protein K04G7.1 0.022
unc-50 Protein UNC-50 0.022
mig-38 Protein MIG-38 0.022
cdh-4 Protein CDH-4 0.022
smgl-1 Protein SMGL-1 0.022
C41H7.5 Protein C41H7.5 0.022
F22D3.2 Protein F22D3.2 0.022
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rac1 CG2248 gene product from transcript CG2248-RA 0.522
mbc myoblast city 0.515
Hem HEM-protein 0.513
Rho1 CG8416 gene product from transcript CG8416-RB 0.504
Ephrin CG1862 gene product from transcript CG1862-RA 0.416
Sra-1 specifically Rac1-associated protein 1 0.384
robo roundabout 0.372
cpb capping protein beta 0.343
da daughterless 0.326
chic chickadee 0.325
Arp66B Actin-related protein 66B 0.313
ena enabled 0.309
Vrp1 Verprolin 1 0.283
Rac2 CG8556 gene product from transcript CG8556-RA 0.184
par-1 CG8201 gene product from transcript CG8201-RA 0.181
S6k RPS6-p70-protein kinase 0.158
Sop2 Suppressor of profilin 2 0.151
Arp14D Actin-related protein 14D 0.119
RanBPM Ran-binding protein M 0.089
Dlic Dynein light intermediate chain 0.088
Abl Abl tyrosine kinase 0.079
Arc-p34 CG10954 gene product from transcript CG10954-RA 0.077
Mrtf Myocardin-related transcription factor 0.073
cta concertina 0.068
Pak3 CG14895 gene product from transcript CG14895-RA 0.066
numb CG3779 gene product from transcript CG3779-RB 0.057
Src64B Src oncogene at 64B 0.054
baz bazooka 0.053
l(2)k16918 lethal (2) k16918 0.052
wb wing blister 0.051
twi twist 0.050
Dcr-1 Dicer-1 0.049
Myo31DF Myosin 31DF 0.048
Abi Abelson interacting protein 0.047
twf twinfilin 0.045
zfh1 Zn finger homeodomain 1 0.044
BicD Bicaudal D 0.043
Rpn6 Proteasome p44.5 subunit 0.041
Rala Ras-related protein 0.040
mid midline 0.040
mats mob as tumor suppressor 0.040
lqfR liquid facets-Related 0.038
comm commissureless 0.037
sim single-minded 0.036
Dscam Down syndrome cell adhesion molecule 0.035
CG17082 CG17082 gene product from transcript CG17082-RD 0.033
kon kon-tiki 0.032
bsk basket 0.032
flr flare 0.032
cpa capping protein alpha 0.032
Chc Clathrin heavy chain 0.031
Ilk Integrin linked kinase 0.031
Six4 CG3871 gene product from transcript CG3871-RA 0.030
FucT6 alpha1,6-fucosyltransferase 0.030
CG14869 CG14869 gene product from transcript CG14869-RB 0.030
tai taiman 0.029
sli slit 0.029
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.028
kuz kuzbanian 0.028
pll pelle 0.028
pod1 CG4532 gene product from transcript CG4532-RF 0.028
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.027
otk off-track 0.027
LamC Lamin C 0.027
Gyc76C Guanylyl cyclase at 76C 0.026
trio CG18214 gene product from transcript CG18214-RA 0.026
p120ctn Adherens junction protein p120 0.026
Wnt5 Wnt oncogene analog 5 0.025
exba extra bases 0.025
RhoGAPp190 CG32555 gene product from transcript CG32555-RB 0.024
Cortactin CG3637 gene product from transcript CG3637-RA 0.024
msn misshapen 0.024
RhoGAP93B CG3421 gene product from transcript CG3421-RA 0.024
CG3563 CG3563 gene product from transcript CG3563-RA 0.023
hkb huckebein 0.023
lace CG4162 gene product from transcript CG4162-RA 0.023
btl breathless 0.023
in inturned 0.023
Pros25 Proteasome 25kD subunit 0.022
Cdc42 CG12530 gene product from transcript CG12530-RA 0.022
tup tailup 0.022
bin biniou 0.021
lea leak 0.020
Arf51F ADP ribosylation factor 51F 0.020
Pkc98E Protein C kinase 98E 0.020
HSPC300 CG30173 gene product from transcript CG30173-RA 0.020
fz frizzled 0.019
Lim3 CG10699 gene product from transcript CG10699-RB 0.019
blow blown fuse 0.019
Stat92E Signal-transducer and activator of transcription protein at 92E 0.018
rols rolling pebbles 0.018
CG11791 CG11791 gene product from transcript CG11791-RB 0.018
hd humpty dumpty 0.017
zip zipper 0.017
beta-Spec beta Spectrin 0.016
spo spook 0.016
kel kelch 0.015
kni knirps 0.015
Pak PAK-kinase 0.015
Tl Toll 0.015
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Homo sapiens
Name Description Probability Func Analog Organism
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.990
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.982
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.916
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.865
ILK integrin-linked kinase 0.844
BAIAP2 BAI1-associated protein 2 0.648
GRB7 growth factor receptor-bound protein 7 0.637
ZNF746 zinc finger protein 746 0.618
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.377
GAS7 growth arrest-specific 7 0.323
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.323
PRKCZ protein kinase C, zeta 0.303
VAV1 vav 1 guanine nucleotide exchange factor 0.265
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.226
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.210
NCKAP1 NCK-associated protein 1 0.202
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.196
JUP junction plakoglobin 0.171
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.170
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.169
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.166
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.163
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.156
SH3GL3 SH3-domain GRB2-like 3 0.119
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.117
TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila) 0.116
PLCG1 phospholipase C, gamma 1 0.110
LRRK2 leucine-rich repeat kinase 2 0.109
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.098
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.098
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.097
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.096
CD2AP CD2-associated protein 0.089
ATN1 atrophin 1 0.086
MAPK8 mitogen-activated protein kinase 8 0.084
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.083
CAPZB capping protein (actin filament) muscle Z-line, beta 0.081
LIMS1 LIM and senescent cell antigen-like domains 1 0.074
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.070
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.060
NUMB numb homolog (Drosophila) 0.060
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.059
EPS8 epidermal growth factor receptor pathway substrate 8 0.054
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.051
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.050
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.046
SORBS3 sorbin and SH3 domain containing 3 0.045
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.044
PFN1 profilin 1 0.043
LDOC1 leucine zipper, down-regulated in cancer 1 0.043
HCK hemopoietic cell kinase 0.042
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.042
PFDN1 prefoldin subunit 1 0.039
LLGL1 lethal giant larvae homolog 1 (Drosophila) 0.037
EFNA5 ephrin-A5 0.037
ABI2 abl-interactor 2 0.037
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.036
EFNA1 ephrin-A1 0.036
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.034
DOCK1 dedicator of cytokinesis 1 0.034
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.033
TRIP6 thyroid hormone receptor interactor 6 0.032
WASF1 WAS protein family, member 1 0.031
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.031
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.031
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.030
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.029
GRB10 growth factor receptor-bound protein 10 0.029
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.029
TRIP10 thyroid hormone receptor interactor 10 0.027
FYB FYN binding protein 0.027
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.026
FASLG Fas ligand (TNF superfamily, member 6) 0.025
PRKCI protein kinase C, iota 0.025
WASL Wiskott-Aldrich syndrome-like 0.025
DSG2 desmoglein 2 0.024
NCKIPSD NCK interacting protein with SH3 domain 0.024
TCF4 transcription factor 4 0.024
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.023
KITLG KIT ligand 0.023
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.023
PKP3 plakophilin 3 0.023
SH2D1A SH2 domain containing 1A 0.022
DEF6 differentially expressed in FDCP 6 homolog (mouse) 0.022
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.022
LRP6 low density lipoprotein receptor-related protein 6 0.022
CTNND1 catenin (cadherin-associated protein), delta 1 0.022
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.022
NPTN neuroplastin 0.021
FERMT2 fermitin family member 2 0.021
FZD1 frizzled homolog 1 (Drosophila) 0.020
CHRD chordin 0.020
ZNF71 zinc finger protein 71 0.020
IRS1 insulin receptor substrate 1 0.019
PARVA parvin, alpha 0.019
PTK6 PTK6 protein tyrosine kinase 6 0.019
SNAI1 snail homolog 1 (Drosophila) 0.019
RICTOR RPTOR independent companion of MTOR, complex 2 0.018
MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.018
COTL1 coactosin-like 1 (Dictyostelium) 0.018
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism