The network for 'negative regulation of synapse assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of synapse assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.

Danio rerio
Name Description Probability Func Analog Organism
nf1a neurofibromin 1a 0.612
robo2 roundabout homolog 2 0.534
slit2 slit (Drosophila) homolog 2 0.457
slit3 slit (Drosophila) homolog 3 0.436
slc17a6b solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b 0.418
ptpra protein tyrosine phosphatase, receptor type, A 0.364
lhx2b LIM homeobox 2b 0.349
twist3 twist3 0.347
lama4 laminin, alpha 4 0.327
pcdh8 protocadherin 8 0.282
ikzf5 IKAROS family zinc finger 5 0.282
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.273
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.253
antxr1 anthrax toxin receptor 1 0.235
kdelr3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 0.232
btr30 bloodthirsty-related gene family, member 30 0.213
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.208
plxnb2a plexin b2a 0.203
cd99l2 CD99 antigen-like 2 0.191
robo3 roundabout homolog 3 0.190
btk Bruton agammaglobulinemia tyrosine kinase 0.178
lpp LIM domain containing preferred translocation partner in lipoma 0.166
mef2d myocyte enhancer factor 2d 0.153
akap12b A kinase (PRKA) anchor protein (gravin) 12b 0.151
slit1b slit homolog 1b (Drosophila) 0.150
skia nuclear oncoprotein skia 0.148
ldb2a LIM-domain binding factor 2a 0.145
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.142
tcf12 transcription factor 12 0.137
spna2 spectrin alpha 2 0.135
cyfip2 cytoplasmic FMR1 interacting protein 2 0.134
gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a 0.132
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.128
antxr2a anthrax toxin receptor 2a 0.123
zdhhc8b zinc finger, DHHC-type containing 8b 0.115
celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 0.115
tmem88a transmembrane protein 88 a 0.114
srsf2 serine/arginine-rich splicing factor 2 0.111
slit1a slit homolog 1a (Drosophila) 0.110
cstf3 cleavage stimulation factor, 3' pre-RNA, subunit 3 0.110
ss18 synovial sarcoma translocation, chromosome 18 (H. sapiens) 0.109
col14a1 collagen, type XIV, alpha 1 0.108
mapk1 mitogen-activated protein kinase 1 0.107
efnb2a ephrin B2a 0.105
pxn paxillin 0.104
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.102
boc brother of CDO 0.101
agtr2 angiotensin II receptor, type 2 0.101
znf703 zinc finger protein 703 0.100
gsna gelsolin a 0.093
zgc:101724 zgc:101724 0.091
trim8 tripartite motif-containing 8 0.091
si:dkey-204a24.2 si:dkey-204a24.2 0.090
zbtb4 zinc finger and BTB domain containing 4 0.090
ncor2 nuclear receptor co-repressor 2 0.089
fli1b friend leukemia integration 1b 0.089
acvr1l activin A receptor, type I like 0.089
gng3 guanine nucleotide binding protein (G protein), gamma 3 0.086
tnc tenascin C 0.086
zgc:112257 zgc:112257 0.085
ptpn11a protein tyrosine phosphatase, non-receptor type 11, a 0.085
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.083
nf1b neurofibromin 1b 0.081
msxd muscle segment homeobox D 0.081
angpt1 angiopoietin 1 0.079
midn midnolin 0.078
prpf40a PRP40 pre-mRNA processing factor 40 homolog A (yeast) 0.076
axin1 axin 1 0.076
hoxd3a homeo box D3a 0.076
ndel1a nudE nuclear distribution gene E homolog like 1 (A. nidulans) A 0.074
si:ch211-232m7.1 si:ch211-232m7.1 0.074
ptger4a prostaglandin E receptor 4 (subtype EP4) a 0.073
vasp vasodilator-stimulated phosphoprotein 0.071
esyt3 extended synaptotagmin-like protein 3 0.070
gng5 guanine nucleotide binding protein (G protein), gamma 5 0.069
rbl1 retinoblastoma-like 1 (p107) 0.069
scn1lab sodium channel, voltage-gated, type I like, alpha b 0.068
phc2 polyhomeotic-like 2 (Drosophila) 0.068
fcho2 FCH domain only 2 0.068
copz1 coatomer protein complex, subunit zeta 1 0.067
hgd homogentisate 1,2-dioxygenase 0.067
ube2v2 ubiquitin-conjugating enzyme E2 variant 2 0.066
rnf128a ring finger protein 128a 0.066
kpna4 karyopherin alpha 4 (importin alpha 3) 0.066
sardh sarcosine dehydrogenase 0.065
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.065
eomesb eomesodermin homolog b 0.064
ptprb protein tyrosine phosphatase, receptor type, b 0.064
si:ch211-272f3.4 si:ch211-272f3.4 0.063
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.062
ptk2.1 protein tyrosine kinase 2a 0.062
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.061
styk1 serine/threonine/tyrosine kinase 1 0.061
ube4b ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) 0.061
fcer1gl Fc receptor, IgE, high affinity I, gamma polypeptide like 0.061
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.061
cd8a CD8 antigen, alpha polypeptide 0.061
id:ibd5149 id:ibd5149 0.060
nrarpb notch-regulated ankyrin repeat protein b 0.060
psen1 presenilin 1 0.060
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CaMKII Calcium/calmodulin-dependent protein kinase II 0.954
Ras85D Ras oncogene at 85D 0.896
ena enabled 0.804
trio CG18214 gene product from transcript CG18214-RA 0.804
wit wishful thinking 0.778
Hem HEM-protein 0.775
Pten CG5671 gene product from transcript CG5671-RB 0.763
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.704
neuroligin CG13772 gene product from transcript CG13772-RA 0.678
Mad Mothers against dpp 0.631
insc inscuteable 0.614
mys myospheroid 0.588
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.584
rut rutabaga 0.559
cdm cadmus 0.544
Pk61C Protein kinase 61C 0.534
scb scab 0.515
drpr draper 0.463
Dad Daughters against dpp 0.461
jeb jelly belly 0.439
Dap160 Dynamin associated protein 160 0.434
brp bruchpilot 0.423
RhoGAP92B CG4755 gene product from transcript CG4755-RA 0.419
Ephrin CG1862 gene product from transcript CG1862-RA 0.411
Rheb CG1081 gene product from transcript CG1081-RA 0.394
caz cabeza 0.370
cpb capping protein beta 0.348
Fak56D Focal Adhesion Kinase 0.345
stai stathmin 0.336
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.323
Pak PAK-kinase 0.316
Eps-15 Epidermal growth factor receptor pathway substrate clone 15 0.312
G-oalpha47A G protein oalpha 47A 0.308
robo roundabout 0.302
unc-104 CG8566 gene product from transcript CG8566-RB 0.295
nwk nervous wreck 0.291
faf fat facets 0.291
baz bazooka 0.275
Ank2 Ankyrin 2 0.234
Hip14 Huntingtin-interacting protein 14 0.232
stj straightjacket 0.231
skpA CG16983 gene product from transcript CG16983-RD 0.220
kn knot 0.189
Mob2 CG11711 gene product from transcript CG11711-RC 0.186
chb chromosome bows 0.180
Nrx-1 Neurexin 1 0.176
hiw highwire 0.169
lea leak 0.166
dock dreadlocks 0.164
Sema-1a CG18405 gene product from transcript CG18405-RD 0.164
cv-c crossveinless c 0.163
lap like-AP180 0.163
cpx complexin 0.162
tbce tubulin-specific chaperone E 0.151
rap retina aberrant in pattern 0.138
synj synaptojanin 0.132
Gem3 Gemin3 0.131
Rac1 CG2248 gene product from transcript CG2248-RA 0.122
beta4GalNAcTA CG8536 gene product from transcript CG8536-RA 0.122
put punt 0.118
wb wing blister 0.115
Ent2 Equilibrative nucleoside transporter 2 0.115
CG17184 CG17184 gene product from transcript CG17184-RB 0.114
dys dysfusion 0.105
hppy happyhour 0.104
shot short stop 0.102
mnb minibrain 0.100
chic chickadee 0.100
myoglianin CG1838 gene product from transcript CG1838-RD 0.100
GluRIIA Glutamate receptor IIA 0.100
plexB plexin B 0.097
shn schnurri 0.095
beta-Spec beta Spectrin 0.092
if inflated 0.091
babo baboon 0.090
Rab3 Rab-protein 3 0.090
fog folded gastrulation 0.090
dnc dunce 0.085
Jra Jun-related antigen 0.084
plexA plexin A 0.084
numb CG3779 gene product from transcript CG3779-RB 0.083
rux roughex 0.083
Pak3 CG14895 gene product from transcript CG14895-RA 0.082
TBPH CG10327 gene product from transcript CG10327-RC 0.081
hts hu li tai shao 0.080
dia diaphanous 0.079
oa2 octopamine receptor 2 0.078
Mical Molecule interacting with CasL 0.078
Stat92E Signal-transducer and activator of transcription protein at 92E 0.077
spas spastin 0.077
Snap25 Synapse protein 25 0.077
ewg erect wing 0.076
mew multiple edematous wings 0.076
CG13253 CG13253 gene product from transcript CG13253-RB 0.076
twin CG31137 gene product from transcript CG31137-RB 0.075
drk downstream of receptor kinase 0.074
pAbp polyA-binding protein 0.074
Dscam Down syndrome cell adhesion molecule 0.074
Wnk CG7177 gene product from transcript CG7177-RA 0.071
stnB stoned B 0.068
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Ephb2 Eph receptor B2 0.984
Wnt7b wingless-related MMTV integration site 7B 0.981
Axin1 axin 1 0.977
Gdnf glial cell line derived neurotrophic factor 0.967
Ret ret proto-oncogene 0.941
Enah enabled homolog (Drosophila) 0.933
Robo1 roundabout homolog 1 (Drosophila) 0.933
Epha4 Eph receptor A4 0.916
Akt1 thymoma viral proto-oncogene 1 0.906
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.890
Ptprc protein tyrosine phosphatase, receptor type, C 0.860
Slit2 slit homolog 2 (Drosophila) 0.852
Efnb2 ephrin B2 0.849
Lhx1 LIM homeobox protein 1 0.848
Pxn paxillin 0.782
Bcar1 breast cancer anti-estrogen resistance 1 0.778
Fas Fas (TNF receptor superfamily member 6) 0.776
Gli2 GLI-Kruppel family member GLI2 0.735
Lama5 laminin, alpha 5 0.733
Vasp vasodilator-stimulated phosphoprotein 0.716
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.707
Ptk2 PTK2 protein tyrosine kinase 2 0.699
Slit3 slit homolog 3 (Drosophila) 0.664
Apc adenomatosis polyposis coli 0.653
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.632
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.620
Csnk1g2 casein kinase 1, gamma 2 0.620
Irs1 insulin receptor substrate 1 0.574
Efnb1 ephrin B1 0.546
Ephb3 Eph receptor B3 0.540
Inpp5d inositol polyphosphate-5-phosphatase D 0.521
Col4a3 collagen, type IV, alpha 3 0.519
Src Rous sarcoma oncogene 0.513
Gli3 GLI-Kruppel family member GLI3 0.509
Prkce protein kinase C, epsilon 0.496
Gli1 GLI-Kruppel family member GLI1 0.489
Evl Ena-vasodilator stimulated phosphoprotein 0.488
Cbl Casitas B-lineage lymphoma 0.485
Ptk7 PTK7 protein tyrosine kinase 7 0.484
Stx12 syntaxin 12 0.479
Bnc1 basonuclin 1 0.476
Ptpre protein tyrosine phosphatase, receptor type, E 0.475
Nf2 neurofibromatosis 2 0.458
Efna4 ephrin A4 0.449
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.439
Cd22 CD22 antigen 0.427
Fgfr4 fibroblast growth factor receptor 4 0.419
Mapkap1 mitogen-activated protein kinase associated protein 1 0.419
Rasa1 RAS p21 protein activator 1 0.409
Rarg retinoic acid receptor, gamma 0.399
Itgal integrin alpha L 0.391
Gsk3b glycogen synthase kinase 3 beta 0.389
L1cam L1 cell adhesion molecule 0.384
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.384
Wipf1 WAS/WASL interacting protein family, member 1 0.383
Wnt2b wingless related MMTV integration site 2b 0.380
Fyn Fyn proto-oncogene 0.376
Fjx1 four jointed box 1 (Drosophila) 0.373
Tsc1 tuberous sclerosis 1 0.364
Pax2 paired box gene 2 0.358
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.356
Ilk integrin linked kinase 0.355
Fzd1 frizzled homolog 1 (Drosophila) 0.353
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.345
Gata5 GATA binding protein 5 0.343
Plcg2 phospholipase C, gamma 2 0.339
Hcls1 hematopoietic cell specific Lyn substrate 1 0.335
Adra2c adrenergic receptor, alpha 2c 0.328
Pou3f3 POU domain, class 3, transcription factor 3 0.327
Tbx2 T-box 2 0.323
Pten phosphatase and tensin homolog 0.323
Was Wiskott-Aldrich syndrome homolog (human) 0.312
Fzd2 frizzled homolog 2 (Drosophila) 0.309
Tbx3 T-box 3 0.308
Lcp2 lymphocyte cytosolic protein 2 0.308
Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.304
Myo1f myosin IF 0.303
Pou3f1 POU domain, class 3, transcription factor 1 0.303
Fgf5 fibroblast growth factor 5 0.303
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.301
Smurf1 SMAD specific E3 ubiquitin protein ligase 1 0.296
Wt1 Wilms tumor 1 homolog 0.294
Cdk14 cyclin-dependent kinase 14 0.283
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.278
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.278
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.274
Col13a1 collagen, type XIII, alpha 1 0.258
Itga3 integrin alpha 3 0.257
Efna5 ephrin A5 0.254
Fgf8 fibroblast growth factor 8 0.253
Dctn1 dynactin 1 0.249
Bcl2 B-cell leukemia/lymphoma 2 0.244
Fgfr1 fibroblast growth factor receptor 1 0.243
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.242
Celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) 0.241
Wnt10b wingless related MMTV integration site 10b 0.240
Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.240
Itgb2 integrin beta 2 0.237
Efs embryonal Fyn-associated substrate 0.234
Abl2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) 0.233
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism