The network for 'leukocyte homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

leukocyte homeostasis

The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.

Danio rerio
Name Description Probability Func Analog Organism
dntt deoxynucleotidyltransferase, terminal 0.601
tgfb3 transforming growth factor, beta 3 0.479
anxa1b annexin A1b 0.356
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.349
il7r interleukin 7 receptor 0.313
pycard PYD and CARD domain containing 0.237
ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.209
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.205
rag1 recombination activating gene 1 0.191
mef2ca myocyte enhancer factor 2ca 0.168
jam2a junctional adhesion molecule 2a 0.159
tert telomerase reverse transcriptase 0.142
cldne claudin e 0.128
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.120
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.108
cbfb core-binding factor, beta subunit 0.092
krt4 keratin 4 0.090
csf1ra colony stimulating factor 1 receptor, a 0.083
si:dkey-12o15.1 si:dkey-12o15.1 0.078
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.075
tnfrsf18 tumor necrosis factor receptor superfamily, member 18 0.073
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.073
crb2a crumbs homolog 2a 0.072
tmem2 transmembrane protein 2 0.071
ptprc protein tyrosine phosphatase, receptor type, C 0.071
arpc1b actin related protein 2/3 complex, subunit 1B 0.068
lrrc33 leucine rich repeat containing 33 0.064
thy1 Thy-1 cell surface antigen 0.064
ighz immunoglobulin heavy constant zeta 0.064
icn2 ictacalcin 2 0.062
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.061
bnip3lb BCL2/adenovirus E1B interacting protein 3-like b 0.061
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.060
anxa2a annexin A2a 0.060
atpif1 ATPase inhibitory factor 1 0.059
ncf1 neutrophil cytosolic factor 1 0.058
svil supervillin 0.057
anxa1a annexin A1a 0.057
cdc42l cell division cycle 42, like 0.056
rpl7a ribosomal protein L7a 0.055
lpp LIM domain containing preferred translocation partner in lipoma 0.055
mef2cb myocyte enhancer factor 2cb 0.053
csnk1a1 casein kinase 1, alpha 1 0.053
dlx5a distal-less homeobox gene 5a 0.052
ryr1b ryanodine receptor 1b (skeletal) 0.052
cmyb transcription factor cmyb 0.052
LOC569128 hypothetical protein LOC569128 0.052
aurkb aurora kinase B 0.051
disc1 disrupted in schizophrenia 1 0.051
stc1l stanniocalcin 1, like 0.050
slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.048
mst1rb macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b 0.048
ptger4a prostaglandin E receptor 4 (subtype EP4) a 0.047
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.046
mef2a myocyte enhancer factor 2a 0.046
ints6 integrator complex subunit 6 0.045
mbnl2 muscleblind-like 2 (Drosophila) 0.045
rad21 RAD21 homolog (S. pombe) 0.045
jag1b jagged 1b 0.044
taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto 0.043
capns1b calpain, small subunit 1 b 0.043
col1a2 collagen, type I, alpha 2 0.042
tnfsf18 tumor necrosis factor (ligand) superfamily, member 18 0.042
jak1 Janus kinase 1 0.042
alas2 aminolevulinate, delta-, synthetase 2 0.042
tbx1 T-box 1 0.041
yrk Yes-related kinase 0.040
mmp13a matrix metalloproteinase 13a 0.040
mfn2 mitofusin 2 0.040
im:7154036 im:7154036 0.039
zgc:91835 zgc:91835 0.039
LOC553366 hypothetical protein LOC553366 0.039
ednra endothelin receptor type A 0.039
anxa1c annexin A1c 0.038
emilin2b elastin microfibril interfacer 2b 0.038
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.037
cdc42 cell division cycle 42 0.037
runx3 runt-related transcription factor 3 0.036
tcf21 transcription factor 21 0.036
ck2a2a casein kinase 2 alpha 2a 0.036
scinla scinderin like a 0.036
appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.036
tbx5b T-box 5b 0.036
og9x OG9 homeobox gene 0.036
gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.036
fgf20a fibroblast growth factor 20a 0.035
thsd7a thrombospondin, type I, domain containing 7A 0.035
zgc:112211 zgc:112211 0.035
rps3 ribosomal protein S3 0.034
gmfg glia maturation factor, gamma 0.034
wu:fb18f06 wu:fb18f06 0.034
kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 0.034
mpx myeloid-specific peroxidase 0.033
ppial peptidylprolyl isomerase A, like 0.033
stat5.1 signal transducer and activator of transcription 5.1 0.033
psen1 presenilin 1 0.032
hand2 heart and neural crest derivatives expressed transcript 2 0.032
tbx22 T-box 22 0.031
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.031
evpl envoplakin 0.031
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.302
BCL2L1 BCL2-like 1 0.234
SYK spleen tyrosine kinase 0.196
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.111
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.109
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.091
BID BH3 interacting domain death agonist 0.090
BCL2 B-cell CLL/lymphoma 2 0.064
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.061
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.045
BAX BCL2-associated X protein 0.044
MSN moesin 0.034
LAT linker for activation of T cells 0.031
EGFR epidermal growth factor receptor 0.030
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.029
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.026
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.024
BAK1 BCL2-antagonist/killer 1 0.023
S100A10 S100 calcium binding protein A10 0.020
CARD11 caspase recruitment domain family, member 11 0.020
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.019
DLG1 discs, large homolog 1 (Drosophila) 0.019
CXCR4 chemokine (C-X-C motif) receptor 4 0.018
LCK lymphocyte-specific protein tyrosine kinase 0.017
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.017
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.016
PLCG1 phospholipase C, gamma 1 0.015
FAS Fas (TNF receptor superfamily, member 6) 0.015
IL8 interleukin 8 0.014
INSR insulin receptor 0.013
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.012
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.012
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.012
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.012
NCF1 neutrophil cytosolic factor 1 0.012
NOXA1 NADPH oxidase activator 1 0.011
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.011
IL2RB interleukin 2 receptor, beta 0.011
APAF1 apoptotic peptidase activating factor 1 0.011
EP300 E1A binding protein p300 0.010
VIM vimentin 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Inpp5d inositol polyphosphate-5-phosphatase D 0.996
Il2rg interleukin 2 receptor, gamma chain 0.990
Lyz2 lysozyme 2 0.972
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.957
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.936
Il6st interleukin 6 signal transducer 0.931
Ikzf1 IKAROS family zinc finger 1 0.905
Tcra T-cell receptor alpha chain 0.880
Stat3 signal transducer and activator of transcription 3 0.874
Ptgs2 prostaglandin-endoperoxide synthase 2 0.858
Stat5b signal transducer and activator of transcription 5B 0.834
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.831
Ptprc protein tyrosine phosphatase, receptor type, C 0.819
Rc3h1 RING CCCH (C3H) domains 1 0.796
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.783
Pten phosphatase and tensin homolog 0.772
Fas Fas (TNF receptor superfamily member 6) 0.764
Bax BCL2-associated X protein 0.758
Cbl Casitas B-lineage lymphoma 0.729
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.690
Stat5a signal transducer and activator of transcription 5A 0.687
Mmp9 matrix metallopeptidase 9 0.680
Prf1 perforin 1 (pore forming protein) 0.680
Hif1a hypoxia inducible factor 1, alpha subunit 0.656
Hdac5 histone deacetylase 5 0.649
Cxcl2 chemokine (C-X-C motif) ligand 2 0.624
Lat linker for activation of T cells 0.617
Il2 interleukin 2 0.615
Csf1 colony stimulating factor 1 (macrophage) 0.613
Adam17 a disintegrin and metallopeptidase domain 17 0.610
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.599
Lck lymphocyte protein tyrosine kinase 0.589
Trp53 transformation related protein 53 0.564
Smad4 MAD homolog 4 (Drosophila) 0.559
Tgfbr2 transforming growth factor, beta receptor II 0.557
Cdk1 cyclin-dependent kinase 1 0.551
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.551
Vegfa vascular endothelial growth factor A 0.550
Igh immunoglobulin heavy chain complex 0.549
Ccr1 chemokine (C-C motif) receptor 1 0.539
Cd19 CD19 antigen 0.502
Il6 interleukin 6 0.484
Foxp3 forkhead box P3 0.458
Myd88 myeloid differentiation primary response gene 88 0.457
Tnf tumor necrosis factor 0.456
Rxra retinoid X receptor alpha 0.456
Stat6 signal transducer and activator of transcription 6 0.435
Kit kit oncogene 0.420
Nckap1l NCK associated protein 1 like 0.411
Il10 interleukin 10 0.377
Ttc7 tetratricopeptide repeat domain 7 0.372
Tcirg1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 0.362
Pick1 protein interacting with C kinase 1 0.346
Socs1 suppressor of cytokine signaling 1 0.332
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.326
Tlr4 toll-like receptor 4 0.323
Lyst lysosomal trafficking regulator 0.321
Ifng interferon gamma 0.316
Dysf dysferlin 0.313
Mcl1 myeloid cell leukemia sequence 1 0.313
Cyld cylindromatosis (turban tumor syndrome) 0.307
Hdac7 histone deacetylase 7 0.303
Jak3 Janus kinase 3 0.300
Arnt aryl hydrocarbon receptor nuclear translocator 0.299
Foxc2 forkhead box C2 0.291
Anxa1 annexin A1 0.291
Cd247 CD247 antigen 0.290
Selp selectin, platelet 0.288
Grb2 growth factor receptor bound protein 2 0.288
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.279
Il1a interleukin 1 alpha 0.274
Ly6d lymphocyte antigen 6 complex, locus D 0.274
Cd40 CD40 antigen 0.273
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.269
H2-Aa histocompatibility 2, class II antigen A, alpha 0.267
Flt4 FMS-like tyrosine kinase 4 0.266
Rag2 recombination activating gene 2 0.248
Dok1 docking protein 1 0.240
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.237
Batf basic leucine zipper transcription factor, ATF-like 0.237
Jak2 Janus kinase 2 0.233
Cd14 CD14 antigen 0.226
Tgfb1 transforming growth factor, beta 1 0.225
Was Wiskott-Aldrich syndrome homolog (human) 0.225
Egln1 EGL nine homolog 1 (C. elegans) 0.219
Irf9 interferon regulatory factor 9 0.217
Tcrd T-cell receptor delta chain 0.215
Ikbkg inhibitor of kappaB kinase gamma 0.213
Ncf1 neutrophil cytosolic factor 1 0.213
Spna1 spectrin alpha 1 0.210
Ric8 resistance to inhibitors of cholinesterase 8 homolog (C. elegans) 0.210
Fadd Fas (TNFRSF6)-associated via death domain 0.206
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.204
Wdr1 WD repeat domain 1 0.204
Kdr kinase insert domain protein receptor 0.200
Pou2f2 POU domain, class 2, transcription factor 2 0.199
Hbb-b1 hemoglobin, beta adult major chain 0.187
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.186
Birc5 baculoviral IAP repeat-containing 5 0.186
Apaf1 apoptotic peptidase activating factor 1 0.184
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Cd53 Cd53 molecule 0.291
Lcp1 lymphocyte cytosolic protein 1 0.226
Hck hemopoietic cell kinase 0.194
Slfn2 schlafen 2 0.192
Il8rb interleukin 8 receptor, beta 0.142
Sell selectin L 0.131
Aif1 allograft inflammatory factor 1 0.130
Tgfbr3 transforming growth factor, beta receptor III 0.123
Tp53 tumor protein p53 0.104
Flt1 FMS-related tyrosine kinase 1 0.097
Limd2 LIM domain containing 2 0.092
Ptprc protein tyrosine phosphatase, receptor type, C 0.088
Lyz2 lysozyme 2 0.086
Il1r1 interleukin 1 receptor, type I 0.082
Prrx1 paired related homeobox 1 0.070
Cd37 CD37 molecule 0.070
Cd4 Cd4 molecule 0.069
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.066
Laptm5 lysosomal protein transmembrane 5 0.062
RT1-Ba RT1 class II, locus Ba 0.058
Icam1 intercellular adhesion molecule 1 0.057
S1pr2 sphingosine-1-phosphate receptor 2 0.056
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.055
Cd14 CD14 molecule 0.048
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.046
Lepr leptin receptor 0.046
Arpc1b actin related protein 2/3 complex, subunit 1B 0.039
Cd247 Cd247 molecule 0.037
Vcan versican 0.036
Fcer1g Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.035
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.035
Aebp1 AE binding protein 1 0.034
Creb1 cAMP responsive element binding protein 1 0.033
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.030
Sh2b3 SH2B adaptor protein 3 0.027
Inpp5d inositol polyphosphate-5-phosphatase D 0.026
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.026
Pecam1 platelet/endothelial cell adhesion molecule 1 0.025
Fgfr2 fibroblast growth factor receptor 2 0.024
Cxcr4 chemokine (C-X-C motif) receptor 4 0.023
Plau plasminogen activator, urokinase 0.023
Cd38 CD38 molecule 0.022
Il1b interleukin 1 beta 0.022
Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.022
Nos3 nitric oxide synthase 3, endothelial cell 0.022
Dctn4 dynactin 4 0.021
Cd2 Cd2 molecule 0.021
Ptch1 patched homolog 1 (Drosophila) 0.020
Tgfb1 transforming growth factor, beta 1 0.019
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.019
Tyrobp Tyro protein tyrosine kinase binding protein 0.019
Il2rg interleukin 2 receptor, gamma 0.018
Casp1 caspase 1 0.018
Arnt aryl hydrocarbon receptor nuclear translocator 0.018
Prkch protein kinase C, eta 0.017
Sh3bgrl3 SH3 domain binding glutamic acid-rich protein-like 3 0.017
Il2rb interleukin 2 receptor, beta 0.016
Cd48 Cd48 molecule 0.016
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.016
Marcks myristoylated alanine rich protein kinase C substrate 0.015
Tcrb T-cell receptor beta chain 0.015
Utrn utrophin 0.015
Alox5ap arachidonate 5-lipoxygenase activating protein 0.015
Arrb2 arrestin, beta 2 0.015
Ddx54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 0.015
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.015
Cd5 Cd5 molecule 0.015
Met met proto-oncogene 0.014
Cdh5 cadherin 5 0.014
Jak2 Janus kinase 2 0.014
Mrc1 mannose receptor, C type 1 0.013
Trhr2 thyrotropin releasing hormone receptor 2 0.013
Adam7 ADAM metallopeptidase domain 7 0.013
Ncf1 neutrophil cytosolic factor 1 0.013
Gucy2d guanylate cyclase 2d 0.013
Ciita class II, major histocompatibility complex, transactivator 0.013
Lamc1 laminin, gamma 1 0.013
Fn1 fibronectin 1 0.012
Fgf7 fibroblast growth factor 7 0.012
LOC100360169 rCG21044-like 0.012
Cdh17 cadherin 17 0.012
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.012
Cd44 Cd44 molecule 0.012
Vim vimentin 0.012
Sirpa signal-regulatory protein alpha 0.012
Zbp1 Z-DNA binding protein 1 0.011
Bat3 HLA-B-associated transcript 3 0.011
Ms4a6b membrane-spanning 4-domains, subfamily A, member 6B 0.010
Crygf crystallin, gamma F 0.010
Phkg1 phosphorylase kinase, gamma 1 0.010
Gzmk granzyme K 0.010
Tln1 talin 1 0.010
RT1-DMb RT1 class II, locus DMb 0.010
Selp selectin P 0.010
LOC100361571 keratin associated protein 1-3-like 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism