The network for 'mitotic dna integrity checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitotic dna integrity checkpoint

A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.

Danio rerio
Name Description Probability Func Analog Organism
snrpc small nuclear ribonucleoprotein polypeptide C 0.742
ccnb1 cyclin B1 0.742
sass6 spindle assembly 6 homolog (C. elegans) 0.734
ung uracil-DNA glycosylase 0.685
skp2 S-phase kinase-associated protein 2 (p45) 0.655
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.643
ccne cyclin E 0.641
ccnb2 cyclin B2 0.635
ccnd1 cyclin D1 0.632
stil TAL1 (SCL) interrupting locus 0.550
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.522
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.507
orc1 origin recognition complex, subunit 1 0.458
zff9 zinc finger protein 9 0.449
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.446
brd2a bromodomain-containing 2a 0.411
chaf1b chromatin assembly factor 1, subunit B 0.397
tfam transcription factor A, mitochondrial 0.393
smc3 structural maintenance of chromosomes 3 0.390
ccna2 cyclin A2 0.389
cand1 cullin-associated and neddylation-dissociated 1 0.384
aurkb aurora kinase B 0.380
dhfr dihydrofolate reductase 0.378
atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.359
plk1 polo-like kinase 1 (Drosophila) 0.346
nasp nuclear autoantigenic sperm protein (histone-binding) 0.336
ube2i ubiquitin-conjugating enzyme E2I 0.330
dnmt5 DNA (cytosine-5-)-methyltransferase 5 0.320
esco2 establishment of cohesion 1 homolog 2 0.319
trip13 thyroid hormone receptor interactor 13 0.307
sumo3a SMT3 suppressor of mif two 3 homolog 3a 0.304
wdr18 WD repeat domain 18 0.304
pcna proliferating cell nuclear antigen 0.297
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.295
calm3b calmodulin 3b (phosphorylase kinase, delta) 0.282
wdr76 WD repeat domain 76 0.274
hat1 histone acetyltransferase 1 0.268
gmnn geminin, DNA replication inhibitor 0.268
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.262
zgc:110113 zgc:110113 0.244
psmd4a proteasome (prosome, macropain) 26S subunit, non-ATPase, 4a 0.242
zgc:174506 zgc:174506 0.235
gins2 GINS complex subunit 2 0.230
chek1 CHK1 checkpoint homolog (S. pombe) 0.225
cul3a cullin 3a 0.221
prim1 primase polypeptide 1 0.220
med28 mediator complex subunit 28 0.213
naa15b N(alpha)-acetyltransferase 15, NatA auxiliary subunit b 0.213
mobkl3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.208
orc6 origin recognition complex, subunit 6 0.206
tbx5a T-box 5a 0.202
aggf1 angiogenic factor with G patch and FHA domains 1 0.199
senp3a SUMO1/sentrin/SMT3 specific peptidase 3a 0.195
cdc25 cell division cycle 25 homolog 0.193
ncapg non-SMC condensin I complex, subunit G 0.190
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.186
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.186
top2a topoisomerase (DNA) II alpha 0.184
hells helicase, lymphoid-specific 0.182
ncbp2 nuclear cap binding protein subunit 2 0.173
coro1b coronin, actin binding protein, 1B 0.167
zgc:73273 zgc:73273 0.166
cdt1 chromatin licensing and DNA replication factor 1 0.164
cdk2 cyclin-dependent kinase 2 0.162
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.161
fanci Fanconi anemia, complementation group I 0.160
suv39h1b suppressor of variegation 3-9 homolog 1b 0.158
ube2i2 ubiquitin-conjugating enzyme E2I2 0.156
ctcf CCCTC-binding factor (zinc finger protein) 0.156
ddb2 damage-specific DNA binding protein 2 0.154
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.146
mycl1a v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) a 0.143
lsm8 LSM8 homolog, U6 small nuclear RNA associated 0.143
cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 0.136
slbp stem-loop binding protein 0.136
nudcd2 NudC domain containing 2 0.136
caprin1a cell cycle associated protein 1a 0.130
mab21l1 mab-21-like 1 0.129
lrmp lymphoid-restricted membrane protein 0.127
ahctf1 AT hook containing transcription factor 1 0.126
palb2 partner and localizer of BRCA2 0.124
morf4l1 mortality factor 4 like 1 0.123
wdhd1 WD repeat and HMG-box DNA binding protein 1 0.123
rasl11b RAS-like, family 11, member B 0.122
rpa3 replication protein A3 0.121
shfm1 split hand/foot malformation (ectrodactyly) type 1 0.119
usp4 ubiquitin specific protease 4 (proto-oncogene) 0.118
wrb tryptophan rich basic protein 0.117
zgc:110337 zgc:110337 0.116
zgc:153910 zgc:153910 0.115
pola1 polymerase (DNA directed), alpha 1 0.113
eif4e1c eukaryotic translation initiation factor 4E family member 1c 0.113
dtl denticleless homolog (Drosophila) 0.109
snrpd1 small nuclear ribonucleoprotein D1 polypeptide 0.108
crip2 cysteine-rich protein 2 0.108
ppp2r5eb protein phosphatase 2, regulatory subunit B', epsilon isoform b 0.107
cry3 cryptochrome 3 0.107
vps52 vacuolar protein sorting 52 (yeast) 0.107
kpna3 karyopherin (importin) alpha 3 0.106
pif1 PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) 0.104
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
lok loki 0.988
mus205 mutagen-sensitive 205 0.979
pic piccolo 0.936
CSN3 COP9 complex homolog subunit 3 0.882
MED6 Mediator complex subunit 6 0.867
BRWD3 CG31132 gene product from transcript CG31132-RA 0.847
cdc2c CG10498 gene product from transcript CG10498-RC 0.844
His2Av Histone H2A variant 0.758
skpA CG16983 gene product from transcript CG16983-RD 0.721
Cdk4 Cyclin-dependent kinase 4 0.688
Mcm3 Minichromosome maintenance 3 0.663
p53 CG33336 gene product from transcript CG33336-RB 0.638
cdm cadmus 0.631
CSN5 COP9 complex homolog subunit 5 0.613
Brca2 Breast cancer 2, early onset homolog 0.591
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.568
Nup50 Nucleoporin 50 0.560
Dlic Dynein light intermediate chain 0.541
Bap55 Brahma associated protein 55kD 0.526
lin19 lin-19-like 0.522
MED17 Mediator complex subunit 17 0.521
CG13298 CG13298 gene product from transcript CG13298-RA 0.513
rad50 CG6339 gene product from transcript CG6339-RD 0.513
l(2)NC136 lethal (2) NC136 0.490
Iswi Imitation SWI 0.478
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.470
CSN4 COP9 complex homolog subunit 4 0.460
imd immune deficiency 0.449
Ge-1 CG6181 gene product from transcript CG6181-RA 0.430
tral trailer hitch 0.428
mre11 meiotic recombination 11 0.426
Dref DNA replication-related element factor 0.424
CSN7 COP9 complex homolog subunit 7 0.402
mus201 mutagen-sensitive 201 0.396
CG10414 CG10414 gene product from transcript CG10414-RA 0.390
cdc2 CG5363 gene product from transcript CG5363-RA 0.389
fzy fizzy 0.385
CG10754 CG10754 gene product from transcript CG10754-RA 0.373
RanGap Ran GTPase activating protein 0.360
Pp2A-29B Protein phosphatase 2A at 29B 0.360
dah discontinuous actin hexagon 0.358
MED20 Mediator complex subunit 20 0.356
eIF4AIII CG7483 gene product from transcript CG7483-RA 0.340
alph alphabet 0.333
pie pineapple eye 0.330
CG10139 CG10139 gene product from transcript CG10139-RA 0.319
Rpb11 CG6840 gene product from transcript CG6840-RA 0.317
glu gluon 0.313
CG14641 CG14641 gene product from transcript CG14641-RA 0.302
Sfmbt Scm-related gene containing four mbt domains 0.300
Ada2b CG9638 gene product from transcript CG9638-RA 0.297
fl(2)d female lethal d 0.288
mus301 mutagen-sensitive 301 0.284
mus101 mutagen-sensitive 101 0.283
Acf1 ATP-dependent chromatin assembly factor large subunit 0.280
MED31 Mediator complex subunit 31 0.280
Caf1 Chromatin assembly factor 1 subunit 0.279
BEAF-32 Boundary element-associated factor of 32kD 0.278
Patr-1 Protein associated with topo II related - 1 0.271
CycC Cyclin C 0.268
esc extra sexcombs 0.268
spn-B spindle B 0.260
RecQ5 homolog of RecQ 0.257
kto kohtalo 0.253
wee CG4488 gene product from transcript CG4488-RA 0.247
eIF5 CG9177 gene product from transcript CG9177-RE 0.242
CSN6 COP9 complex homolog subunit 6 0.234
mei-9 meiotic 9 0.228
mus209 mutagen-sensitive 209 0.226
U2af50 U2 small nuclear riboprotein auxiliary factor 50 0.221
CG18764 CG18764 gene product from transcript CG18764-RA 0.213
Rpd3 CG7471 gene product from transcript CG7471-RA 0.212
Trf2 TATA box binding protein-related factor 2 0.212
CG17282 CG17282 gene product from transcript CG17282-RA 0.207
MED11 Mediator complex subunit 11 0.207
swm second mitotic wave missing 0.206
Dredd Death related ced-3/Nedd2-like protein 0.206
Rel Relish 0.203
key kenny 0.199
tos tosca 0.194
mus308 mutagen-sensitive 308 0.193
Uba1 Ubiquitin activating enzyme 1 0.192
rept reptin 0.184
mus309 mutagen-sensitive 309 0.176
CG9715 CG9715 gene product from transcript CG9715-RA 0.175
CG4699 CG4699 gene product from transcript CG4699-RJ 0.174
CG8159 CG8159 gene product from transcript CG8159-RB 0.174
RpS11 Ribosomal protein S11 0.173
Spf45 CG17540 gene product from transcript CG17540-RB 0.173
Klp3A Kinesin-like protein at 3A 0.171
Cas CAS/CSE1 segregation protein 0.169
4EHP CG33100 gene product from transcript CG33100-RA 0.166
Bj1 Bj1 protein 0.166
ranshi CG9793 gene product from transcript CG9793-RA 0.165
Nup153 Nucleoporin 153 0.164
pasha partner of drosha 0.164
hkl hook-like 0.161
alphaTub67C alpha-Tubulin at 67C 0.160
Cap-G CG34438 gene product from transcript CG34438-RF 0.157
mus304 mutagen-sensitive 304 0.156
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Homo sapiens
Name Description Probability Func Analog Organism
RB1 retinoblastoma 1 1.000
BRCA1 breast cancer 1, early onset 1.000
TP53 tumor protein p53 1.000
CDK2 cyclin-dependent kinase 2 0.998
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.997
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.995
PCNA proliferating cell nuclear antigen 0.978
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.952
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.891
E2F1 E2F transcription factor 1 0.882
HDAC1 histone deacetylase 1 0.824
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.820
PARP1 poly (ADP-ribose) polymerase 1 0.802
MCM6 minichromosome maintenance complex component 6 0.777
JUN jun proto-oncogene 0.776
SKP2 S-phase kinase-associated protein 2 (p45) 0.698
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.663
MCM7 minichromosome maintenance complex component 7 0.657
PLK1 polo-like kinase 1 0.639
XIAP X-linked inhibitor of apoptosis 0.616
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.599
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.587
RPA1 replication protein A1, 70kDa 0.579
CCNA2 cyclin A2 0.573
RAD50 RAD50 homolog (S. cerevisiae) 0.530
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.527
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.517
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.496
TOPBP1 topoisomerase (DNA) II binding protein 1 0.464
MSH6 mutS homolog 6 (E. coli) 0.458
CUL4A cullin 4A 0.452
HDAC2 histone deacetylase 2 0.448
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.440
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.413
WRN Werner syndrome, RecQ helicase-like 0.404
MED1 mediator complex subunit 1 0.401
CDK6 cyclin-dependent kinase 6 0.390
NBN nibrin 0.387
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 0.347
COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) 0.304
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.294
RBL1 retinoblastoma-like 1 (p107) 0.286
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.284
CNOT8 CCR4-NOT transcription complex, subunit 8 0.256
CCND3 cyclin D3 0.255
CDK8 cyclin-dependent kinase 8 0.254
CCND1 cyclin D1 0.253
APAF1 apoptotic peptidase activating factor 1 0.253
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.245
BLM Bloom syndrome, RecQ helicase-like 0.244
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.241
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.232
ATM ataxia telangiectasia mutated 0.218
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.218
CUL2 cullin 2 0.207
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.197
SMAD7 SMAD family member 7 0.193
FAS Fas (TNF receptor superfamily, member 6) 0.190
POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) 0.173
FOS FBJ murine osteosarcoma viral oncogene homolog 0.173
RPA2 replication protein A2, 32kDa 0.168
RBBP4 retinoblastoma binding protein 4 0.168
PAX3 paired box 3 0.162
WWOX WW domain containing oxidoreductase 0.160
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.158
COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) 0.152
EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe) 0.151
RBBP8 retinoblastoma binding protein 8 0.133
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.133
CASP8AP2 caspase 8 associated protein 2 0.132
H2AFX H2A histone family, member X 0.130
CCNE1 cyclin E1 0.126
MCM3 minichromosome maintenance complex component 3 0.125
UNG uracil-DNA glycosylase 0.124
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.123
CNOT6 CCR4-NOT transcription complex, subunit 6 0.118
MCM2 minichromosome maintenance complex component 2 0.117
CDT1 chromatin licensing and DNA replication factor 1 0.114
DAXX death-domain associated protein 0.112
BTG1 B-cell translocation gene 1, anti-proliferative 0.110
DDB2 damage-specific DNA binding protein 2, 48kDa 0.108
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.105
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.104
POU3F2 POU class 3 homeobox 2 0.102
CDC25A cell division cycle 25 homolog A (S. pombe) 0.101
RBL2 retinoblastoma-like 2 (p130) 0.101
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.100
UBXN7 UBX domain protein 7 0.098
UBA1 ubiquitin-like modifier activating enzyme 1 0.091
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.090
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.088
FADD Fas (TNFRSF6)-associated via death domain 0.087
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.083
POU5F1 POU class 5 homeobox 1 0.082
UBE3A ubiquitin protein ligase E3A 0.080
YAP1 Yes-associated protein 1 0.078
CNOT7 CCR4-NOT transcription complex, subunit 7 0.076
CNOT1 CCR4-NOT transcription complex, subunit 1 0.075
GPI glucose-6-phosphate isomerase 0.074
TFDP1 transcription factor Dp-1 0.072
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
POL30 Pol30p 0.254
RAD52 Rad52p 0.195
BUB3 Bub3p 0.179
RPB3 Rpb3p 0.177
CDC6 Cdc6p 0.153
RAD53 Rad53p 0.147
MCM6 Mcm6p 0.131
SPT5 Spt5p 0.120
RPO26 Rpo26p 0.106
MCM2 Mcm2p 0.104
TOF1 Tof1p 0.095
BUB1 Bub1p 0.087
MRC1 Mrc1p 0.084
DBF4 Dbf4p 0.082
PSF1 Psf1p 0.080
MCM4 Mcm4p 0.080
RCO1 Rco1p 0.079
MCM10 Mcm10p 0.075
ASF1 Asf1p 0.063
DPB11 Dpb11p 0.060
MAD2 Mad2p 0.057
DPB2 Dpb2p 0.054
CTF4 Ctf4p 0.051
SRS2 Srs2p 0.049
CDC20 Cdc20p 0.048
GBP2 Gbp2p 0.048
SLD2 Sld2p 0.044
MAD3 Mad3p 0.041
LCD1 Lcd1p 0.041
ELG1 Elg1p 0.041
RFA1 Rfa1p 0.040
THP2 Thp2p 0.037
RRM3 Rrm3p 0.035
MPT5 Mpt5p 0.035
RPB10 Rpb10p 0.034
MCM5 Mcm5p 0.033
RIF1 Rif1p 0.032
CTF18 Ctf18p 0.030
RAD17 Rad17p 0.026
SWI4 Swi4p 0.026
DST1 Dst1p 0.026
KEM1 Kem1p 0.026
POL2 Pol2p 0.025
RAD24 Rad24p 0.025
RTF1 Rtf1p 0.024
MSA1 Msa1p 0.024
POL1 Pol1p 0.023
CLN3 Cln3p 0.023
RAD27 Rad27p 0.021
UBC4 Ubc4p 0.021
POL32 Pol32p 0.021
MGS1 Mgs1p 0.021
TEL1 Tel1p 0.020
MAD1 Mad1p 0.020
YLR264C-A hypothetical protein 0.020
POL3 Pol3p 0.020
ZIP1 Zip1p 0.020
HO Hop 0.020
SLD3 Sld3p 0.019
SRD1 Srd1p 0.019
ADH2 Adh2p 0.019
SCC2 Scc2p 0.019
YLR162W hypothetical protein 0.019
DNA2 Dna2p 0.019
PEX22 Pex22p 0.019
GIC1 Gic1p 0.018
LEU2 Leu2p 0.018
TIF4632 Tif4632p 0.017
SLK19 Slk19p 0.017
CUP1-1 Cup1-1p 0.017
SAS4 Sas4p 0.017
SUB2 Sub2p 0.017
SGS1 Sgs1p 0.017
MTW1 Mtw1p 0.017
ZDS2 Zds2p 0.016
SDC1 Sdc1p 0.016
HHT2 Hht2p 0.016
MF(ALPHA)2 Mf(alpha)2p 0.016
URA3 Ura3p 0.016
YOL038C-A hypothetical protein 0.016
ARG8 Arg8p 0.016
UME1 Ume1p 0.016
REV1 Rev1p 0.016
FAR10 Far10p 0.016
DUN1 Dun1p 0.016
SMC4 Smc4p 0.016
MMS21 Mms21p 0.016
WSS1 Wss1p 0.015
HPR1 Hpr1p 0.015
CRP1 Crp1p 0.015
HXT3 Hxt3p 0.015
CHL1 Chl1p 0.015
SLN1 Sln1p 0.015
MER1 Mer1p 0.015
MSH3 Msh3p 0.015
RPB7 Rpb7p 0.015
SWC7 Swc7p 0.015
FAR3 Far3p 0.015
PRP28 Prp28p 0.015
TYE7 Tye7p 0.014