The network for 'desmosome organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

desmosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.

Danio rerio
Name Description Probability Func Analog Organism
dspa desmoplakin a 0.786
krt8 keratin 8 0.638
dsc2l desmocollin 2 like 0.603
pkp3 plakophilin 3 0.403
krt4 keratin 4 0.365
jup junction plakoglobin 0.337
ppl periplakin 0.277
dsg2 desmoglein 2 0.193
krt5 keratin 5 0.188
pkp1 plakophilin 1 0.161
slc38a3 solute carrier family 38, member 3 0.141
rassf7b Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b 0.124
sdprb serum deprivation response b 0.109
si:ch211-166a6.5 si:ch211-166a6.5 0.092
esrp1 epithelial splicing regulatory protein 1 0.086
zgc:152778 zgc:152778 0.084
ptgs2a prostaglandin-endoperoxide synthase 2a 0.079
foxa3 forkhead box A3 0.072
perp PERP, TP53 apoptosis effector 0.068
ahnak AHNAK nucleoprotein 0.059
celsr1a cadherin EGF LAG seven-pass G-type receptor 1a 0.057
tjp2a tight junction protein 2a (zona occludens 2) 0.052
mid1ip1a MID1 interacting protein 1a 0.050
cldnb claudin b 0.048
wu:fb36d12 wu:fb36d12 0.046
pvrl1b poliovirus receptor-related 1b 0.044
lsr lipolysis stimulated lipoprotein receptor 0.042
si:ch211-157f15.1 si:ch211-157f15.1 0.040
cdh1 cadherin 1, epithelial 0.034
pvrl1a poliovirus receptor-related 1a 0.030
capn9 calpain 9 0.029
gata3 GATA-binding protein 3 0.025
si:dkey-261h17.1 si:dkey-261h17.1 0.025
nog3 noggin 3 0.025
tbeta-a beta thymosin-like protein 2 0.024
spint1a serine peptidase inhibitor, Kunitz type 1 a 0.024
tfe3b transcription factor binding to IGHM enhancer 3b 0.023
rhov ras homolog gene family, member V 0.022
cx35.4 connexin 35.4 0.021
her9 hairy-related 9 0.021
igf2a insulin-like growth factor 2a 0.020
ints6 integrator complex subunit 6 0.020
klf2a Kruppel-like factor 2a 0.020
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.020
aim1a absent in melanoma 1a 0.020
nuak2 NUAK family, SNF1-like kinase, 2 0.019
cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.018
btg2 B-cell translocation gene 2 0.017
fn1 fibronectin 1 0.016
p2rx3b purinergic receptor P2X, ligand-gated ion channel, 3b 0.016
tp63 tumor protein p63 0.015
bmper BMP binding endothelial regulator 0.015
phox2b paired-like homeobox 2b 0.015
frzb frizzled-related protein 0.014
cd9b CD9 antigen, b 0.014
limk2 LIM domain kinase 2 0.013
emp2 epithelial membrane protein 2 0.013
snf8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.013
thsd7a thrombospondin, type I, domain containing 7A 0.013
zgc:100864 zgc:100864 0.013
si:ch73-60e21.1 si:ch73-60e21.1 0.013
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.013
yap1 Yes-associated protein 1 0.013
cadm1a cell adhesion molecule 1a 0.013
guca1c guanylate cyclase activator 1C 0.013
rasl11b RAS-like, family 11, member B 0.013
wls wntless homolog (Drosophila) 0.012
ptpra protein tyrosine phosphatase, receptor type, A 0.012
igf3 insulin-like growth factor 3 0.012
hist1h4l histone 1, H4, like 0.012
atp1b1a ATPase, Na+/K+ transporting, beta 1a polypeptide 0.012
klf3 Kruppel-like factor 3 (basic) 0.012
cldnc claudin c 0.012
tjp1 tight junction protein 1 (zona occludens 1) 0.012
olfm1b olfactomedin 1b 0.012
clstn2 calsyntenin 2 0.011
dnmt8 DNA (cytosine-5-)-methyltransferase 8 0.011
epha2 eph receptor A2 0.011
net1 neuroepithelial cell transforming gene 1 0.011
tbx2b T-box 2b 0.011
si:ch211-217k17.9 si:ch211-217k17.9 0.011
stmn2b stathmin-like 2b 0.011
lect1 leukocyte cell derived chemotaxin 1 0.011
sf3b1 splicing factor 3b, subunit 1 0.011
pard3 par-3 partitioning defective 3 homolog (C. elegans) 0.010
plxna4 plexin A4 0.010
si:dkeyp-113d7.7 si:dkeyp-113d7.7 0.010
s100u S100 calcium binding protein U 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
DSP desmoplakin 0.887
JUP junction plakoglobin 0.716
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.601
DSG2 desmoglein 2 0.523
PVRL4 poliovirus receptor-related 4 0.508
MARK3 MAP/microtubule affinity-regulating kinase 3 0.199
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.176
PRKCA protein kinase C, alpha 0.159
SFN stratifin 0.158
KRT14 keratin 14 0.125
PKP2 plakophilin 2 0.076
JUB jub, ajuba homolog (Xenopus laevis) 0.061
NCF1 neutrophil cytosolic factor 1 0.048
EGFR epidermal growth factor receptor 0.040
KRT18 keratin 18 0.037
RICTOR RPTOR independent companion of MTOR, complex 2 0.031
DSC2 desmocollin 2 0.030
PSEN1 presenilin 1 0.027
PVRL3 poliovirus receptor-related 3 0.024
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.023
FRMD5 FERM domain containing 5 0.023
KRT8 keratin 8 0.019
TRIM9 tripartite motif containing 9 0.018
KRT5 keratin 5 0.016
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.011
PRKCD protein kinase C, delta 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 0.366
Tcfap2c transcription factor AP-2, gamma 0.298
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.137
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.121
Kitl kit ligand 0.089
Dsg2 desmoglein 2 0.069
Ldb3 LIM domain binding 3 0.065
Spint1 serine protease inhibitor, Kunitz type 1 0.063
Apc adenomatosis polyposis coli 0.053
Shh sonic hedgehog 0.051
Lrp6 low density lipoprotein receptor-related protein 6 0.050
Ctnna1 catenin (cadherin associated protein), alpha 1 0.049
Llgl2 lethal giant larvae homolog 2 (Drosophila) 0.045
Trp63 transformation related protein 63 0.038
Fgfr2 fibroblast growth factor receptor 2 0.037
Dsp desmoplakin 0.037
Sfn stratifin 0.035
Irf6 interferon regulatory factor 6 0.034
Smad4 MAD homolog 4 (Drosophila) 0.034
Perp PERP, TP53 apoptosis effector 0.033
Krt14 keratin 14 0.026
Epha1 Eph receptor A1 0.024
Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) 0.023
Klk10 kallikrein related-peptidase 10 0.023
Arhgef5 Rho guanine nucleotide exchange factor (GEF) 5 0.023
C77080 expressed sequence C77080 0.022
Clock circadian locomotor output cycles kaput 0.022
Krt7 keratin 7 0.022
Cldn4 claudin 4 0.021
Epha2 Eph receptor A2 0.020
Bmpr1a bone morphogenetic protein receptor, type 1A 0.020
Krt19 keratin 19 0.020
Ctnnd1 catenin (cadherin associated protein), delta 1 0.019
Cxadr coxsackie virus and adenovirus receptor 0.019
4833422F24Rik RIKEN cDNA 4833422F24 gene 0.018
Emx1 empty spiracles homolog 1 (Drosophila) 0.018
Ovol1 OVO homolog-like 1 (Drosophila) 0.017
Rb1 retinoblastoma 1 0.017
Pcdh1 protocadherin 1 0.017
Otx2 orthodenticle homolog 2 (Drosophila) 0.017
Il11 interleukin 11 0.016
Sprr1a small proline-rich protein 1A 0.016
Numb numb gene homolog (Drosophila) 0.016
Trim62 tripartite motif-containing 62 0.016
Ptgfrn prostaglandin F2 receptor negative regulator 0.015
Cdcp1 CUB domain containing protein 1 0.015
Mpzl2 myelin protein zero-like 2 0.015
Fam83h family with sequence similarity 83, member H 0.015
Map2k3 mitogen-activated protein kinase kinase 3 0.014
Scn5a sodium channel, voltage-gated, type V, alpha 0.014
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.014
Ccnd1 cyclin D1 0.013
Krt8 keratin 8 0.013
Hbegf heparin-binding EGF-like growth factor 0.013
Krtdap keratinocyte differentiation associated protein 0.012
Gli3 GLI-Kruppel family member GLI3 0.012
S100a14 S100 calcium binding protein A14 0.012
Ly6d lymphocyte antigen 6 complex, locus D 0.012
Efna1 ephrin A1 0.012
Pkp1 plakophilin 1 0.012
Phldb2 pleckstrin homology-like domain, family B, member 2 0.011
Lad1 ladinin 0.011
Tax1bp3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.011
Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 0.011
Spert spermatid associated 0.011
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.011
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.011
Bmp4 bone morphogenetic protein 4 0.011
Foxc1 forkhead box C1 0.011
Rhpn2 rhophilin, Rho GTPase binding protein 2 0.010
Trp53 transformation related protein 53 0.010
S100a3 S100 calcium binding protein A3 0.010
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism