|
muscle tissue development
|
GO:0060537 |
308 |
0.967
|
|
|
rhythmic process
|
GO:0048511 |
174 |
0.963
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.937
|
|
|
spermatogenesis
|
GO:0007283 |
284 |
0.925
|
|
|
male gamete generation
|
GO:0048232 |
285 |
0.916
|
|
|
columnar cuboidal epithelial cell differentiation
|
GO:0002065 |
82 |
0.889
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.868
|
|
|
urogenital system development
|
GO:0001655 |
261 |
0.832
|
|
|
regulation of cellular senescence
|
GO:2000772 |
6 |
0.831
|
|
|
cellular senescence
|
GO:0090398 |
11 |
0.820
|
|
|
developmental maturation
|
GO:0021700 |
193 |
0.803
|
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
45 |
0.781
|
|
|
epithelial cell development
|
GO:0002064 |
159 |
0.777
|
|
|
digestive tract development
|
GO:0048565 |
190 |
0.775
|
|
|
response to oxygen levels
|
GO:0070482 |
62 |
0.765
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.764
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
82 |
0.756
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
64 |
0.754
|
|
|
regulation of dna templated transcription in response to stress
|
GO:0043620 |
9 |
0.744
|
|
|
circadian rhythm
|
GO:0007623 |
114 |
0.733
|
|
|
cell fate commitment
|
GO:0045165 |
210 |
0.718
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.699
|
|
|
wnt signaling pathway
|
GO:0016055 |
188 |
0.698
|
|
|
response to peptide hormone
|
GO:0043434 |
127 |
0.684
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
130 |
0.673
|
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.648
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
150 |
0.643
|
Rat |
|
epidermis development
|
GO:0008544 |
187 |
0.633
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.624
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.614
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.609
|
|
|
cell aging
|
GO:0007569 |
35 |
0.604
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
147 |
0.593
|
|
|
fat cell differentiation
|
GO:0045444 |
160 |
0.587
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.585
|
|
|
regulation of transcription from rna polymerase ii promoter in response to stress
|
GO:0043618 |
8 |
0.566
|
|
|
regulation of peptide secretion
|
GO:0002791 |
77 |
0.565
|
|
|
regulation of cell aging
|
GO:0090342 |
9 |
0.564
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
115 |
0.560
|
|
|
response to radiation
|
GO:0009314 |
165 |
0.549
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.548
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.543
|
|
|
dendrite development
|
GO:0016358 |
115 |
0.541
|
Fly |
|
metanephric glomerular mesangium development
|
GO:0072223 |
3 |
0.540
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.537
|
|
|
regulation of intracellular steroid hormone receptor signaling pathway
|
GO:0033143 |
18 |
0.535
|
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.532
|
|
|
erythrocyte differentiation
|
GO:0030218 |
88 |
0.525
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.524
|
|
|
ossification
|
GO:0001503 |
216 |
0.517
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
141 |
0.515
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.508
|
|
|
skeletal muscle organ development
|
GO:0060538 |
163 |
0.506
|
|
|
regulation of peptide transport
|
GO:0090087 |
91 |
0.498
|
|
|
cellular response to antibiotic
|
GO:0071236 |
4 |
0.498
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
139 |
0.495
|
|
|
protein targeting
|
GO:0006605 |
143 |
0.494
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.493
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
189 |
0.492
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.488
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.476
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.461
|
|
|
response to organic cyclic compound
|
GO:0014070 |
198 |
0.447
|
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.441
|
Mouse |
|
axonogenesis
|
GO:0007409 |
274 |
0.441
|
|
|
nitrogen compound transport
|
GO:0071705 |
271 |
0.434
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.432
|
|
|
cellular response to gamma radiation
|
GO:0071480 |
4 |
0.429
|
|
|
striated muscle tissue development
|
GO:0014706 |
293 |
0.428
|
|
|
germ cell development
|
GO:0007281 |
185 |
0.428
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.419
|
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.413
|
|
|
peptide transport
|
GO:0015833 |
133 |
0.411
|
|
|
endocrine system development
|
GO:0035270 |
98 |
0.411
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.405
|
|
|
skeletal muscle cell differentiation
|
GO:0035914 |
66 |
0.403
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.401
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
81 |
0.398
|
|
|
regulation of protein sumoylation
|
GO:0033233 |
4 |
0.398
|
Mouse |
|
regulation of fat cell differentiation
|
GO:0045598 |
81 |
0.395
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.393
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.391
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.388
|
|
|
negative regulation of fat cell differentiation
|
GO:0045599 |
36 |
0.380
|
|
|
intracellular steroid hormone receptor signaling pathway
|
GO:0030518 |
29 |
0.379
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.379
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.377
|
|
|
development of primary female sexual characteristics
|
GO:0046545 |
73 |
0.377
|
Rat |
|
negative regulation of tor signaling
|
GO:0032007 |
13 |
0.375
|
|
|
placenta development
|
GO:0001890 |
140 |
0.373
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.373
|
|
|
regulation of microvillus assembly
|
GO:0032534 |
3 |
0.372
|
|
|
protein import into nucleus translocation
|
GO:0000060 |
12 |
0.369
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
59 |
0.368
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.368
|
|
|
protein localization to nucleus
|
GO:0034504 |
121 |
0.366
|
|
|
nuclear import
|
GO:0051170 |
95 |
0.365
|
|
|
single organism nuclear import
|
GO:1902593 |
95 |
0.362
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
78 |
0.358
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.353
|
|
|
regulation of inflammatory response
|
GO:0050727 |
147 |
0.352
|
|
|
regulation of tor signaling
|
GO:0032006 |
17 |
0.348
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.345
|
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.345
|
|
|
kidney development
|
GO:0001822 |
213 |
0.339
|
|
|
response to insulin
|
GO:0032868 |
100 |
0.338
|
|
|
cellular protein catabolic process
|
GO:0044257 |
155 |
0.335
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.330
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
303 |
0.324
|
|
|
female gamete generation
|
GO:0007292 |
74 |
0.322
|
|
|
response to hypoxia
|
GO:0001666 |
58 |
0.317
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
77 |
0.314
|
|
|
regulation of actin filament based process
|
GO:0032970 |
99 |
0.306
|
|
|
gliogenesis
|
GO:0042063 |
141 |
0.305
|
|
|
insulin secretion
|
GO:0030073 |
89 |
0.304
|
|
|
columnar cuboidal epithelial cell development
|
GO:0002066 |
29 |
0.296
|
|
|
skin development
|
GO:0043588 |
220 |
0.293
|
|
|
amide transport
|
GO:0042886 |
138 |
0.292
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.289
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.289
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
30 |
0.288
|
Mouse |
|
female sex differentiation
|
GO:0046660 |
84 |
0.285
|
Rat |
|
asymmetric neuroblast division
|
GO:0055059 |
1 |
0.284
|
|
|
oogenesis
|
GO:0048477 |
56 |
0.281
|
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.281
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.279
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
151 |
0.278
|
Fly |
|
cellular macromolecule catabolic process
|
GO:0044265 |
206 |
0.275
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.270
|
|
|
creatinine metabolic process
|
GO:0046449 |
3 |
0.265
|
|
|
mitochondrion organization
|
GO:0007005 |
134 |
0.265
|
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.264
|
|
|
regulation of b cell proliferation
|
GO:0030888 |
39 |
0.263
|
Human |
|
positive regulation of cytokine production
|
GO:0001819 |
174 |
0.260
|
|
|
decidualization
|
GO:0046697 |
10 |
0.260
|
|
|
response to steroid hormone
|
GO:0048545 |
56 |
0.260
|
Rat |
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
65 |
0.256
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.256
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
122 |
0.256
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.254
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.254
|
|
|
sensory perception
|
GO:0007600 |
245 |
0.254
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
92 |
0.254
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
145 |
0.253
|
|
|
male sex differentiation
|
GO:0046661 |
109 |
0.252
|
|
|
protein import
|
GO:0017038 |
101 |
0.248
|
|
|
response to ionizing radiation
|
GO:0010212 |
42 |
0.247
|
|
|
sertoli cell differentiation
|
GO:0060008 |
18 |
0.246
|
|
|
negative regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0045736 |
9 |
0.245
|
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.241
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
87 |
0.236
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.233
|
Human |
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
73 |
0.230
|
|
|
development of primary sexual characteristics
|
GO:0045137 |
143 |
0.227
|
Rat |
|
cellular response to radiation
|
GO:0071478 |
28 |
0.226
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
123 |
0.226
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.226
|
Human |
|
respiratory system development
|
GO:0060541 |
190 |
0.224
|
|
|
regulation of circadian rhythm
|
GO:0042752 |
58 |
0.223
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.222
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.222
|
|
|
regulation of b cell activation
|
GO:0050864 |
81 |
0.221
|
Human |
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.219
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
112 |
0.219
|
|
|
regulation of transcription from rna polymerase ii promoter in response to oxidative stress
|
GO:0043619 |
2 |
0.215
|
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.214
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.214
|
|
|
regulation of peptidase activity
|
GO:0052547 |
96 |
0.211
|
|
|
response to extracellular stimulus
|
GO:0009991 |
127 |
0.211
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
118 |
0.210
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
84 |
0.210
|
|
|
gland development
|
GO:0048732 |
330 |
0.208
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.205
|
|
|
cellular response to decreased oxygen levels
|
GO:0036294 |
18 |
0.205
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
129 |
0.204
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
85 |
0.203
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
83 |
0.203
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
187 |
0.201
|
Mouse |
|
proteoglycan biosynthetic process
|
GO:0030166 |
20 |
0.200
|
|
|
male gonad development
|
GO:0008584 |
88 |
0.199
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
323 |
0.199
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
34 |
0.198
|
|
|
digestive system development
|
GO:0055123 |
200 |
0.197
|
|
|
peptide secretion
|
GO:0002790 |
114 |
0.196
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.196
|
|
|
regulation of hormone levels
|
GO:0010817 |
211 |
0.196
|
|
|
citrate metabolic process
|
GO:0006101 |
3 |
0.195
|
|
|
epidermis morphogenesis
|
GO:0048730 |
33 |
0.195
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.193
|
|
|
axon guidance
|
GO:0007411 |
141 |
0.193
|
|
|
positive regulation of canonical wnt signaling pathway
|
GO:0090263 |
29 |
0.192
|
|
|
response to x ray
|
GO:0010165 |
11 |
0.189
|
|
|
protein processing
|
GO:0016485 |
163 |
0.189
|
|
|
regionalization
|
GO:0003002 |
337 |
0.187
|
Fly |
|
b cell proliferation
|
GO:0042100 |
53 |
0.185
|
Human |
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.183
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.180
|
Mouse |
|
organ growth
|
GO:0035265 |
117 |
0.180
|
|
|
protein acylation
|
GO:0043543 |
64 |
0.180
|
|
|
pole plasm assembly
|
GO:0007315 |
2 |
0.179
|
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.178
|
|
|
female gonad development
|
GO:0008585 |
71 |
0.178
|
Rat |
|
triglyceride biosynthetic process
|
GO:0019432 |
17 |
0.176
|
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.173
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
230 |
0.172
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
73 |
0.172
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
49 |
0.170
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.169
|
|
|
glomerulus development
|
GO:0032835 |
40 |
0.166
|
|
|
cytokine production
|
GO:0001816 |
319 |
0.166
|
|
|
oocyte maturation
|
GO:0001556 |
18 |
0.166
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
78 |
0.166
|
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.165
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.164
|
|
|
protein maturation
|
GO:0051604 |
176 |
0.163
|
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.161
|
|
|
regulation of vascular endothelial growth factor production
|
GO:0010574 |
13 |
0.161
|
|
|
positive regulation of insulin receptor signaling pathway
|
GO:0046628 |
4 |
0.160
|
|
|
chemotaxis
|
GO:0006935 |
247 |
0.160
|
|
|
salivary gland development
|
GO:0007431 |
37 |
0.160
|
|
|
response to nutrient levels
|
GO:0031667 |
109 |
0.158
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
64 |
0.156
|
|
|
oocyte differentiation
|
GO:0009994 |
35 |
0.156
|
|
|
positive regulation vascular endothelial growth factor production
|
GO:0010575 |
10 |
0.156
|
|
|
gonad development
|
GO:0008406 |
141 |
0.156
|
Rat |
|
cellular amide metabolic process
|
GO:0043603 |
58 |
0.156
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
84 |
0.155
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
132 |
0.155
|
|
|
neuron projection guidance
|
GO:0097485 |
141 |
0.154
|
|
|
cell maturation
|
GO:0048469 |
127 |
0.154
|
|
|
response to uv
|
GO:0009411 |
44 |
0.154
|
|
|
multicellular organism growth
|
GO:0035264 |
161 |
0.154
|
|
|
positive regulation of intracellular estrogen receptor signaling pathway
|
GO:0033148 |
4 |
0.152
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.150
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.150
|
|
|
embryonic placenta development
|
GO:0001892 |
98 |
0.147
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.146
|
|
|
positive regulation of hormone metabolic process
|
GO:0032352 |
3 |
0.146
|
|
|
mitotic cell cycle arrest
|
GO:0071850 |
4 |
0.145
|
|
|
cell fate specification
|
GO:0001708 |
72 |
0.145
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
81 |
0.145
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.145
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
133 |
0.144
|
|
|
lung development
|
GO:0030324 |
164 |
0.142
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.140
|
|
|
regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0000079 |
16 |
0.139
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.136
|
|
|
development of primary male sexual characteristics
|
GO:0046546 |
88 |
0.136
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
56 |
0.135
|
|
|
regulation of organ morphogenesis
|
GO:2000027 |
144 |
0.135
|
Fly |
|
regulation of reproductive process
|
GO:2000241 |
66 |
0.135
|
|
|
response to growth factor
|
GO:0070848 |
198 |
0.134
|
|
|
muscle system process
|
GO:0003012 |
141 |
0.134
|
|
|
hair cycle
|
GO:0042633 |
90 |
0.131
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.131
|
Human |
|
stem cell differentiation
|
GO:0048863 |
268 |
0.131
|
|
|
bmp signaling pathway
|
GO:0030509 |
93 |
0.128
|
|
|
positive regulation of cell morphogenesis involved in differentiation
|
GO:0010770 |
72 |
0.128
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
84 |
0.127
|
|
|
regulation of engulfment of apoptotic cell
|
GO:1901074 |
2 |
0.127
|
|
|
prostate gland development
|
GO:0030850 |
48 |
0.126
|
|
|
positive regulation of cell activation
|
GO:0050867 |
158 |
0.125
|
|
|
muscle cell differentiation
|
GO:0042692 |
261 |
0.125
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.124
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.124
|
|
|
gamma delta t cell differentiation
|
GO:0042492 |
11 |
0.123
|
|
|
positive regulation of cell development
|
GO:0010720 |
237 |
0.123
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
88 |
0.123
|
|
|
vascular endothelial growth factor production
|
GO:0010573 |
13 |
0.123
|
|
|
succinate metabolic process
|
GO:0006105 |
4 |
0.121
|
|
|
valine metabolic process
|
GO:0006573 |
4 |
0.120
|
|
|
regulation of ovulation
|
GO:0060278 |
3 |
0.120
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.120
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.120
|
|
|
cellular response to starvation
|
GO:0009267 |
57 |
0.120
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
128 |
0.119
|
|
|
angiogenesis
|
GO:0001525 |
201 |
0.119
|
|
|
hair follicle morphogenesis
|
GO:0031069 |
29 |
0.119
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.118
|
Human |
|
response to acid chemical
|
GO:0001101 |
111 |
0.117
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.116
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
43 |
0.115
|
|
|
circulatory system process
|
GO:0003013 |
197 |
0.114
|
|
|
negative regulation of ripoptosome assembly involved in necroptotic process
|
GO:1902443 |
3 |
0.114
|
|
|
response to glucocorticoid
|
GO:0051384 |
20 |
0.114
|
Rat |
|
connective tissue development
|
GO:0061448 |
179 |
0.114
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
45 |
0.113
|
|
|
creatine metabolic process
|
GO:0006600 |
4 |
0.112
|
|
|
innate immune response
|
GO:0045087 |
157 |
0.112
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
96 |
0.111
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
128 |
0.110
|
|
|
protein kinase b signaling
|
GO:0043491 |
74 |
0.110
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
83 |
0.109
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
93 |
0.109
|
|
|
hormone mediated signaling pathway
|
GO:0009755 |
23 |
0.109
|
|
|
regulation of cell projection organization
|
GO:0031344 |
206 |
0.109
|
Fly |
|
regulation of hormone secretion
|
GO:0046883 |
88 |
0.109
|
|
|
mesenchyme development
|
GO:0060485 |
152 |
0.109
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
108 |
0.108
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.108
|
|
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097192 |
55 |
0.107
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
147 |
0.107
|
|
|
regulation of neuron projection development
|
GO:0010975 |
169 |
0.107
|
Fly |
|
cellular response to external stimulus
|
GO:0071496 |
88 |
0.106
|
|
|
skin morphogenesis
|
GO:0043589 |
38 |
0.106
|
|
|
signal transduction in absence of ligand
|
GO:0038034 |
55 |
0.105
|
|
|
skeletal system morphogenesis
|
GO:0048705 |
203 |
0.104
|
|
|
sulfur compound metabolic process
|
GO:0006790 |
100 |
0.103
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
194 |
0.103
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
94 |
0.103
|
|
|
skeletal system development
|
GO:0001501 |
356 |
0.103
|
|
|
morphogenesis of a branching structure
|
GO:0001763 |
203 |
0.103
|
|
|
microtubule based process
|
GO:0007017 |
236 |
0.102
|
|
|
cell differentiation involved in kidney development
|
GO:0061005 |
33 |
0.102
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.102
|
|
|
hormone metabolic process
|
GO:0042445 |
86 |
0.102
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
61 |
0.101
|
|
|
cellular response to steroid hormone stimulus
|
GO:0071383 |
33 |
0.101
|
Rat |
|
ovarian follicle development
|
GO:0001541 |
40 |
0.101
|
Rat |
|
renal system development
|
GO:0072001 |
225 |
0.100
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
2 |
0.100
|
|
|
hair follicle development
|
GO:0001942 |
85 |
0.100
|
|
|
positive regulation of glial cell proliferation
|
GO:0060252 |
4 |
0.100
|
|
|
regulation of protein targeting
|
GO:1903533 |
61 |
0.100
|
|
|
negative regulation of ovulation
|
GO:0060280 |
1 |
0.099
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
11 |
0.098
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
192 |
0.098
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
112 |
0.097
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.097
|
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
43 |
0.097
|
|
|
spermatid development
|
GO:0007286 |
108 |
0.096
|
|
|
mesonephric tubule development
|
GO:0072164 |
94 |
0.096
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
164 |
0.096
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.095
|
|
|
sulfur compound biosynthetic process
|
GO:0044272 |
37 |
0.095
|
|
|
blood circulation
|
GO:0008015 |
195 |
0.095
|
|
|
alpha amino acid metabolic process
|
GO:1901605 |
59 |
0.094
|
|
|
cell division
|
GO:0051301 |
120 |
0.094
|
|
|
necroptotic process
|
GO:0070266 |
21 |
0.093
|
|
|
peptidyl lysine acetylation
|
GO:0018394 |
45 |
0.093
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
178 |
0.093
|
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
26 |
0.093
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
215 |
0.093
|
|
|
positive regulation of intracellular steroid hormone receptor signaling pathway
|
GO:0033145 |
4 |
0.092
|
|
|
synaptic transmission
|
GO:0007268 |
329 |
0.092
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
58 |
0.092
|
|
|
cell growth
|
GO:0016049 |
130 |
0.092
|
|
|
glial cell differentiation
|
GO:0010001 |
131 |
0.092
|
|
|
positive regulation of cell proliferation involved in heart valve morphogenesis
|
GO:0003251 |
1 |
0.091
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
183 |
0.091
|
|
|
asymmetric stem cell division
|
GO:0098722 |
3 |
0.091
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
61 |
0.090
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.090
|
|
|
regulation of peptide hormone secretion
|
GO:0090276 |
75 |
0.090
|
|
|
nephron development
|
GO:0072006 |
109 |
0.089
|
|
|
response to light stimulus
|
GO:0009416 |
135 |
0.088
|
|
|
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902043 |
13 |
0.088
|
|
|
stem cell development
|
GO:0048864 |
219 |
0.088
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
34 |
0.088
|
|
|
regulation of hormone metabolic process
|
GO:0032350 |
15 |
0.088
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
85 |
0.087
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
140 |
0.087
|
|
|
peptidyl lysine modification
|
GO:0018205 |
77 |
0.087
|
|
|
membrane organization
|
GO:0061024 |
245 |
0.086
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
53 |
0.086
|
|
|
lactation
|
GO:0007595 |
25 |
0.085
|
|
|
regulation of feeding behavior
|
GO:0060259 |
3 |
0.084
|
|
|
negative regulation of necroptotic process
|
GO:0060546 |
9 |
0.084
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.084
|
|
|
pancreas development
|
GO:0031016 |
57 |
0.084
|
|
|
regulation of tolerance induction dependent upon immune response
|
GO:0002652 |
1 |
0.084
|
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
59 |
0.083
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
88 |
0.083
|
|
|
regulation of protein import into nucleus translocation
|
GO:0033158 |
2 |
0.083
|
|
|
regulation of microvillus organization
|
GO:0032530 |
3 |
0.083
|
|
|
regulation of vasculature development
|
GO:1901342 |
88 |
0.083
|
|
|
regulation of microtubule polymerization
|
GO:0031113 |
7 |
0.083
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
104 |
0.083
|
|
|
gastrulation
|
GO:0007369 |
116 |
0.081
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.081
|
|
|
histone acetylation
|
GO:0016573 |
41 |
0.081
|
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
70 |
0.081
|
|
|
motor neuron axon guidance
|
GO:0008045 |
26 |
0.080
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
74 |
0.080
|
|
|
regulation of chemotaxis
|
GO:0050920 |
53 |
0.080
|
|
|
immature b cell differentiation
|
GO:0002327 |
10 |
0.080
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
60 |
0.080
|
|
|
acylglycerol biosynthetic process
|
GO:0046463 |
18 |
0.080
|
|
|
spermatid differentiation
|
GO:0048515 |
115 |
0.080
|
|
|
transmission of nerve impulse
|
GO:0019226 |
76 |
0.079
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.079
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
88 |
0.079
|
|
|
t cell differentiation in thymus
|
GO:0033077 |
77 |
0.079
|
|
|
response to testosterone
|
GO:0033574 |
3 |
0.079
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
98 |
0.078
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
0.078
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.078
|
|
|
negative regulation of glial cell proliferation
|
GO:0060253 |
4 |
0.078
|
|
|
maternal process involved in female pregnancy
|
GO:0060135 |
32 |
0.077
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.077
|
|
|
negative regulation of leukocyte differentiation
|
GO:1902106 |
51 |
0.077
|
|
|
lipid biosynthetic process
|
GO:0008610 |
179 |
0.077
|
|
|
positive regulation of response to wounding
|
GO:1903036 |
66 |
0.076
|
|
|
locomotory behavior
|
GO:0007626 |
195 |
0.076
|
|
|
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090100 |
43 |
0.075
|
|
|
positive regulation of smooth muscle cell migration
|
GO:0014911 |
4 |
0.075
|
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
9 |
0.075
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
27 |
0.075
|
|
|
basement membrane organization
|
GO:0071711 |
8 |
0.075
|
|
|
regulation of blood pressure
|
GO:0008217 |
93 |
0.074
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
62 |
0.074
|
|
|
cardiac muscle hypertrophy
|
GO:0003300 |
23 |
0.073
|
|
|
positive regulation of growth
|
GO:0045927 |
104 |
0.073
|
|
|
intestinal epithelial cell differentiation
|
GO:0060575 |
14 |
0.073
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
76 |
0.073
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
35 |
0.073
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
57 |
0.072
|
Mouse |
|
hormone secretion
|
GO:0046879 |
128 |
0.072
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.071
|
|
|
taurine metabolic process
|
GO:0019530 |
4 |
0.071
|
|
|
hindbrain development
|
GO:0030902 |
128 |
0.071
|
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
59 |
0.070
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
70 |
0.070
|
|
|
hepaticobiliary system development
|
GO:0061008 |
67 |
0.070
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.069
|
Human |
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.069
|
|
|
smoothened signaling pathway
|
GO:0007224 |
105 |
0.069
|
|
|
positive regulation of circadian rhythm
|
GO:0042753 |
7 |
0.069
|
|
|
neuronal action potential
|
GO:0019228 |
54 |
0.068
|
|
|
stem cell maintenance
|
GO:0019827 |
130 |
0.068
|
|
|
establishment or maintenance of cytoskeleton polarity
|
GO:0030952 |
2 |
0.068
|
|
|
kidney epithelium development
|
GO:0072073 |
121 |
0.067
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.067
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
8 |
0.067
|
|
|
positive regulation of neuron projection development
|
GO:0010976 |
79 |
0.067
|
|
|
ribonucleotide metabolic process
|
GO:0009259 |
291 |
0.067
|
|
|
drug catabolic process
|
GO:0042737 |
2 |
0.066
|
|
|
regulation of keratinocyte proliferation
|
GO:0010837 |
15 |
0.066
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.066
|
|
|
microtubule polymerization
|
GO:0046785 |
12 |
0.066
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.066
|
|
|
mammary gland epithelium development
|
GO:0061180 |
65 |
0.066
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
221 |
0.066
|
|
|
protein sumoylation
|
GO:0016925 |
14 |
0.065
|
Mouse |
|
negative regulation of epithelial cell proliferation involved in prostate gland development
|
GO:0060770 |
7 |
0.065
|
|
|
oocyte axis specification
|
GO:0007309 |
2 |
0.064
|
|
|
hair cycle phase
|
GO:0044851 |
16 |
0.064
|
|
|
lateral line system development
|
GO:0048925 |
1 |
0.064
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
181 |
0.064
|
|
|
mammary gland duct morphogenesis
|
GO:0060603 |
38 |
0.064
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
141 |
0.064
|
|
|
mitotic cell cycle process
|
GO:1903047 |
159 |
0.064
|
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
4 |
0.063
|
|
|
response to retinoic acid
|
GO:0032526 |
56 |
0.063
|
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.063
|
|
|
regulation of cellular carbohydrate metabolic process
|
GO:0010675 |
75 |
0.063
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
71 |
0.063
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
122 |
0.063
|
|
|
cellular response to gonadotropin stimulus
|
GO:0071371 |
4 |
0.063
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
85 |
0.063
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.062
|
|
|
carbohydrate biosynthetic process
|
GO:0016051 |
74 |
0.062
|
|
|
liver development
|
GO:0001889 |
66 |
0.062
|
|
|
peptide hormone secretion
|
GO:0030072 |
109 |
0.062
|
|
|
regulation of chromatin modification
|
GO:1903308 |
57 |
0.061
|
|
|
positive regulation of inflammatory response
|
GO:0050729 |
47 |
0.061
|
|
|
negative regulation of phosphatidylinositol 3 kinase activity
|
GO:0043553 |
1 |
0.061
|
|
|
microtubule polymerization or depolymerization
|
GO:0031109 |
26 |
0.061
|
|
|
chromatin organization
|
GO:0006325 |
206 |
0.061
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.061
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
126 |
0.061
|
|
|
b cell differentiation
|
GO:0030183 |
78 |
0.061
|
|
|
cellular response to inorganic substance
|
GO:0071241 |
37 |
0.061
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
36 |
0.060
|
|
|
ensheathment of neurons
|
GO:0007272 |
76 |
0.060
|
|
|
negative regulation of keratinocyte proliferation
|
GO:0010839 |
7 |
0.060
|
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
51 |
0.060
|
|
|
regulation of triglyceride biosynthetic process
|
GO:0010866 |
10 |
0.060
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
122 |
0.060
|
|
|
cell adhesion
|
GO:0007155 |
329 |
0.060
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.060
|
|
|
cellular lactam metabolic process
|
GO:0072338 |
3 |
0.060
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.059
|
Human |
|
positive regulation of t cell proliferation
|
GO:0042102 |
52 |
0.059
|
|
|
organic anion transport
|
GO:0015711 |
137 |
0.059
|
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
119 |
0.059
|
|
|
cellular response to ionizing radiation
|
GO:0071479 |
11 |
0.059
|
|