IMP

Process View

Mus musculus

3 genes annotated in mouse

negative regulation of ripoptosome assembly involved in necroptotic process

GO:1902443

Any process that stops, prevents or reduces the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of ripoptosome assembly involved in necroptotic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of ripoptosome assembly involved in necroptotic process" (in gray)

Name	Description	Probability	Func Analog Organism
Ikbkg	inhibitor of kappaB kinase gamma	0.999
Ikbkb	inhibitor of kappaB kinase beta	0.963
Traf6	TNF receptor-associated factor 6	0.923
Traf2	TNF receptor-associated factor 2	0.882
Chuk	conserved helix-loop-helix ubiquitous kinase	0.872
Tgfbr1	transforming growth factor, beta receptor I	0.859
Hccs	holocytochrome c synthetase	0.759
Myd88	myeloid differentiation primary response gene 88	0.677
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.635
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.572
Tlr4	toll-like receptor 4	0.484
Skil	SKI-like	0.462
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.279
Smad5	MAD homolog 5 (Drosophila)	0.204
Smad1	MAD homolog 1 (Drosophila)	0.191
Diablo	diablo homolog (Drosophila)	0.189
Casp8	caspase 8	0.187
Map3k2	mitogen-activated protein kinase kinase kinase 2	0.187
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.179
Cd40	CD40 antigen	0.150
Tgfbr2	transforming growth factor, beta receptor II	0.133
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.119
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.115
Foxp3	forkhead box P3	0.114
Ahr	aryl-hydrocarbon receptor	0.114
Naip2	NLR family, apoptosis inhibitory protein 2	0.112
Map2k4	mitogen-activated protein kinase kinase 4	0.106
Pten	phosphatase and tensin homolog	0.094
Stat3	signal transducer and activator of transcription 3	0.077
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.076
Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.075
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.072
Naip5	NLR family, apoptosis inhibitory protein 5	0.067	Mouse
Malt1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.064
Irak1	interleukin-1 receptor-associated kinase 1	0.061
Birc3	baculoviral IAP repeat-containing 3	0.060	Mouse
Card11	caspase recruitment domain family, member 11	0.052
Cytip	cytohesin 1 interacting protein	0.052
Naip6	NLR family, apoptosis inhibitory protein 6	0.051	Mouse
A230046K03Rik	RIKEN cDNA A230046K03 gene	0.050
Zufsp	zinc finger with UFM1-specific peptidase domain	0.048
Il10	interleukin 10	0.046
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.042
Tfrc	transferrin receptor	0.041
Trp53	transformation related protein 53	0.041
Htra2	HtrA serine peptidase 2	0.038
Chd2	chromodomain helicase DNA binding protein 2	0.038
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.037
Pikfyve	phosphoinositide kinase, FYVE finger containing	0.036
Nlrp3	NLR family, pyrin domain containing 3	0.035
Ccr2	chemokine (C-C motif) receptor 2	0.032
Mx1	myxovirus (influenza virus) resistance 1	0.032
Lair1	leukocyte-associated Ig-like receptor 1	0.030
Cyld	cylindromatosis (turban tumor syndrome)	0.030
Tbce	tubulin-specific chaperone E	0.027
Casp1	caspase 1	0.027
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.027
Itch	itchy, E3 ubiquitin protein ligase	0.026
Nlrc5	NLR family, CARD domain containing 5	0.025
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.025
Ly96	lymphocyte antigen 96	0.025
Braf	Braf transforming gene	0.024
Pyhin1	pyrin and HIN domain family, member 1	0.024
Nr2c2	nuclear receptor subfamily 2, group C, member 2	0.022
Il6st	interleukin 6 signal transducer	0.022
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.021
Hspa1b	heat shock protein 1B	0.021
Ate1	arginyltransferase 1	0.020
Cd33	CD33 antigen	0.020
Lpxn	leupaxin	0.020
Kif5b	kinesin family member 5B	0.019
Bcl10	B-cell leukemia/lymphoma 10	0.019
Tlr2	toll-like receptor 2	0.019
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.019
Slc35a3	solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3	0.019
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.019
Hif1a	hypoxia inducible factor 1, alpha subunit	0.019
Frk	fyn-related kinase	0.018
Snx13	sorting nexin 13	0.018
Ms4a6b	membrane-spanning 4-domains, subfamily A, member 6B	0.018
Lcor	ligand dependent nuclear receptor corepressor	0.018
Jag1	jagged 1	0.018
Atp11c	ATPase, class VI, type 11C	0.018
Tbk1	TANK-binding kinase 1	0.018
Fpr2	formyl peptide receptor 2	0.018
Abcb4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	0.017
Klhl24	kelch-like 24 (Drosophila)	0.017
Zcchc6	zinc finger, CCHC domain containing 6	0.017
Usp12	ubiquitin specific peptidase 12	0.017
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.016
Cd84	CD84 antigen	0.016
Cd86	CD86 antigen	0.016
Atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.016
Adamdec1	ADAM-like, decysin 1	0.016
Zfp40	zinc finger protein 40	0.016
Xrn1	5'-3' exoribonuclease 1	0.016
Stk17b	serine/threonine kinase 17b (apoptosis-inducing)	0.016
BC006779	cDNA sequence BC006779	0.016
Cflar	CASP8 and FADD-like apoptosis regulator	0.015
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.015
C78704	expressed sequence C78704	0.015
Cd180	CD180 antigen	0.015
Rgs18	regulator of G-protein signaling 18	0.015
Rfx5	regulatory factor X, 5 (influences HLA class II expression)	0.015
Klra17	killer cell lectin-like receptor, subfamily A, member 17	0.015
Tifa	TRAF-interacting protein with forkhead-associated domain	0.015
Epsti1	epithelial stromal interaction 1 (breast)	0.014
Unc93b1	unc-93 homolog B1 (C. elegans)	0.014
Rgs1	regulator of G-protein signaling 1	0.014
Tlr1	toll-like receptor 1	0.014
Tab3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.014
Rictor	RPTOR independent companion of MTOR, complex 2	0.014
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.014
Adam17	a disintegrin and metallopeptidase domain 17	0.014
Pign	phosphatidylinositol glycan anchor biosynthesis, class N	0.013
Creb1	cAMP responsive element binding protein 1	0.013
Trim30d	tripartite motif-containing 30D	0.013
Ccnl1	cyclin L1	0.013
2810474O19Rik	RIKEN cDNA 2810474O19 gene	0.013
Cd19	CD19 antigen	0.013
Casp3	caspase 3	0.013
Rp2h	retinitis pigmentosa 2 homolog (human)	0.013
Cd300lf	CD300 antigen like family member F	0.013
Morc3	microrchidia 3	0.013
Dhx40	DEAH (Asp-Glu-Ala-His) box polypeptide 40	0.012
Peli1	pellino 1	0.012
Il2	interleukin 2	0.012
Zfp146	zinc finger protein 146	0.012
Cr2	complement receptor 2	0.012
Gbp1	guanylate binding protein 1	0.012
Pion	pigeon homolog (Drosophila)	0.012
Clnk	cytokine-dependent hematopoietic cell linker	0.012
Mtmr1	myotubularin related protein 1	0.012
Gpr65	G-protein coupled receptor 65	0.012
Zc3h7a	zinc finger CCCH type containing 7 A	0.011
Prdm1	PR domain containing 1, with ZNF domain	0.011
Cd14	CD14 antigen	0.011
Serpinb7	serine (or cysteine) peptidase inhibitor, clade B, member 7	0.011
Irak4	interleukin-1 receptor-associated kinase 4	0.011
Irak3	interleukin-1 receptor-associated kinase 3	0.011
Fcgr4	Fc receptor, IgG, low affinity IV	0.011
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.011
Evi2b	ecotropic viral integration site 2b	0.011
Arhgap5	Rho GTPase activating protein 5	0.011
Oasl1	2'-5' oligoadenylate synthetase-like 1	0.011
Clec4d	C-type lectin domain family 4, member d	0.011
Uimc1	ubiquitin interaction motif containing 1	0.011
Clec4e	C-type lectin domain family 4, member e	0.011
Irg1	immunoresponsive gene 1	0.011
Btk	Bruton agammaglobulinemia tyrosine kinase	0.011
Rlf	rearranged L-myc fusion sequence	0.011
Gm7609	predicted pseudogene 7609	0.010
Col4a3bp	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	0.010
Clec2i	C-type lectin domain family 2, member i	0.010
Rnf31	ring finger protein 31	0.010
Kynu	kynureninase (L-kynurenine hydrolase)	0.010
Ms4a8a	membrane-spanning 4-domains, subfamily A, member 8A	0.010
Gmfb	glia maturation factor, beta	0.010
Mapk9	mitogen-activated protein kinase 9	0.010
Dmtf1	cyclin D binding myb-like transcription factor 1	0.010