IMP

Process View

Mus musculus

2 genes annotated in mouse

regulation of transcription from rna polymerase ii promoter in response to oxidative stress

Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of transcription from rna polymerase ii promoter in response to oxidative stress"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of transcription from rna polymerase ii promoter in response to oxidative stress" (in gray)

Name	Description	Probability	Func Analog Organism
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.534
Hif1a	hypoxia inducible factor 1, alpha subunit	0.313
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.297
Vhl	von Hippel-Lindau tumor suppressor	0.232
Ahr	aryl-hydrocarbon receptor	0.215
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.177
Trib3	tribbles homolog 3 (Drosophila)	0.166
Mt1	metallothionein 1	0.113
Lepr	leptin receptor	0.091
Egfr	epidermal growth factor receptor	0.085
Gpr50	G-protein-coupled receptor 50	0.084
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.068
Il6st	interleukin 6 signal transducer	0.064
Fos	FBJ osteosarcoma oncogene	0.060
Adam17	a disintegrin and metallopeptidase domain 17	0.053
Pten	phosphatase and tensin homolog	0.047
Insr	insulin receptor	0.045
Agpat2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.044
Otp	orthopedia homolog (Drosophila)	0.040
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.038
Cav1	caveolin 1, caveolae protein	0.033
Sim2	single-minded homolog 2 (Drosophila)	0.033	Mouse
Nos3	nitric oxide synthase 3, endothelial cell	0.033
Rdh10	retinol dehydrogenase 10 (all-trans)	0.033
Efna2	ephrin A2	0.032
Sim1	single-minded homolog 1 (Drosophila)	0.032	Mouse
Foxo1	forkhead box O1	0.031
Epor	erythropoietin receptor	0.030
Onecut1	one cut domain, family member 1	0.029
Egln3	EGL nine homolog 3 (C. elegans)	0.027
Tsga10	testis specific 10	0.027
Klf6	Kruppel-like factor 6	0.026
Foxa2	forkhead box A2	0.026
Ghr	growth hormone receptor	0.026
Ifngr1	interferon gamma receptor 1	0.026
Stat3	signal transducer and activator of transcription 3	0.026
Fgf8	fibroblast growth factor 8	0.025
Rxra	retinoid X receptor alpha	0.024
Wasf1	WASP family 1	0.024
Hoxc8	homeobox C8	0.023
Dusp1	dual specificity phosphatase 1	0.023
Tlr4	toll-like receptor 4	0.023
Errfi1	ERBB receptor feedback inhibitor 1	0.023
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.022
Hoxd9	homeobox D9	0.022
Clcnka	chloride channel Ka	0.021
Grb10	growth factor receptor bound protein 10	0.021
Fzd8	frizzled homolog 8 (Drosophila)	0.020
Smad5	MAD homolog 5 (Drosophila)	0.020
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.020
Ebf3	early B-cell factor 3	0.020
Braf	Braf transforming gene	0.020
Foxd2	forkhead box D2	0.020
Sall3	sal-like 3 (Drosophila)	0.020
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.019
Myod1	myogenic differentiation 1	0.019
Hoxa10	homeobox A10	0.019
Sumo1	SMT3 suppressor of mif two 3 homolog 1 (yeast)	0.019
Pparg	peroxisome proliferator activated receptor gamma	0.018
Jun	Jun oncogene	0.018
Ifrd1	interferon-related developmental regulator 1	0.018
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.018
Tcfap2c	transcription factor AP-2, gamma	0.018
Tgfbr3	transforming growth factor, beta receptor III	0.018
Spry4	sprouty homolog 4 (Drosophila)	0.018
Fzd4	frizzled homolog 4 (Drosophila)	0.018
Mep1a	meprin 1 alpha	0.018
Spp1	secreted phosphoprotein 1	0.018
Csf1	colony stimulating factor 1 (macrophage)	0.018
Pou3f1	POU domain, class 3, transcription factor 1	0.017
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.017
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.017
Ptprb	protein tyrosine phosphatase, receptor type, B	0.017
Tgfbr1	transforming growth factor, beta receptor I	0.017
Efnb2	ephrin B2	0.017
Pou3f2	POU domain, class 3, transcription factor 2	0.016
Ccdc96	coiled-coil domain containing 96	0.016
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.016
Igfbp1	insulin-like growth factor binding protein 1	0.016
Gata3	GATA binding protein 3	0.016
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.015
Tbx15	T-box 15	0.015
Fgf4	fibroblast growth factor 4	0.015
Ldlr	low density lipoprotein receptor	0.015
Atxn1	ataxin 1	0.015
Mt2	metallothionein 2	0.015
Gdnf	glial cell line derived neurotrophic factor	0.015
Tead3	TEA domain family member 3	0.015
Tmod3	tropomodulin 3	0.015
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.015
Efna5	ephrin A5	0.015
Mlph	melanophilin	0.014
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.014
Dmtf1	cyclin D binding myb-like transcription factor 1	0.014
Lhx6	LIM homeobox protein 6	0.014
Apoe	apolipoprotein E	0.014
Dlg1	discs, large homolog 1 (Drosophila)	0.014
Plcg1	phospholipase C, gamma 1	0.014
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.013
Alk	anaplastic lymphoma kinase	0.013
Cdh4	cadherin 4	0.013
Fst	follistatin	0.013
Lhx1	LIM homeobox protein 1	0.013
Rictor	RPTOR independent companion of MTOR, complex 2	0.013
Hoxa11	homeobox A11	0.013
Adam9	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	0.013
Nfia	nuclear factor I/A	0.013
Col12a1	collagen, type XII, alpha 1	0.012
Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	0.012
Ncoa3	nuclear receptor coactivator 3	0.012
Hipk3	homeodomain interacting protein kinase 3	0.012
Stxbp3a	syntaxin binding protein 3A	0.012
Per3	period homolog 3 (Drosophila)	0.012
Hoxd13	homeobox D13	0.012
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.012
Klf4	Kruppel-like factor 4 (gut)	0.012
Hoxd10	homeobox D10	0.012
Ephb2	Eph receptor B2	0.012
Pitx1	paired-like homeodomain transcription factor 1	0.012
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.012
Ar	androgen receptor	0.011
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.011
Ihh	Indian hedgehog	0.011
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.011
Fam164c	family with sequence similarity 164, member C	0.011
Fosl2	fos-like antigen 2	0.011
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.011
Pax2	paired box gene 2	0.011
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.011
Dab1	disabled homolog 1 (Drosophila)	0.011
Tgfa	transforming growth factor alpha	0.011
Itgav	integrin alpha V	0.011
Gdf11	growth differentiation factor 11	0.011
Ptgs2	prostaglandin-endoperoxide synthase 2	0.011
Dapk3	death-associated protein kinase 3	0.011
Flt1	FMS-like tyrosine kinase 1	0.011
Mcl1	myeloid cell leukemia sequence 1	0.011
Espn	espin	0.011
Arnt	aryl hydrocarbon receptor nuclear translocator	0.011	Human
Sox3	SRY-box containing gene 3	0.011
Slc27a1	solute carrier family 27 (fatty acid transporter), member 1	0.011
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.011
Hnf4a	hepatic nuclear factor 4, alpha	0.011
Zfp185	zinc finger protein 185	0.011
Foxo3	forkhead box O3	0.011
Hoxa4	homeobox A4	0.011
Syt7	synaptotagmin VII	0.011
Nrk	Nik related kinase	0.011
Hoxd4	homeobox D4	0.011
Ero1l	ERO1-like (S. cerevisiae)	0.011
Vegfa	vascular endothelial growth factor A	0.011
Ctsl	cathepsin L	0.011
Nkx6-1	NK6 homeobox 1	0.011
En2	engrailed 2	0.010
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.010
Psen1	presenilin 1	0.010
Irx1	Iroquois related homeobox 1 (Drosophila)	0.010
Tmem123	transmembrane protein 123	0.010
Gata2	GATA binding protein 2	0.010
Insm1	insulinoma-associated 1	0.010
Wt1	Wilms tumor 1 homolog	0.010
Ncoa2	nuclear receptor coactivator 2	0.010
Tead4	TEA domain family member 4	0.010
Dcx	doublecortin	0.010