IMP

Process View

Mus musculus

9 genes annotated in mouse

negative regulation of necroptotic process

Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of necroptotic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of necroptotic process" (in gray)

Name	Description	Probability	Func Analog Organism
Ikbkg	inhibitor of kappaB kinase gamma	1.000
Casp4	caspase 4, apoptosis-related cysteine peptidase	1.000	Mouse
Casp1	caspase 1	0.991	Mouse
Tlr4	toll-like receptor 4	0.987
Traf2	TNF receptor-associated factor 2	0.976
Sharpin	SHANK-associated RH domain interacting protein	0.956	Mouse
Pycard	PYD and CARD domain containing	0.931
Gbp5	guanylate binding protein 5	0.931
Myd88	myeloid differentiation primary response gene 88	0.839
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.830
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.815
Il18	interleukin 18	0.772
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.724
Nlrp3	NLR family, pyrin domain containing 3	0.700
Ikbkb	inhibitor of kappaB kinase beta	0.696
Casp8	caspase 8	0.678
Traf6	TNF receptor-associated factor 6	0.637
Aim2	absent in melanoma 2	0.567
Rnf31	ring finger protein 31	0.557
Il1b	interleukin 1 beta	0.522
Itch	itchy, E3 ubiquitin protein ligase	0.388
Cyld	cylindromatosis (turban tumor syndrome)	0.376
Rbck1	RanBP-type and C3HC4-type zinc finger containing 1	0.356
Smad5	MAD homolog 5 (Drosophila)	0.353
Birc3	baculoviral IAP repeat-containing 3	0.320
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.253
Hif1a	hypoxia inducible factor 1, alpha subunit	0.240
Casp7	caspase 7	0.228	Mouse
Chuk	conserved helix-loop-helix ubiquitous kinase	0.204
Ly96	lymphocyte antigen 96	0.200
Hccs	holocytochrome c synthetase	0.197
Gbp7	guanylate binding protein 7	0.188
Fas	Fas (TNF receptor superfamily member 6)	0.187
Tnf	tumor necrosis factor	0.187
Naip2	NLR family, apoptosis inhibitory protein 2	0.172
Gbp3	guanylate binding protein 3	0.105
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.098
Ahr	aryl-hydrocarbon receptor	0.084
Ripk3	receptor-interacting serine-threonine kinase 3	0.079
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.066
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.065
Smad1	MAD homolog 1 (Drosophila)	0.062
Casp3	caspase 3	0.055	Mouse
Cd40	CD40 antigen	0.053
Eya2	eyes absent 2 homolog (Drosophila)	0.050
Gja1	gap junction protein, alpha 1	0.048
Ifi47	interferon gamma inducible protein 47	0.045
Map3k2	mitogen-activated protein kinase kinase kinase 2	0.044
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.043
Il15	interleukin 15	0.043
Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.042
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.038
Fadd	Fas (TNFRSF6)-associated via death domain	0.037
Il1r1	interleukin 1 receptor, type I	0.036
Cflar	CASP8 and FADD-like apoptosis regulator	0.035
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.034
Foxp3	forkhead box P3	0.033
Stat3	signal transducer and activator of transcription 3	0.033
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.027
Fgl2	fibrinogen-like protein 2	0.027
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.027
Vwa5a	von Willebrand factor A domain containing 5A	0.026
Nat2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.026
Diablo	diablo homolog (Drosophila)	0.026
Ctsc	cathepsin C	0.025
Cd14	CD14 antigen	0.025
Coro1b	coronin, actin binding protein 1B	0.025
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.024
Pgm1	phosphoglucomutase 1	0.023
Stat1	signal transducer and activator of transcription 1	0.023
Plscr1	phospholipid scramblase 1	0.023
Glrx3	glutaredoxin 3	0.022
Lyz2	lysozyme 2	0.022
Gbp2	guanylate binding protein 2	0.022
Ifi203	interferon activated gene 203	0.021
Mdfic	MyoD family inhibitor domain containing	0.020
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.019
Xiap	X-linked inhibitor of apoptosis	0.019	Mouse
Rbl1	retinoblastoma-like 1 (p107)	0.018
Mndal	myeloid nuclear differentiation antigen like	0.018
Cd38	CD38 antigen	0.018
Trim30d	tripartite motif-containing 30D	0.018
Aim1	absent in melanoma 1	0.018
Ccr1	chemokine (C-C motif) receptor 1	0.018
Pml	promyelocytic leukemia	0.018
Trim30a	tripartite motif-containing 30A	0.017
Trim21	tripartite motif-containing 21	0.017
Htra2	HtrA serine peptidase 2	0.017
Skil	SKI-like	0.017
Wls	wntless homolog (Drosophila)	0.017
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.017
Map2k4	mitogen-activated protein kinase kinase 4	0.017
Sirt7	sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)	0.017
Stat6	signal transducer and activator of transcription 6	0.016
Hspa1b	heat shock protein 1B	0.016
Malt1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.016
Irf1	interferon regulatory factor 1	0.016
Fbxl6	F-box and leucine-rich repeat protein 6	0.016
Irak4	interleukin-1 receptor-associated kinase 4	0.015
Mep1a	meprin 1 alpha	0.015
Nmi	N-myc (and STAT) interactor	0.015
Ticam1	toll-like receptor adaptor molecule 1	0.015
Adam10	a disintegrin and metallopeptidase domain 10	0.015
Apaf1	apoptotic peptidase activating factor 1	0.014
5033414D02Rik	RIKEN cDNA 5033414D02 gene	0.014
Ctsl	cathepsin L	0.014
Irgm1	immunity-related GTPase family M member 1	0.014
Apeh	acylpeptide hydrolase	0.013
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.013
Wrn	Werner syndrome homolog (human)	0.013
Sri	sorcin	0.013
Anxa4	annexin A4	0.013
Eml3	echinoderm microtubule associated protein like 3	0.013
Parp14	poly (ADP-ribose) polymerase family, member 14	0.012
Zufsp	zinc finger with UFM1-specific peptidase domain	0.012
AI607873	expressed sequence AI607873	0.012
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.012
Prf1	perforin 1 (pore forming protein)	0.012
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.011
Pla2g4a	phospholipase A2, group IVA (cytosolic, calcium-dependent)	0.011
AW112010	expressed sequence AW112010	0.011
Ifnar1	interferon (alpha and beta) receptor 1	0.011
Nfya	nuclear transcription factor-Y alpha	0.011
Casp12	caspase 12	0.011	Mouse
Hdgf	hepatoma-derived growth factor	0.011
Pqlc3	PQ loop repeat containing	0.010
Leprot	leptin receptor overlapping transcript	0.010