IMP

Process View

Mus musculus

11 genes annotated in mouse

cellular senescence

A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular senescence"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular senescence" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	1.000	Human
Pten	phosphatase and tensin homolog	1.000
Igh	immunoglobulin heavy chain complex	0.961
Id1	inhibitor of DNA binding 1	0.922	Mouse
Id3	inhibitor of DNA binding 3	0.898	Mouse
Apc	adenomatosis polyposis coli	0.895
Clock	circadian locomotor output cycles kaput	0.882
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.834
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.831
Ahr	aryl-hydrocarbon receptor	0.820
Mdm2	transformed mouse 3T3 cell double minute 2	0.789
Skil	SKI-like	0.740
Mapk14	mitogen-activated protein kinase 14	0.713	Human
Esr1	estrogen receptor 1 (alpha)	0.688
Nf1	neurofibromatosis 1	0.638
Tcf3	transcription factor 3	0.399
Ctnnb1	catenin (cadherin associated protein), beta 1	0.396
Per2	period homolog 2 (Drosophila)	0.381
Braf	Braf transforming gene	0.364
Smad4	MAD homolog 4 (Drosophila)	0.364
Mdm4	transformed mouse 3T3 cell double minute 4	0.350
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.347
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.251
Ccnd2	cyclin D2	0.217
Ccnd1	cyclin D1	0.205
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.189
Tgfbr2	transforming growth factor, beta receptor II	0.185	Mouse
Cry1	cryptochrome 1 (photolyase-like)	0.182
Eng	endoglin	0.152
Smad6	MAD homolog 6 (Drosophila)	0.138
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.125
Ric8	resistance to inhibitors of cholinesterase 8 homolog (C. elegans)	0.124
Trp73	transformation related protein 73	0.123
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.122
Runx1	runt related transcription factor 1	0.120
Rb1	retinoblastoma 1	0.103
Kiss1	KiSS-1 metastasis-suppressor	0.100
Raf1	v-raf-leukemia viral oncogene 1	0.086
Cry2	cryptochrome 2 (photolyase-like)	0.081
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.079	Human
Tgfbr1	transforming growth factor, beta receptor I	0.066	Mouse
Shc1	src homology 2 domain-containing transforming protein C1	0.066
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.064
Dok1	docking protein 1	0.064
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.064
Ptch1	patched homolog 1	0.062
Atf2	activating transcription factor 2	0.061
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.061
Gnrh1	gonadotropin releasing hormone 1	0.060
Ar	androgen receptor	0.057
Acvr1	activin A receptor, type 1	0.056	Mouse
Abl2	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	0.052	Mouse
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.052
Ece1	endothelin converting enzyme 1	0.050
Tcf4	transcription factor 4	0.050
Xiap	X-linked inhibitor of apoptosis	0.049
Cd40	CD40 antigen	0.048
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.043
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.043
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.042
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.041
Rc3h1	RING CCCH (C3H) domains 1	0.041
Stk11	serine/threonine kinase 11	0.039
Hes1	hairy and enhancer of split 1 (Drosophila)	0.039
Cdh5	cadherin 5	0.038
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.037
Npas2	neuronal PAS domain protein 2	0.037
Sox9	SRY-box containing gene 9	0.037
Daxx	Fas death domain-associated protein	0.033
Mapk11	mitogen-activated protein kinase 11	0.032
Ikzf1	IKAROS family zinc finger 1	0.031
Hsp90b1	heat shock protein 90, beta (Grp94), member 1	0.031
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.031
Psen1	presenilin 1	0.030
Bcl6	B-cell leukemia/lymphoma 6	0.030
Smad7	MAD homolog 7 (Drosophila)	0.028
Tgfb1	transforming growth factor, beta 1	0.028
Srebf2	sterol regulatory element binding factor 2	0.027
Nbn	nibrin	0.027
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.026
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.026
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.025
Yap1	yes-associated protein 1	0.025
Cdk4	cyclin-dependent kinase 4	0.025
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.025
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.024
En1	engrailed 1	0.024
Foxp3	forkhead box P3	0.023
Vegfa	vascular endothelial growth factor A	0.023
Csf1	colony stimulating factor 1 (macrophage)	0.023
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.022
Sim1	single-minded homolog 1 (Drosophila)	0.022
Ghr	growth hormone receptor	0.022
Map2k2	mitogen-activated protein kinase kinase 2	0.021
Thbs1	thrombospondin 1	0.021
Cdc34	cell division cycle 34 homolog (S. cerevisiae)	0.020
Met	met proto-oncogene	0.020
Foxc1	forkhead box C1	0.020
Tbx4	T-box 4	0.019
Rara	retinoic acid receptor, alpha	0.019
Huwe1	HECT, UBA and WWE domain containing 1	0.018
Ep300	E1A binding protein p300	0.018
Mapkapk2	MAP kinase-activated protein kinase 2	0.017	Mouse
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.017
Fmn1	formin 1	0.017
Foxo3	forkhead box O3	0.017
Ncoa3	nuclear receptor coactivator 3	0.016
Kiss1r	KISS1 receptor	0.015
Tsc1	tuberous sclerosis 1	0.015
Inhbb	inhibin beta-B	0.015
Rbl2	retinoblastoma-like 2	0.015
Tnf	tumor necrosis factor	0.015
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.015
Vasp	vasodilator-stimulated phosphoprotein	0.014
Smad3	MAD homolog 3 (Drosophila)	0.014
Socs5	suppressor of cytokine signaling 5	0.014
Notch2	Notch gene homolog 2 (Drosophila)	0.014
E2f1	E2F transcription factor 1	0.014
Kpna1	karyopherin (importin) alpha 1	0.013
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.013
Fbn1	fibrillin 1	0.012
Smn1	survival motor neuron 1	0.012
Pkdcc	protein kinase domain containing, cytoplasmic	0.012
Magea5	melanoma antigen, family A, 5	0.012	Human
Nos3	nitric oxide synthase 3, endothelial cell	0.012
Xpa	xeroderma pigmentosum, complementation group A	0.012
Stat3	signal transducer and activator of transcription 3	0.012
Stk4	serine/threonine kinase 4	0.011
Twist1	twist homolog 1 (Drosophila)	0.011	Human
Eif4a1	eukaryotic translation initiation factor 4A1	0.011
Notch1	Notch gene homolog 1 (Drosophila)	0.011
Aicda	activation-induced cytidine deaminase	0.011
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.011
Prdm1	PR domain containing 1, with ZNF domain	0.011
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.011
Traf3ip2	TRAF3 interacting protein 2	0.011
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.011
Mapk9	mitogen-activated protein kinase 9	0.011
Hip1	huntingtin interacting protein 1	0.010
Bmp2	bone morphogenetic protein 2	0.010
Obfc2b	oligonucleotide/oligosaccharide-binding fold containing 2B	0.010
Rint1	RAD50 interactor 1	0.010
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.010
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.010
Jun	Jun oncogene	0.010
Msh2	mutS homolog 2 (E. coli)	0.010
Tgfbr3	transforming growth factor, beta receptor III	0.010