IMP

Process View

Mus musculus

21 genes annotated in mouse

necroptotic process

A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "necroptotic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "necroptotic process" (in gray)

Name	Description	Probability	Func Analog Organism
Tnf	tumor necrosis factor	1.000
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.999	Mouse
Casp8	caspase 8	0.999
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.991	Mouse
Ikbkg	inhibitor of kappaB kinase gamma	0.969
Tlr4	toll-like receptor 4	0.952
Traf2	TNF receptor-associated factor 2	0.928
Il10	interleukin 10	0.913
Itch	itchy, E3 ubiquitin protein ligase	0.901
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.886
Myd88	myeloid differentiation primary response gene 88	0.835
Ikbkb	inhibitor of kappaB kinase beta	0.811
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.771
Fadd	Fas (TNFRSF6)-associated via death domain	0.765
Cd40	CD40 antigen	0.754
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.694
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.631
Lta	lymphotoxin A	0.609	Mouse
Traf6	TNF receptor-associated factor 6	0.604
Bcl3	B-cell leukemia/lymphoma 3	0.577
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.554
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.544
Casp1	caspase 1	0.448	Mouse
Gbp5	guanylate binding protein 5	0.438
Nlrp3	NLR family, pyrin domain containing 3	0.435
Ripk3	receptor-interacting serine-threonine kinase 3	0.418
Sharpin	SHANK-associated RH domain interacting protein	0.392	Mouse
Rnf31	ring finger protein 31	0.353
Hccs	holocytochrome c synthetase	0.351
Fas	Fas (TNF receptor superfamily member 6)	0.347
Cd19	CD19 antigen	0.326
Pten	phosphatase and tensin homolog	0.317
Pycard	PYD and CARD domain containing	0.314
Il7	interleukin 7	0.295
Trp53	transformation related protein 53	0.260
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.259
Tox	thymocyte selection-associated high mobility group box	0.247
Ifng	interferon gamma	0.247
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.237
Il6st	interleukin 6 signal transducer	0.230
Il1r1	interleukin 1 receptor, type I	0.227
Aim2	absent in melanoma 2	0.225
Hif1a	hypoxia inducible factor 1, alpha subunit	0.218
C1qbp	complement component 1, q subcomponent binding protein	0.203
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.179
Stim2	stromal interaction molecule 2	0.159
Casp7	caspase 7	0.154	Mouse
Igh	immunoglobulin heavy chain complex	0.147
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.146	Mouse
Cyld	cylindromatosis (turban tumor syndrome)	0.145
Lrrk2	leucine-rich repeat kinase 2	0.137
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.119
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.106
Tlr2	toll-like receptor 2	0.098
Casp3	caspase 3	0.096	Mouse
Ahr	aryl-hydrocarbon receptor	0.093
Cxcl13	chemokine (C-X-C motif) ligand 13	0.091
Ptgs2	prostaglandin-endoperoxide synthase 2	0.087
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.083
Il6	interleukin 6	0.079
Card11	caspase recruitment domain family, member 11	0.078
Stat3	signal transducer and activator of transcription 3	0.076
2310061I04Rik	RIKEN cDNA 2310061I04 gene	0.071
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.070	Mouse
Sfn	stratifin	0.070
Prkcd	protein kinase C, delta	0.065
Mlkl	mixed lineage kinase domain-like	0.060
Il18	interleukin 18	0.059
Cd44	CD44 antigen	0.059
Emx1	empty spiracles homolog 1 (Drosophila)	0.057
Bcl6	B-cell leukemia/lymphoma 6	0.051
Ly96	lymphocyte antigen 96	0.049
Il15	interleukin 15	0.049
Ticam1	toll-like receptor adaptor molecule 1	0.048
Ctnnb1	catenin (cadherin associated protein), beta 1	0.047
Socs1	suppressor of cytokine signaling 1	0.045
Il1b	interleukin 1 beta	0.044
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.044
Rel	reticuloendotheliosis oncogene	0.043
Naip2	NLR family, apoptosis inhibitory protein 2	0.042
Icos	inducible T-cell co-stimulator	0.041
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.039
Rb1	retinoblastoma 1	0.038
Aldh2	aldehyde dehydrogenase 2, mitochondrial	0.036
Il2ra	interleukin 2 receptor, alpha chain	0.036
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.035
Csf1	colony stimulating factor 1 (macrophage)	0.034
Apoe	apolipoprotein E	0.034
Ccl2	chemokine (C-C motif) ligand 2	0.033
Ltb	lymphotoxin B	0.031
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.030
Irf6	interferon regulatory factor 6	0.030
Pdcd1lg2	programmed cell death 1 ligand 2	0.029
Psen1	presenilin 1	0.028
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.028
Eya2	eyes absent 2 homolog (Drosophila)	0.027
Slc4a7	solute carrier family 4, sodium bicarbonate cotransporter, member 7	0.026
Naip6	NLR family, apoptosis inhibitory protein 6	0.025	Mouse
Gja1	gap junction protein, alpha 1	0.023
Smad5	MAD homolog 5 (Drosophila)	0.022
Lyz2	lysozyme 2	0.022
Gbp1	guanylate binding protein 1	0.022
Cd160	CD160 antigen	0.021
Rbl1	retinoblastoma-like 1 (p107)	0.021
Vegfb	vascular endothelial growth factor B	0.021
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.021
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.021
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.020
Ubd	ubiquitin D	0.020
Gbp7	guanylate binding protein 7	0.020
Irf1	interferon regulatory factor 1	0.018
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.018
Htra2	HtrA serine peptidase 2	0.018
Mrpl3	mitochondrial ribosomal protein L3	0.017
Ccl1	chemokine (C-C motif) ligand 1	0.017
Diablo	diablo homolog (Drosophila)	0.017
Cd28	CD28 antigen	0.017
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.017
Prf1	perforin 1 (pore forming protein)	0.016
Il2	interleukin 2	0.016
Cd40lg	CD40 ligand	0.016	Mouse
Eml3	echinoderm microtubule associated protein like 3	0.016
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.016
Mvp	major vault protein	0.016
Irak3	interleukin-1 receptor-associated kinase 3	0.016
Vwa5a	von Willebrand factor A domain containing 5A	0.015
Dsg4	desmoglein 4	0.015
Ltbr	lymphotoxin B receptor	0.015
Pdcd1	programmed cell death 1	0.015
Rbck1	RanBP-type and C3HC4-type zinc finger containing 1	0.015
Traf3ip2	TRAF3 interacting protein 2	0.014
Stat6	signal transducer and activator of transcription 6	0.014
Malt1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.014
Trim30d	tripartite motif-containing 30D	0.014
Skil	SKI-like	0.014
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.014
Birc3	baculoviral IAP repeat-containing 3	0.014
Mdm2	transformed mouse 3T3 cell double minute 2	0.013
Oas3	2'-5' oligoadenylate synthetase 3	0.013
Nos2	nitric oxide synthase 2, inducible	0.013
Btk	Bruton agammaglobulinemia tyrosine kinase	0.013
Hhat	hedgehog acyltransferase	0.013
Kpna3	karyopherin (importin) alpha 3	0.013
Il1a	interleukin 1 alpha	0.013
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.013	Mouse
Fkbp3	FK506 binding protein 3	0.013
Atp11c	ATPase, class VI, type 11C	0.012
Fgl2	fibrinogen-like protein 2	0.012
Cd80	CD80 antigen	0.012
Ccl4	chemokine (C-C motif) ligand 4	0.012
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.012
Il12rb1	interleukin 12 receptor, beta 1	0.012
Cd274	CD274 antigen	0.012
Prss30	protease, serine, 30	0.012
Bid	BH3 interacting domain death agonist	0.012
Ifnar1	interferon (alpha and beta) receptor 1	0.011
Notch2	Notch gene homolog 2 (Drosophila)	0.011
Atp5b	ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit	0.011
Xrn1	5'-3' exoribonuclease 1	0.011
Il22	interleukin 22	0.011
Ubc	ubiquitin C	0.011
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.011
Batf	basic leucine zipper transcription factor, ATF-like	0.011
Eef1a2	eukaryotic translation elongation factor 1 alpha 2	0.011
Gzmc	granzyme C	0.011
Ly75	lymphocyte antigen 75	0.010
Ctsl	cathepsin L	0.010
Stx11	syntaxin 11	0.010
Hr	hairless	0.010
Ehf	ets homologous factor	0.010
Cdh17	cadherin 17	0.010
Tlr7	toll-like receptor 7	0.010
Cdh1	cadherin 1	0.010
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.010