IMP

Process View

Mus musculus

9 genes annotated in mouse

regulation of cell aging

Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of cell aging"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of cell aging" (in gray)

Name	Description	Probability	Func Analog Organism
Pten	phosphatase and tensin homolog	0.977
Trp53	transformation related protein 53	0.946
Acvr1	activin A receptor, type 1	0.905	Mouse
Ahr	aryl-hydrocarbon receptor	0.564
Fbn1	fibrillin 1	0.511
Apc	adenomatosis polyposis coli	0.487
Smad4	MAD homolog 4 (Drosophila)	0.328
Clock	circadian locomotor output cycles kaput	0.239
Tgfbr2	transforming growth factor, beta receptor II	0.218	Mouse
Eng	endoglin	0.197
Ptk2	PTK2 protein tyrosine kinase 2	0.167
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.153
Smad3	MAD homolog 3 (Drosophila)	0.107
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.106
Ctnnb1	catenin (cadherin associated protein), beta 1	0.102
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.086
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.073
Nf1	neurofibromatosis 1	0.070
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.063
Tgfbr3	transforming growth factor, beta receptor III	0.061
Ric8	resistance to inhibitors of cholinesterase 8 homolog (C. elegans)	0.061
Vegfa	vascular endothelial growth factor A	0.056
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.055
Ccnd2	cyclin D2	0.055
Trp73	transformation related protein 73	0.052	Mouse
Cdh5	cadherin 5	0.051
Sox9	SRY-box containing gene 9	0.046
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.045
Fgfr1	fibroblast growth factor receptor 1	0.043
En1	engrailed 1	0.041
Ccnd1	cyclin D1	0.039
Nos3	nitric oxide synthase 3, endothelial cell	0.039
Smo	smoothened homolog (Drosophila)	0.037
Notch1	Notch gene homolog 1 (Drosophila)	0.037
Shc1	src homology 2 domain-containing transforming protein C1	0.033
Yap1	yes-associated protein 1	0.032
Dok1	docking protein 1	0.029
Foxc1	forkhead box C1	0.029
Braf	Braf transforming gene	0.028
Pparg	peroxisome proliferator activated receptor gamma	0.028
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.028
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.027
Per2	period homolog 2 (Drosophila)	0.027
Npas2	neuronal PAS domain protein 2	0.025
Hoxa3	homeobox A3	0.025
Tgfbr1	transforming growth factor, beta receptor I	0.025	Mouse
Ece1	endothelin converting enzyme 1	0.023
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.023
Gata4	GATA binding protein 4	0.022
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.021
Tgfb2	transforming growth factor, beta 2	0.021
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.020
Smn1	survival motor neuron 1	0.020
Prkg1	protein kinase, cGMP-dependent, type I	0.019
Pcmtd2	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	0.018
Fgf8	fibroblast growth factor 8	0.018
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.018
Igh	immunoglobulin heavy chain complex	0.017
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.016
Vcl	vinculin	0.016
Xiap	X-linked inhibitor of apoptosis	0.016
Rxra	retinoid X receptor alpha	0.016
Pdgfb	platelet derived growth factor, B polypeptide	0.016
Emx1	empty spiracles homolog 1 (Drosophila)	0.015
Ank	progressive ankylosis	0.015
Rara	retinoic acid receptor, alpha	0.014
Smad2	MAD homolog 2 (Drosophila)	0.014
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.014
Skil	SKI-like	0.013
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.013
Abl2	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	0.013	Mouse
Aplnr	apelin receptor	0.013
Hif1a	hypoxia inducible factor 1, alpha subunit	0.013
Meox2	mesenchyme homeobox 2	0.013
Mapk8	mitogen-activated protein kinase 8	0.012
Prdm1	PR domain containing 1, with ZNF domain	0.012
Cry2	cryptochrome 2 (photolyase-like)	0.012
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.012
Rc3h1	RING CCCH (C3H) domains 1	0.012
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.012	Mouse
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.011
Bmp2	bone morphogenetic protein 2	0.011
Hipk3	homeodomain interacting protein kinase 3	0.011
Esr1	estrogen receptor 1 (alpha)	0.011
Smad6	MAD homolog 6 (Drosophila)	0.011
Rarg	retinoic acid receptor, gamma	0.011
Wnt3a	wingless-related MMTV integration site 3A	0.011
Ghr	growth hormone receptor	0.011
Mapk14	mitogen-activated protein kinase 14	0.010
Pno1	partner of NOB1 homolog (S. cerevisiae)	0.010
Vhl	von Hippel-Lindau tumor suppressor	0.010
Otx2	orthodenticle homolog 2 (Drosophila)	0.010
Klhl7	kelch-like 7 (Drosophila)	0.010
Prrx2	paired related homeobox 2	0.010
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.010
Hes1	hairy and enhancer of split 1 (Drosophila)	0.010
Gli3	GLI-Kruppel family member GLI3	0.010
Sh3pxd2b	SH3 and PX domains 2B	0.010