IMP

Process View

Mus musculus

6 genes annotated in mouse

Multi-species View

regulation of cellular senescence

GO:2000772

Any process that modulates the frequency, rate or extent of cellular senescence.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of cellular senescence"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of cellular senescence" (in gray)

Name	Description	Probability	Func Analog Organism
Tgfbr1	transforming growth factor, beta receptor I	0.970	Mouse
Tgfbr2	transforming growth factor, beta receptor II	0.970	Mouse
Trp53	transformation related protein 53	0.927
Pten	phosphatase and tensin homolog	0.925
Ahr	aryl-hydrocarbon receptor	0.831
Apc	adenomatosis polyposis coli	0.735
Cry1	cryptochrome 1 (photolyase-like)	0.691
Acvr1	activin A receptor, type 1	0.651	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.388
Clock	circadian locomotor output cycles kaput	0.375
Eng	endoglin	0.329
Vegfa	vascular endothelial growth factor A	0.273
Smad4	MAD homolog 4 (Drosophila)	0.229
Ccnd1	cyclin D1	0.191
Shc1	src homology 2 domain-containing transforming protein C1	0.186
Cdh5	cadherin 5	0.179
Ric8	resistance to inhibitors of cholinesterase 8 homolog (C. elegans)	0.171
Ece1	endothelin converting enzyme 1	0.159
Ccnd2	cyclin D2	0.153
Sox9	SRY-box containing gene 9	0.140
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.139
Esr1	estrogen receptor 1 (alpha)	0.135
Kiss1r	KISS1 receptor	0.123
Ctnnb1	catenin (cadherin associated protein), beta 1	0.084
Ar	androgen receptor	0.082
Ghr	growth hormone receptor	0.080
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.077
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.077
Kiss1	KiSS-1 metastasis-suppressor	0.072
Rara	retinoic acid receptor, alpha	0.072
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.071
Fgf8	fibroblast growth factor 8	0.070
Nf1	neurofibromatosis 1	0.069
Xiap	X-linked inhibitor of apoptosis	0.068
Nos3	nitric oxide synthase 3, endothelial cell	0.068
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.066
Per2	period homolog 2 (Drosophila)	0.064
Tgfbr3	transforming growth factor, beta receptor III	0.056
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.053
Skil	SKI-like	0.050
Gnrh1	gonadotropin releasing hormone 1	0.047
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.046
Tgfb2	transforming growth factor, beta 2	0.045
Diablo	diablo homolog (Drosophila)	0.045
Npas2	neuronal PAS domain protein 2	0.045
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.043
Ednra	endothelin receptor type A	0.042
Abl2	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	0.041	Mouse
Csf1	colony stimulating factor 1 (macrophage)	0.037
Igh	immunoglobulin heavy chain complex	0.034
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.032
Fbn1	fibrillin 1	0.031
Bmp2	bone morphogenetic protein 2	0.029
Dok1	docking protein 1	0.028
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.025
Foxc1	forkhead box C1	0.024
Hipk3	homeodomain interacting protein kinase 3	0.022
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.022
Cdk4	cyclin-dependent kinase 4	0.022
Hic1	hypermethylated in cancer 1	0.021
Hes1	hairy and enhancer of split 1 (Drosophila)	0.021
Ptk2	PTK2 protein tyrosine kinase 2	0.021
Myc	myelocytomatosis oncogene	0.021
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.020
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.020
Trp73	transformation related protein 73	0.019
Rc3h1	RING CCCH (C3H) domains 1	0.019
Smad5	MAD homolog 5 (Drosophila)	0.019
Mdm2	transformed mouse 3T3 cell double minute 2	0.019
Itgav	integrin alpha V	0.017
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.017	Mouse
Braf	Braf transforming gene	0.017
Prkg1	protein kinase, cGMP-dependent, type I	0.017
Hoxa3	homeobox A3	0.016
Mkl2	MKL/myocardin-like 2	0.016
Il2rg	interleukin 2 receptor, gamma chain	0.015
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.015
Prrx2	paired related homeobox 2	0.015
Kif3a	kinesin family member 3A	0.015
Vcl	vinculin	0.014
Irs2	insulin receptor substrate 2	0.014
Inhba	inhibin beta-A	0.014
Rarg	retinoic acid receptor, gamma	0.013
Rbl2	retinoblastoma-like 2	0.013
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.013
Il6st	interleukin 6 signal transducer	0.013
Jun	Jun oncogene	0.013
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.013
Hip1	huntingtin interacting protein 1	0.013
Ext1	exostoses (multiple) 1	0.012
Prrx1	paired related homeobox 1	0.012
Sdc3	syndecan 3	0.012
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.011
Npc1	Niemann Pick type C1	0.011
Prdm1	PR domain containing 1, with ZNF domain	0.011
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.011
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.011
Ep300	E1A binding protein p300	0.011
Stk11	serine/threonine kinase 11	0.011
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.010
Smad7	MAD homolog 7 (Drosophila)	0.010
Stat3	signal transducer and activator of transcription 3	0.010