IMP

Process View

Homo sapiens

16 genes annotated in human

Multi-species View

extracellular matrix disassembly

GO:0022617

A process that results in the breakdown of the extracellular matrix.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "extracellular matrix disassembly"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "extracellular matrix disassembly" (in gray)

Name	Description	Probability	Func Analog Organism
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.884
FGF1	fibroblast growth factor 1 (acidic)	0.865
FLOT2	flotillin 2	0.736	Human
FLOT1	flotillin 1	0.683
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.441
LAMB1	laminin, beta 1	0.283	Human
MAPK8	mitogen-activated protein kinase 8	0.190
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.188
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.137
TGFB1	transforming growth factor, beta 1	0.117
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.093
NCF2	neutrophil cytosolic factor 2	0.077
FGFR2	fibroblast growth factor receptor 2	0.070	Human
CTGF	connective tissue growth factor	0.065
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.065
COL11A2	collagen, type XI, alpha 2	0.053
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.053
CD63	CD63 molecule	0.050
TM4SF1	transmembrane 4 L six family member 1	0.049
CTSB	cathepsin B	0.049
PDIA3	protein disulfide isomerase family A, member 3	0.048
COL1A1	collagen, type I, alpha 1	0.045
CYBA	cytochrome b-245, alpha polypeptide	0.038
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.037
PSAP	prosaposin	0.035
PLAUR	plasminogen activator, urokinase receptor	0.034
SNAPIN	SNAP-associated protein	0.033
NCK2	NCK adaptor protein 2	0.033
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.032
GLRX	glutaredoxin (thioltransferase)	0.031
APP	amyloid beta (A4) precursor protein	0.028
TIMP1	TIMP metallopeptidase inhibitor 1	0.027
FGF10	fibroblast growth factor 10	0.027
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.025
FGF2	fibroblast growth factor 2 (basic)	0.023
COL5A2	collagen, type V, alpha 2	0.023
FGFR1	fibroblast growth factor receptor 1	0.023	Human
ADAM15	ADAM metallopeptidase domain 15	0.023
GAST	gastrin	0.022
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.022	Human
FAP	fibroblast activation protein, alpha	0.022
TGFB3	transforming growth factor, beta 3	0.021
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.021	Human
CXCL12	chemokine (C-X-C motif) ligand 12	0.020
POSTN	periostin, osteoblast specific factor	0.019
THBS2	thrombospondin 2	0.019
FRS2	fibroblast growth factor receptor substrate 2	0.018
LAMC2	laminin, gamma 2	0.018	Human
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.017
LOX	lysyl oxidase	0.017
SNX33	sorting nexin 33	0.017
THBS1	thrombospondin 1	0.016
TRIM9	tripartite motif containing 9	0.016
COL7A1	collagen, type VII, alpha 1	0.016
FGFR3	fibroblast growth factor receptor 3	0.015	Human
TNC	tenascin C	0.015
VCAN	versican	0.015
S100A2	S100 calcium binding protein A2	0.015
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.015
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.014	Human
CRP	C-reactive protein, pentraxin-related	0.014
CD68	CD68 molecule	0.013
PRMT6	protein arginine methyltransferase 6	0.013
GAA	glucosidase, alpha; acid	0.013
FBN1	fibrillin 1	0.013
PXDN	peroxidasin homolog (Drosophila)	0.013
CST2	cystatin SA	0.012	Human
HEXB	hexosaminidase B (beta polypeptide)	0.012
FGF7	fibroblast growth factor 7	0.012
NPC2	Niemann-Pick disease, type C2	0.012
LUM	lumican	0.012
INHBA	inhibin, beta A	0.012
CFB	complement factor B	0.012
PRKCD	protein kinase C, delta	0.012
COL6A3	collagen, type VI, alpha 3	0.012
TTR	transthyretin	0.012
PLAU	plasminogen activator, urokinase	0.011	Human
CST4	cystatin S	0.011	Human
CTSD	cathepsin D	0.011
DCN	decorin	0.011
SOS1	son of sevenless homolog 1 (Drosophila)	0.011
GPNMB	glycoprotein (transmembrane) nmb	0.010
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.010
CCL11	chemokine (C-C motif) ligand 11	0.010
CCL22	chemokine (C-C motif) ligand 22	0.010
FN1	fibronectin 1	0.010