IMP
Process View
wnt signaling pathway planar cell polarity pathway
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.
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Click on a gene's description to view its network relationships with genes known to be involved in "wnt signaling pathway planar cell polarity pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| LRRK2 | leucine-rich repeat kinase 2 | 0.941 | ||
| CDC42 | cell division cycle 42 (GTP binding protein, 25kDa) | 0.853 | ||
| RHOA | ras homolog gene family, member A | 0.802 | ||
| AFF1 | AF4/FMR2 family, member 1 | 0.598 | ||
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.319 | ||
| EGFR | epidermal growth factor receptor | 0.304 | ||
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.179 | ||
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.152 | Mouse | |
| AXIN1 | axin 1 | 0.106 | ||
| CSNK1E | casein kinase 1, epsilon | 0.085 | ||
| PARD6A | par-6 partitioning defective 6 homolog alpha (C. elegans) | 0.079 | ||
| MYO6 | myosin VI | 0.077 | ||
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.076 | ||
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.076 | ||
| CEP164 | centrosomal protein 164kDa | 0.074 | ||
| RIN1 | Ras and Rab interactor 1 | 0.072 | ||
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.062 | ||
| MED29 | mediator complex subunit 29 | 0.062 | ||
| DOT1L | DOT1-like, histone H3 methyltransferase (S. cerevisiae) | 0.059 | ||
| NCKAP1 | NCK-associated protein 1 | 0.058 | ||
| ZNF512B | zinc finger protein 512B | 0.056 | ||
| F11R | F11 receptor | 0.049 | ||
| TSG101 | tumor susceptibility gene 101 | 0.048 | ||
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.045 | ||
| DVL3 | dishevelled, dsh homolog 3 (Drosophila) | 0.043 | ||
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.042 | ||
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.042 | ||
| PRKCI | protein kinase C, iota | 0.038 | ||
| JAM3 | junctional adhesion molecule 3 | 0.036 | ||
| WT1 | Wilms tumor 1 | 0.032 | ||
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.032 | ||
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.032 | ||
| WNT3A | wingless-type MMTV integration site family, member 3A | 0.032 | ||
| PRKCZ | protein kinase C, zeta | 0.030 | ||
| ABI2 | abl-interactor 2 | 0.030 | ||
| SH3RF3 | SH3 domain containing ring finger 3 | 0.027 | ||
| JUB | jub, ajuba homolog (Xenopus laevis) | 0.027 | ||
| WASF1 | WAS protein family, member 1 | 0.026 | ||
| FGFR1 | fibroblast growth factor receptor 1 | 0.024 | ||
| AFF4 | AF4/FMR2 family, member 4 | 0.024 | ||
| SH3BGRL | SH3 domain binding glutamic acid-rich protein like | 0.023 | ||
| ATXN1 | ataxin 1 | 0.021 | ||
| JAM2 | junctional adhesion molecule 2 | 0.021 | ||
| MUC1 | mucin 1, cell surface associated | 0.019 | ||
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.019 | ||
| CDK19 | cyclin-dependent kinase 19 | 0.018 | ||
| FZD1 | frizzled homolog 1 (Drosophila) | 0.018 | Mouse | |
| GRB7 | growth factor receptor-bound protein 7 | 0.017 | ||
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.017 | Mouse Rat | |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.016 | ||
| CHN2 | chimerin (chimaerin) 2 | 0.016 | ||
| GSK3B | glycogen synthase kinase 3 beta | 0.016 | ||
| PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | 0.015 | ||
| MED24 | mediator complex subunit 24 | 0.015 | ||
| PIK3CB | phosphoinositide-3-kinase, catalytic, beta polypeptide | 0.015 | ||
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.014 | ||
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 0.014 | ||
| ARHGAP1 | Rho GTPase activating protein 1 | 0.014 | ||
| TNS4 | tensin 4 | 0.014 | ||
| DKK1 | dickkopf homolog 1 (Xenopus laevis) | 0.013 | ||
| SNIP1 | Smad nuclear interacting protein 1 | 0.013 | ||
| MSH5 | mutS homolog 5 (E. coli) | 0.013 | ||
| SPRR2A | small proline-rich protein 2A | 0.011 | ||
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.011 | ||
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.010 | ||
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.010 | Mouse Fly |