IMP

Process View

Homo sapiens

4 genes annotated in human

negative regulation of insulin like growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of insulin like growth factor receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of insulin like growth factor receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
BMPR1A	bone morphogenetic protein receptor, type IA	0.884
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.748
IGF2	insulin-like growth factor 2 (somatomedin A)	0.695
BMPR1B	bone morphogenetic protein receptor, type IB	0.479
INO80B	INO80 complex subunit B	0.437
BCAR1	breast cancer anti-estrogen resistance 1	0.374
C17orf28	chromosome 17 open reading frame 28	0.183
NOG	noggin	0.171
SORBS3	sorbin and SH3 domain containing 3	0.122
FSTL1	follistatin-like 1	0.121
COL1A1	collagen, type I, alpha 1	0.107
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.084
SPDEF	SAM pointed domain containing ets transcription factor	0.076
FBLN1	fibulin 1	0.070
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.070
ADAM12	ADAM metallopeptidase domain 12	0.064
SORBS1	sorbin and SH3 domain containing 1	0.056
BMP2	bone morphogenetic protein 2	0.053
ZFYVE9	zinc finger, FYVE domain containing 9	0.039
IGFBP5	insulin-like growth factor binding protein 5	0.038
PTRF	polymerase I and transcript release factor	0.034
IGF1	insulin-like growth factor 1 (somatomedin C)	0.029
EHD2	EH-domain containing 2	0.028
BMP4	bone morphogenetic protein 4	0.026	Human
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.026
HSPG2	heparan sulfate proteoglycan 2	0.025
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	0.023	Human
PRKCDBP	protein kinase C, delta binding protein	0.020
COL6A1	collagen, type VI, alpha 1	0.020
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.019
RTKN	rhotekin	0.018
HAND1	heart and neural crest derivatives expressed 1	0.018
LTBP3	latent transforming growth factor beta binding protein 3	0.018
PLAT	plasminogen activator, tissue	0.017
COL2A1	collagen, type II, alpha 1	0.017
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.017
CXCL14	chemokine (C-X-C motif) ligand 14	0.017
DLG5	discs, large homolog 5 (Drosophila)	0.017
GAS1	growth arrest-specific 1	0.016
FST	follistatin	0.016
RBPMS	RNA binding protein with multiple splicing	0.016
SOCS7	suppressor of cytokine signaling 7	0.016
FOXF1	forkhead box F1	0.016
MYL9	myosin, light chain 9, regulatory	0.016
FMOD	fibromodulin	0.016
LAMB2	laminin, beta 2 (laminin S)	0.015
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.015
SFRP4	secreted frizzled-related protein 4	0.014
PDLIM4	PDZ and LIM domain 4	0.014
RARG	retinoic acid receptor, gamma	0.014
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.014
COL4A2	collagen, type IV, alpha 2	0.013
HTRA1	HtrA serine peptidase 1	0.013
EFNB3	ephrin-B3	0.013
FHL2	four and a half LIM domains 2	0.013
RAB3IL1	RAB3A interacting protein (rabin3)-like 1	0.013
C10orf116	chromosome 10 open reading frame 116	0.013
CD34	CD34 molecule	0.013
TAGLN	transgelin	0.012
ISLR	immunoglobulin superfamily containing leucine-rich repeat	0.012
GPC3	glypican 3	0.012
BMP6	bone morphogenetic protein 6	0.012	Human
SOSTDC1	sclerostin domain containing 1	0.012
FLNC	filamin C, gamma	0.012
TF	transferrin	0.012
EDN1	endothelin 1	0.012
TGFB1	transforming growth factor, beta 1	0.012
AHNAK2	AHNAK nucleoprotein 2	0.012
FGF4	fibroblast growth factor 4	0.012
TIMP3	TIMP metallopeptidase inhibitor 3	0.011
PRRX2	paired related homeobox 2	0.011
COPZ2	coatomer protein complex, subunit zeta 2	0.011
CXCL12	chemokine (C-X-C motif) ligand 12	0.011
APOD	apolipoprotein D	0.011
PITX2	paired-like homeodomain 2	0.011
GAS6	growth arrest-specific 6	0.011
SOD3	superoxide dismutase 3, extracellular	0.011
C1R	complement component 1, r subcomponent	0.011
WISP2	WNT1 inducible signaling pathway protein 2	0.011
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.011
MYOC	myocilin, trabecular meshwork inducible glucocorticoid response	0.011
TPM2	tropomyosin 2 (beta)	0.011
GSTM5	glutathione S-transferase mu 5	0.010
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.010
ETNK2	ethanolamine kinase 2	0.010
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.010
INHBB	inhibin, beta B	0.010
SLC16A2	solute carrier family 16, member 2 (monocarboxylic acid transporter 8)	0.010
SH3D19	SH3 domain containing 19	0.010
SCUBE2	signal peptide, CUB domain, EGF-like 2	0.010
GLIS2	GLIS family zinc finger 2	0.010
BMP7	bone morphogenetic protein 7	0.010	Human
NKX3-2	NK3 homeobox 2	0.010
WNT11	wingless-type MMTV integration site family, member 11	0.010